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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Depression & Addiction Treatment Centers Near You

Depression and addiction frequently co-occur, requiring integrated treatment approaches. Find dual diagnosis treatment centers addressing both mental health and substance use disorders through coordinated care and evidence-based therapies.

Found 7,770 rehab centers specializing in depression across the United States.

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Find Depression and Addiction Treatment Centers Near You

Browse dual diagnosis treatment centers below. Filter for programs treating depression and substance abuse together.

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Veterans Affairs Medical Center

The Veterans Affairs Medical Center in Salem, VA, is a leading facility providing extensive support for adults and young adults grappling with addiction and comorbid mental health challenges. They offer inpatient hospital detoxification and treatment, with a dedicated focus on active-duty military members. Through personalized strategies like 12-step facilitation and anger management, the center ensures each patient receives tailored care. This commitment to quality rehabilitation for adult men, women, young adults, and active-duty service members makes it a distinguished choice for recovery.

Veterans Affairs Medical Center
Palm Beach Gardens, FL

The Veterans Affairs Medical Center located in Palm Beach Gardens, FL provides an extensive array of services for those in need of addiction rehabilitation. This facility features hospital inpatient detox programs and round-the-clock inpatient care, alongside intensive outpatient options. It employs proven methodologies like 12-step programs, brief interventions, and cognitive behavioral therapy. Specific programs are tailored for adult men and women, as well as clients who have faced sexual abuse. Focusing on both adult and young adult populations, this center is committed to delivering high-quality care and assistance to individuals grappling with substance use disorders and concurrent mental health challenges.

Veterans Affairs Medical Center

Situated in Clarksburg, WV, the Veterans Affairs Medical Center delivers extensive rehabilitation options for both adults and young adults. The center focuses on detoxification, treatment for substance use, and addressing co-occurring mental health issues. It provides inpatient hospital care with an emphasis on 12-step programs, anger management strategies, and brief intervention techniques. Tailored initiatives are designed for those who have faced trauma, individuals managing co-occurring conditions, and veterans in need of specialized assistance. The center adopts a gender-specific treatment model to ensure effective care for both men and women in a nurturing atmosphere. For those seeking proficient rehabilitation support, this facility is committed to offering customized care to assist individuals on their journey to recovery.

Veterans Affairs Medical Center

The Veterans Affairs Medical Center in San Francisco, CA, provides extensive rehabilitation programs designed for adults and older adults. Their expertise lies in treating addiction, substance abuse, and dual diagnoses. They offer various levels of care, including intensive outpatient, standard outpatient, and outpatient detoxification. The center employs therapeutic strategies like anger management, brief intervention, and cognitive behavioral therapy. They serve both men and women, with specific considerations for survivors of intimate partner violence. The Veterans Affairs Medical Center distinguishes itself through its dedication to individual patient needs and high-quality treatment.

Veterans Affairs Medical Center

Situated in Omaha, NE, the Veterans Affairs Medical Center provides an extensive array of services for those in need of detoxification and treatment for substance use disorders. The center focuses on delivering specialized assistance to adults facing co-occurring substance use and severe mental health challenges, as well as children grappling with significant emotional issues. Treatment options include inpatient detoxification and round-the-clock hospital care, employing methodologies such as 12-step facilitation, anger management strategies, and brief intervention techniques. Programs are specifically designed for active-duty military members, as well as adult men and women. Committed to offering top-notch, personalized care, this facility serves adults, seniors, and young adults across all genders, ensuring that the distinct needs of each individual are addressed.

Veterans Affairs Medical Center

The Veterans Affairs Medical Center in Chillicothe, OH, delivers extensive rehabilitative care designed for adults and young adults. Its expertise lies in addressing substance use disorders and co-occurring conditions, providing services through hospital inpatient, round-the-clock inpatient, and intensive outpatient formats. The center emphasizes methods like 12-step facilitation, anger management, and brief interventions, serving individuals with trauma, dual diagnoses (mental health and substance use), and military veterans. The Veterans Affairs Medical Center offers dedicated treatment for both men and women, maintaining a high standard of care in a nurturing setting.

Veterans Affairs Medical Center

The Providence VA Medical Center in Rhode Island provides a complete spectrum of addiction treatment. This institution focuses on detox, substance use disorder care, and dual diagnosis for all ages. Offering inpatient detox and intensive outpatient programs, the center delivers effective therapy including anger management, cognitive behavioral techniques, and brief counseling. Tailored services are available for active duty military, women, individuals affected by intimate partner violence, and domestic abuse survivors. Serving males and females across adult and young adult demographics, the facility is dedicated to personalized recovery plans.

Veterans Affairs Miami Medical Ctr

Situated in Miami, FL, the Veterans Affairs Miami Medical Ctr delivers extensive rehabilitation services designed for both adults and teens dealing with substance use issues alongside mental health challenges. This center offers inpatient detoxification and treatment programs emphasizing 12-step approaches, anger management, and short intervention strategies. It features specialized programs for adult women, individuals who have faced trauma, and clients with dual diagnoses of mental health and substance use disorders. Committed to providing high-quality care, the center accommodates both men and women, developing personalized treatment plans that cater to the distinct requirements of each patient.

Veterans Alcoholic Rehab Prog (VARP)

Veterans Alcoholic Rehab Prog (VARP) in San Bernardino, CA, provides extensive addiction treatment services for adult women, older adults, and younger individuals. This center is adept at addressing dual diagnoses involving substance abuse and significant mental health conditions. VARP emphasizes extended residential stays, incorporating 12-step programs, anger control techniques, and cognitive behavioral therapy. The program also serves adult women with a history of sexual abuse or trauma. VARP offers transitional living, halfway housing, and sober living residences to foster a nurturing recovery setting. Clients can anticipate superior care and customized treatment strategies.

Veterans Alcoholic Rehab Prog (VARP)

Veterans Alcoholic Rehab Prog (VARP) in San Bernardino, CA, provides extensive, tailored care for those addressing addiction and needing a supportive place to live. They offer varied residential stays including extended, brief, and around-the-clock options. Their treatment methods include 12-step support, strategies for managing anger, and cognitive behavioral techniques. VARP supports adult women struggling with addiction and co-occurring severe mental health conditions, with particular attention given to individuals with a history of sexual abuse or trauma. This center is dedicated to meeting the specific requirements of its female clientele, delivering excellent support for adults, older adults, and young adults on their path to recovery.

Veterans Alcoholic Rehab Prog (VARP)

Situated in San Bernardino, CA, the Veterans Alcoholic Rehab Prog (VARP) specializes in substance use treatment for women, seniors, and young adults. This center creates a secure space for long-term residential care, emphasizing 12-step facilitation, anger management, and cognitive behavioral therapy. It features transitional housing options and assistance for those dealing with both substance use and significant mental health challenges. Distinct services are available for adult women, survivors of sexual abuse, and individuals coping with trauma. VARP is committed to delivering exceptional care for those in need of thorough rehabilitation services in a nurturing and gender-sensitive setting.

Veterans Alcoholic Rehab Prog (VARP)

Veterans Alcoholic Rehab Prog (VARP) located in San Bernardino, CA, delivers an extensive array of services aimed at adult male individuals facing challenges with substance abuse disorders. The center features options for long-term residential, short-term residential, and transitional living, integrating methods such as 12-step facilitation, anger management, and cognitive behavioral therapy. VARP is particularly focused on addressing co-occurring substance use disorders alongside significant mental health challenges, including trauma and experiences of sexual abuse. Programs are customized for adult men, seniors, and young adults, ensuring personalized support. By emphasizing high-quality and specialized care, this center commits to aiding clients throughout their recovery process.

Veterans Alcoholic Rehab Prog (VARP)

Veterans Alcoholic Rehab Prog (VARP) in San Bernardino, CA, delivers targeted addiction recovery services for adult men, featuring transitional and halfway house accommodations. They provide varied program lengths including long-term, short-term, and 24-hour residential care, employing proven methods such as 12-step facilitation, anger management, and cognitive behavioral therapy. Specializing in assisting clients with a history of trauma or sexual abuse, VARP supports adults, seniors, and young adults managing dual diagnoses of substance use and mental health disorders. The center distinguishes itself through its dedication to high-quality, individualized support for male veterans on their path to sobriety.

Veterans Alcoholic Rehab Prog (VARP)

Veterans Alcoholic Rehab Prog (VARP) in San Bernardino, CA, delivers extensive substance abuse recovery services for adult males. This residential program emphasizes long-term stays, integrating proven therapeutic modalities such as 12-step programs, anger management, and cognitive behavioral techniques. VARP is particularly adept at addressing dual diagnoses, managing co-occurring substance use disorders and severe mental health conditions. Specialized interventions are available for individuals with histories of sexual abuse or trauma. Additionally, the center provides supportive transitional and sober living options. Catering to adult, senior, and young adult men, VARP is dedicated to offering superior care within a nurturing setting designed for restoration and lasting sobriety.

Veterans Alcoholic Rehab Prog (VARP)

Situated in San Bernardino, CA, the Veterans Alcoholic Rehab Prog (VARP) provides an extensive array of specialized services. This center focuses on substance abuse treatment, transitional living options, and sober housing. Emphasizing care for individuals facing both substance use disorders and significant mental health challenges, the program is designed for adults experiencing emotional difficulties. VARP features both long-term and short-term residential programs, integrating approaches such as 12-step support, anger management, and cognitive behavioral therapy. Notable offerings include specialized programs for adult women, those with trauma backgrounds, and individuals who have suffered from sexual abuse. This women-focused facility accommodates adults, seniors, and young adults, ensuring personalized and compassionate care.

Veterans Alcoholic Rehab Prog (VARP)

Veterans Alcoholic Rehab Prog (VARP) in San Bernardino, CA, provides specialized substance abuse treatment and temporary housing for adult male veterans. They offer diverse program lengths, including extended, brief, and immediate residential care, emphasizing 12-step recovery, emotional regulation techniques, and cognitive restructuring. VARP is particularly adept at addressing dual diagnoses involving addiction and severe mental health conditions in adult men. Their approach is uniquely tailored to veterans who have faced trauma or sexual assault, serving adult males across different age groups who are looking for effective, caring support.

Veterans Alcoholic Rehab Prog (VARP)

Situated in San Bernardino, CA, the Veterans Alcoholic Rehab Prog (VARP) provides an extensive array of services aimed at adults and seniors in need of substance abuse rehabilitation and transitional living solutions. This center focuses on addressing both concurrent substance use disorders and significant mental health challenges in adults, as well as serious emotional issues in children. VARP offers a variety of treatment options including long-term, short-term, and round-the-clock residential care, employing evidence-based methods like 12-step programs, anger management strategies, and cognitive behavioral therapy. They also feature specialized programs designed for adult women, individuals who have faced sexual abuse, and those with trauma histories, making it a commendable choice for women seeking focused assistance and guidance.

Veterans Alcoholic Rehab Prog (VARP)

Veterans Alcoholic Rehab Prog (VARP) located in San Bernardino, CA, provides premier treatment for substance use disorders and transitional housing specifically for women. This facility is adept at addressing both substance use and significant mental health challenges, offering various options including long-term care, short-term programs, and around-the-clock residential services. Emphasizing approaches such as 12-step support, anger management techniques, and cognitive behavioral strategies, VARP serves adult women, seniors, and younger adults alike. Additionally, specialized programs aimed at helping survivors of sexual abuse and trauma distinguish this center from others. Those in search of thorough, gender-specific treatment provided by knowledgeable professionals will receive outstanding assistance at VARP.

Veterans Alcoholic Rehab Prog (VARP)

Situated in San Bernardino, California, Veterans Alcoholic Rehab Prog (VARP) delivers extensive substance use treatment tailored for adult male veterans. This center emphasizes long-term residential services, incorporating 12-step facilitation, anger management, and cognitive behavioral therapy into its approach. VARP is particularly adept at addressing co-occurring substance use disorders alongside serious mental health conditions in adults, as well as emotional challenges in children. The program is designed for adult men, encompassing both seniors and younger individuals, especially those with a history of trauma or sexual abuse. Offering transitional housing and a nurturing atmosphere, VARP is committed to delivering exceptional care and guidance for those seeking recovery.

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Situated in Blythe, California, Veterans Alcoholic Rehab Prog (VARP) specializes in addiction recovery for adult male veterans. The center offers extended residential services within a nurturing setting, complemented by transitional housing alternatives. Utilizing proven treatment modalities, including 12-step facilitation, anger management sessions, and cognitive behavioral therapy, the program addresses both substance use disorders and accompanying mental health issues. VARP specifically supports clients with histories of trauma or sexual abuse, creating a secure environment for recovery. With a dedicated focus on adult men, this facility delivers thorough care aimed at helping individuals reclaim their lives from addiction.

Depression & Substance Use Disorder: Key Facts

Classification

Major Depressive Disorder + Substance Use Disorder (Dual Diagnosis)

Co-occurrence

~1 in 3 people with depression also have SUD (NIDA)

Prevalence

21 million adults with major depressive episode/year (NIMH)

Self-medication

Depression is the #1 reason for substance self-medication

Treatment approach

Integrated dual diagnosis (treat both simultaneously)

Key therapies

CBT, DBT, medication management, group therapy

Medications

SSRIs (non-addictive), SNRIs — safe during addiction treatment

Prognosis

Significantly better outcomes with integrated treatment vs sequential

If you or someone you know is experiencing suicidal thoughts, call 988 (Suicide & Crisis Lifeline) or text 988 immediately. Help is available 24/7.

Depression and Addiction: The Dual Diagnosis Connection

How depression and addiction feed each other

Depression and substance use disorder share a deeply intertwined relationship. Depression causes persistent feelings of emptiness, hopelessness, and emotional pain that drive many people toward alcohol or drugs as a form of self-medication. Substances may provide temporary relief, but they alter brain chemistry in ways that worsen depressive symptoms over time — creating a destructive cycle that accelerates both conditions.

The self-medication cycle

The self-medication cycle is the most common pathway from depression to addiction. A person experiencing persistent sadness, fatigue, or emotional numbness turns to alcohol, opioids, or stimulants to feel better temporarily. As tolerance builds, they need more of the substance to achieve the same relief. Meanwhile, the substance disrupts serotonin and dopamine regulation in the brain, deepening the depression. When the substance wears off, the depression returns worse than before — driving further substance use.

Why treating one without the other fails

Treating addiction without addressing underlying depression leaves the root cause intact. The person achieves sobriety but continues suffering from untreated depression, making relapse nearly inevitable as they seek relief. Conversely, treating depression without addressing active substance use is ineffective because ongoing drug or alcohol use undermines the neurochemical changes that antidepressants and therapy work to achieve. This is why dual diagnosis treatment — addressing both conditions simultaneously — produces significantly better outcomes than treating either condition alone.

Signs of Co-Occurring Depression and Substance Abuse

Recognizing co-occurring depression and substance abuse can be challenging because symptoms overlap. Watch for these warning signs:

Emotional and behavioral signs

  • Persistent sadness combined with increased substance use
  • Withdrawal from friends, family, and activities once enjoyed
  • Using drugs or alcohol specifically to cope with emptiness or hopelessness
  • Feelings of worthlessness or excessive guilt alongside substance use
  • Loss of motivation or interest in recovery efforts

Physical signs

  • Significant changes in sleep patterns — insomnia or oversleeping
  • Appetite and weight changes (loss or gain)
  • Chronic fatigue even with adequate rest
  • Increased substance tolerance requiring higher doses
  • Neglect of personal hygiene and self-care

How Dual Diagnosis Treatment Works

Integrated approach

Dual diagnosis treatment treats depression and addiction as interconnected conditions rather than separate problems. Instead of completing addiction treatment first and then addressing depression (the sequential approach that often fails), integrated programs work on both simultaneously. This means therapy sessions address how depressive thoughts drive substance use, while psychiatric care stabilizes mood to support sobriety.

Psychiatric evaluation during early sobriety

Accurate diagnosis of depression requires evaluation during a period of sobriety, because many substances can mimic or mask depressive symptoms. Alcohol is a depressant that causes sadness and lethargy. Stimulant withdrawal causes profound depression. A psychiatrist experienced in dual diagnosis will conduct thorough assessments during early sobriety to distinguish substance-induced mood changes from underlying major depressive disorder, ensuring the right treatment plan.

Coordinated care teams

Effective dual diagnosis programs use coordinated care teams where psychiatrists, addiction counselors, therapists, and medical staff communicate about each patient's progress. The psychiatrist managing antidepressant medication works closely with the addiction counselor guiding recovery, so treatment decisions account for both conditions. This prevents the common problem of one provider unknowingly undermining another's treatment plan.

Medication management alongside addiction treatment

One of the most important aspects of dual diagnosis care is safe medication management. Antidepressants like SSRIs and SNRIs are non-addictive and can be prescribed safely during addiction treatment. A psychiatrist monitors medication effectiveness, adjusts dosages, and watches for interactions — all while the person is actively working on recovery from substance use disorder.

Evidence-Based Therapies for Depression in Recovery

Cognitive Behavioral Therapy (CBT)

Cognitive Behavioral Therapy (CBT) is the gold standard for treating co-occurring depression and addiction. CBT helps identify negative thought patterns that drive both depressive episodes and substance use — such as "nothing will ever get better" or "I can't cope without drinking." Patients learn to challenge these distortions and replace them with realistic, constructive thinking. Research consistently shows CBT reduces both depressive symptoms and substance use relapse rates.

Dialectical Behavior Therapy (DBT)

Dialectical Behavior Therapy (DBT) is particularly effective for people with severe depression, emotional dysregulation, or self-harm behaviors alongside addiction. DBT teaches four core skill sets: mindfulness, distress tolerance, emotion regulation, and interpersonal effectiveness. These skills directly address the emotional pain that drives self-medication and provide healthier alternatives to substance use.

Group therapy

Group therapy combats the isolation that is central to both depression and addiction. Hearing others share similar struggles reduces shame and hopelessness. Dual diagnosis groups specifically address how depression and substance use interact, offering peer support from people who understand both conditions. Group settings also build social skills and accountability that support long-term recovery.

Medication management

Antidepressant medications are a critical component of treatment for many people with co-occurring depression and addiction. SSRIs (selective serotonin reuptake inhibitors) like sertraline and fluoxetine are first-line treatments because they are effective, well-tolerated, and — importantly — non-addictive. They carry no abuse potential and do not produce euphoria, making them safe to prescribe during addiction recovery. SNRIs like venlafaxine and duloxetine are also effective alternatives.

Levels of Care for Depression and Addiction

When residential treatment is needed

Residential treatment is recommended when depression is severe — particularly when suicidal ideation is present, when the person has made previous suicide attempts, or when outpatient treatment has failed. Residential programs provide 24/7 psychiatric monitoring, immediate medication adjustments, and a safe environment removed from triggers. People with severe addiction alongside major depression often need this level of structured support to stabilize both conditions.

Intensive Outpatient Programs (IOP)

Intensive Outpatient Programs provide 9–20 hours of structured therapy per week while allowing patients to live at home. IOP is appropriate for moderate depression with addiction, for people stepping down from residential care, or when the person has a stable living environment and support system. Dual diagnosis IOP programs include both addiction counseling and psychiatric services.

Outpatient care with medication management

Standard outpatient treatment works well for mild to moderate depression with substance use disorder, especially when combined with antidepressant medication. This typically involves weekly therapy sessions, regular psychiatric check-ins for medication management, and support group participation. Outpatient care allows people to maintain work, family, and daily responsibilities while receiving treatment.

Choosing the right level of care

The appropriate level of care depends on several factors: severity of depression (mild vs. severe with suicidal thoughts), severity of addiction, previous treatment attempts and outcomes, strength of social support, co-occurring medical conditions, and safety concerns. A professional assessment by a dual diagnosis specialist can determine the best starting point. Many people move through multiple levels of care as they progress in recovery.

Antidepressant Medications in Recovery

SSRIs: the first-line treatment

Selective serotonin reuptake inhibitors (SSRIs) such as sertraline (Zoloft), fluoxetine (Prozac), and escitalopram (Lexapro) are the most commonly prescribed antidepressants for people in addiction recovery. They work by increasing serotonin availability in the brain, gradually improving mood, sleep, and motivation over 4–6 weeks. SSRIs are not addictive, do not produce a high, and have no abuse potential — making them fundamentally different from the substances being treated.

SNRIs and bupropion

Serotonin-norepinephrine reuptake inhibitors (SNRIs) like venlafaxine (Effexor) and duloxetine (Cymbalta) target both serotonin and norepinephrine, which can be helpful for depression with prominent fatigue or chronic pain. Bupropion (Wellbutrin) is another option that acts on dopamine and norepinephrine — it can help with depression, low energy, and is also used to support smoking cessation. None of these medications carry addiction risk.

Addressing the stigma around psychiatric medication

Many people in recovery resist antidepressants because they feel taking any medication contradicts sobriety. This misconception is dangerous. Antidepressants are not mood-altering substances in the way drugs of abuse are — they restore normal brain chemistry rather than creating artificial highs. Untreated depression is one of the strongest predictors of addiction relapse. Taking prescribed, non-addictive medication to manage a medical condition is not a failure of recovery — it supports it.

Why stopping psychiatric meds leads to relapse

A common and harmful pattern occurs when people in recovery stop their antidepressants because they feel better, believe they no longer need them, or face pressure from others to be "medication-free." When depression returns — often within weeks — the emotional pain drives them back to substances. Antidepressant treatment for co-occurring depression should be maintained for at least 12 months after stabilization, and many people benefit from long-term maintenance. Any changes to psychiatric medication should be made gradually under medical supervision.

Frequently Asked Questions About Depression and Addiction

What is dual diagnosis treatment for depression and addiction?

Dual diagnosis treatment addresses both depression and substance use disorders simultaneously through integrated care. This approach recognizes that mental health and addiction affect each other and must be treated together for lasting recovery. Treatment includes psychiatric care, medication management, therapy (CBT, DBT), and specialized counseling that addresses both conditions comprehensively.

Can depression cause substance abuse?

Yes, depression significantly increases the risk of substance abuse. Many people self-medicate depression symptoms with alcohol or drugs, seeking temporary relief from emotional pain, low energy, or insomnia. However, substance use worsens depression long-term by disrupting serotonin and dopamine regulation, creating a vicious cycle. Proper treatment addresses root causes of depression while providing healthier coping strategies than substances.

Will antidepressants interfere with addiction treatment?

No, appropriate antidepressant medication actively supports recovery. Quality dual diagnosis programs work with psychiatrists to find effective antidepressant treatment while addressing addiction. Medications like SSRIs and SNRIs are non-addictive and help stabilize mood, making it easier to engage in therapy and maintain sobriety. Never stop psychiatric medications without medical guidance.

How do I find a treatment center for depression and addiction?

Look for centers explicitly offering dual diagnosis or co-occurring disorder treatment. Verify they have licensed mental health professionals, psychiatric services, medication management capabilities, and experience treating both conditions together. Use our directory to filter for dual diagnosis programs, read reviews, and verify accreditation. Contact admissions teams to discuss your specific needs.

Is residential treatment necessary for depression and addiction?

Not always. Treatment level depends on severity of both conditions, previous treatment attempts, safety concerns, and support system. Some people do well with intensive outpatient care plus medication management. Residential treatment provides 24/7 support for severe depression, suicide risk, or when outpatient treatment hasn't succeeded. A professional assessment determines the most appropriate level of care.

Can addiction cause depression or does depression cause addiction?

The relationship is bidirectional — it works both ways. Depression can lead to substance abuse through self-medication, as people use drugs or alcohol to escape emotional pain. At the same time, chronic substance use alters brain chemistry in ways that cause or worsen depression — alcohol is a central nervous system depressant, stimulant withdrawal causes profound depression, and opioid use disrupts the brain's natural mood regulation. In many cases, both conditions develop and reinforce each other simultaneously, which is why integrated dual diagnosis treatment is essential for lasting recovery.

Will I need antidepressants forever?

Not necessarily. Many people take antidepressants for 12–24 months after their mood stabilizes, then gradually taper off under medical supervision. However, some people with recurrent major depression (three or more episodes) benefit from long-term maintenance medication. The decision depends on depression severity, number of past episodes, family history, and individual response to treatment. What is critical is never stopping antidepressants abruptly — doing so can cause withdrawal symptoms and trigger relapse in both depression and addiction. Always work with your prescribing psychiatrist to make any medication changes.

Medical Review and Sources

Medically Reviewed Updated April 10, 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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