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Medically Reviewed Content
Updated: August 2026
Sources: SAMHSA, NIDA

Depression & Addiction Treatment Centers Near You

Depression and addiction frequently co-occur, requiring integrated treatment approaches. Find dual diagnosis treatment centers addressing both mental health and substance use disorders through coordinated care and evidence-based therapies.

Found 7,770 rehab centers specializing in depression across the United States.

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Find Depression and Addiction Treatment Centers Near You

Browse dual diagnosis treatment centers below. Filter for programs treating depression and substance abuse together.

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Middletown Clinic
Middletown, NY

Situated in Middletown, NY, the Middletown Clinic delivers extensive outpatient services for adults and seniors dealing with substance use issues. The center features targeted programs designed for men, women, and individuals who have faced sexual abuse. Treatment modalities encompass 12-step facilitation, brief interventions, and cognitive behavioral therapy, ensuring that care is tailored to each individual's needs. With options for outpatient methadone/buprenorphine or naltrexone treatment, the facility addresses a wide range of client requirements. The Middletown Clinic emphasizes high-quality care and personalized programs, serving as a crucial support system for those pursuing effective addiction recovery.

Midwest Detox Center

Midwest Detox Center, situated in Maumee, OH, delivers extensive addiction recovery solutions for adolescents and adults. Their offerings encompass detoxification protocols, comprehensive substance use disorder therapy, and targeted interventions for individuals facing dual diagnoses of substance abuse and significant mental health conditions or severe emotional disturbances in youth. The center provides a range of treatment modalities, including extended residential stays, partial hospitalization programs, and standard outpatient services, accommodating a wide spectrum of recovery requirements. Dedicated programs are also available for active military members, adult men, and adult women. Employing therapeutic strategies like 12-step integration, emotional regulation training, and short-term counseling, Midwest Detox Center is committed to personalized treatment plans. This establishment fosters a nurturing setting conducive to healing and enhances overall wellness.

Midwest Recovery Center

Midwest Recovery Center, based in Toledo, OH, delivers a diverse array of rehabilitation services. This center focuses on treating substance use issues and effectively manages co-occurring disorders related to drug and alcohol abuse as well as mental health challenges. The offerings include intensive outpatient programs, standard outpatient services, and day treatment. Utilizing methods like 12-step programs, anger management strategies, and brief therapeutic interventions, the facility serves both adults and young adults from various backgrounds. Additionally, specialized programs are available for active-duty military personnel, men, and women. Midwest Recovery Center is committed to offering exceptional care and guidance to assist individuals in their recovery process.

Milestone Recovery

Milestone Recovery, situated in Phoenix, AZ, delivers a full spectrum of addiction treatment for adults and adolescents. The center features intensive outpatient, extended residential stays, and outpatient services, emphasizing 12-step principles, emotional regulation techniques, and short-term counseling. Tailored programs are available for military personnel, adult males, and adult females, guaranteeing personalized support. Beyond substance abuse, Milestone Recovery also manages dual-diagnosis conditions affecting adults and youths. Committed to high standards of care, Milestone Recovery is devoted to guiding individuals toward lasting sobriety.

Milford Counseling Inc

Milford Counseling Inc, located in Milford, MI, delivers a complete spectrum of substance abuse treatment options. Their offerings include intensive outpatient, standard outpatient, and flexible outpatient programs. Employing strategies like 12-step facilitation, anger management techniques, and brief intervention, they serve a diverse clientele, encompassing adults, young people, men, and women. Specialized adolescent programs and gender-specific support groups are also available, providing personalized recovery journeys. Milford Counseling Inc is dedicated to providing high-quality assistance and resources for individuals pursuing sobriety, transitional living, or needing halfway house services.

Mill Creek Community Hospital

Mill Creek Community Hospital located in Erie, PA, offers a wide range of addiction recovery services. This facility provides inpatient detoxification, around-the-clock hospital care, and intensive outpatient programs, designed for both adults and young adults battling substance use issues. The center employs methods such as 12-step facilitation, cognitive-behavioral therapy, and brief interventions to deliver personalized treatment. With dedicated programs for active military personnel and specific groups of adult men and women, Mill Creek Community Hospital ensures that treatment is both gender-specific and age-appropriate. Clients can look forward to receiving high-quality, evidence-based support tailored to meet their individual needs at this esteemed rehabilitation facility.

MidMichigan Community Health Services

MidMichigan Community Health Services, located in Houghton Lake, MI, delivers specialized outpatient care focused on substance dependency, detoxification, and the management of co-occurring mental health conditions for individuals of all ages. Their services encompass outpatient detox, medication-assisted treatment using methadone, buprenorphine, and naltrexone. Therapeutic modalities employed include 12-step facilitation, brief intervention, and cognitive behavioral therapy. The center is equipped to assist adult men and women, including survivors of intimate partner violence, and offers gender-specific programming for adults and young adults. A commitment to exceptional care and personalized recovery strategies is central to their mission.

Milestone Addiction Treatment LLC

Milestone Addiction Treatment LLC, located in Merchantville, NJ, delivers a full spectrum of care for individuals struggling with substance use disorders. They offer various levels of outpatient treatment, including intensive, standard, and regular programs, all customized to meet each client's specific requirements. Their treatment methodologies emphasize 12-step principles, anger management techniques, and brief intervention strategies, making them well-equipped to address co-occurring mental health conditions. Additionally, Milestone Addiction Treatment LLC provides targeted support for active military personnel, adult men, and women. The center is open to all genders, fostering a welcoming atmosphere conducive to successful recovery.

Miller Care Group
Indianapolis, IN

Miller Care Group, situated in Indianapolis, IN, provides extensive support for those battling addiction and co-occurring mental health issues. Their offerings include intensive outpatient care, standard outpatient services, and outpatient detox, all employing proven methods like 12-step guidance, emotional regulation techniques, and short-term intervention strategies. Tailored programs are available for active military personnel, younger individuals, and adult men, serving a broad spectrum of ages from adults to seniors across all genders. Miller Care Group stands as a dependable institution dedicated to offering superior care and fostering sustained recovery and emotional well-being.

Mind Over Matter Therapeutic Servs LLC

Mind Over Matter Therapeutic Servs LLC in Tompkinsville, KY, provides extensive care for addiction and co-occurring mental health issues. Their services include intensive outpatient, outpatient, and standard outpatient programs, employing methods like anger management, CBT, and the Matrix Model. Tailored for adolescents, adult men, and adult women, the center also accommodates adults and seniors, aiming to deliver effective recovery support across various demographics.

Middle Peninsula/Northern Neck CSB

Middle Peninsula/Northern Neck CSB in Gloucester, VA, delivers extensive addiction treatment for individuals of all ages facing co-occurring mental health challenges. Their services include robust outpatient options and intensive programs, complemented by detoxification support. Employing methods like 12-step facilitation and anger management, they craft customized recovery plans. Dedicated tracks for teens and older adults, alongside specialized care for those with concurrent pain and substance use issues, underscore their commitment to all-encompassing recovery. Prioritizing excellence and individualized support, this center is devoted to guiding clients toward lasting wellness.

Mile High Behavioral Healthcare

Nestled in Westminster, Colorado, Mile High Behavioral Healthcare is dedicated to providing specialized care for adults struggling with substance use disorders, with a particular emphasis on individuals experiencing co-occurring serious mental health conditions. The center features a range of residential treatment options, including extended stays, continuous 24-hour supervision, and shorter program durations. Employing evidence-based strategies such as 12-step facilitation and anger management techniques, the facility is equipped to support adult women who have experienced intimate partner violence, domestic abuse, or sexual trauma. Mile High Behavioral Healthcare serves a diverse clientele encompassing adults, seniors, and young adults, cultivating a secure and nurturing setting for women pursuing thorough recovery. Discover personalized attention and impactful therapeutic interventions at Mile High Behavioral Healthcare.

Mile High Council on Alcoholism and

The Mile High Council on Alcoholism, situated in Denver, CO, delivers extensive substance abuse services for individuals of all ages, addressing co-occurring mental health conditions. They offer various levels of care, including intensive outpatient, outpatient, and medication-assisted treatment with methadone or buprenorphine. Employing proven methods such as cognitive behavioral therapy and community reinforcement, the center has distinct programs for teenagers, adult men, and women, welcoming diverse populations. Support extends to transitional housing and halfway house arrangements, fostering a nurturing atmosphere for recovery. Committed to serving adults and seniors across all gender identities, this facility is dedicated to providing personalized, high-quality care.

Milestones
Corvallis, OR

Nestled in Corvallis, OR, Milestones stands as a beacon of comprehensive care for those battling substance use disorders. We cultivate a nurturing atmosphere where individuals can embark on their journey to recovery. Our facility offers a spectrum of treatment durations, encompassing extended stays, shorter programs, and round-the-clock residential support. Milestones extends its specialized services to adult women, active duty military personnel, and survivors of intimate partner violence, acknowledging and addressing unique challenges. Our therapeutic framework integrates proven methodologies such as 12-step facilitation, anger management strategies, and brief intervention techniques. Catering to a diverse demographic, including adults, seniors, and young adults, Milestones prioritizes personalized recovery plans, with a particular focus on our female clientele. Driven by a dedication to excellence and empathy, Milestones is steadfast in its mission to guide individuals toward enduring sobriety.

Milestones Ranch Malibu

Milestones Ranch Malibu, located in Malibu, CA, specializes in providing high-quality rehabilitation options for both adults and young adults facing challenges related to substance use and concurrent mental health concerns. Emphasizing various treatment durations including long-term, 24-hour residential, and short-term stays, this center delivers personalized care that addresses the unique needs of each client. The facility employs evidence-based techniques such as 12-step programs, anger management, and short intervention strategies. Notably, Milestones Ranch Malibu offers tailored programs for individuals who have undergone trauma, as well as for those dealing with both mental health and substance use disorders. The center also features gender-specific treatment alternatives to foster a nurturing and inclusive atmosphere for all individuals pursuing recovery.

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Middlesex Human Service Agency Inc, located in Boston, MA, provides extended residential care for adults facing substance use issues and those dealing with significant mental health disorders. Additionally, it supports children with severe emotional challenges. The facility employs specialized methodologies, including 12-step programs, anger management techniques, and brief intervention strategies. Programs are customized to address the needs of adult males, individuals with dual diagnoses, and those involved in the legal system. This center serves a diverse clientele, including adults, seniors, and young adults, delivering high-quality care in a 24-hour residential environment. With a primary emphasis on male clients, the center offers thorough assistance for individuals on their path to recovery.

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The Midwestern CT Council of Alcoholism, located in Torrington, CT, provides tailored programs for substance use recovery in a supportive atmosphere. Emphasizing intensive outpatient treatment as well as various outpatient options, this center offers thorough assistance for both adults and young adults. It employs methods such as anger management, brief interventions, and cognitive behavioral therapy, accommodating clients of all genders. Distinct programs are designed for adult men, adult women, and those who have undergone intimate partner or domestic violence. The center's dedication to personalized care and proven treatment strategies guarantees effective support for individuals on their path to overcoming substance use challenges.

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Millenium Clinic Inc, located in Hollywood, FL, provides a wide range of services aimed at treating substance use disorders and addressing complex mental health conditions that may occur simultaneously. The center features various treatment formats, including intensive outpatient, outpatient, and day treatment programs, as well as options for telehealth therapy. With specialized programs designed for teens, adult males, and females, the clinic addresses the needs of various demographics. Emphasizing personalized care and treatment strategies, Millenium Clinic Inc is recognized as a reliable provider for individuals seeking rehabilitation support in the Hollywood region.

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The Millenium Clinic of Dade Inc located in Miami, FL, provides targeted outpatient services for individuals dealing with substance abuse as well as serious mental health issues. This center specializes in outpatient day programs and partial hospitalization, employing proven methods such as anger management, brief intervention, and cognitive behavioral therapy. The facility creates customized programs for adult males, adult females, and those affected by intimate partner violence, ensuring thorough support for adults and young adults of all gender identities. With an emphasis on quality and personalized treatment, this clinic stands out as an excellent option for those in search of effective, empathetic addiction recovery solutions in Miami.

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Las Vegas, NV

"Mind Body Solutions, located in Las Vegas, NV, offers a comprehensive range of outpatient services for detoxification, substance use treatment, and co-occurring conditions in adults and children/adolescents. The facility provides specialized programs for active duty military, adolescents, and adult men, catering to a diverse population. With treatment formats including outpatient detoxification and methadone/buprenorphine/naltrexone therapy, the center utilizes evidence-based approaches such as anger management, brief intervention, and contingency management to promote recovery. Serving both male and female clients, this facility focuses on delivering high-quality care to support individuals on their path to wellness."

Depression & Substance Use Disorder: Key Facts

Classification

Major Depressive Disorder + Substance Use Disorder (Dual Diagnosis)

Co-occurrence

~1 in 3 people with depression also have SUD (NIDA)

Prevalence

21 million adults with major depressive episode/year (NIMH)

Self-medication

Depression is the #1 reason for substance self-medication

Treatment approach

Integrated dual diagnosis (treat both simultaneously)

Key therapies

CBT, DBT, medication management, group therapy

Medications

SSRIs (non-addictive), SNRIs — safe during addiction treatment

Prognosis

Significantly better outcomes with integrated treatment vs sequential

If you or someone you know is experiencing suicidal thoughts, call 988 (Suicide & Crisis Lifeline) or text 988 immediately. Help is available 24/7.

Depression and Addiction: The Dual Diagnosis Connection

How depression and addiction feed each other

Depression and substance use disorder share a deeply intertwined relationship. Depression causes persistent feelings of emptiness, hopelessness, and emotional pain that drive many people toward alcohol or drugs as a form of self-medication. Substances may provide temporary relief, but they alter brain chemistry in ways that worsen depressive symptoms over time — creating a destructive cycle that accelerates both conditions.

The self-medication cycle

The self-medication cycle is the most common pathway from depression to addiction. A person experiencing persistent sadness, fatigue, or emotional numbness turns to alcohol, opioids, or stimulants to feel better temporarily. As tolerance builds, they need more of the substance to achieve the same relief. Meanwhile, the substance disrupts serotonin and dopamine regulation in the brain, deepening the depression. When the substance wears off, the depression returns worse than before — driving further substance use.

Why treating one without the other fails

Treating addiction without addressing underlying depression leaves the root cause intact. The person achieves sobriety but continues suffering from untreated depression, making relapse nearly inevitable as they seek relief. Conversely, treating depression without addressing active substance use is ineffective because ongoing drug or alcohol use undermines the neurochemical changes that antidepressants and therapy work to achieve. This is why dual diagnosis treatment — addressing both conditions simultaneously — produces significantly better outcomes than treating either condition alone.

Signs of Co-Occurring Depression and Substance Abuse

Recognizing co-occurring depression and substance abuse can be challenging because symptoms overlap. Watch for these warning signs:

Emotional and behavioral signs

  • Persistent sadness combined with increased substance use
  • Withdrawal from friends, family, and activities once enjoyed
  • Using drugs or alcohol specifically to cope with emptiness or hopelessness
  • Feelings of worthlessness or excessive guilt alongside substance use
  • Loss of motivation or interest in recovery efforts

Physical signs

  • Significant changes in sleep patterns — insomnia or oversleeping
  • Appetite and weight changes (loss or gain)
  • Chronic fatigue even with adequate rest
  • Increased substance tolerance requiring higher doses
  • Neglect of personal hygiene and self-care

How Dual Diagnosis Treatment Works

Integrated approach

Dual diagnosis treatment treats depression and addiction as interconnected conditions rather than separate problems. Instead of completing addiction treatment first and then addressing depression (the sequential approach that often fails), integrated programs work on both simultaneously. This means therapy sessions address how depressive thoughts drive substance use, while psychiatric care stabilizes mood to support sobriety.

Psychiatric evaluation during early sobriety

Accurate diagnosis of depression requires evaluation during a period of sobriety, because many substances can mimic or mask depressive symptoms. Alcohol is a depressant that causes sadness and lethargy. Stimulant withdrawal causes profound depression. A psychiatrist experienced in dual diagnosis will conduct thorough assessments during early sobriety to distinguish substance-induced mood changes from underlying major depressive disorder, ensuring the right treatment plan.

Coordinated care teams

Effective dual diagnosis programs use coordinated care teams where psychiatrists, addiction counselors, therapists, and medical staff communicate about each patient's progress. The psychiatrist managing antidepressant medication works closely with the addiction counselor guiding recovery, so treatment decisions account for both conditions. This prevents the common problem of one provider unknowingly undermining another's treatment plan.

Medication management alongside addiction treatment

One of the most important aspects of dual diagnosis care is safe medication management. Antidepressants like SSRIs and SNRIs are non-addictive and can be prescribed safely during addiction treatment. A psychiatrist monitors medication effectiveness, adjusts dosages, and watches for interactions — all while the person is actively working on recovery from substance use disorder.

Evidence-Based Therapies for Depression in Recovery

Cognitive Behavioral Therapy (CBT)

Cognitive Behavioral Therapy (CBT) is the gold standard for treating co-occurring depression and addiction. CBT helps identify negative thought patterns that drive both depressive episodes and substance use — such as "nothing will ever get better" or "I can't cope without drinking." Patients learn to challenge these distortions and replace them with realistic, constructive thinking. Research consistently shows CBT reduces both depressive symptoms and substance use relapse rates.

Dialectical Behavior Therapy (DBT)

Dialectical Behavior Therapy (DBT) is particularly effective for people with severe depression, emotional dysregulation, or self-harm behaviors alongside addiction. DBT teaches four core skill sets: mindfulness, distress tolerance, emotion regulation, and interpersonal effectiveness. These skills directly address the emotional pain that drives self-medication and provide healthier alternatives to substance use.

Group therapy

Group therapy combats the isolation that is central to both depression and addiction. Hearing others share similar struggles reduces shame and hopelessness. Dual diagnosis groups specifically address how depression and substance use interact, offering peer support from people who understand both conditions. Group settings also build social skills and accountability that support long-term recovery.

Medication management

Antidepressant medications are a critical component of treatment for many people with co-occurring depression and addiction. SSRIs (selective serotonin reuptake inhibitors) like sertraline and fluoxetine are first-line treatments because they are effective, well-tolerated, and — importantly — non-addictive. They carry no abuse potential and do not produce euphoria, making them safe to prescribe during addiction recovery. SNRIs like venlafaxine and duloxetine are also effective alternatives.

Levels of Care for Depression and Addiction

When residential treatment is needed

Residential treatment is recommended when depression is severe — particularly when suicidal ideation is present, when the person has made previous suicide attempts, or when outpatient treatment has failed. Residential programs provide 24/7 psychiatric monitoring, immediate medication adjustments, and a safe environment removed from triggers. People with severe addiction alongside major depression often need this level of structured support to stabilize both conditions.

Intensive Outpatient Programs (IOP)

Intensive Outpatient Programs provide 9–20 hours of structured therapy per week while allowing patients to live at home. IOP is appropriate for moderate depression with addiction, for people stepping down from residential care, or when the person has a stable living environment and support system. Dual diagnosis IOP programs include both addiction counseling and psychiatric services.

Outpatient care with medication management

Standard outpatient treatment works well for mild to moderate depression with substance use disorder, especially when combined with antidepressant medication. This typically involves weekly therapy sessions, regular psychiatric check-ins for medication management, and support group participation. Outpatient care allows people to maintain work, family, and daily responsibilities while receiving treatment.

Choosing the right level of care

The appropriate level of care depends on several factors: severity of depression (mild vs. severe with suicidal thoughts), severity of addiction, previous treatment attempts and outcomes, strength of social support, co-occurring medical conditions, and safety concerns. A professional assessment by a dual diagnosis specialist can determine the best starting point. Many people move through multiple levels of care as they progress in recovery.

Antidepressant Medications in Recovery

SSRIs: the first-line treatment

Selective serotonin reuptake inhibitors (SSRIs) such as sertraline (Zoloft), fluoxetine (Prozac), and escitalopram (Lexapro) are the most commonly prescribed antidepressants for people in addiction recovery. They work by increasing serotonin availability in the brain, gradually improving mood, sleep, and motivation over 4–6 weeks. SSRIs are not addictive, do not produce a high, and have no abuse potential — making them fundamentally different from the substances being treated.

SNRIs and bupropion

Serotonin-norepinephrine reuptake inhibitors (SNRIs) like venlafaxine (Effexor) and duloxetine (Cymbalta) target both serotonin and norepinephrine, which can be helpful for depression with prominent fatigue or chronic pain. Bupropion (Wellbutrin) is another option that acts on dopamine and norepinephrine — it can help with depression, low energy, and is also used to support smoking cessation. None of these medications carry addiction risk.

Addressing the stigma around psychiatric medication

Many people in recovery resist antidepressants because they feel taking any medication contradicts sobriety. This misconception is dangerous. Antidepressants are not mood-altering substances in the way drugs of abuse are — they restore normal brain chemistry rather than creating artificial highs. Untreated depression is one of the strongest predictors of addiction relapse. Taking prescribed, non-addictive medication to manage a medical condition is not a failure of recovery — it supports it.

Why stopping psychiatric meds leads to relapse

A common and harmful pattern occurs when people in recovery stop their antidepressants because they feel better, believe they no longer need them, or face pressure from others to be "medication-free." When depression returns — often within weeks — the emotional pain drives them back to substances. Antidepressant treatment for co-occurring depression should be maintained for at least 12 months after stabilization, and many people benefit from long-term maintenance. Any changes to psychiatric medication should be made gradually under medical supervision.

Frequently Asked Questions About Depression and Addiction

What is dual diagnosis treatment for depression and addiction?

Dual diagnosis treatment addresses both depression and substance use disorders simultaneously through integrated care. This approach recognizes that mental health and addiction affect each other and must be treated together for lasting recovery. Treatment includes psychiatric care, medication management, therapy (CBT, DBT), and specialized counseling that addresses both conditions comprehensively.

Can depression cause substance abuse?

Yes, depression significantly increases the risk of substance abuse. Many people self-medicate depression symptoms with alcohol or drugs, seeking temporary relief from emotional pain, low energy, or insomnia. However, substance use worsens depression long-term by disrupting serotonin and dopamine regulation, creating a vicious cycle. Proper treatment addresses root causes of depression while providing healthier coping strategies than substances.

Will antidepressants interfere with addiction treatment?

No, appropriate antidepressant medication actively supports recovery. Quality dual diagnosis programs work with psychiatrists to find effective antidepressant treatment while addressing addiction. Medications like SSRIs and SNRIs are non-addictive and help stabilize mood, making it easier to engage in therapy and maintain sobriety. Never stop psychiatric medications without medical guidance.

How do I find a treatment center for depression and addiction?

Look for centers explicitly offering dual diagnosis or co-occurring disorder treatment. Verify they have licensed mental health professionals, psychiatric services, medication management capabilities, and experience treating both conditions together. Use our directory to filter for dual diagnosis programs, read reviews, and verify accreditation. Contact admissions teams to discuss your specific needs.

Is residential treatment necessary for depression and addiction?

Not always. Treatment level depends on severity of both conditions, previous treatment attempts, safety concerns, and support system. Some people do well with intensive outpatient care plus medication management. Residential treatment provides 24/7 support for severe depression, suicide risk, or when outpatient treatment hasn't succeeded. A professional assessment determines the most appropriate level of care.

Can addiction cause depression or does depression cause addiction?

The relationship is bidirectional — it works both ways. Depression can lead to substance abuse through self-medication, as people use drugs or alcohol to escape emotional pain. At the same time, chronic substance use alters brain chemistry in ways that cause or worsen depression — alcohol is a central nervous system depressant, stimulant withdrawal causes profound depression, and opioid use disrupts the brain's natural mood regulation. In many cases, both conditions develop and reinforce each other simultaneously, which is why integrated dual diagnosis treatment is essential for lasting recovery.

Will I need antidepressants forever?

Not necessarily. Many people take antidepressants for 12–24 months after their mood stabilizes, then gradually taper off under medical supervision. However, some people with recurrent major depression (three or more episodes) benefit from long-term maintenance medication. The decision depends on depression severity, number of past episodes, family history, and individual response to treatment. What is critical is never stopping antidepressants abruptly — doing so can cause withdrawal symptoms and trigger relapse in both depression and addiction. Always work with your prescribing psychiatrist to make any medication changes.

Medical Review and Sources

Medically Reviewed Updated April 10, 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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