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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Depression & Addiction Treatment Centers Near You

Depression and addiction frequently co-occur, requiring integrated treatment approaches. Find dual diagnosis treatment centers addressing both mental health and substance use disorders through coordinated care and evidence-based therapies.

Found 7,770 rehab centers specializing in depression across the United States.

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Find Depression and Addiction Treatment Centers Near You

Browse dual diagnosis treatment centers below. Filter for programs treating depression and substance abuse together.

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Set Free Alaska
Wasilla, AK

Set Free Alaska, located in Wasilla, AK, provides comprehensive, science-backed recovery services for individuals of all ages grappling with addiction and related psychological issues. The center offers flexible care levels including intensive outpatient, outpatient, and standard outpatient plans, all customized to suit each person's unique requirements. Emphasizing therapeutic approaches like anger management, cognitive behavioral therapy, and trauma-informed practices, Set Free Alaska is adept at addressing multifaceted mental health concerns. Their services extend to adults and adolescents of any gender, guaranteeing individualized support throughout their path to wellness.

Seven 2 Seven Medical Services LLC

Seven 2 Seven Medical Services LLC, located in Glen Burnie, MD, provides an extensive selection of outpatient treatment options designed for both adults and seniors. With a focus on detoxification, treatment for substance use, and addressing co-occurring disorders, this center offers outpatient detoxification services along with methadone and buprenorphine therapies. The facility employs evidence-based methods, including cognitive behavioral therapy and motivational incentives. Programs are customized for various groups, including active-duty military personnel, adolescents, and adult men, ensuring that each individual receives the appropriate care. Serving both men and women, Seven 2 Seven Medical Services LLC is committed to delivering high-quality support for those aiming to overcome addiction and mental health issues.

Seven Hills Hospital

At Seven Hills Hospital, located in Henderson, NV, we provide extensive support for individuals of all ages grappling with substance abuse and intertwined mental health challenges. Our services encompass inpatient detoxification and therapeutic care within a hospital setting. We employ proven methods such as 12-step facilitation, anger management techniques, and brief intervention strategies. Seven Hills Hospital is distinguished by its specific treatment tracks for active military personnel, teenagers, and adult men, catering to the unique needs of various groups. Recognizing the importance of tailored care, we offer distinct programs for both male and female patients, fostering an individualized and encouraging atmosphere. Choose Seven Hills Hospital for dependable, high-quality rehabilitation and recovery.

Shanti Recovery and Wellness

Situated in Portland, OR, Shanti Recovery and Wellness delivers extensive outpatient rehabilitation services for both adults and children. Focusing on substance use disorders, the center also addresses accompanying mental health issues. With programs designed for military personnel, teenagers, and adult males, Shanti Recovery and Wellness utilizes proven methods such as cognitive behavioral therapy and motivational interviewing. The center provides personalized outpatient treatments with methadone/buprenorphine or naltrexone to cater to individual recovery needs. Committed to offering excellent, tailored care for all clients, this center aims to foster enduring health and recovery.

Sharp Mesa Vista Hospital

Sharp Mesa Vista Hospital, situated in San Diego, California, is a premier facility dedicated to comprehensive care for individuals undergoing detoxification and addressing substance use challenges. This center is particularly adept at supporting patients who are also managing co-occurring mental health conditions. Offering structured inpatient programs designed for adults and seniors, the hospital provides round-the-clock support within a medical environment. Sharp Mesa Vista Hospital employs scientifically validated methods, including 12-step program integration, techniques for managing anger, and short-term therapeutic interventions, to foster successful recovery. The facility is equipped to serve both male and female patients, establishing itself as a reliable provider of high-quality rehabilitation.

Sharehouse Grand Forks
Grand Forks, ND

Sharehouse Grand Forks, located in Grand Forks, ND, delivers extensive programs for individuals struggling with substance abuse and co-occurring serious mental health conditions. They serve adults and young adults, offering various care durations including extended, brief, and round-the-clock residential options. Their therapeutic methods are rooted in proven techniques such as 12-step recovery support, emotional regulation skills, and cognitive behavioral strategies. The center has tailored services designed for adult men, adult women, and those with a history of trauma. Emphasizing personalized treatment plans, Sharehouse Grand Forks is dedicated to providing effective recovery support for both men and women facing addiction and mental health concerns.

ShareHouse Inc

ShareHouse Inc, located in Fargo, ND, delivers extensive programs for addiction recovery and supportive living accommodations. This establishment focuses on tailored care for adults facing dual diagnoses of substance abuse and significant mental health challenges, alongside emotional difficulties in youth. Their offerings encompass intensive outpatient, day treatment, and standard outpatient care. ShareHouse Inc utilizes proven methods including 12-step guidance, strategies for managing anger, and short-term interventions. Primarily serving adults and young adults of any gender who have co-occurring conditions or legal entanglements, ShareHouse Inc is dedicated to providing top-tier assistance and resources for those pursuing lasting sobriety and personal growth.

ShareHouse Inc

ShareHouse Inc, situated in Fargo, ND, specializes in comprehensive care for adult men struggling with addiction and co-occurring mental health challenges. They provide both extended and brief residential stays, utilizing proven methods such as cognitive behavioral therapy and anger management. ShareHouse Inc is equipped to support individuals with a history of trauma, ensuring a secure and nurturing space for healing. Their approach includes strong emphasis on 12-step principles, offering complete services for adults, older adults, and younger adults. For individuals desiring a structured, gender-specific recovery program, ShareHouse Inc is committed to delivering exceptional, personalized treatment.

ShareHouse Inc

ShareHouse Inc, located in Fargo, ND, provides an all-encompassing approach to substance abuse recovery, paired with transitional housing solutions including sober living facilities and halfway houses. Their services are designed for adults facing both substance use challenges and significant mental health concerns, as well as children dealing with emotional issues. With various options available, including long-term and short-term residential stays, the center utilizes proven methods such as 12-step programs, anger management techniques, and cognitive behavioral therapy. ShareHouse Inc is dedicated to offering tailored support for adult men, women, and individuals who have gone through trauma, ensuring high-quality, personalized care for all adults and young adults, regardless of gender.

Seven Hills Behavioral Health

Seven Hills Behavioral Health in Milford, MA, provides outpatient care for adults dealing with substance use and/or co-occurring mental health concerns, as well as for children experiencing emotional disturbances. Their therapeutic modalities include anger management techniques, brief intervention strategies, and cognitive behavioral therapy. The center features tailored programs for adolescents, survivors of intimate partner violence, domestic violence, and individuals who have endured sexual abuse. Their services are designed for adults and children/adolescents across all gender identities. With a holistic approach and a strong emphasis on personalized treatment plans, Seven Hills Behavioral Health stands out as a leading option for effective rehabilitation services within the Milford community.

Shade of the Tree
Spirit Lake, IA

In Spirit Lake, IA, Shade of the Tree provides extensive outpatient services for substance use disorders, prioritizing excellent patient care. This center serves adults and older adults of any gender, with ongoing outpatient services available for active military members, teenagers, and adult males. Employing a comprehensive, mind-body-spirit approach, Shade of the Tree is committed to aiding individuals in their journey toward lasting recovery. By offering tailored programs designed for different demographics and age ranges, this facility guarantees individualized support specific to each person's unique requirements. For anyone searching for proficient and empathetic treatment for addiction, Shade of the Tree is a dependable option in Spirit Lake.

Shasta County Health and Human Servs

Shasta County Health and Human Servs in Redding, CA, delivers thorough substance abuse care for adult women facing trauma, domestic abuse, or intimate partner violence. This center features diverse treatment options, including intensive outpatient, outpatient, and standard outpatient services. Their expertise lies in applying proven methods like anger management, cognitive behavioral therapy, and the Matrix Model. Catering to adult women, seniors, and young adult females, this facility prioritizes tailored support for those pursuing recovery from addiction.

Seventy Times Seven
Baltimore, MD

Seventy Times Seven in Baltimore, MD, provides thorough addiction recovery services and supportive housing. This center excels in addressing dual diagnoses of substance abuse and significant mental health conditions in adults, along with severe emotional challenges in youth. Their offerings encompass inpatient hospital care, intensive outpatient therapy, and extended residential stays. The therapeutic approach combines cognitive behavioral techniques, motivational interviewing, and methods for preventing relapse. Designed for adult men, adult women, and individuals with co-occurring conditions, the center delivers customized support to adult men, women, and young adults. Clients can anticipate high-caliber treatment and specialized approaches to aid their path to wellness.

Shalom House
Dover, DE

Shalom House, situated in Dover, DE, provides advanced substance abuse care within a long-term residential framework for adult males. The center excels in offering transitional living, halfway house services, and sober living options. Employing approaches like 12-step facilitation, brief intervention, and motivational rewards, Shalom House serves active military personnel, adult men, and survivors of domestic abuse. Catering to adults, seniors, and young adults, this facility delivers excellent, gender-focused recovery programs in an encouraging and organized setting.

Shalom House
Dover, DE

Situated in Dover, DE, Shalom House provides extensive treatment for substance use and transitional housing aimed at adult males. This center excels in long-term residential support, ensuring clients receive assistance around the clock. Emphasizing strategies such as 12-step programs, brief interventions, and motivational rewards, Shalom House customizes its offerings to address the unique requirements of each individual. Specific initiatives are designed for active military members, adult males, and survivors of intimate partner violence. Catering to adult men of various ages, including seniors and young adults, this facility maintains a high standard of care within a nurturing setting. For those looking for a structured sober living environment, Shalom House is committed to supporting you throughout your recovery process.

Sheehan Womens Program

The Sheehan Women's Program located in Tewksbury, MA, specializes in long-term residential care specifically for adult women dealing with substance use disorders and associated challenges. This center ensures a secure atmosphere that includes options for transitional living like halfway houses and sober homes. The program employs a range of methodologies, including 12-step support, anger management techniques, and short therapeutic interventions. It is designed for women who have suffered from intimate partner violence, domestic abuse, and sexual trauma. Catering to adult women, this program emphasizes the empowerment of its clients, promoting enduring recovery and overall well-being in a nurturing, gender-focused environment.

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Set Free Alaska, located in Homer, AK, delivers extensive treatment options for individuals facing severe mental health challenges and substance use issues, including services for both adults and children. The center offers a range of programs, including intensive outpatient, outpatient, and standard outpatient treatments, employing methodologies like anger management, cognitive behavioral therapy, and brief interventions. Tailored programs are available for those with histories of trauma as well as individuals dealing with concurrent mental health and substance use conditions. With dedicated services for adults, seniors, and young adults of all genders, this rehabilitation center prioritizes providing high-quality care within a supportive atmosphere.

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Set Free Alaska, situated in Homer, Alaska, focuses on providing long-term residential care for adults facing substance use issues and co-occurring mental health disorders, as well as for children dealing with emotional challenges. The center utilizes proven methods, including 12-step programs, anger management techniques, and cognitive behavioral therapy. Specialized initiatives are designed for individuals who have undergone trauma and for those grappling with both mental health and substance abuse problems. Catering to adult, senior, and young adult males, Set Free Alaska emphasizes a thorough and personalized treatment process within a nurturing setting. Committed to promoting effective and lasting recovery, the center strives to meet the unique needs of each client.

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Set Free DAT Center, located in Houston, TX, provides a wide array of treatment options for substance abuse for both adults and youth. Their offerings encompass support for individuals facing combined challenges of substance misuse and significant mental health disorders, accommodating various client needs. The center features multiple treatment formats, including intensive and regular outpatient programs, employing proven strategies like 12-step principles, anger management techniques, and cognitive behavioral therapy. Furthermore, Set Free DAT Center has unique programs designed specifically for active military personnel, as well as distinct services for adult men and women, ensuring individualized treatment plans. The center is committed to delivering high-quality care, fostering a supportive and nurturing environment for all clients.

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Warren, MI

Located in Warren, MI, SHAR Macomb provides an extensive variety of substance use treatment options. This center is dedicated to addressing co-occurring substance use disorders along with significant mental health issues in adults and serious emotional challenges in children. Emphasizing long-term residential, 24-hour residential, and short-term residential offerings, SHAR Macomb delivers personalized care utilizing methods such as 12-step facilitation, anger management, and brief intervention strategies. Specialized programs are available for adult men, adult women, and individuals who have faced trauma. Catering to adults and young adults of all genders, this facility emphasizes high-quality care and customized treatment plans aimed at fostering enduring recovery.

Depression & Substance Use Disorder: Key Facts

Classification

Major Depressive Disorder + Substance Use Disorder (Dual Diagnosis)

Co-occurrence

~1 in 3 people with depression also have SUD (NIDA)

Prevalence

21 million adults with major depressive episode/year (NIMH)

Self-medication

Depression is the #1 reason for substance self-medication

Treatment approach

Integrated dual diagnosis (treat both simultaneously)

Key therapies

CBT, DBT, medication management, group therapy

Medications

SSRIs (non-addictive), SNRIs — safe during addiction treatment

Prognosis

Significantly better outcomes with integrated treatment vs sequential

If you or someone you know is experiencing suicidal thoughts, call 988 (Suicide & Crisis Lifeline) or text 988 immediately. Help is available 24/7.

Depression and Addiction: The Dual Diagnosis Connection

How depression and addiction feed each other

Depression and substance use disorder share a deeply intertwined relationship. Depression causes persistent feelings of emptiness, hopelessness, and emotional pain that drive many people toward alcohol or drugs as a form of self-medication. Substances may provide temporary relief, but they alter brain chemistry in ways that worsen depressive symptoms over time — creating a destructive cycle that accelerates both conditions.

The self-medication cycle

The self-medication cycle is the most common pathway from depression to addiction. A person experiencing persistent sadness, fatigue, or emotional numbness turns to alcohol, opioids, or stimulants to feel better temporarily. As tolerance builds, they need more of the substance to achieve the same relief. Meanwhile, the substance disrupts serotonin and dopamine regulation in the brain, deepening the depression. When the substance wears off, the depression returns worse than before — driving further substance use.

Why treating one without the other fails

Treating addiction without addressing underlying depression leaves the root cause intact. The person achieves sobriety but continues suffering from untreated depression, making relapse nearly inevitable as they seek relief. Conversely, treating depression without addressing active substance use is ineffective because ongoing drug or alcohol use undermines the neurochemical changes that antidepressants and therapy work to achieve. This is why dual diagnosis treatment — addressing both conditions simultaneously — produces significantly better outcomes than treating either condition alone.

Signs of Co-Occurring Depression and Substance Abuse

Recognizing co-occurring depression and substance abuse can be challenging because symptoms overlap. Watch for these warning signs:

Emotional and behavioral signs

  • Persistent sadness combined with increased substance use
  • Withdrawal from friends, family, and activities once enjoyed
  • Using drugs or alcohol specifically to cope with emptiness or hopelessness
  • Feelings of worthlessness or excessive guilt alongside substance use
  • Loss of motivation or interest in recovery efforts

Physical signs

  • Significant changes in sleep patterns — insomnia or oversleeping
  • Appetite and weight changes (loss or gain)
  • Chronic fatigue even with adequate rest
  • Increased substance tolerance requiring higher doses
  • Neglect of personal hygiene and self-care

How Dual Diagnosis Treatment Works

Integrated approach

Dual diagnosis treatment treats depression and addiction as interconnected conditions rather than separate problems. Instead of completing addiction treatment first and then addressing depression (the sequential approach that often fails), integrated programs work on both simultaneously. This means therapy sessions address how depressive thoughts drive substance use, while psychiatric care stabilizes mood to support sobriety.

Psychiatric evaluation during early sobriety

Accurate diagnosis of depression requires evaluation during a period of sobriety, because many substances can mimic or mask depressive symptoms. Alcohol is a depressant that causes sadness and lethargy. Stimulant withdrawal causes profound depression. A psychiatrist experienced in dual diagnosis will conduct thorough assessments during early sobriety to distinguish substance-induced mood changes from underlying major depressive disorder, ensuring the right treatment plan.

Coordinated care teams

Effective dual diagnosis programs use coordinated care teams where psychiatrists, addiction counselors, therapists, and medical staff communicate about each patient's progress. The psychiatrist managing antidepressant medication works closely with the addiction counselor guiding recovery, so treatment decisions account for both conditions. This prevents the common problem of one provider unknowingly undermining another's treatment plan.

Medication management alongside addiction treatment

One of the most important aspects of dual diagnosis care is safe medication management. Antidepressants like SSRIs and SNRIs are non-addictive and can be prescribed safely during addiction treatment. A psychiatrist monitors medication effectiveness, adjusts dosages, and watches for interactions — all while the person is actively working on recovery from substance use disorder.

Evidence-Based Therapies for Depression in Recovery

Cognitive Behavioral Therapy (CBT)

Cognitive Behavioral Therapy (CBT) is the gold standard for treating co-occurring depression and addiction. CBT helps identify negative thought patterns that drive both depressive episodes and substance use — such as "nothing will ever get better" or "I can't cope without drinking." Patients learn to challenge these distortions and replace them with realistic, constructive thinking. Research consistently shows CBT reduces both depressive symptoms and substance use relapse rates.

Dialectical Behavior Therapy (DBT)

Dialectical Behavior Therapy (DBT) is particularly effective for people with severe depression, emotional dysregulation, or self-harm behaviors alongside addiction. DBT teaches four core skill sets: mindfulness, distress tolerance, emotion regulation, and interpersonal effectiveness. These skills directly address the emotional pain that drives self-medication and provide healthier alternatives to substance use.

Group therapy

Group therapy combats the isolation that is central to both depression and addiction. Hearing others share similar struggles reduces shame and hopelessness. Dual diagnosis groups specifically address how depression and substance use interact, offering peer support from people who understand both conditions. Group settings also build social skills and accountability that support long-term recovery.

Medication management

Antidepressant medications are a critical component of treatment for many people with co-occurring depression and addiction. SSRIs (selective serotonin reuptake inhibitors) like sertraline and fluoxetine are first-line treatments because they are effective, well-tolerated, and — importantly — non-addictive. They carry no abuse potential and do not produce euphoria, making them safe to prescribe during addiction recovery. SNRIs like venlafaxine and duloxetine are also effective alternatives.

Levels of Care for Depression and Addiction

When residential treatment is needed

Residential treatment is recommended when depression is severe — particularly when suicidal ideation is present, when the person has made previous suicide attempts, or when outpatient treatment has failed. Residential programs provide 24/7 psychiatric monitoring, immediate medication adjustments, and a safe environment removed from triggers. People with severe addiction alongside major depression often need this level of structured support to stabilize both conditions.

Intensive Outpatient Programs (IOP)

Intensive Outpatient Programs provide 9–20 hours of structured therapy per week while allowing patients to live at home. IOP is appropriate for moderate depression with addiction, for people stepping down from residential care, or when the person has a stable living environment and support system. Dual diagnosis IOP programs include both addiction counseling and psychiatric services.

Outpatient care with medication management

Standard outpatient treatment works well for mild to moderate depression with substance use disorder, especially when combined with antidepressant medication. This typically involves weekly therapy sessions, regular psychiatric check-ins for medication management, and support group participation. Outpatient care allows people to maintain work, family, and daily responsibilities while receiving treatment.

Choosing the right level of care

The appropriate level of care depends on several factors: severity of depression (mild vs. severe with suicidal thoughts), severity of addiction, previous treatment attempts and outcomes, strength of social support, co-occurring medical conditions, and safety concerns. A professional assessment by a dual diagnosis specialist can determine the best starting point. Many people move through multiple levels of care as they progress in recovery.

Antidepressant Medications in Recovery

SSRIs: the first-line treatment

Selective serotonin reuptake inhibitors (SSRIs) such as sertraline (Zoloft), fluoxetine (Prozac), and escitalopram (Lexapro) are the most commonly prescribed antidepressants for people in addiction recovery. They work by increasing serotonin availability in the brain, gradually improving mood, sleep, and motivation over 4–6 weeks. SSRIs are not addictive, do not produce a high, and have no abuse potential — making them fundamentally different from the substances being treated.

SNRIs and bupropion

Serotonin-norepinephrine reuptake inhibitors (SNRIs) like venlafaxine (Effexor) and duloxetine (Cymbalta) target both serotonin and norepinephrine, which can be helpful for depression with prominent fatigue or chronic pain. Bupropion (Wellbutrin) is another option that acts on dopamine and norepinephrine — it can help with depression, low energy, and is also used to support smoking cessation. None of these medications carry addiction risk.

Addressing the stigma around psychiatric medication

Many people in recovery resist antidepressants because they feel taking any medication contradicts sobriety. This misconception is dangerous. Antidepressants are not mood-altering substances in the way drugs of abuse are — they restore normal brain chemistry rather than creating artificial highs. Untreated depression is one of the strongest predictors of addiction relapse. Taking prescribed, non-addictive medication to manage a medical condition is not a failure of recovery — it supports it.

Why stopping psychiatric meds leads to relapse

A common and harmful pattern occurs when people in recovery stop their antidepressants because they feel better, believe they no longer need them, or face pressure from others to be "medication-free." When depression returns — often within weeks — the emotional pain drives them back to substances. Antidepressant treatment for co-occurring depression should be maintained for at least 12 months after stabilization, and many people benefit from long-term maintenance. Any changes to psychiatric medication should be made gradually under medical supervision.

Frequently Asked Questions About Depression and Addiction

What is dual diagnosis treatment for depression and addiction?

Dual diagnosis treatment addresses both depression and substance use disorders simultaneously through integrated care. This approach recognizes that mental health and addiction affect each other and must be treated together for lasting recovery. Treatment includes psychiatric care, medication management, therapy (CBT, DBT), and specialized counseling that addresses both conditions comprehensively.

Can depression cause substance abuse?

Yes, depression significantly increases the risk of substance abuse. Many people self-medicate depression symptoms with alcohol or drugs, seeking temporary relief from emotional pain, low energy, or insomnia. However, substance use worsens depression long-term by disrupting serotonin and dopamine regulation, creating a vicious cycle. Proper treatment addresses root causes of depression while providing healthier coping strategies than substances.

Will antidepressants interfere with addiction treatment?

No, appropriate antidepressant medication actively supports recovery. Quality dual diagnosis programs work with psychiatrists to find effective antidepressant treatment while addressing addiction. Medications like SSRIs and SNRIs are non-addictive and help stabilize mood, making it easier to engage in therapy and maintain sobriety. Never stop psychiatric medications without medical guidance.

How do I find a treatment center for depression and addiction?

Look for centers explicitly offering dual diagnosis or co-occurring disorder treatment. Verify they have licensed mental health professionals, psychiatric services, medication management capabilities, and experience treating both conditions together. Use our directory to filter for dual diagnosis programs, read reviews, and verify accreditation. Contact admissions teams to discuss your specific needs.

Is residential treatment necessary for depression and addiction?

Not always. Treatment level depends on severity of both conditions, previous treatment attempts, safety concerns, and support system. Some people do well with intensive outpatient care plus medication management. Residential treatment provides 24/7 support for severe depression, suicide risk, or when outpatient treatment hasn't succeeded. A professional assessment determines the most appropriate level of care.

Can addiction cause depression or does depression cause addiction?

The relationship is bidirectional — it works both ways. Depression can lead to substance abuse through self-medication, as people use drugs or alcohol to escape emotional pain. At the same time, chronic substance use alters brain chemistry in ways that cause or worsen depression — alcohol is a central nervous system depressant, stimulant withdrawal causes profound depression, and opioid use disrupts the brain's natural mood regulation. In many cases, both conditions develop and reinforce each other simultaneously, which is why integrated dual diagnosis treatment is essential for lasting recovery.

Will I need antidepressants forever?

Not necessarily. Many people take antidepressants for 12–24 months after their mood stabilizes, then gradually taper off under medical supervision. However, some people with recurrent major depression (three or more episodes) benefit from long-term maintenance medication. The decision depends on depression severity, number of past episodes, family history, and individual response to treatment. What is critical is never stopping antidepressants abruptly — doing so can cause withdrawal symptoms and trigger relapse in both depression and addiction. Always work with your prescribing psychiatrist to make any medication changes.

Medical Review and Sources

Medically Reviewed Updated April 10, 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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