Naltrexone Treatment Centers in South Dakota
Medically reviewed by Sarah Mitchell, LCSWLast reviewed: April 2026
Our directory lists 20 naltrexone providers across South Dakota, with the largest concentrations in Sioux Falls (2), Yankton (2) and Hot Springs (1).
Naltrexone (Vivitrol, Revia) is an opioid antagonist used to treat both alcohol use disorder and opioid dependence. Available as a daily oral tablet or monthly extended-release injection, it blocks opioid receptors to reduce cravings and prevent relapse.
Treatment landscape in South Dakota:
- South Dakota Medicaid covers addiction services
- Native American treatment programs
- Community-centered recovery approach
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Naltrexone providers in South Dakota

Sioux Falls VAHCS
Sioux Falls, SD
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VA Black Hills Healthcare System
Hot Springs, SD
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Flandreau Santee Sioux Tribe
Flandreau, SD
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New Dawn Enterprises
Vale, SD
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Arch
Sioux Falls, SD
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Capital Area Counseling Services
Pierre, SD
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Fort Thompson Service Unit
Fort Thompson, SD
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Lewis and Clark Behavioral Hlth Servs
Yankton, SD
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Rapid City
Rapid City, SD
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South Dakota Human Services Center
Yankton, SD
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Showing 11 of 20 naltrexone providers in South Dakota. Browse all centers in South Dakota
South Dakota Medicaid
South Dakota Medicaid covers buprenorphine and naltrexone; methadone access is extremely limited and concentrated in Sioux Falls and Rapid City.
State regulations
South Dakota Division of Behavioral Health licenses OTPs; the state has one of the lowest OTP-per-capita rates in the country.
- Federal, or any government funding for substance use treatment programs10
- Medicaid9
- Cash or self-payment8
- Private health insurance8
- IHS/Tribal/Urban (ITU) funds6
- Medicare5
- Outpatient9
- Regular outpatient treatment9
- Outpatient methadone/buprenorphine or naltrexone treatment7
- Intensive outpatient treatment6
- Residential/24-hour residential4
Frequently Asked Questions About Naltrexone in South Dakota
Can undocumented immigrants access naltrexone in South Dakota?
Many South Dakota providers accept self-pay, sliding-fee, or grant-funded patients regardless of immigration status. Federally funded community health centers and some South Dakota Medicaid-contracted clinics offer MAT on a sliding scale. Providers are not required to report immigration status.
Is the first visit to a naltrexone provider free?
Some South Dakota programs offer a free screening or phone intake; others charge an initial assessment fee ($100–$300 self-pay). Federally qualified health centers often waive the first visit. Ask up front about assessment fees when you schedule your appointment.
Does South Dakota Medicaid cover naltrexone treatment?
Yes. South Dakota Medicaid covers FDA-approved medications for opioid use disorder, including naltrexone, plus the associated counseling, drug testing, and clinic visits. Specific formulary details (preferred agents, long-acting injectables) vary by plan — check with your South Dakota Medicaid managed-care organization.
What if my health plan is out of state — can I use it in South Dakota for naltrexone?
Most PPO plans cover out-of-state MAT at in-network rates if the provider is part of the national network. HMO plans typically restrict coverage to in-state providers; call member services before starting naltrexone in South Dakota to verify.
Is naltrexone treatment legal and regulated in South Dakota?
Yes. naltrexone is a federally approved medication used legally across South Dakota. Methadone is dispensed only at SAMHSA-certified Opioid Treatment Programs (OTPs); buprenorphine is prescribed by licensed clinicians; naltrexone has no prescriber waiver requirement. State licensing agencies oversee all naltrexone providers.
Does the length of time in naltrexone affect my probation or custody case?
Typically no — South Dakota family and criminal courts increasingly recognize MAT as standard medical care. Longer continuous treatment is often viewed favorably by courts as evidence of stability. Share treatment documentation with your attorney for court proceedings.
What documents do I need to start naltrexone?
Bring a photo ID, insurance or South Dakota Medicaid card (if applicable), and a list of current medications. Proof of address and pharmacy information speed up buprenorphine prescribing. Intake staff will walk you through paperwork at your first visit.
How soon after the first visit do I come back?
Follow-up within 3–7 days is standard after the first naltrexone visit to confirm response and titrate the dose. South Dakota clinics may see stable patients weekly for the first month, then space visits out as stability is achieved.
Will naltrexone make me tired or affect my ability to work in South Dakota?
During induction (first 1–2 weeks), mild drowsiness is common. Once stabilized, most patients fully resume work, including safety-sensitive jobs such as CDL driving, subject to any employer drug-testing policies. South Dakota clinicians can issue letters documenting stability.
What pain medication can I receive during delivery while on naltrexone?
Standard labor epidurals are fully compatible with MAT. If post-operative opioid pain relief is needed after cesarean, higher doses may be required due to tolerance. The South Dakota anesthesiology and MAT teams coordinate the post-operative pain plan before delivery.
Is telehealth counseling available with naltrexone in South Dakota?
Yes. South Dakota MAT programs routinely deliver individual counseling and group therapy by video. Telehealth counseling is reimbursed at parity by South Dakota Medicaid and most commercial insurers under current state and federal parity rules.
Can I keep my naltrexone treatment private from my health-insurance company?
If you use insurance, the insurer sees billed services (including MAT). They cannot share that with your employer or family. If you strongly value privacy from insurance, self-pay is the only fully insulated option.
Other Treatment Options in South Dakota
Naltrexone Treatment in Other States
Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)