Buprenorphine Treatment Centers in South Dakota
Medically reviewed by NWVCIL Editorial TeamLast reviewed: May 2026
Our directory lists 22 buprenorphine providers across South Dakota, with the largest concentrations in Sioux Falls (2), Hot Springs (1) and Flandreau (1).
South Dakota recorded 95 drug overdose deaths in 2023 — an 11.2-per-100,000 age-adjusted rate, the second-lowest in the nation after Nebraska — but the state has one of the most limited MAT infrastructures in the country, with only 1 SAMHSA-certified Opioid Treatment Program licensed by the South Dakota Division of Behavioral Health. NWVCIL's directory tracks 10 buprenorphine providers in South Dakota, with 2 in Sioux Falls and a small number in Flandreau and Fort Thompson, the latter two serving tribal communities. South Dakota Medicaid covers buprenorphine and naltrexone for opioid use disorder; methadone access is extremely limited and concentrated in Sioux Falls. 27 of the 37 verified facilities in our directory accept Medicaid, and 22 offer telehealth — for a state where the nearest specialty addiction-medicine practice may be 200+ miles away in some western counties, telehealth-delivered MAT is often the only practical option. The state Division of Behavioral Health partners with Indian Health Service and tribal-health programs serving the Lakota, Dakota, and Nakota reservations. For a South Dakotan starting buprenorphine, common pathways include: scheduling an intake at a community-based behavioral-health agency in Sioux Falls or Rapid City, an Indian Health Service or tribal-health clinic for enrolled members, a Federally Qualified Health Center for sliding-fee or Medicaid patients, or a telehealth visit with a South Dakota-licensed prescriber (the most common route for residents outside the two metros). Most providers can prescribe Suboxone, Subutex, Zubsolv, or the monthly Sublocade injection. SAMHSA's national helpline (1-800-662-4357) and the 988 Suicide and Crisis Lifeline are available 24/7.
Treatment landscape in South Dakota:
- South Dakota recorded 95 drug overdose deaths in 2023 at 11.2 per 100,000 (CDC NCHS) — among the lowest U.S. rates.
- 10 buprenorphine providers and 1 methadone Opioid Treatment Program serve the state; Sioux Falls anchors access.
- South Dakota Medicaid covers buprenorphine and naltrexone; methadone access is extremely limited.
- The Division of Behavioral Health licenses OTPs; most rural MAT is delivered through buprenorphine prescribing in primary care.
Buprenorphine in South Dakota — By the Numbers
11.2
per 100,000 drug overdose mortality (CDC 2023)
95
total overdose deaths in South Dakota (2023)
10
buprenorphine providers in our directory
22 / 37
facilities offering telehealth
27
accept Medicaid for treatment
1
SAMHSA-certified Opioid Treatment Programs
Top cities by buprenorphine provider density
Sioux Falls (2) · Flandreau (1) · Fort Thompson (1)
Sources: CDC NCHS Drug Overdose Mortality (2023) · SAMHSA Treatment Locator · NWVCIL directory snapshot, May 2026
South Dakota Medicaid
South Dakota Medicaid covers buprenorphine and naltrexone; methadone access is extremely limited and concentrated in Sioux Falls and Rapid City.
State regulations
South Dakota Division of Behavioral Health licenses OTPs; the state has one of the lowest OTP-per-capita rates in the country.
- Federal, or any government funding for substance use treatment programs10
- Medicaid8
- Cash or self-payment7
- Private health insurance7
- Medicare6
- IHS/Tribal/Urban (ITU) funds5
- Outpatient9
- Regular outpatient treatment9
- Outpatient methadone/buprenorphine or naltrexone treatment7
- Intensive outpatient treatment6
- Residential/24-hour residential4
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Buprenorphine Treatment Providers in South Dakota
Buprenorphine providers in South Dakota

Sioux Falls VAHCS
Sioux Falls, SD
Services:

VA Black Hills Healthcare System
Hot Springs, SD
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Flandreau Santee Sioux Tribe
Flandreau, SD
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New Dawn Enterprises
Vale, SD
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Volunteers of America Dakotas
Sioux Falls, SD
Services:

Anpetu Luta Otipi/Kyle Campus
Kyle, SD
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Capital Area Counseling Services
Pierre, SD
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Fort Thompson Service Unit
Fort Thompson, SD
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Lewis and Clark Behavioral Hlth Servs
Yankton, SD
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Rapid City
Rapid City, SD
Services:
Showing 10 of 22 buprenorphine providers in South Dakota. Browse all centers in South Dakota
Frequently Asked Questions About Buprenorphine in South Dakota
Can undocumented immigrants access buprenorphine in South Dakota?
Many South Dakota providers accept self-pay, sliding-fee, or grant-funded patients regardless of immigration status. Federally funded community health centers and some South Dakota Medicaid-contracted clinics offer MAT on a sliding scale. Providers are not required to report immigration status.
How much does Vivitrol (naltrexone injection) cost without insurance?
Vivitrol monthly cost without insurance typically falls between $1,100 and $1,500 per injection in South Dakota. The manufacturer Alkermes offers a patient-assistance co-pay savings card; state-funded programs also cover Vivitrol for uninsured patients in many counties.
How do I enroll in South Dakota Medicaid to pay for buprenorphine?
You can apply to South Dakota Medicaid online at the South Dakota state website, in person at a county office, or through buprenorphine providers that offer enrollment assistance. Most applications are decided within 45 days; emergency Medicaid may be available sooner for urgent care.
Does TRICARE cover buprenorphine for active-duty or retired military?
Yes. TRICARE Prime and Select cover the full MAT benefit including buprenorphine. Active-duty service members may need command notification; retirees and dependents do not. Humana Military or Health Net Federal handles TRICARE claims depending on the South Dakota region.
What agency regulates buprenorphine providers in South Dakota?
South Dakota’s state behavioral-health authority licenses MAT facilities, and the Substance Abuse and Mental Health Services Administration (SAMHSA) certifies Opioid Treatment Programs. The Drug Enforcement Administration (DEA) regulates controlled-substance handling at every MAT site.
What is the shortest effective course of buprenorphine?
Evidence supports a minimum of 6–12 months of continuous MAT for most patients. Courses shorter than 3 months are associated with high relapse and overdose rates. Your South Dakota clinician will set an individualized duration target after the first month of treatment.
What happens if no buprenorphine providers have immediate openings in my area?
South Dakota’s opioid-response infrastructure funds bridge clinics, emergency-department induction, and telehealth buprenorphine specifically to fill same-day gaps. If the closest clinic has a waitlist, your intake counselor will refer you to the next nearest opening.
What happens if my drug screen is positive at the first visit?
A positive urine drug screen is expected for most patients entering MAT — it confirms the diagnosis. Positive screens are not used to deny admission at any South Dakota SAMHSA-certified OTP. Your clinician interprets results and builds an individualized plan from there.
Does buprenorphine interact with other medications?
Yes. Benzodiazepines, alcohol, and some sleep medications significantly increase sedation risk. HIV medications and certain antibiotics can alter methadone levels. Always share your full medication list with the South Dakota MAT clinician so interactions can be managed.
Will my baby go through withdrawal if I take buprenorphine?
Neonatal Opioid Withdrawal Syndrome (NOWS) can occur in infants exposed to methadone or buprenorphine prenatally and is routinely monitored at South Dakota delivery hospitals. NOWS is manageable with skilled nursing care; most infants go home within days to weeks with normal outcomes.
What is peer-recovery support and is it available in South Dakota?
Peer-recovery support workers are trained individuals with lived recovery experience who provide mentoring, accompaniment to appointments, and navigation of resources. South Dakota Medicaid reimburses peer-support services; most mid-sized buprenorphine providers employ certified peer specialists.
Can my family get information about my buprenorphine treatment without my consent?
No. Your South Dakota clinic cannot share any information with family members without a signed release specifying who, what information, and for how long. Patients under 18 may have parental involvement requirements — rules vary.
Other Treatment Options in South Dakota
Buprenorphine Treatment in Other States
Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)