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Medication-Assisted Treatment (MAT) Centers

Medication-Assisted Treatment (MAT) combines FDA-approved medications with counseling and behavioral therapies for comprehensive addiction care. MAT is the gold standard for opioid and alcohol use disorders, significantly reducing overdose deaths and improving treatment outcomes.

Found 13 treatment centers offering medication-assisted treatment (mat) across the United States.

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Showing 13 of 13 medication-assisted treatment (mat) treatment centers

Sioux Falls VAHCS
Sioux Falls, SD

Sioux Falls VAHCS, located in Sioux Falls, SD, delivers extensive addiction recovery programs for adults and adolescents. Their offerings include robust outpatient care, including detoxification and specialized services for those with co-occurring mental health and substance use conditions. Emphasizing strategies like 12-step facilitation, anger management techniques, and brief intervention methods, this center supports individuals who have faced intimate partner violence, trauma, or domestic abuse. Sioux Falls VAHCS welcomes both men and women, dedicated to providing excellent support for each person's path to healing.

Flandreau Santee Sioux Tribe

Situated in Flandreau, SD, the Flandreau Santee Sioux Tribe rehabilitation center specializes in treating substance use disorders along with co-existing mental health conditions in both adults and children. The center offers a variety of outpatient services, such as methadone or buprenorphine therapies, naltrexone treatment, anger management sessions, brief interventions, and cognitive behavioral therapy. It features customized programs for adult men, women, and clients facing dual diagnoses, addressing a wide spectrum of needs. Catering to adults and seniors of all genders, the Flandreau Santee Sioux Tribe center emphasizes high-quality care to foster long-term recovery and overall wellness.

Sioux Falls Treatment Center LLC

Located in Sioux Falls, SD, Sioux Falls Treatment Center LLC specializes in outpatient detox services and treatment for substance use disorders, offering methadone, buprenorphine, and naltrexone options for both adults and young adults. The center employs evidence-based techniques, including brief interventions, cognitive-behavioral therapy, and motivational incentives, making it distinct for its tailored treatment plans. Their commitment to quality care ensures a nurturing atmosphere for clients of all genders who are in search of effective, personalized support in overcoming addiction.

Volunteers of America Dakotas

Volunteers of America Dakotas, situated in Sioux Falls, SD, delivers thorough addiction recovery programs for adults and older individuals. This location features intensive outpatient therapy, extended stay residential accommodations, and standard outpatient services. Dedicated tracks exist for teenagers, adult women, and individuals who have faced traumatic experiences, allowing for tailored support. Employing methods like 12-step guidance, emotional regulation techniques, and short-term counseling, the facility prioritizes personalized recovery plans. Volunteers of America Dakotas accepts all genders, providing effective rehabilitation in an understanding and caring setting.

Wellfully Wellspring Inc

Wellfully Wellspring Inc, situated in Rapid City, SD, specializes in extensive substance use rehabilitation for both adults and youth facing co-occurring mental health challenges. The facility offers various programs, including hospital inpatient care, 24-hour inpatient services, and intensive outpatient options. Emphasizing methods like 12-step facilitation, anger management, and brief interventions, the center customizes its services to meet the distinct requirements of each client. Additionally, it features specialized programs for adolescents, as well as for victims of intimate partner violence, domestic abuse, and sexual trauma. Wellfully Wellspring Inc accommodates clients of all genders, fostering an inclusive and nurturing atmosphere. Discover exceptional care and tailored treatment at this prominent rehabilitation facility.

Sisseton Wahpeton Sioux Tribe

Nestled in Sisseton, SD, the Sisseton Wahpeton Sioux Tribe rehabilitation center provides diverse therapeutic interventions, encompassing addiction recovery, supportive housing, and sober living arrangements. The center features hospital-level inpatient services and intensive outpatient care, employing therapeutic modalities like 12-step integration, emotional regulation training, and cognitive behavioral techniques. Tailored services are available for adult men and women, individuals affected by intimate partner violence, and survivors of domestic abuse. This facility, which welcomes adult and young adult clients of all genders, delivers effective care within a culturally appreciative setting, representing a strong option for individuals pursuing all-encompassing addiction treatment.

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Situated in Rapid City, SD, the Addiction Recovery Centers of the provides an extensive array of substance abuse treatment services tailored for both adults and young adults. The center offers various treatment formats, including intensive outpatient therapy, outpatient care, and standard outpatient programs. By employing research-supported methodologies like 12-step approaches, cognitive behavioral therapy, and motivational incentives, this facility serves both men and women, including those with trauma backgrounds. With tailored programs catering to distinct genders and age categories, the center guarantees individualized attention and assistance for those aiming to conquer addiction.

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Anpetu Luta Otipi/Kyle Campus in Kyle, SD, delivers comprehensive, evidence-based addiction recovery solutions for individuals of all ages. They offer a spectrum of care including medical detox, intensive outpatient services, extended residential stays, and standard outpatient options. Employing proven methods like CBT, the Matrix Model, and motivational interviewing, the center customizes treatment plans to suit each person's unique journey. With dedicated tracks for youth, adult men, and adult women, Anpetu Luta Otipi/Kyle Campus provides inclusive and gender-affirming support. Renowned for its high-quality, individualized approach, this facility stands as a reliable resource for effective addiction treatment.

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Capital Area Counseling Services, located in Pierre, SD, provides expert treatment for adults facing substance use challenges alongside mental health disorders, as well as support for children dealing with significant emotional issues. Their wide-ranging programs feature intensive outpatient services and options for outpatient treatment using methadone, buprenorphine, or naltrexone. Employing proven methodologies such as brief interventions, cognitive behavioral therapy, and the Matrix Model, this center addresses the needs of adolescents, women, and those who have encountered trauma. With an emphasis on personalized care, it offers rehabilitation services to both men and women of various ages in a nurturing atmosphere.

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Situated in Sioux Falls, SD, Glory House of Sioux Falls provides extended residential care for adult males dealing with substance use issues. This center specializes in addressing the needs of individuals with concurrent mental health challenges, employing proven methods such as Cognitive Behavioral Therapy and the Matrix Model. Aiming to support clients who have undergone trauma, the program is designed for adults, seniors, and younger individuals in a nurturing and secure atmosphere. With options for transitional housing and sober living, Glory House of Sioux Falls is committed to delivering excellent support for those on their journey to overcome addiction and mental health difficulties.

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Huron, SD

Nestled in Huron, SD, Our Home Inc delivers a wide range of rehabilitation services aimed at individuals facing challenges related to substance abuse and concurrent mental health issues. The facility provides various treatment options, including hospital inpatient care, round-the-clock inpatient services, and extended residential programs. Its expertise lies in methods such as 12-step support, anger management strategies, and cognitive behavioral techniques. Additionally, the center offers specialized programs for teenagers, as well as for adults, children/adolescents, and young adults who are survivors of intimate partner violence, domestic violence, and sexual abuse. Our Home Inc is committed to offering personalized care and high-quality treatment, establishing itself as an excellent resource for those in need of effective rehabilitation services.

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Rapid City, SD

Situated in Rapid City, SD, Rapid City serves as a premier rehabilitation center that delivers extensive services for individuals dealing with substance use issues, transitional housing, and co-occurring mental health conditions. The center offers a variety of programs, including intensive outpatient services and outpatient care tailored for both adults and young adults, especially those who have faced traumatic experiences. Employing proven methodologies such as cognitive behavioral therapy and motivational interviewing, Rapid City provides a nurturing atmosphere for men and women who are on their journey to recovery. With an emphasis on personalized treatment and positive outcomes, this center is committed to supporting clients in achieving enduring sobriety and mental health stability.

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Sioux Falls, SD

Sands Freedom Center, situated in Sioux Falls, SD, delivers comprehensive evidence-based therapies for individuals battling substance use disorders and co-occurring mental health conditions. Their offerings encompass intensive outpatient, extended residential, and standard outpatient care, employing proven methods like cognitive behavioral therapy, Contingency management, and the Matrix Model. Sands Freedom Center is equipped to serve adult men and women, younger adults, and those who have endured trauma, providing bespoke support designed for each person's unique journey. This establishment prioritizes exceptional and individualized recovery paths, fostering a nurturing atmosphere for those pursuing healing and wellness.

Frequently Asked Questions

About Medication-Assisted Treatment (MAT)

Medication-Assisted Treatment (MAT) represents the gold standard for treating opioid and alcohol use disorders. By combining FDA-approved medications with counseling and behavioral therapies, MAT addresses both the biological and psychological aspects of addiction. Research consistently demonstrates that MAT reduces overdose deaths by more than 50%, improves treatment retention, and supports long-term recovery.

MAT Medications for Opioid Use Disorder

Three FDA-approved medications treat opioid addiction:

  • Methadone: Full opioid agonist eliminating withdrawal and cravings; administered daily at certified opioid treatment programs (OTPs). Longest track record with extensive research supporting effectiveness.
  • Buprenorphine (Suboxone, Sublocade): Partial opioid agonist with ceiling effect, reducing abuse potential; prescribed by certified physicians in office settings or as monthly injection. Offers greater flexibility and privacy.
  • Naltrexone (Vivitrol): Opioid antagonist blocking opioid effects; requires complete detox before starting; available as daily pill or monthly injection. Best for motivated individuals after detox completion.

MAT for Alcohol Use Disorder

FDA-approved medications for alcohol addiction:

  • Naltrexone: Reduces cravings and blocks rewarding effects of alcohol; available as daily pill or monthly injection
  • Acamprosate (Campral): Helps restore brain chemistry balance; reduces cravings and supports abstinence
  • Disulfiram (Antabuse): Causes unpleasant reaction if alcohol consumed; provides deterrent for impulsive drinking

Comprehensive Treatment Approach

MAT is never medication alone. Quality programs integrate counseling, behavioral therapies, case management, recovery support services, treatment for co-occurring conditions, and peer support. The medication component allows individuals to engage fully in therapy and recovery activities by eliminating withdrawal, cravings, and physiological barriers to recovery.

Addressing Stigma and Misconceptions

MAT faces unfortunate stigma, with some viewing it as "replacing one drug with another." This is false. MAT medications are prescribed at stable therapeutic doses, don't produce euphoria, allow normal functioning, and are medicine treating a medical condition. Research overwhelming supports MAT as most effective treatment for opioid use disorder. Organizations like SAMHSA, NIDA, and medical professional societies strongly endorse MAT.

Finding MAT Treatment

Look for programs offering multiple MAT medication options, addiction medicine physicians, comprehensive counseling services, individualized treatment planning, support for long-term medication management, and evidence-based behavioral therapies. Our directory helps locate opioid treatment centers and programs offering MAT.

MAT resources and information:

Find Medication-Assisted Treatment (MAT) by State

Browse medication-assisted treatment (mat) programs in states with the most treatment options:

Medically ReviewedUpdated: February 2026
Sources:SAMHSANIDACDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)