NWVCIL Logo
Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Suboxone Clinic Near You: Buprenorphine Treatment for Opioid Addiction

Find a Suboxone clinic near you. Buprenorphine — sold under brand names Suboxone, Sublocade, Subutex, Zubsolv, and Brixadi — is the most-prescribed MAT for opioid use disorder. It is a partial mu-opioid agonist with a ceiling effect that dramatically reduces overdose risk vs. methadone. After the MAT Act of 2023 eliminated the X-waiver requirement, any licensed prescriber can prescribe buprenorphine in office-based settings (OBOT), via telehealth, or at retail pharmacies. Buprenorphine is a Schedule III controlled substance and is covered by Medicaid in all 50 states.

Found 7,094 treatment centers offering buprenorphine (suboxone) across the United States.

Need Help Finding the Right Treatment Center?

Speak with a compassionate specialist now - 100% free & confidential

Call +1 (833) 244-3031
Available 24/7
All 50 States
Filters:

Showing 21 of 7094 results

Spectrum Healthcare
Cottonwood, AZ

Spectrum Healthcare, situated in Cottonwood, Arizona, provides tailored outpatient rehabilitation for individuals, both young and old, struggling with addiction and concurrent mental health conditions. Their approach emphasizes personalized support through a variety of outpatient options, including medication-assisted treatment with methadone, buprenorphine, or naltrexone. This center is dedicated to serving a diverse clientele, ensuring a welcoming atmosphere for all who are pursuing lasting recovery. Discover dedicated assistance and treatment crafted specifically for your journey at this establishment.

Spectrum Healthcare LLC

Spectrum Healthcare LLC, located in Oak Creek, WI, delivers specialized outpatient addiction recovery services designed for adults and young adults. Their approach focuses on critical areas such as anger management, cognitive behavioral therapy, and motivational interviewing, ensuring each client receives a personalized path toward sustained sobriety. The facility is equipped to serve distinct groups with dedicated programs for active duty military members, adult men, and adult women, recognizing the unique needs of each demographic. Spectrum Healthcare LLC employs scientifically-backed methods for addiction treatment, including outpatient options with methadone, buprenorphine, or naltrexone. They are committed to offering high-quality care to all individuals, both male and female, who are pursuing comprehensive and successful rehabilitation.

Spectrum Health Systems Inc

Spectrum Health Systems Inc, located in Westborough, MA, delivers exceptional services for substance use disorders along with specialized attention for individuals facing concurrent mental health challenges. The facility provides both residential and short-term residential treatment options designed for adults and young adults. By employing evidence-based methods such as 12-step programs, brief interventions, and cognitive behavioral therapy, this center effectively supports adult men and women dealing with co-occurring conditions. Committed to personalized care, Spectrum Health Systems Inc effectively distinguishes itself by offering extensive rehabilitation solutions, ensuring clients receive high-quality and impactful treatment tailored to their unique needs.

Spectrum Health Systems Inc

"Spectrum Health Systems Inc, located in Southbridge, MA, offers comprehensive substance use treatment for adults and young adults. This facility provides outpatient care, including specialized treatment for co-occurring substance use and serious mental health conditions. Utilizing evidence-based approaches such as cognitive behavioral therapy and motivational interviewing, the program also offers contingency management to support recovery. Spectrum Health Systems Inc caters to active duty military personnel, adult men, and women, ensuring individualized care for each patient. With a focus on quality and tailored treatment plans, this center is dedicated to helping individuals achieve lasting recovery."

Spectrum Health Systems Inc

Spectrum Health Systems Inc, situated in Westborough, MA, provides an extensive array of services aimed at treating addiction. The center offers both long-term and short-term residential care for individuals grappling with substance use disorders, along with transitional housing solutions. It focuses on assisting adults with co-occurring issues of addiction and severe mental health disorders, as well as addressing significant emotional challenges in children. With dedicated programs designed for adult men and women, young adults, and survivors of intimate partner or domestic violence, the center delivers customized treatment plans to meet varied requirements. Spectrum Health Systems Inc employs strategies such as anger management, community reinforcement, and the Matrix Model, ensuring high-quality support for every individual on their path to recovery.

Spectrum Healthcare

Situated in Prescott, AZ, Spectrum Healthcare provides targeted outpatient services for addiction, co-occurring conditions, and significant mental health issues in adults, as well as emotional issues in children. This center offers outpatient treatments involving methadone, buprenorphine, or naltrexone, along with personalized counseling for substance use disorders and consistent outpatient care. Emphasizing customized treatment, Spectrum Healthcare serves adults and seniors regardless of gender. Its dedication to high-quality care and personalized programs positions it as a leading option for individuals in need of tailored addiction recovery solutions.

Spectrum Health Systems Inc

Spectrum Health Systems Inc, located in Weymouth, MA, provides a wide range of substance abuse treatment options. These include outpatient services as well as outpatient care involving methadone, buprenorphine, or naltrexone. The center employs various evidence-based practices such as cognitive behavioral therapy, motivational interviewing, and contingency management/motivational incentives. It serves both men and women, including individuals who have faced intimate partner or domestic violence. Spectrum Health Systems Inc focuses on delivering personalized treatment in a nurturing atmosphere, aiming to support adults and young adults in their journey toward sustained recovery.

Spectrum Health Systems Inc

Spectrum Health Systems Inc., located in Worcester, MA, offers targeted outpatient support for adults grappling with substance use disorders and concurrent severe mental health challenges, as well as for children experiencing emotional disruptions. Their therapeutic offerings encompass a range of methods such as anger management, cognitive behavioral therapy, and brief intervention strategies. Distinctive programs are available for active military personnel, adult men, and women. Primarily serving adults and young adults of all genders, this facility ensures high-quality recovery assistance through outpatient services, medication-assisted treatment with methadone/buprenorphine or naltrexone, and standard outpatient programming. Spectrum Health Systems Inc. is committed to delivering thorough and personalized care to individuals pursuing a path to recovery.

Spectrum Healthcare
Camp Verde, AZ

Nestled in Camp Verde, Arizona, Spectrum Healthcare is a dedicated provider of focused treatment for individuals, both young and old, who are navigating substance use challenges alongside significant mental health conditions. The center extends outpatient care options, incorporating medication-assisted treatment like methadone, buprenorphine, or naltrexone. Its core philosophy revolves around providing personalized counseling for substance use disorders, ensuring each client receives an approach tailored to their unique needs. Spectrum Healthcare warmly welcomes adults and seniors, irrespective of gender. The institution distinguishes itself through its commitment to crafting individualized treatment strategies and delivering high-caliber support. For anyone searching for thorough recovery services within an encouraging setting, Spectrum Healthcare is committed to guiding you toward wellness.

Spectrum Health and Human Services

Situated in Springville, NY, Spectrum Health and Human Services delivers outpatient treatment for substance use disorders, serving both adults and youths who also face co-occurring mental health issues. The center features dedicated programs aimed at individuals managing both mental health challenges and substance use, with emphasis on anger management, cognitive behavioral therapy, and short-term interventions. Offering personalized outpatient options such as methadone/buprenorphine or naltrexone therapy, the facility is dedicated to supporting men and women in pursuit of effective treatment. Spectrum Health and Human Services is recognized for its holistic method in tackling addiction and mental health problems within a nurturing and expert environment.

Spectra Health
Grand Forks, ND

Situated in Grand Forks, ND, Spectra Health specializes in outpatient programs for substance use designed for both adults and young adults. The facility offers various treatment modalities, including standard outpatient services as well as outpatient care for those on methadone, buprenorphine, or naltrexone. Spectra Health employs proven strategies such as brief interventions, cognitive behavioral therapy, and motivational incentives to facilitate the recovery process. With an emphasis on individualized attention, the center serves both men and women. For those in search of effective addiction treatment that is tailored to their needs, Spectra Health is committed to supporting you on your path to recovery.

Spectrum Health Systems Inc

Spectrum Health Systems Inc, located in Worcester, MA, delivers extensive treatment for substance use disorders, addressing the needs of both adults and children with co-existing mental health conditions. This center offers various outpatient therapies, including methadone and buprenorphine protocols along with cognitive behavioral therapy. Specialized programs are available for active duty military personnel, teens, and adult males. By incorporating unique methods such as anger management and short-term interventions, the facility guarantees personalized support for every client. Committed to providing effective, research-backed treatment, Spectrum Health Systems Inc emphasizes recovery and overall wellness for all individuals, regardless of gender.

Spectrum Health Systems Inc

Spectrum Health Systems Inc, located in Milford, MA, provides a range of outpatient services for individuals dealing with substance use disorders and co-occurring mental health challenges. They also support children facing emotional disturbances. Their services encompass outpatient methadone/buprenorphine treatment and standard outpatient care, utilizing therapeutic modalities like 12-step facilitation, cognitive behavioral therapy, and brief interventions. The center serves adult men and women, including those with a history of trauma, and focuses on adult and young adult populations of all genders, delivering personalized and thorough care to foster sustained recovery.

SpectraCare Health Systems

SpectraCare Health Systems, located in Ozark, AL, provides extensive treatment options for substance use disorders, along with targeted support for individuals facing co-existing mental health challenges in adults or severe emotional issues in children. Their services encompass intensive outpatient programs, general outpatient care, and treatment options such as methadone/buprenorphine or naltrexone for outpatient clients. The center employs proven therapeutic methods, including cognitive behavioral therapy, the Matrix Model, and relapse prevention strategies, creating customized treatment plans based on each person's unique situation. Catering to active duty military members, adolescents, and adult males, SpectraCare is dedicated to delivering high-quality care for individuals of all ages and genders, facilitating effective and sustained recovery.

SpectraCare Health Systems

SpectraCare Health Systems, situated in Dothan, AL, delivers extensive support for individuals battling substance abuse and those facing dual diagnoses of addiction and significant mental health challenges. This establishment features both long-term and brief residential treatment options, incorporating scientifically validated methods like 12-step programs, cognitive behavioral therapy, and the Matrix Model. SpectraCare Health Systems serves a broad spectrum of clients, including active military members, adult men, adult women, and young adults of any gender, demonstrating a dedication to personalized care and successful recovery.

Spectrum Health Systems Inc

Spectrum Health Systems Inc, located in Framingham, MA, delivers extensive outpatient services for individuals facing substance use challenges along with co-occurring mental health issues for both adults and children. The center features targeted programs designed for those who have undergone intimate partner violence, sexual trauma, or other adverse experiences. Treatment methodologies incorporate anger management, brief intervention techniques, and cognitive behavioral therapy. Prioritizing high-quality care, this facility serves male and female adults as well as young adults. Their services include standard outpatient programming as well as specialized outpatient options utilizing methadone, buprenorphine, or naltrexone. Spectrum Health Systems Inc is committed to offering effective and empathetic support to aid individuals on their road to recovery.

Placeholder image
Larimore, ND

Spectra Health in Larimore, ND, delivers comprehensive outpatient substance abuse recovery services for adults and adolescents. Their program offerings encompass standard outpatient care, medication-assisted treatment (methadone/buprenorphine or naltrexone), and general outpatient services. Employing proven therapeutic methods including brief interventions, cognitive behavioral therapy, and motivational incentives, the center prioritizes personalized treatment plans. Spectra Health's commitment to gender-specific programming for both men and women underscores their dedication to offering effective addiction treatment and supporting individuals through their recovery journey.

Placeholder image

SpectraCare Health Systems located in Dothan, Alabama, specializes in addressing substance use disorders and concurrent mental health issues for both adults and children. The facility offers a range of treatment modalities, including intensive outpatient programs, standard outpatient services, and options for medication-assisted treatments such as methadone, buprenorphine, or naltrexone. By employing evidence-based methods such as cognitive behavioral therapy, the Matrix Model, and strategies for relapse prevention, the center customizes its services to meet the unique requirements of each client. There are also specialized programs designed for active duty military personnel, as well as for adult men and women. Catering to individuals across the gender spectrum, SpectraCare Health Systems is committed to providing thorough and high-quality support for those pursuing recovery from addiction and mental health difficulties.

Placeholder image

SpectraCare Health Systems, located in Geneva, AL, specializes in providing targeted treatment for substance use disorders in adults, including individuals experiencing simultaneous mental health challenges. The center offers both intensive outpatient and outpatient programs, alongside treatment options such as methadone, buprenorphine, or naltrexone. Employing research-backed methods, including cognitive behavioral therapy and the Matrix Model, SpectraCare prioritizes strategies aimed at preventing relapse. This center also distinguishes itself by offering customized programs specifically for active-duty military members, adolescents, and adult males. Catering to both adults and young people, the facility delivers tailored support for individuals of all genders. With a strong emphasis on high-quality, personalized care, SpectraCare Health Systems is a reliable option for comprehensive rehabilitation solutions.

Placeholder image

SpectraCare Health Systems in Eufaula, AL, provides extensive care for individuals battling substance abuse, including those also experiencing significant mental health conditions. The center supports adults with dual diagnoses and children with serious emotional challenges. Treatment options include intensive outpatient services, standard outpatient care, and medication-assisted treatment with methadone, buprenorphine, or naltrexone. They are adept at utilizing therapies like cognitive behavioral therapy, the Matrix Model, and relapse prevention strategies. SpectraCare Health Systems serves adolescents, adult men, and adult women, with distinct programs designed for all age groups and genders. Their commitment is to delivering high-quality, research-backed treatment to aid in successful recovery.

Placeholder image

Spectrum Healthcare Inc located in Jersey City, NJ, presents an extensive selection of services for addiction recovery for both adults and young adults. This center focuses on detox services, treatment for substance use disorders, and managing co-occurring conditions. They offer intensive outpatient programs along with outpatient treatments using methadone, buprenorphine, or naltrexone. Emphasizing cognitive behavioral therapy, anger management techniques, and short-term intervention strategies, Spectrum Healthcare Inc serves a diverse clientele that includes adult women and men. Furthermore, they provide specialized care for individuals dealing with HIV/AIDS and those facing mental health challenges, ensuring tailored support for each client. Experience exceptional care and assistance at Spectrum Healthcare Inc.

Frequently Asked Questions

What is buprenorphine and how does it treat opioid addiction?
Buprenorphine is a partial opioid agonist medication approved by the FDA for treating opioid use disorder. It binds to the same receptors as heroin and fentanyl but produces a much weaker effect, reducing cravings and withdrawal symptoms without causing intense euphoria. Buprenorphine has a ceiling effect, meaning its opioid effects plateau at moderate doses, making it safer than methadone in terms of overdose risk.
What is the difference between Suboxone and Subutex?
Suboxone contains two active ingredients — buprenorphine and naloxone — while Subutex contains only buprenorphine without naloxone. The naloxone in Suboxone is included as an abuse deterrent; it remains inactive when taken sublingually as prescribed but triggers withdrawal if the medication is injected. Subutex is generally reserved for patients who cannot tolerate naloxone, such as pregnant women.
What is a Sublocade injection and how does it work?
Sublocade is a once-monthly injectable form of buprenorphine administered as a subcutaneous injection in the abdominal area. After injection, the medication forms a solid deposit under the skin that slowly releases buprenorphine over the course of a month. This eliminates daily dosing and removes the possibility of missed doses or medication diversion.
What are the common side effects of Suboxone?
Common Suboxone side effects include headache, nausea, constipation, insomnia, sweating, and mouth numbness or pain from sublingual administration. Some patients also experience dizziness, drowsiness, and blurred vision, particularly when starting treatment. Most side effects diminish within the first few weeks as the body adjusts. Patients should report difficulty breathing or signs of allergic reaction immediately.
What happens during Suboxone withdrawal?
Suboxone withdrawal occurs when a patient stops taking the medication abruptly after prolonged use, with symptoms including muscle aches, anxiety, insomnia, nausea, and irritability. A medically supervised taper is strongly recommended, typically reducing the dose by small increments over weeks or months. The risk of opioid relapse is significantly higher during unsupervised discontinuation.
How does Suboxone compare to methadone?
Suboxone and methadone are both effective for opioid use disorder but differ in key ways. Methadone is a full opioid agonist dispensed daily at licensed clinics, while Suboxone is a partial agonist that can be prescribed by qualified physicians and taken at home. Suboxone carries a lower overdose risk due to its ceiling effect and offers greater convenience, though methadone may be more appropriate for patients with severe, long-standing dependence.
How can I find a Suboxone clinic or doctor near me?
The most reliable way to find a Suboxone provider is through SAMHSA's online treatment locator at findtreatment.gov, which allows you to search by location and filter for buprenorphine providers. Many primary care offices, addiction treatment centers, and telehealth platforms now offer Suboxone prescriptions following the elimination of the federal X-waiver requirement in early 2023.
What is Zubsolv and how is it different from Suboxone?
Zubsolv is a brand-name buprenorphine and naloxone sublingual tablet that features a mint flavor and dissolves faster under the tongue than other options. Due to its higher bioavailability, Zubsolv uses different dosing strengths — a Zubsolv 5.7 mg/1.4 mg tablet is considered equivalent to a Suboxone 8 mg/2 mg dose. Patients switching between products should work closely with their prescriber for correct dose conversion.
Does Medicaid cover Suboxone treatment?
Yes — Medicaid covers buprenorphine (including Suboxone, Sublocade, Subutex, Zubsolv, and Brixadi) for opioid use disorder in all 50 states, as required by the SUPPORT Act of 2018. Medicaid is the largest single payer for MAT in the US. Coverage details vary by state — some require prior authorization or limit certain formulations. Many OBOT clinics accept Medicaid directly; telehealth Suboxone providers also bill Medicaid in most states. Bring your Medicaid card to your intake appointment.
Can I get Suboxone through telehealth?
Yes. After the MAT Act of 2023 permanently eliminated the X-waiver requirement, any licensed prescriber can prescribe Suboxone via telehealth in most states. The DEA also extended COVID-era telehealth flexibilities through at least 2025, allowing virtual Suboxone induction without a prior in-person visit. Several specialty platforms — Bicycle Health, Ophelia, Workit Health, Boulder Care — offer Medicaid-accepting telehealth Suboxone treatment. Telehealth has dramatically expanded access in rural and underserved areas with no nearby OBOT physicians.

About Buprenorphine (Suboxone)

Buprenorphine is classified as a partial opioid agonist, meaning it activates opioid receptors in the brain but to a much lesser degree than full agonists such as heroin, fentanyl, or oxycodone. This partial activation suppresses withdrawal symptoms and reduces cravings without producing dangerous respiratory depression or intense euphoria. Buprenorphine also has an unusually high binding affinity for the mu-opioid receptor, effectively blocking other opioids from attaching — providing a protective effect against relapse-related overdose.

How Buprenorphine Works

One of the defining features of buprenorphine is its ceiling effect — after a certain dose threshold, increasing the amount does not produce additional opioid effects. This dramatically reduces the risk of fatal overdose compared to methadone or illicit opioids. The ceiling effect, combined with its long duration of action (24 to 72 hours), makes buprenorphine one of the safest and most effective tools in medication-assisted treatment (MAT). Approved by the FDA in 2002, buprenorphine was a breakthrough because it could be prescribed in outpatient settings rather than requiring daily clinic visits.

Buprenorphine Brand Comparison: Suboxone, Subutex, Sublocade, Zubsolv, Brixadi

Buprenorphine is available under several FDA-approved brand names, each with distinct formulations, dosing schedules, and clinical use cases. The comparison below highlights the key differences:

BrandActive ingredientFormFrequencySettingFDA yearBest for
SuboxoneBuprenorphine + naloxoneSublingual film / tabletDailyOBOT, telehealth, retail pharmacy2002Most prescribed; naloxone deters injection misuse
SubutexBuprenorphine (alone)Sublingual tabletDailyOBOT2002Pregnancy; documented naloxone sensitivity
SublocadeBuprenorphine extended-releaseSubcutaneous injection (ATRIGEL depot)MonthlyClinic-administered2017No daily dosing; eliminates diversion risk
ZubsolvBuprenorphine + naloxoneSublingual tablet (higher bioavailability)DailyOBOT2013Faster dissolution; mint flavor; lower mg/dose
BrixadiBuprenorphine extended-releaseSubcutaneous injectionWeekly or monthlyClinic2023Newer alternative to Sublocade; weekly option for induction

All five medications are Schedule III controlled substances and equivalent in clinical efficacy at appropriate doses. The choice depends on adherence patterns, lifestyle, insurance coverage, and clinical context (e.g., pregnancy, prior injection use, daily-dosing burden). Many patients begin on sublingual Suboxone for stabilization and transition to monthly Sublocade or weekly Brixadi after sustained recovery.

Buprenorphine Side Effects

Common buprenorphine side effects include:

  • Headache and dizziness
  • Nausea and vomiting, especially during induction
  • Constipation and insomnia
  • Excessive sweating
  • Mouth numbness or oral discomfort from sublingual formulations

More serious side effects may include respiratory depression (particularly when combined with benzodiazepines or alcohol), liver problems, and allergic reactions. For most patients, side effects are mild and resolve within one to two weeks. The benefits in preventing relapse and overdose death significantly outweigh the risks.

Buprenorphine Dosage and Induction

Treatment begins with an induction phase where the patient must be in mild to moderate opioid withdrawal. Common induction doses range from 2 mg to 8 mg on the first day, with increases over the following days. Most patients stabilize on 8 mg to 24 mg per day, with 16 mg being the most commonly prescribed dose. Research suggests doses of 16 mg or higher are associated with better retention and outcomes. Dosage should always be adjusted under medical supervision.

Buprenorphine/Naloxone Combination

Many buprenorphine formulations include naloxone as an abuse deterrent. When taken sublingually as directed, naloxone has very low bioavailability and produces no clinical effect. However, if someone attempts to inject the medication, the naloxone component becomes fully active and triggers severe withdrawal. This design discourages injection misuse while having no impact on patients who take the medication correctly. The combination is the standard first-line formulation for opioid addiction treatment.

Suboxone: Sublingual Buprenorphine

Suboxone is the most recognized brand name for buprenorphine-naloxone and is most commonly dispensed as a sublingual film (Suboxone strips) that dissolves under the tongue. Suboxone has transformed opioid treatment by enabling millions of patients to receive effective pharmacotherapy in outpatient settings without the daily clinic visits required by methadone programs.

Suboxone Side Effects

Commonly reported Suboxone side effects include headache, nausea, tongue or mouth irritation, constipation, insomnia, sweating, and decreased libido. The sublingual film can cause irritation or small sores inside the mouth — rotating placement between under the tongue and against the cheek helps minimize this. Patients should not eat, drink, or smoke while the film is dissolving.

Suboxone Strips: Film vs. Tablet

Suboxone strips (sublingual film) have largely replaced the original tablet form. The film dissolves more quickly (two to four minutes), provides more consistent absorption, and is harder to divert due to individual foil packaging. Generic buprenorphine-naloxone tablets are often less expensive and may be preferred for cost reasons. Both are therapeutically equivalent when taken as prescribed.

Suboxone Treatment Programs

Comprehensive Suboxone treatment typically includes three phases:

  • Induction: Initial dosing under medical supervision, requiring the patient to be in early withdrawal
  • Stabilization: Dose adjustment until cravings and withdrawal are minimal, usually one to two months
  • Maintenance: Stable dosing for an extended period — often a year or longer — combined with counseling and behavioral therapy

Evidence consistently shows that longer treatment durations are associated with better outcomes. Most addiction medicine experts recommend a minimum of one to two years of maintenance therapy.

Find a Suboxone Clinic Near You — OBOT & Telehealth Options

Finding a Suboxone clinic has become significantly easier since the federal government eliminated the X-waiver requirement in January 2023, meaning any provider with a standard DEA license can now prescribe Suboxone. Patients can search SAMHSA's treatment locator at findtreatment.gov or use our directory to locate nearby facilities that offer buprenorphine-based treatment.

Suboxone Doctors Near Me

Beyond SAMHSA's locator, many state health departments maintain directories of addiction treatment providers. Telehealth has dramatically expanded access — several platforms now offer virtual Suboxone consultations, which is especially valuable for patients in rural areas. When selecting a provider, look for those offering comprehensive treatment including counseling, not just medication prescriptions.

Suboxone Withdrawal and Tapering

Suboxone withdrawal can include muscle aches, anxiety, insomnia, nausea, sweating, and intense opioid cravings. A gradual, medically supervised taper is recommended — typically reducing the dose by 10 to 25 percent every one to four weeks. Slower tapers over several months produce fewer symptoms and lower relapse rates. There is no medically mandated time limit for Suboxone treatment, and many patients benefit from indefinite maintenance.

Suboxone vs Methadone

Suboxone can be prescribed in office settings and taken at home, carries lower overdose risk due to its ceiling effect, and offers greater scheduling flexibility. Methadone is a full agonist that may be more effective for severe, long-standing dependence but must be dispensed at licensed clinics with daily visits. Neither is inherently superior — the best choice keeps the patient in treatment. Some patients may also benefit from naltrexone, a non-opioid alternative.

Sublocade: Monthly Buprenorphine Injection

Sublocade delivers buprenorphine as a once-monthly subcutaneous injection in the abdominal area using the ATRIGEL delivery system, which forms a solid biodegradable depot that slowly releases medication. Patients must first stabilize on sublingual buprenorphine (8 mg+ daily) for at least seven days. Treatment typically begins with two 300 mg injections, followed by maintenance on 300 mg or 100 mg. Sublocade eliminates concerns about daily adherence, missed doses, and medication diversion.

Sublocade Side Effects

The most common Sublocade side effects are injection-site reactions (pain, itching, redness, or a noticeable lump), nausea, constipation, headache, and fatigue. The injection-site lump is normal and gradually diminishes as medication is absorbed. Patients should avoid rubbing or massaging the site. Elevated liver enzymes may also occur but are usually mild and transient.

Subutex: Buprenorphine Without Naloxone

Subutex was the original brand-name buprenorphine product. While the brand has been discontinued, generic buprenorphine-only tablets remain available. Buprenorphine monotherapy is typically reserved for pregnant patients (to avoid naloxone exposure to the fetus), patients with documented naloxone sensitivity, or sometimes during the induction phase before transitioning to the combination product.

Subutex vs Suboxone

The primary difference is the absence of naloxone in Subutex. Because Subutex lacks the abuse-deterrent naloxone component, it may carry slightly higher diversion risk, and many insurance formularies prioritize the combination as the default. Current clinical guidelines favor buprenorphine-only formulations primarily for pregnancy and naloxone sensitivity.

Zubsolv: Alternative Buprenorphine Brand

Zubsolv is a buprenorphine-naloxone sublingual tablet featuring a mint flavor and faster dissolution (under two minutes). Due to enhanced bioavailability, Zubsolv uses different dose strengths — a 5.7 mg/1.4 mg tablet equals a Suboxone 8 mg/2 mg dose. Zubsolv is available in multiple strengths for flexible dosing during both induction and maintenance.

Buprenorphine resources:

Find Buprenorphine (Suboxone) by State

Browse buprenorphine (suboxone) programs in states with the most treatment options.

Explore Related Options

Related conditions, treatment approaches, and levels of care.

Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)