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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Depression & Addiction Treatment Centers Near You

Depression and addiction frequently co-occur, requiring integrated treatment approaches. Find dual diagnosis treatment centers addressing both mental health and substance use disorders through coordinated care and evidence-based therapies.

Found 7,770 rehab centers specializing in depression across the United States.

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Find Depression and Addiction Treatment Centers Near You

Browse dual diagnosis treatment centers below. Filter for programs treating depression and substance abuse together.

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Sheer Recovery
San Juan Capistrano, CA

Situated in San Juan Capistrano, California, Sheer Recovery delivers a wide array of services for addiction treatment. This center specializes in residential detox and offers several residential programs designed for both adults and young adults. Emphasizing 12-step methodologies, anger management strategies, and intervention techniques, Sheer Recovery provides personalized support to effectively tackle concurrent substance abuse and mental health challenges. Unique programs are available for active duty service members, as well as for adult men and women. Welcoming clients of all genders, Sheer Recovery is recognized for its exceptional care and dedication to fostering sustainable recovery.

Sheer Recovery
San Juan Capistrano, CA

Sheer Recovery, located in San Juan Capistrano, CA, offers a wide range of addiction rehabilitation services designed for adults and young adults. This center focuses on detoxification, treatment for substance use disorders, and addressing co-occurring mental health issues. They provide various levels of outpatient care, including intensive outpatient programs and day treatment options. Emphasizing 12-step principles, anger management strategies, and targeted brief interventions, Sheer Recovery serves active duty military members as well as both men and women. Their customized programs for diverse age groups ensure that all clients receive personalized treatment aimed at promoting successful recovery. Opt for Sheer Recovery to benefit from evidence-backed methods and heartfelt guidance throughout the recovery process.

Sheer Recovery LLC
Dana Point, CA

Sheer Recovery LLC, situated in Dana Point, CA, provides a broad array of treatment services for individuals looking to overcome substance use issues and simultaneous mental health challenges. The center features residential detox options, around-the-clock care, and short-term residential programs specifically designed for both adults and young adults. Catering to active duty military personnel, as well as adult men and women, Sheer Recovery LLC utilizes research-backed methodologies like 12-step facilitation, anger management, and brief interventions to foster enduring recovery. Their dedication to high-quality care and personalized treatment strategies positions this facility as a reputable option for individuals in search of effective addiction support.

Shelbyville Comprehensive Trt Center

Shelbyville Comprehensive Trt Center, located in Shelbyville, KY, specializes in outpatient detox and treatment for substance use disorders. The center employs various therapeutic methods, including cognitive behavioral therapy, anger management, and the Matrix Model, addressing the needs of adult clients, both men and women, along with those who have faced trauma. With an emphasis on providing personalized care, this facility develops specific programs for different genders, ensuring that every client receives the support necessary for recovery. If you or someone you care about is in search of thorough and effective addiction treatment options, Shelbyville Comprehensive Trt Center could be the ideal choice.

Shenandoah Community Health

Shenandoah Community Health in Martinsburg, WV, delivers outpatient services for detoxification and substance use. This center focuses on addressing dual diagnoses of substance use and significant mental health conditions in adults, alongside emotional challenges in children. Their therapeutic interventions encompass 12-step integration, anger management techniques, and brief intervention strategies. Catering to active military personnel, adult men, and women, the facility serves adults and young adults of all genders, offering a nurturing setting for those pursuing thorough addiction treatment.

Shepherds Shelter/Ross Rehab

Shepherds Shelter/Ross Rehab, located in Mount Sterling, KY, is dedicated to addressing substance abuse issues and providing transitional housing for adult males. The center offers both long-term residential and outpatient services, with a strong emphasis on 12-step programs, anger management techniques, and short-term intervention strategies. This facility is equipped to serve active duty military members, adult males, and those who have faced intimate partner violence. With a focus on adults, seniors, and young adults, the center features a gender-specific program designed to meet the unique needs of male clients. Committed to high-quality, personalized care, Shepherds Shelter/Ross Rehab supports individuals on their path to recovery.

Siena Francis House Miracles Treatment

Siena Francis House Miracles Treatment, located in Omaha, NE, specializes in providing long-term and around-the-clock residential treatment for substance use issues, catering to both adult men and women, including individuals with trauma backgrounds. The facility emphasizes a holistic method to recovery, incorporating 12-step programs, anger management techniques, and cognitive behavioral therapy. They design customized treatment plans for both young adults and adults, ensuring that each person receives specialized attention. With a strong emphasis on gender-sensitive care, Siena Francis House Miracles Treatment fosters a nurturing atmosphere for clients of all genders aiming to conquer addiction. The center's dedication to high-quality service establishes it as a guiding light for individuals embarking on their recovery journeys.

Shoreline Family Healthcare

Shoreline Family Healthcare in Branford, CT, provides outpatient services for individuals, encompassing adults and children who are dealing with substance use disorders alongside serious mental health conditions. The facility features targeted programs designed for active military personnel, teenagers, and adult males. Their therapeutic interventions include strategies for managing anger, brief counseling, and cognitive behavioral therapy. Patients can access medication-assisted treatment using methadone, buprenorphine, or naltrexone, in addition to standard outpatient care. Catering to adults and seniors regardless of gender, this center is dedicated to delivering effective rehabilitation that is personalized to each person's specific requirements, cultivating a nurturing setting conducive to healing and sustained recovery.

Sierra at Scottsdale
Scottsdale, AZ

Sierra at Scottsdale, situated in Scottsdale, AZ, provides targeted care for adults and young adults grappling with substance use disorders alongside significant mental health or emotional challenges. The center offers a range of treatment intensities, including intensive outpatient, standard outpatient, and partial hospitalization. Their therapeutic approach emphasizes anger management, brief interventions, and cognitive behavioral therapy, all customized to each individual's specific requirements. Specialized programs are available for active duty military personnel, adult men, and adult women. This facility caters to all genders, delivering expert rehabilitation services within a nurturing setting.

Shepherds House Inc
Lexington, KY

Shepherds House Inc, situated in Lexington, KY, is dedicated to providing targeted rehabilitation services for adult males facing challenges related to substance use disorders. This center offers various treatment options, such as long-term residential programs, outpatient care, and intensive outpatient services. Employing strategies like 12-step methods, anger management, and brief interventions, the facility supports clients recovering from intimate partner violence, domestic abuse, and sexual trauma. With its emphasis on adult men, including seniors and young adults, Shepherds House Inc fosters a nurturing atmosphere for those striving for recovery and a healthier way of life.

Sierra Native Alliance

Sierra Native Alliance, located in Auburn, CA, provides extensive substance abuse recovery services for adults, accommodating individuals facing dual diagnoses of mental health disorders. Their specialized offerings extend to active military members, teenagers, and adult males, with a spectrum of treatment intensities including intensive outpatient, outpatient, and standard outpatient programs. Employing scientifically validated methods like anger management, brief intervention, and cognitive behavioral therapy, the center welcomes individuals of any gender and age. Sierra Native Alliance is committed to delivering tailored and effective treatment, guiding clients toward lasting sobriety.

Shelby County Treatment Center

Nestled in Alabaster, AL, the Shelby County Treatment Center is dedicated to assisting adults and young adults navigating the challenges of substance use and co-occurring mental health conditions. The center delivers robust intensive outpatient and outpatient detoxification services, employing proven methods like 12-step facilitation, anger management techniques, and brief intervention strategies. Offering distinct programs for active duty military personnel, adult men, and adult women, the facility prioritizes individualized care. Committed to high standards and personalized recovery plans, the center welcomes both male and female individuals in pursuit of healing within a nurturing setting.

Shreveport Behavioral Health Clinic

Situated in Shreveport, LA, the Shreveport Behavioral Health Clinic specializes in addressing substance use disorders along with associated severe mental health challenges in adults. The center offers a range of treatment options including intensive outpatient programs, general outpatient services, as well as methadone or buprenorphine/naltrexone treatments on an outpatient basis. Emphasizing methods like 12-step facilitation, cognitive behavioral therapy, and the Matrix Model, the clinic customizes its approach to suit each individual's requirements. Additionally, there are dedicated programs for active military personnel, adolescents, and adult males. The clinic provides comprehensive care for adults and seniors across all genders, ensuring effective treatment through gender-sensitive programs and individualized strategies.

Sibus Treatment Services LLC

Situated in Elkridge, MD, Sibus Treatment Services LLC specializes in outpatient programs for substance use treatment, prioritizing high-quality care. This center offers outpatient services featuring methadone, buprenorphine, or naltrexone, in addition to counseling for substance use disorders and telehealth therapy. Sibus Treatment Services LLC serves both adult men and women, including those who have faced sexual abuse. With tailored programs for adults and young adults of all genders, this facility fosters a nurturing atmosphere for individuals on their journey to recovery from addiction.

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Situated in Shelbyville, IL, Shelby County Community Services provides high-quality outpatient substance use treatment. The center employs a variety of methods, including 12-step facilitation, brief intervention, and cognitive behavioral therapy to support adolescents as well as adult men and women. Catering primarily to adults and seniors, it offers tailored care for both genders. Shelby County Community Services is recognized for its individualized treatment plans and extensive support, making it an ideal choice for those pursuing recovery. This facility serves as a source of encouragement for individuals looking for effective addiction treatment in a friendly atmosphere.

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Shiloh Psychological Consulting PLLC, located in New York, NY, specializes in the treatment of substance use disorders and co-occurring mental health issues for both adults and children. The center offers a range of programs, including intensive outpatient, outpatient, and regular outpatient care. Emphasizing approaches like 12-step facilitation, anger management, and brief interventions, they create customized treatment plans for individuals with varying needs. The center features specialized programs designed for active duty military personnel, adult males, and individuals who have experienced intimate partner violence. With a commitment to providing exceptional, person-centered rehabilitation services, Shiloh Psychological Consulting PLLC supports adults and young adults of all genders in achieving sustained recovery.

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Shipowick Smith Counseling LLC, situated in Wenatchee, WA, provides thorough substance abuse recovery services for adults and older individuals. Their programs include intensive outpatient, standard outpatient, and flexible outpatient options. Employing proven methods such as cognitive behavioral therapy, motivational interviewing, and relapse prevention strategies, the facility delivers tailored support to every client. Shipowick Smith Counseling LLC is experienced in assisting individuals with co-occurring mental health and substance use issues, serving both men and women. Committed to high-standard care and customized recovery journeys, the center is devoted to aiding people in achieving lasting sobriety.

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The Shoalwater Bay Indian Tribe rehabilitation center, situated in Tokeland, WA, delivers expert assistance for individuals battling substance use disorders and accompanying mental health challenges. This establishment features comprehensive outpatient care, general outpatient services, and medication-assisted treatment including methadone, buprenorphine, or naltrexone. Employing therapeutic techniques such as brief intervention, cognitive behavioral therapy, and the Matrix Model, the center supports adults and older adults, alongside specific programs tailored for active military personnel, teenagers, and adult men. Open to both men and women, the facility is committed to high-standard care and personalized treatment plans to foster sustained recovery.

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Shoreline Recovery Center located in Encinitas, CA, specializes in treating adult men who are facing substance use challenges alongside mental health issues. This center offers various treatment programs, including intensive outpatient, outpatient, and day treatment, utilizing proven methodologies such as 12-step facilitation and strategies for managing anger. Customized programs are designed for individuals who have faced traumatic experiences. By prioritizing high-quality care, the center serves a diverse population including adults, seniors, and young adults, ensuring a well-rounded recovery process. If you or someone you know is looking for empathetic and effective support for substance use problems, Shoreline Recovery Center is committed to guiding you on the path to recovery.

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Sierra County Behavioral Health, located in Loyalton, CA, specializes in outpatient programs aimed at assisting individuals dealing with substance use issues, particularly those who also face serious mental health challenges or emotional disturbances. The center employs a variety of evidence-based methodologies, including brief interventions, motivational interviewing, and strategies to prevent relapse. They feature specific programs designed for adult men and women, as well as those who have faced domestic violence or intimate partner issues. By offering services to both adults and youth, this center ensures that clients receive customized care tailored to their needs. Sierra County Behavioral Health is committed to providing exceptional, personalized rehabilitation services that facilitate the recovery journey for each individual.

Depression & Substance Use Disorder: Key Facts

Classification

Major Depressive Disorder + Substance Use Disorder (Dual Diagnosis)

Co-occurrence

~1 in 3 people with depression also have SUD (NIDA)

Prevalence

21 million adults with major depressive episode/year (NIMH)

Self-medication

Depression is the #1 reason for substance self-medication

Treatment approach

Integrated dual diagnosis (treat both simultaneously)

Key therapies

CBT, DBT, medication management, group therapy

Medications

SSRIs (non-addictive), SNRIs — safe during addiction treatment

Prognosis

Significantly better outcomes with integrated treatment vs sequential

If you or someone you know is experiencing suicidal thoughts, call 988 (Suicide & Crisis Lifeline) or text 988 immediately. Help is available 24/7.

Depression and Addiction: The Dual Diagnosis Connection

How depression and addiction feed each other

Depression and substance use disorder share a deeply intertwined relationship. Depression causes persistent feelings of emptiness, hopelessness, and emotional pain that drive many people toward alcohol or drugs as a form of self-medication. Substances may provide temporary relief, but they alter brain chemistry in ways that worsen depressive symptoms over time — creating a destructive cycle that accelerates both conditions.

The self-medication cycle

The self-medication cycle is the most common pathway from depression to addiction. A person experiencing persistent sadness, fatigue, or emotional numbness turns to alcohol, opioids, or stimulants to feel better temporarily. As tolerance builds, they need more of the substance to achieve the same relief. Meanwhile, the substance disrupts serotonin and dopamine regulation in the brain, deepening the depression. When the substance wears off, the depression returns worse than before — driving further substance use.

Why treating one without the other fails

Treating addiction without addressing underlying depression leaves the root cause intact. The person achieves sobriety but continues suffering from untreated depression, making relapse nearly inevitable as they seek relief. Conversely, treating depression without addressing active substance use is ineffective because ongoing drug or alcohol use undermines the neurochemical changes that antidepressants and therapy work to achieve. This is why dual diagnosis treatment — addressing both conditions simultaneously — produces significantly better outcomes than treating either condition alone.

Signs of Co-Occurring Depression and Substance Abuse

Recognizing co-occurring depression and substance abuse can be challenging because symptoms overlap. Watch for these warning signs:

Emotional and behavioral signs

  • Persistent sadness combined with increased substance use
  • Withdrawal from friends, family, and activities once enjoyed
  • Using drugs or alcohol specifically to cope with emptiness or hopelessness
  • Feelings of worthlessness or excessive guilt alongside substance use
  • Loss of motivation or interest in recovery efforts

Physical signs

  • Significant changes in sleep patterns — insomnia or oversleeping
  • Appetite and weight changes (loss or gain)
  • Chronic fatigue even with adequate rest
  • Increased substance tolerance requiring higher doses
  • Neglect of personal hygiene and self-care

How Dual Diagnosis Treatment Works

Integrated approach

Dual diagnosis treatment treats depression and addiction as interconnected conditions rather than separate problems. Instead of completing addiction treatment first and then addressing depression (the sequential approach that often fails), integrated programs work on both simultaneously. This means therapy sessions address how depressive thoughts drive substance use, while psychiatric care stabilizes mood to support sobriety.

Psychiatric evaluation during early sobriety

Accurate diagnosis of depression requires evaluation during a period of sobriety, because many substances can mimic or mask depressive symptoms. Alcohol is a depressant that causes sadness and lethargy. Stimulant withdrawal causes profound depression. A psychiatrist experienced in dual diagnosis will conduct thorough assessments during early sobriety to distinguish substance-induced mood changes from underlying major depressive disorder, ensuring the right treatment plan.

Coordinated care teams

Effective dual diagnosis programs use coordinated care teams where psychiatrists, addiction counselors, therapists, and medical staff communicate about each patient's progress. The psychiatrist managing antidepressant medication works closely with the addiction counselor guiding recovery, so treatment decisions account for both conditions. This prevents the common problem of one provider unknowingly undermining another's treatment plan.

Medication management alongside addiction treatment

One of the most important aspects of dual diagnosis care is safe medication management. Antidepressants like SSRIs and SNRIs are non-addictive and can be prescribed safely during addiction treatment. A psychiatrist monitors medication effectiveness, adjusts dosages, and watches for interactions — all while the person is actively working on recovery from substance use disorder.

Evidence-Based Therapies for Depression in Recovery

Cognitive Behavioral Therapy (CBT)

Cognitive Behavioral Therapy (CBT) is the gold standard for treating co-occurring depression and addiction. CBT helps identify negative thought patterns that drive both depressive episodes and substance use — such as "nothing will ever get better" or "I can't cope without drinking." Patients learn to challenge these distortions and replace them with realistic, constructive thinking. Research consistently shows CBT reduces both depressive symptoms and substance use relapse rates.

Dialectical Behavior Therapy (DBT)

Dialectical Behavior Therapy (DBT) is particularly effective for people with severe depression, emotional dysregulation, or self-harm behaviors alongside addiction. DBT teaches four core skill sets: mindfulness, distress tolerance, emotion regulation, and interpersonal effectiveness. These skills directly address the emotional pain that drives self-medication and provide healthier alternatives to substance use.

Group therapy

Group therapy combats the isolation that is central to both depression and addiction. Hearing others share similar struggles reduces shame and hopelessness. Dual diagnosis groups specifically address how depression and substance use interact, offering peer support from people who understand both conditions. Group settings also build social skills and accountability that support long-term recovery.

Medication management

Antidepressant medications are a critical component of treatment for many people with co-occurring depression and addiction. SSRIs (selective serotonin reuptake inhibitors) like sertraline and fluoxetine are first-line treatments because they are effective, well-tolerated, and — importantly — non-addictive. They carry no abuse potential and do not produce euphoria, making them safe to prescribe during addiction recovery. SNRIs like venlafaxine and duloxetine are also effective alternatives.

Levels of Care for Depression and Addiction

When residential treatment is needed

Residential treatment is recommended when depression is severe — particularly when suicidal ideation is present, when the person has made previous suicide attempts, or when outpatient treatment has failed. Residential programs provide 24/7 psychiatric monitoring, immediate medication adjustments, and a safe environment removed from triggers. People with severe addiction alongside major depression often need this level of structured support to stabilize both conditions.

Intensive Outpatient Programs (IOP)

Intensive Outpatient Programs provide 9–20 hours of structured therapy per week while allowing patients to live at home. IOP is appropriate for moderate depression with addiction, for people stepping down from residential care, or when the person has a stable living environment and support system. Dual diagnosis IOP programs include both addiction counseling and psychiatric services.

Outpatient care with medication management

Standard outpatient treatment works well for mild to moderate depression with substance use disorder, especially when combined with antidepressant medication. This typically involves weekly therapy sessions, regular psychiatric check-ins for medication management, and support group participation. Outpatient care allows people to maintain work, family, and daily responsibilities while receiving treatment.

Choosing the right level of care

The appropriate level of care depends on several factors: severity of depression (mild vs. severe with suicidal thoughts), severity of addiction, previous treatment attempts and outcomes, strength of social support, co-occurring medical conditions, and safety concerns. A professional assessment by a dual diagnosis specialist can determine the best starting point. Many people move through multiple levels of care as they progress in recovery.

Antidepressant Medications in Recovery

SSRIs: the first-line treatment

Selective serotonin reuptake inhibitors (SSRIs) such as sertraline (Zoloft), fluoxetine (Prozac), and escitalopram (Lexapro) are the most commonly prescribed antidepressants for people in addiction recovery. They work by increasing serotonin availability in the brain, gradually improving mood, sleep, and motivation over 4–6 weeks. SSRIs are not addictive, do not produce a high, and have no abuse potential — making them fundamentally different from the substances being treated.

SNRIs and bupropion

Serotonin-norepinephrine reuptake inhibitors (SNRIs) like venlafaxine (Effexor) and duloxetine (Cymbalta) target both serotonin and norepinephrine, which can be helpful for depression with prominent fatigue or chronic pain. Bupropion (Wellbutrin) is another option that acts on dopamine and norepinephrine — it can help with depression, low energy, and is also used to support smoking cessation. None of these medications carry addiction risk.

Addressing the stigma around psychiatric medication

Many people in recovery resist antidepressants because they feel taking any medication contradicts sobriety. This misconception is dangerous. Antidepressants are not mood-altering substances in the way drugs of abuse are — they restore normal brain chemistry rather than creating artificial highs. Untreated depression is one of the strongest predictors of addiction relapse. Taking prescribed, non-addictive medication to manage a medical condition is not a failure of recovery — it supports it.

Why stopping psychiatric meds leads to relapse

A common and harmful pattern occurs when people in recovery stop their antidepressants because they feel better, believe they no longer need them, or face pressure from others to be "medication-free." When depression returns — often within weeks — the emotional pain drives them back to substances. Antidepressant treatment for co-occurring depression should be maintained for at least 12 months after stabilization, and many people benefit from long-term maintenance. Any changes to psychiatric medication should be made gradually under medical supervision.

Frequently Asked Questions About Depression and Addiction

What is dual diagnosis treatment for depression and addiction?

Dual diagnosis treatment addresses both depression and substance use disorders simultaneously through integrated care. This approach recognizes that mental health and addiction affect each other and must be treated together for lasting recovery. Treatment includes psychiatric care, medication management, therapy (CBT, DBT), and specialized counseling that addresses both conditions comprehensively.

Can depression cause substance abuse?

Yes, depression significantly increases the risk of substance abuse. Many people self-medicate depression symptoms with alcohol or drugs, seeking temporary relief from emotional pain, low energy, or insomnia. However, substance use worsens depression long-term by disrupting serotonin and dopamine regulation, creating a vicious cycle. Proper treatment addresses root causes of depression while providing healthier coping strategies than substances.

Will antidepressants interfere with addiction treatment?

No, appropriate antidepressant medication actively supports recovery. Quality dual diagnosis programs work with psychiatrists to find effective antidepressant treatment while addressing addiction. Medications like SSRIs and SNRIs are non-addictive and help stabilize mood, making it easier to engage in therapy and maintain sobriety. Never stop psychiatric medications without medical guidance.

How do I find a treatment center for depression and addiction?

Look for centers explicitly offering dual diagnosis or co-occurring disorder treatment. Verify they have licensed mental health professionals, psychiatric services, medication management capabilities, and experience treating both conditions together. Use our directory to filter for dual diagnosis programs, read reviews, and verify accreditation. Contact admissions teams to discuss your specific needs.

Is residential treatment necessary for depression and addiction?

Not always. Treatment level depends on severity of both conditions, previous treatment attempts, safety concerns, and support system. Some people do well with intensive outpatient care plus medication management. Residential treatment provides 24/7 support for severe depression, suicide risk, or when outpatient treatment hasn't succeeded. A professional assessment determines the most appropriate level of care.

Can addiction cause depression or does depression cause addiction?

The relationship is bidirectional — it works both ways. Depression can lead to substance abuse through self-medication, as people use drugs or alcohol to escape emotional pain. At the same time, chronic substance use alters brain chemistry in ways that cause or worsen depression — alcohol is a central nervous system depressant, stimulant withdrawal causes profound depression, and opioid use disrupts the brain's natural mood regulation. In many cases, both conditions develop and reinforce each other simultaneously, which is why integrated dual diagnosis treatment is essential for lasting recovery.

Will I need antidepressants forever?

Not necessarily. Many people take antidepressants for 12–24 months after their mood stabilizes, then gradually taper off under medical supervision. However, some people with recurrent major depression (three or more episodes) benefit from long-term maintenance medication. The decision depends on depression severity, number of past episodes, family history, and individual response to treatment. What is critical is never stopping antidepressants abruptly — doing so can cause withdrawal symptoms and trigger relapse in both depression and addiction. Always work with your prescribing psychiatrist to make any medication changes.

Medical Review and Sources

Medically Reviewed Updated April 10, 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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