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Medically Reviewed Content
Updated: August 2026
Sources: SAMHSA, NIDA

Suboxone Clinic Near You: Buprenorphine Treatment for Opioid Addiction

Find a Suboxone clinic near you. Buprenorphine — sold under brand names Suboxone, Sublocade, Subutex, Zubsolv, and Brixadi — is the most-prescribed MAT for opioid use disorder. It is a partial mu-opioid agonist with a ceiling effect that dramatically reduces overdose risk vs. methadone. After the MAT Act of 2023 eliminated the X-waiver requirement, any licensed prescriber can prescribe buprenorphine in office-based settings (OBOT), via telehealth, or at retail pharmacies. Buprenorphine is a Schedule III controlled substance and is covered by Medicaid in all 50 states.

Found 7,145 treatment centers offering buprenorphine (suboxone) across the United States.

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Crossroads
Phoenix, AZ

Crossroads, located in Phoenix, AZ, specializes in substance use recovery for adult males through various formats including intensive outpatient care, long-term residential options, and general outpatient services. The center incorporates techniques such as 12-step programs, anger management strategies, and brief intervention methods. Crossroads also offers customized treatments for military personnel, adult men, and those recovering from intimate partner violence, ensuring a well-rounded approach to care. Catering to adults, seniors, and younger adults, this facility primarily addresses the needs of male clients by providing high-quality, evidence-informed treatment. If you or someone close to you is in need of compassionate and effective addiction recovery with a specific focus, Crossroads is committed to guiding you on the path to healing.

Crossroads
Phoenix, AZ

Situated in Phoenix, AZ, Crossroads stands out as a leading rehabilitation facility dedicated to addressing substance use disorders specifically for adult males. The center provides an array of services including intensive outpatient programs, long-term residential treatment, and additional outpatient options, all designed to meet the distinct needs of each individual. Emphasizing methods such as 12-step support, anger management, and cognitive behavioral techniques, Crossroads adopts a thorough approach to the recovery journey. This center distinguishes itself with specialized offerings for active military members, adult men, and those who have faced intimate partner violence. Catering to adults of various ages, including seniors and young adults, Crossroads is committed to delivering exceptional care focused on male individuals seeking assistance with addiction.

Crossroads
Scarborough, ME

Situated in Scarborough, Maine, Crossroads provides targeted therapeutic interventions for adults and adolescents facing challenges with substance abuse, often alongside significant mental health conditions or emotional difficulties. The facility offers a range of treatment modalities including intensive outpatient care, day treatment, and partial hospitalization services. Crossroads employs proven therapeutic strategies such as anger management techniques, cognitive behavioral therapy, and motivational incentives to foster lasting recovery. While specializing in programs for adult women, Crossroads serves both male and female individuals, delivering personalized support and care tailored to their unique needs. The commitment at Crossroads is to deliver exceptional, all-encompassing treatment designed to guide individuals toward successful recuperation.

Crossroads
Mesa, AZ

Crossroads, situated in Mesa, Arizona, provides thorough substance abuse treatment tailored for adult women battling addiction. This center offers various levels of care, including intensive outpatient, extended residential stays, and standard outpatient services. Their therapeutic approaches encompass 12-step facilitation, anger management techniques, and cognitive behavioral therapy. Specialized programs are available for active duty military members, adult women, and survivors of intimate partner violence. Crossroads serves adults across all age groups, with a particular emphasis on female clients. Their dedication to high-quality care establishes a nurturing setting for individuals pursuing freedom from substance use disorders, delivering personalized treatment strategies and empathetic assistance at every stage of recovery.

Crossroads
Phoenix, AZ

Crossroads in Phoenix, AZ, provides focused substance abuse care via intensive outpatient, outpatient, and medication-assisted treatment (MAT) options including methadone, buprenorphine, and naltrexone. Their therapeutic framework incorporates 12-step facilitation, anger management, and cognitive behavioral therapy. Recognizing varied needs, they offer distinct programs for active military personnel, adult men, and adult women. This center is equipped to assist adults and young adults of all genders, delivering personalized support. Crossroads is committed to offering excellent care within a nurturing setting, emphasizing successful recovery pathways. For those in Phoenix looking for thorough addiction treatment, Crossroads is prepared to assist in your journey to sobriety.

Crossroads
Mesa, AZ

Crossroads, situated in Mesa, AZ, stands as a leading facility dedicated to aiding adults and young adults in overcoming substance dependency. This center provides a multifaceted recovery journey through its outpatient services, including methadone/buprenorphine treatment and standard outpatient programs. The therapeutic framework at Crossroads encompasses 12-step facilitation, anger management techniques, and cognitive behavioral therapy to cater to diverse client requirements. Distinctive offerings for active military members, adult men, and adult women highlight the center's specialized approach. Crossroads is committed to delivering personalized support and care to all individuals, regardless of gender, as they work towards breaking free from addiction and rebuilding their futures.

Crossroads Center
Cincinnati, OH

Crossroads Center in Cincinnati, OH, delivers a complete spectrum of care for individuals grappling with addiction and co-occurring psychological challenges, serving both younger and adult populations. This establishment features intensive outpatient, extended residential stays, and standard outpatient services, all grounded in proven therapeutic methods like cognitive behavioral therapy and strategies for managing anger. Distinct treatment paths are offered for teenagers, adult men, and adult women. Emphasizing personalized attention, Crossroads Center is equipped to support male and female patients of varying ages, offering customized assistance to address each person's specific circumstances. Discover exceptional treatment and achieve sustainable healing at this reputable center, committed to fostering long-term wellness.

Crossroads
Glendale, AZ

Situated in Glendale, AZ, Crossroads stands out as a premier rehabilitation facility specializing in outpatient treatment for substance use disorders. This center provides targeted programs designed for adult men and women as well as active duty military members. Emphasizing methods such as 12-step facilitation, anger management, and cognitive behavioral therapy, Crossroads delivers thorough and customized care that meets each person's unique requirements. The center is welcoming to adults and young adults of any gender, promoting a nurturing and inclusive atmosphere. Committed to high standards in addiction recovery, Crossroads focuses on empowering individuals to attain sustainable recovery through proven strategies and tailored support.

Crossroads
Phoenix, AZ

Situated in Phoenix, AZ, Crossroads specializes in providing extensive treatment for substance use disorders among adult men, seniors, and young adults. The center offers a variety of programs including intensive outpatient, long-term residential, and outpatient options. These programs utilize methodologies such as 12-step facilitation, anger management, and cognitive behavioral therapy. Additionally, there are dedicated initiatives aimed at supporting active duty military members, adult males, and those who have faced intimate partner or domestic violence. With an emphasis on serving male clientele, Crossroads is committed to delivering personalized, high-quality care, fostering an environment conducive to effective and compassionate rehabilitation.

Crossroads
Phoenix, AZ

Crossroads is a specialized rehabilitation facility that offers effective services for those seeking to overcome addiction.

Crossroads
Scottsdale, AZ

Situated in Scottsdale, AZ, Crossroads delivers a wide array of rehabilitation services. The facility focuses on treating substance use disorders, offering transitional housing, and sober living arrangements for adults, seniors, and young adults alike. Crossroads provides various treatment formats, including intensive outpatient programs, long-term residential care, and outpatient services to meet varied requirements. The center features specific programs designed for active military personnel, adult men, and survivors of intimate partner violence. Employing methods such as 12-step facilitation, anger management, and brief interventions, this center guarantees personalized care. With an emphasis on quality and customized support, Crossroads stands out as a reliable option for individuals in need of effective rehabilitation services.

Crossroads
Phoenix, AZ

Situated in Phoenix, AZ, Crossroads serves as a leading rehabilitation facility dedicated to treating substance use disorders among adult males. The center provides various treatment options, including intensive outpatient services, long-term residential care, and standard outpatient programs. Crossroads employs proven methods such as the 12-step approach, anger management strategies, and cognitive behavioral therapy to deliver thorough support. Notably, it offers distinctive programs for active military personnel, adult men, and individuals who have faced intimate partner violence. With a commitment to serving adults, seniors, and young adults, this center emphasizes high-quality and personalized care for every client.

Crossroad Transitional Inc

Crossroad Transitional Inc. in Northridge, CA, provides extensive recovery support for adults and adolescents struggling with addiction and co-occurring mental health conditions. The facility features dedicated programs for active duty military, adult men, and women, offering inpatient detoxification and treatment. Their therapeutic methods include 12-step facilitation, anger management techniques, and brief intervention strategies. Personalized care plans are developed for male and female clients, fostering a nurturing setting. Crossroad Transitional Inc. is recognized for its commitment to high-quality, individualized care, establishing it as a reliable option for effective and empathetic addiction rehabilitation.

Crossroads
Mesa, AZ

Crossroads, situated in Mesa, Arizona, delivers extensive support for men battling substance dependence. Their treatment offerings encompass intensive outpatient services, extended residential stays, and standard outpatient care, all employing methodologies like 12-step facilitation, anger management techniques, and cognitive behavioral therapy. Crossroads is particularly adept at assisting active military members, adult males, and individuals who have faced intimate partner violence. Catering to adults, seniors, and younger adults, this center provides individualized recovery plans specifically for men. The facility's dedication to proven therapeutic methods and targeted interventions guarantees superior care for those addressing addiction challenges.

Crossroads Counseling Inc

Crossroads Counseling Inc, located in Lock Haven, PA, provides a variety of specialized rehabilitation options. The center features intensive outpatient programs, standard outpatient services, and treatments involving methadone, buprenorphine, or naltrexone. With an emphasis on addressing substance use disorders alongside significant mental health challenges, participants can access methods like anger management, brief interventions, and cognitive behavioral therapy. Distinct programs are available for adolescents as well as adult men and women. Catering to adults and seniors of all genders, the center is committed to delivering personalized assistance for individuals striving to recover from addiction and mental health issues. The combination of high-quality care and customized programs establishes Crossroads Counseling Inc as an essential support for those embarking on their recovery journey.

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Windham, ME

Crossroads, located in Windham, ME, provides dedicated care for women grappling with substance use disorders. Their programs are designed for adult women, including those who are pregnant or have recently given birth, and individuals facing both mental health challenges and addiction. With round-the-clock supervision in residential and short-term residential settings, they emphasize techniques like anger management, cognitive behavioral therapy, and the use of motivational incentives. The center welcomes adults of all ages, from young adults to seniors, and exclusively supports female patients. Crossroads distinguishes itself through its personalized strategies for addressing addiction and co-occurring conditions, delivering effective support for those on their journey to recovery.

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Portland, ME

Crossroads, situated in Portland, ME, is a leading addiction treatment facility dedicated to helping adults and children overcome substance use disorders and co-occurring mental health conditions. They offer both residential and intensive short-term residential care, employing evidence-based therapies such as anger management, cognitive behavioral therapy, and motivational incentives. The center places a particular emphasis on providing tailored support for adult women and individuals experiencing co-occurring mental health challenges. Catering to a broad age range, including adults, seniors, and young adults, Crossroads is committed to delivering gender-specific, superior care designed to foster sustained recovery. For those in need of thorough and impactful treatment, this institution stands out as a premier option.

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Bloomsburg, PA

Crossroads Counseling in Bloomsburg, PA, provides comprehensive outpatient substance abuse rehabilitation for adults and young individuals facing concurrent mental health challenges. Their tailored services extend to those with a history of trauma and dual diagnosis, offering specialized interventions. The center employs strategies such as anger management, brief intervention techniques, and cognitive behavioral therapy for both male and female clients. They offer medication-assisted treatment options, including methadone, buprenorphine, or naltrexone, alongside standard outpatient services. Catering to a broad age range, from adults to seniors, Crossroads Counseling is dedicated to delivering individualized and gender-sensitive care to aid in the recovery journey.

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State College, PA

Crossroads Counseling Inc, located in State College, PA, provides a wide array of treatment options for substance use, as well as transitional housing and support for individuals with co-occurring disorders, suitable for both adults and children. Their range of outpatient services features intensive care along with methadone and buprenorphine therapies. Emphasizing techniques such as anger management, brief intervention, and cognitive behavioral therapy, the center offers targeted assistance for adolescents, women, and those who have faced traumatic experiences. Catering to both men and women of all ages, Crossroads Counseling Inc is dedicated to delivering personalized, high-quality care to facilitate the healing and recovery process. If you or someone close to you is in need of reliable rehabilitation services, this center provides a variety of programs designed to address specific challenges.

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Crossroads Counseling Inc. in Wellsboro, PA delivers multifaceted substance abuse recovery programs for individuals of all ages, addressing concurrent mental health challenges. Their offerings include structured intensive outpatient, standard outpatient, and medication-assisted outpatient treatment options. Utilizing therapeutic strategies such as anger management, brief intervention, and cognitive behavioral techniques, Crossroads Counseling Inc. is equipped to support adolescents, those with trauma histories, and individuals managing dual diagnoses. Open to adults and seniors across the gender spectrum, the center is committed to providing excellent care within a nurturing setting.

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Crossroads Counseling Inc, located in Sunbury, PA, provides comprehensive outpatient services for individuals grappling with addiction and concurrent mental health challenges. Their specialized programs address a variety of needs, including anger management, cognitive behavioral therapy, and trauma-informed care, for both adults and younger individuals. Recognizing the complexity of co-occurring disorders, Crossroads Counseling Inc develops individualized treatment strategies. The center is dedicated to offering thorough and supportive care to adults and older adults, irrespective of gender. Their proficiency in outpatient pharmacotherapy, including methadone, buprenorphine, and naltrexone, distinguishes them as a leading provider of customized and impactful recovery solutions.

Frequently Asked Questions

What is buprenorphine and how does it treat opioid addiction?
Buprenorphine is a partial opioid agonist medication approved by the FDA for treating opioid use disorder. It binds to the same receptors as heroin and fentanyl but produces a much weaker effect, reducing cravings and withdrawal symptoms without causing intense euphoria. Buprenorphine has a ceiling effect, meaning its opioid effects plateau at moderate doses, making it safer than methadone in terms of overdose risk.
What is the difference between Suboxone and Subutex?
Suboxone contains two active ingredients — buprenorphine and naloxone — while Subutex contains only buprenorphine without naloxone. The naloxone in Suboxone is included as an abuse deterrent; it remains inactive when taken sublingually as prescribed but triggers withdrawal if the medication is injected. Subutex is generally reserved for patients who cannot tolerate naloxone, such as pregnant women.
What is a Sublocade injection and how does it work?
Sublocade is a once-monthly injectable form of buprenorphine administered as a subcutaneous injection in the abdominal area. After injection, the medication forms a solid deposit under the skin that slowly releases buprenorphine over the course of a month. This eliminates daily dosing and removes the possibility of missed doses or medication diversion.
What are the common side effects of Suboxone?
Common Suboxone side effects include headache, nausea, constipation, insomnia, sweating, and mouth numbness or pain from sublingual administration. Some patients also experience dizziness, drowsiness, and blurred vision, particularly when starting treatment. Most side effects diminish within the first few weeks as the body adjusts. Patients should report difficulty breathing or signs of allergic reaction immediately.
What happens during Suboxone withdrawal?
Suboxone withdrawal occurs when a patient stops taking the medication abruptly after prolonged use, with symptoms including muscle aches, anxiety, insomnia, nausea, and irritability. A medically supervised taper is strongly recommended, typically reducing the dose by small increments over weeks or months. The risk of opioid relapse is significantly higher during unsupervised discontinuation.
How does Suboxone compare to methadone?
Suboxone and methadone are both effective for opioid use disorder but differ in key ways. Methadone is a full opioid agonist dispensed daily at licensed clinics, while Suboxone is a partial agonist that can be prescribed by qualified physicians and taken at home. Suboxone carries a lower overdose risk due to its ceiling effect and offers greater convenience, though methadone may be more appropriate for patients with severe, long-standing dependence.
How can I find a Suboxone clinic or doctor near me?
The most reliable way to find a Suboxone provider is through SAMHSA's online treatment locator at findtreatment.gov, which allows you to search by location and filter for buprenorphine providers. Many primary care offices, addiction treatment centers, and telehealth platforms now offer Suboxone prescriptions following the elimination of the federal X-waiver requirement in early 2023.
What is Zubsolv and how is it different from Suboxone?
Zubsolv is a brand-name buprenorphine and naloxone sublingual tablet that features a mint flavor and dissolves faster under the tongue than other options. Due to its higher bioavailability, Zubsolv uses different dosing strengths — a Zubsolv 5.7 mg/1.4 mg tablet is considered equivalent to a Suboxone 8 mg/2 mg dose. Patients switching between products should work closely with their prescriber for correct dose conversion.
Does Medicaid cover Suboxone treatment?
Yes — Medicaid covers buprenorphine (including Suboxone, Sublocade, Subutex, Zubsolv, and Brixadi) for opioid use disorder in all 50 states, as required by the SUPPORT Act of 2018. Medicaid is the largest single payer for MAT in the US. Coverage details vary by state — some require prior authorization or limit certain formulations. Many OBOT clinics accept Medicaid directly; telehealth Suboxone providers also bill Medicaid in most states. Bring your Medicaid card to your intake appointment.
Can I get Suboxone through telehealth?
Yes. After the MAT Act of 2023 permanently eliminated the X-waiver requirement, any licensed prescriber can prescribe Suboxone via telehealth in most states. The DEA also extended COVID-era telehealth flexibilities through at least 2025, allowing virtual Suboxone induction without a prior in-person visit. Several specialty platforms — Bicycle Health, Ophelia, Workit Health, Boulder Care — offer Medicaid-accepting telehealth Suboxone treatment. Telehealth has dramatically expanded access in rural and underserved areas with no nearby OBOT physicians.

About Buprenorphine (Suboxone)

Buprenorphine is classified as a partial opioid agonist, meaning it activates opioid receptors in the brain but to a much lesser degree than full agonists such as heroin, fentanyl, or oxycodone. This partial activation suppresses withdrawal symptoms and reduces cravings without producing dangerous respiratory depression or intense euphoria. Buprenorphine also has an unusually high binding affinity for the mu-opioid receptor, effectively blocking other opioids from attaching — providing a protective effect against relapse-related overdose.

How Buprenorphine Works

One of the defining features of buprenorphine is its ceiling effect — after a certain dose threshold, increasing the amount does not produce additional opioid effects. This dramatically reduces the risk of fatal overdose compared to methadone or illicit opioids. The ceiling effect, combined with its long duration of action (24 to 72 hours), makes buprenorphine one of the safest and most effective tools in medication-assisted treatment (MAT). Approved by the FDA in 2002, buprenorphine was a breakthrough because it could be prescribed in outpatient settings rather than requiring daily clinic visits.

Buprenorphine Brand Comparison: Suboxone, Subutex, Sublocade, Zubsolv, Brixadi

Buprenorphine is available under several FDA-approved brand names, each with distinct formulations, dosing schedules, and clinical use cases. The comparison below highlights the key differences:

BrandActive ingredientFormFrequencySettingFDA yearBest for
SuboxoneBuprenorphine + naloxoneSublingual film / tabletDailyOBOT, telehealth, retail pharmacy2002Most prescribed; naloxone deters injection misuse
SubutexBuprenorphine (alone)Sublingual tabletDailyOBOT2002Pregnancy; documented naloxone sensitivity
SublocadeBuprenorphine extended-releaseSubcutaneous injection (ATRIGEL depot)MonthlyClinic-administered2017No daily dosing; eliminates diversion risk
ZubsolvBuprenorphine + naloxoneSublingual tablet (higher bioavailability)DailyOBOT2013Faster dissolution; mint flavor; lower mg/dose
BrixadiBuprenorphine extended-releaseSubcutaneous injectionWeekly or monthlyClinic2023Newer alternative to Sublocade; weekly option for induction

All five medications are Schedule III controlled substances and equivalent in clinical efficacy at appropriate doses. The choice depends on adherence patterns, lifestyle, insurance coverage, and clinical context (e.g., pregnancy, prior injection use, daily-dosing burden). Many patients begin on sublingual Suboxone for stabilization and transition to monthly Sublocade or weekly Brixadi after sustained recovery.

Buprenorphine Side Effects

Common buprenorphine side effects include:

  • Headache and dizziness
  • Nausea and vomiting, especially during induction
  • Constipation and insomnia
  • Excessive sweating
  • Mouth numbness or oral discomfort from sublingual formulations

More serious side effects may include respiratory depression (particularly when combined with benzodiazepines or alcohol), liver problems, and allergic reactions. For most patients, side effects are mild and resolve within one to two weeks. The benefits in preventing relapse and overdose death significantly outweigh the risks.

Buprenorphine Dosage and Induction

Treatment begins with an induction phase where the patient must be in mild to moderate opioid withdrawal. Common induction doses range from 2 mg to 8 mg on the first day, with increases over the following days. Most patients stabilize on 8 mg to 24 mg per day, with 16 mg being the most commonly prescribed dose. Research suggests doses of 16 mg or higher are associated with better retention and outcomes. Dosage should always be adjusted under medical supervision.

Buprenorphine/Naloxone Combination

Many buprenorphine formulations include naloxone as an abuse deterrent. When taken sublingually as directed, naloxone has very low bioavailability and produces no clinical effect. However, if someone attempts to inject the medication, the naloxone component becomes fully active and triggers severe withdrawal. This design discourages injection misuse while having no impact on patients who take the medication correctly. The combination is the standard first-line formulation for opioid addiction treatment.

Suboxone: Sublingual Buprenorphine

Suboxone is the most recognized brand name for buprenorphine-naloxone and is most commonly dispensed as a sublingual film (Suboxone strips) that dissolves under the tongue. Suboxone has transformed opioid treatment by enabling millions of patients to receive effective pharmacotherapy in outpatient settings without the daily clinic visits required by methadone programs.

Suboxone Side Effects

Commonly reported Suboxone side effects include headache, nausea, tongue or mouth irritation, constipation, insomnia, sweating, and decreased libido. The sublingual film can cause irritation or small sores inside the mouth — rotating placement between under the tongue and against the cheek helps minimize this. Patients should not eat, drink, or smoke while the film is dissolving.

Suboxone Strips: Film vs. Tablet

Suboxone strips (sublingual film) have largely replaced the original tablet form. The film dissolves more quickly (two to four minutes), provides more consistent absorption, and is harder to divert due to individual foil packaging. Generic buprenorphine-naloxone tablets are often less expensive and may be preferred for cost reasons. Both are therapeutically equivalent when taken as prescribed.

Suboxone Treatment Programs

Comprehensive Suboxone treatment typically includes three phases:

  • Induction: Initial dosing under medical supervision, requiring the patient to be in early withdrawal
  • Stabilization: Dose adjustment until cravings and withdrawal are minimal, usually one to two months
  • Maintenance: Stable dosing for an extended period — often a year or longer — combined with counseling and behavioral therapy

Evidence consistently shows that longer treatment durations are associated with better outcomes. Most addiction medicine experts recommend a minimum of one to two years of maintenance therapy.

Find a Suboxone Clinic Near You — OBOT & Telehealth Options

Finding a Suboxone clinic has become significantly easier since the federal government eliminated the X-waiver requirement in January 2023, meaning any provider with a standard DEA license can now prescribe Suboxone. Patients can search SAMHSA's treatment locator at findtreatment.gov or use our directory to locate nearby facilities that offer buprenorphine-based treatment.

Suboxone Doctors Near Me

Beyond SAMHSA's locator, many state health departments maintain directories of addiction treatment providers. Telehealth has dramatically expanded access — several platforms now offer virtual Suboxone consultations, which is especially valuable for patients in rural areas. When selecting a provider, look for those offering comprehensive treatment including counseling, not just medication prescriptions.

Suboxone Withdrawal and Tapering

Suboxone withdrawal can include muscle aches, anxiety, insomnia, nausea, sweating, and intense opioid cravings. A gradual, medically supervised taper is recommended — typically reducing the dose by 10 to 25 percent every one to four weeks. Slower tapers over several months produce fewer symptoms and lower relapse rates. There is no medically mandated time limit for Suboxone treatment, and many patients benefit from indefinite maintenance.

Suboxone vs Methadone

Suboxone can be prescribed in office settings and taken at home, carries lower overdose risk due to its ceiling effect, and offers greater scheduling flexibility. Methadone is a full agonist that may be more effective for severe, long-standing dependence but must be dispensed at licensed clinics with daily visits. Neither is inherently superior — the best choice keeps the patient in treatment. Some patients may also benefit from naltrexone, a non-opioid alternative.

Sublocade: Monthly Buprenorphine Injection

Sublocade delivers buprenorphine as a once-monthly subcutaneous injection in the abdominal area using the ATRIGEL delivery system, which forms a solid biodegradable depot that slowly releases medication. Patients must first stabilize on sublingual buprenorphine (8 mg+ daily) for at least seven days. Treatment typically begins with two 300 mg injections, followed by maintenance on 300 mg or 100 mg. Sublocade eliminates concerns about daily adherence, missed doses, and medication diversion.

Sublocade Side Effects

The most common Sublocade side effects are injection-site reactions (pain, itching, redness, or a noticeable lump), nausea, constipation, headache, and fatigue. The injection-site lump is normal and gradually diminishes as medication is absorbed. Patients should avoid rubbing or massaging the site. Elevated liver enzymes may also occur but are usually mild and transient.

Subutex: Buprenorphine Without Naloxone

Subutex was the original brand-name buprenorphine product. While the brand has been discontinued, generic buprenorphine-only tablets remain available. Buprenorphine monotherapy is typically reserved for pregnant patients (to avoid naloxone exposure to the fetus), patients with documented naloxone sensitivity, or sometimes during the induction phase before transitioning to the combination product.

Subutex vs Suboxone

The primary difference is the absence of naloxone in Subutex. Because Subutex lacks the abuse-deterrent naloxone component, it may carry slightly higher diversion risk, and many insurance formularies prioritize the combination as the default. Current clinical guidelines favor buprenorphine-only formulations primarily for pregnancy and naloxone sensitivity.

Zubsolv: Alternative Buprenorphine Brand

Zubsolv is a buprenorphine-naloxone sublingual tablet featuring a mint flavor and faster dissolution (under two minutes). Due to enhanced bioavailability, Zubsolv uses different dose strengths — a 5.7 mg/1.4 mg tablet equals a Suboxone 8 mg/2 mg dose. Zubsolv is available in multiple strengths for flexible dosing during both induction and maintenance.

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Medically Reviewed Updated August 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)