NWVCIL Logo
Medically Reviewed Content
Updated: August 2026
Sources: SAMHSA, NIDA

Suboxone Clinic Near You: Buprenorphine Treatment for Opioid Addiction

Find a Suboxone clinic near you. Buprenorphine — sold under brand names Suboxone, Sublocade, Subutex, Zubsolv, and Brixadi — is the most-prescribed MAT for opioid use disorder. It is a partial mu-opioid agonist with a ceiling effect that dramatically reduces overdose risk vs. methadone. After the MAT Act of 2023 eliminated the X-waiver requirement, any licensed prescriber can prescribe buprenorphine in office-based settings (OBOT), via telehealth, or at retail pharmacies. Buprenorphine is a Schedule III controlled substance and is covered by Medicaid in all 50 states.

Found 7,145 treatment centers offering buprenorphine (suboxone) across the United States.

Need Help Finding the Right Treatment Center?

Speak with a compassionate specialist now - 100% free & confidential

Call +1 (833) 244-3031
Available 24/7
All 50 States
Filters:

Showing 21 of 7145 results

Middletown Clinic
Middletown, NY

Situated in Middletown, NY, the Middletown Clinic delivers extensive outpatient services for adults and seniors dealing with substance use issues. The center features targeted programs designed for men, women, and individuals who have faced sexual abuse. Treatment modalities encompass 12-step facilitation, brief interventions, and cognitive behavioral therapy, ensuring that care is tailored to each individual's needs. With options for outpatient methadone/buprenorphine or naltrexone treatment, the facility addresses a wide range of client requirements. The Middletown Clinic emphasizes high-quality care and personalized programs, serving as a crucial support system for those pursuing effective addiction recovery.

Middletown Medical LLC

Middletown Medical LLC, based in Red Bank, NJ, delivers expert care for addiction and co-occurring psychological conditions in individuals of all ages. They offer robust intensive outpatient and outpatient services, incorporating medication-assisted treatment with methadone, buprenorphine, or naltrexone. Utilizing approaches like cognitive behavioral therapy, contingency management, and motivational interviewing, the facility crafts personalized recovery plans. Catering to adults and young adults across all gender identities, Middletown Medical LLC is distinguished by its patient-centered methodology. Clients receive premier, research-backed treatment from a committed team dedicated to fostering sustained healing and well-being.

MidState Health Center

MidState Health Center, located in Bristol, NH, provides a wide range of outpatient services for adults and young adults struggling with substance use disorders. Their offerings encompass outpatient treatments using methadone, buprenorphine, or naltrexone, as well as standard outpatient therapy, brief interventions, cognitive behavioral therapy, and motivational incentives through contingency management. The center particularly excels in supporting pregnant and postpartum women, offering specialized care for both male and female clients. Emphasizing personalized treatment plans and evidence-based methodologies, MidState Health Center is dedicated to delivering effective support for individuals seeking recovery from addiction.

Midwest Center Youngstown

Situated in Youngstown, OH, Midwest Center Youngstown provides extensive care for individuals struggling with addiction, catering to both adults and young adults. Their services encompass detoxification, comprehensive substance use therapy, and individualized treatment plans. The center employs various therapeutic approaches, including 12-step facilitation, anger management techniques, and brief interventions, available through intensive outpatient, outpatient, and standard outpatient programs. Midwest Center Youngstown distinguishes itself with gender-specific tracks for men and women, fostering a secure and welcoming atmosphere. Committed to high standards of care and personalized strategies, the facility is devoted to supporting clients on their journey to sustained recovery.

Midwest Detox
Brookfield, WI

Midwest Detox, situated in Brookfield, WI, delivers expert residential detoxification solutions. This center ensures continuous care for adult men and women, as well as young adults, employing diverse therapeutic methods. Their treatment strategies include 12-step program support, emotional regulation techniques, and cognitive behavioral interventions, all tailored to each person's specific requirements. Midwest Detox distinguishes itself through its dedication to individualized support and fostering long-term sobriety. For a thorough detox experience that acknowledges your specific circumstances, this establishment provides a nurturing space to embark on your path to recovery.

Midwest Detox Center

Midwest Detox Center, situated in Maumee, OH, delivers extensive addiction recovery solutions for adolescents and adults. Their offerings encompass detoxification protocols, comprehensive substance use disorder therapy, and targeted interventions for individuals facing dual diagnoses of substance abuse and significant mental health conditions or severe emotional disturbances in youth. The center provides a range of treatment modalities, including extended residential stays, partial hospitalization programs, and standard outpatient services, accommodating a wide spectrum of recovery requirements. Dedicated programs are also available for active military members, adult men, and adult women. Employing therapeutic strategies like 12-step integration, emotional regulation training, and short-term counseling, Midwest Detox Center is committed to personalized treatment plans. This establishment fosters a nurturing setting conducive to healing and enhances overall wellness.

Midwest Recovery Center

Midwest Recovery Center, based in Toledo, OH, delivers a diverse array of rehabilitation services. This center focuses on treating substance use issues and effectively manages co-occurring disorders related to drug and alcohol abuse as well as mental health challenges. The offerings include intensive outpatient programs, standard outpatient services, and day treatment. Utilizing methods like 12-step programs, anger management strategies, and brief therapeutic interventions, the facility serves both adults and young adults from various backgrounds. Additionally, specialized programs are available for active-duty military personnel, men, and women. Midwest Recovery Center is committed to offering exceptional care and guidance to assist individuals in their recovery process.

Milestone Recovery

Milestone Recovery, situated in Phoenix, AZ, delivers a full spectrum of addiction treatment for adults and adolescents. The center features intensive outpatient, extended residential stays, and outpatient services, emphasizing 12-step principles, emotional regulation techniques, and short-term counseling. Tailored programs are available for military personnel, adult males, and adult females, guaranteeing personalized support. Beyond substance abuse, Milestone Recovery also manages dual-diagnosis conditions affecting adults and youths. Committed to high standards of care, Milestone Recovery is devoted to guiding individuals toward lasting sobriety.

Mill Creek Community Hospital

Mill Creek Community Hospital located in Erie, PA, offers a wide range of addiction recovery services. This facility provides inpatient detoxification, around-the-clock hospital care, and intensive outpatient programs, designed for both adults and young adults battling substance use issues. The center employs methods such as 12-step facilitation, cognitive-behavioral therapy, and brief interventions to deliver personalized treatment. With dedicated programs for active military personnel and specific groups of adult men and women, Mill Creek Community Hospital ensures that treatment is both gender-specific and age-appropriate. Clients can look forward to receiving high-quality, evidence-based support tailored to meet their individual needs at this esteemed rehabilitation facility.

MidMichigan Community Health Services

MidMichigan Community Health Services, located in Houghton Lake, MI, delivers specialized outpatient care focused on substance dependency, detoxification, and the management of co-occurring mental health conditions for individuals of all ages. Their services encompass outpatient detox, medication-assisted treatment using methadone, buprenorphine, and naltrexone. Therapeutic modalities employed include 12-step facilitation, brief intervention, and cognitive behavioral therapy. The center is equipped to assist adult men and women, including survivors of intimate partner violence, and offers gender-specific programming for adults and young adults. A commitment to exceptional care and personalized recovery strategies is central to their mission.

Mile High Treatment and Recovery Inc

Mile High Treatment and Recovery Inc, situated in Denver, CO, provides outpatient detox and treatment for both adults and young adults dealing with substance use issues. The center is dedicated to relapse prevention, offers specialized counseling for substance use disorders, and incorporates telehealth services. Prioritizing personalized care, this facility administers outpatient options, including methadone/buprenorphine or naltrexone treatments, alongside traditional outpatient programs. Catering to a diverse clientele, Mile High Treatment and Recovery Inc is distinguished by its customized strategies for recovery, delivering extensive and quality services that assist individuals in their journey toward health and recovery.

Milestone Addiction Treatment LLC

Milestone Addiction Treatment LLC, located in Merchantville, NJ, delivers a full spectrum of care for individuals struggling with substance use disorders. They offer various levels of outpatient treatment, including intensive, standard, and regular programs, all customized to meet each client's specific requirements. Their treatment methodologies emphasize 12-step principles, anger management techniques, and brief intervention strategies, making them well-equipped to address co-occurring mental health conditions. Additionally, Milestone Addiction Treatment LLC provides targeted support for active military personnel, adult men, and women. The center is open to all genders, fostering a welcoming atmosphere conducive to successful recovery.

Middlesex Recovery PC
Gloucester, MA

Middlesex Recovery PC, located in Gloucester, MA, provides thorough treatment for substance use disorders via outpatient services, which include options for methadone, buprenorphine, or naltrexone. The center employs scientifically-backed methods such as cognitive behavioral therapy, motivational interviewing, and strategies for preventing relapse in order to assist individuals on their recovery path. With a commitment to personalized care, Middlesex Recovery PC serves adults and young adults of any gender. Their customized programs focus on delivering high-quality treatment that meets the distinct needs of each individual, fostering a supportive and effective rehabilitation experience for those seeking assistance with addiction.

Middlesex Recovery PC

Middlesex Recovery PC, located in Stoughton, MA, specializes in providing outpatient treatment options for substance use tailored to both adults and young adults. The center employs a variety of proven methodologies, such as cognitive behavioral therapy, motivational interviewing, and counseling focused on substance use disorders. With a strong emphasis on customized care, Middlesex Recovery PC guarantees that every client receives focused attention. The center offers outpatient treatment alternatives, including methadone, buprenorphine, and naltrexone, to meet a variety of needs. Open to all genders, it serves individuals pursuing meaningful and compassionate recovery from addiction. Middlesex Recovery PC distinguishes itself through its dedication to high-quality care and extensive support for those on their journey to healing.

Milestone Recovery
Old Orchard Beach, ME

Situated in Old Orchard Beach, ME, Milestone Recovery delivers an extensive range of treatment options for adult males struggling with substance use disorders. This center features long-term residential care, outpatient services, and standard outpatient programs, all founded on evidence-based methodologies such as the Matrix Model, Motivational Interviewing, and Relapse Prevention strategies. Milestone Recovery is dedicated specifically to men, accommodating seniors, young adults, and various other individuals in need of focused support within a male-only setting. Additionally, the facility offers transitional housing, a halfway house, and sober living arrangements to promote a nurturing and organized path to recovery. For those in search of tailored care, Milestone Recovery stands as a symbol of hope on the journey to sustained sobriety.

Milestone Recovery
Portland, ME

Situated in Portland, ME, Milestone Recovery delivers an extensive array of services for addiction treatment. The facility offers detoxification and treatment for substance use through both outpatient and residential options. It employs methods such as 12-step facilitation, cognitive behavioral therapy, and motivational interviewing, serving adult men and women, including those who are pregnant or postpartum. Targeting both adult and young adult demographics, Milestone Recovery provides personalized care tailored for both male and female individuals. The center's dedication to high-quality treatment and specialized programs establishes it as a significant asset for individuals in need of effective rehabilitation support.

Mile High Behavioral Healthcare

Nestled in Westminster, Colorado, Mile High Behavioral Healthcare is dedicated to providing specialized care for adults struggling with substance use disorders, with a particular emphasis on individuals experiencing co-occurring serious mental health conditions. The center features a range of residential treatment options, including extended stays, continuous 24-hour supervision, and shorter program durations. Employing evidence-based strategies such as 12-step facilitation and anger management techniques, the facility is equipped to support adult women who have experienced intimate partner violence, domestic abuse, or sexual trauma. Mile High Behavioral Healthcare serves a diverse clientele encompassing adults, seniors, and young adults, cultivating a secure and nurturing setting for women pursuing thorough recovery. Discover personalized attention and impactful therapeutic interventions at Mile High Behavioral Healthcare.

Mile High Council on Alcoholism and

The Mile High Council on Alcoholism, situated in Denver, CO, delivers extensive substance abuse services for individuals of all ages, addressing co-occurring mental health conditions. They offer various levels of care, including intensive outpatient, outpatient, and medication-assisted treatment with methadone or buprenorphine. Employing proven methods such as cognitive behavioral therapy and community reinforcement, the center has distinct programs for teenagers, adult men, and women, welcoming diverse populations. Support extends to transitional housing and halfway house arrangements, fostering a nurturing atmosphere for recovery. Committed to serving adults and seniors across all gender identities, this facility is dedicated to providing personalized, high-quality care.

Milestones Ranch Malibu

Milestones Ranch Malibu, located in Malibu, CA, specializes in providing high-quality rehabilitation options for both adults and young adults facing challenges related to substance use and concurrent mental health concerns. Emphasizing various treatment durations including long-term, 24-hour residential, and short-term stays, this center delivers personalized care that addresses the unique needs of each client. The facility employs evidence-based techniques such as 12-step programs, anger management, and short intervention strategies. Notably, Milestones Ranch Malibu offers tailored programs for individuals who have undergone trauma, as well as for those dealing with both mental health and substance use disorders. The center also features gender-specific treatment alternatives to foster a nurturing and inclusive atmosphere for all individuals pursuing recovery.

Placeholder image

The Midwestern CT Council of Alcoholism, located in Torrington, CT, provides tailored programs for substance use recovery in a supportive atmosphere. Emphasizing intensive outpatient treatment as well as various outpatient options, this center offers thorough assistance for both adults and young adults. It employs methods such as anger management, brief interventions, and cognitive behavioral therapy, accommodating clients of all genders. Distinct programs are designed for adult men, adult women, and those who have undergone intimate partner or domestic violence. The center's dedication to personalized care and proven treatment strategies guarantees effective support for individuals on their path to overcoming substance use challenges.

Placeholder image

Millenium Clinic Inc, located in Hollywood, FL, provides a wide range of services aimed at treating substance use disorders and addressing complex mental health conditions that may occur simultaneously. The center features various treatment formats, including intensive outpatient, outpatient, and day treatment programs, as well as options for telehealth therapy. With specialized programs designed for teens, adult males, and females, the clinic addresses the needs of various demographics. Emphasizing personalized care and treatment strategies, Millenium Clinic Inc is recognized as a reliable provider for individuals seeking rehabilitation support in the Hollywood region.

Frequently Asked Questions

What is buprenorphine and how does it treat opioid addiction?
Buprenorphine is a partial opioid agonist medication approved by the FDA for treating opioid use disorder. It binds to the same receptors as heroin and fentanyl but produces a much weaker effect, reducing cravings and withdrawal symptoms without causing intense euphoria. Buprenorphine has a ceiling effect, meaning its opioid effects plateau at moderate doses, making it safer than methadone in terms of overdose risk.
What is the difference between Suboxone and Subutex?
Suboxone contains two active ingredients — buprenorphine and naloxone — while Subutex contains only buprenorphine without naloxone. The naloxone in Suboxone is included as an abuse deterrent; it remains inactive when taken sublingually as prescribed but triggers withdrawal if the medication is injected. Subutex is generally reserved for patients who cannot tolerate naloxone, such as pregnant women.
What is a Sublocade injection and how does it work?
Sublocade is a once-monthly injectable form of buprenorphine administered as a subcutaneous injection in the abdominal area. After injection, the medication forms a solid deposit under the skin that slowly releases buprenorphine over the course of a month. This eliminates daily dosing and removes the possibility of missed doses or medication diversion.
What are the common side effects of Suboxone?
Common Suboxone side effects include headache, nausea, constipation, insomnia, sweating, and mouth numbness or pain from sublingual administration. Some patients also experience dizziness, drowsiness, and blurred vision, particularly when starting treatment. Most side effects diminish within the first few weeks as the body adjusts. Patients should report difficulty breathing or signs of allergic reaction immediately.
What happens during Suboxone withdrawal?
Suboxone withdrawal occurs when a patient stops taking the medication abruptly after prolonged use, with symptoms including muscle aches, anxiety, insomnia, nausea, and irritability. A medically supervised taper is strongly recommended, typically reducing the dose by small increments over weeks or months. The risk of opioid relapse is significantly higher during unsupervised discontinuation.
How does Suboxone compare to methadone?
Suboxone and methadone are both effective for opioid use disorder but differ in key ways. Methadone is a full opioid agonist dispensed daily at licensed clinics, while Suboxone is a partial agonist that can be prescribed by qualified physicians and taken at home. Suboxone carries a lower overdose risk due to its ceiling effect and offers greater convenience, though methadone may be more appropriate for patients with severe, long-standing dependence.
How can I find a Suboxone clinic or doctor near me?
The most reliable way to find a Suboxone provider is through SAMHSA's online treatment locator at findtreatment.gov, which allows you to search by location and filter for buprenorphine providers. Many primary care offices, addiction treatment centers, and telehealth platforms now offer Suboxone prescriptions following the elimination of the federal X-waiver requirement in early 2023.
What is Zubsolv and how is it different from Suboxone?
Zubsolv is a brand-name buprenorphine and naloxone sublingual tablet that features a mint flavor and dissolves faster under the tongue than other options. Due to its higher bioavailability, Zubsolv uses different dosing strengths — a Zubsolv 5.7 mg/1.4 mg tablet is considered equivalent to a Suboxone 8 mg/2 mg dose. Patients switching between products should work closely with their prescriber for correct dose conversion.
Does Medicaid cover Suboxone treatment?
Yes — Medicaid covers buprenorphine (including Suboxone, Sublocade, Subutex, Zubsolv, and Brixadi) for opioid use disorder in all 50 states, as required by the SUPPORT Act of 2018. Medicaid is the largest single payer for MAT in the US. Coverage details vary by state — some require prior authorization or limit certain formulations. Many OBOT clinics accept Medicaid directly; telehealth Suboxone providers also bill Medicaid in most states. Bring your Medicaid card to your intake appointment.
Can I get Suboxone through telehealth?
Yes. After the MAT Act of 2023 permanently eliminated the X-waiver requirement, any licensed prescriber can prescribe Suboxone via telehealth in most states. The DEA also extended COVID-era telehealth flexibilities through at least 2025, allowing virtual Suboxone induction without a prior in-person visit. Several specialty platforms — Bicycle Health, Ophelia, Workit Health, Boulder Care — offer Medicaid-accepting telehealth Suboxone treatment. Telehealth has dramatically expanded access in rural and underserved areas with no nearby OBOT physicians.

About Buprenorphine (Suboxone)

Buprenorphine is classified as a partial opioid agonist, meaning it activates opioid receptors in the brain but to a much lesser degree than full agonists such as heroin, fentanyl, or oxycodone. This partial activation suppresses withdrawal symptoms and reduces cravings without producing dangerous respiratory depression or intense euphoria. Buprenorphine also has an unusually high binding affinity for the mu-opioid receptor, effectively blocking other opioids from attaching — providing a protective effect against relapse-related overdose.

How Buprenorphine Works

One of the defining features of buprenorphine is its ceiling effect — after a certain dose threshold, increasing the amount does not produce additional opioid effects. This dramatically reduces the risk of fatal overdose compared to methadone or illicit opioids. The ceiling effect, combined with its long duration of action (24 to 72 hours), makes buprenorphine one of the safest and most effective tools in medication-assisted treatment (MAT). Approved by the FDA in 2002, buprenorphine was a breakthrough because it could be prescribed in outpatient settings rather than requiring daily clinic visits.

Buprenorphine Brand Comparison: Suboxone, Subutex, Sublocade, Zubsolv, Brixadi

Buprenorphine is available under several FDA-approved brand names, each with distinct formulations, dosing schedules, and clinical use cases. The comparison below highlights the key differences:

BrandActive ingredientFormFrequencySettingFDA yearBest for
SuboxoneBuprenorphine + naloxoneSublingual film / tabletDailyOBOT, telehealth, retail pharmacy2002Most prescribed; naloxone deters injection misuse
SubutexBuprenorphine (alone)Sublingual tabletDailyOBOT2002Pregnancy; documented naloxone sensitivity
SublocadeBuprenorphine extended-releaseSubcutaneous injection (ATRIGEL depot)MonthlyClinic-administered2017No daily dosing; eliminates diversion risk
ZubsolvBuprenorphine + naloxoneSublingual tablet (higher bioavailability)DailyOBOT2013Faster dissolution; mint flavor; lower mg/dose
BrixadiBuprenorphine extended-releaseSubcutaneous injectionWeekly or monthlyClinic2023Newer alternative to Sublocade; weekly option for induction

All five medications are Schedule III controlled substances and equivalent in clinical efficacy at appropriate doses. The choice depends on adherence patterns, lifestyle, insurance coverage, and clinical context (e.g., pregnancy, prior injection use, daily-dosing burden). Many patients begin on sublingual Suboxone for stabilization and transition to monthly Sublocade or weekly Brixadi after sustained recovery.

Buprenorphine Side Effects

Common buprenorphine side effects include:

  • Headache and dizziness
  • Nausea and vomiting, especially during induction
  • Constipation and insomnia
  • Excessive sweating
  • Mouth numbness or oral discomfort from sublingual formulations

More serious side effects may include respiratory depression (particularly when combined with benzodiazepines or alcohol), liver problems, and allergic reactions. For most patients, side effects are mild and resolve within one to two weeks. The benefits in preventing relapse and overdose death significantly outweigh the risks.

Buprenorphine Dosage and Induction

Treatment begins with an induction phase where the patient must be in mild to moderate opioid withdrawal. Common induction doses range from 2 mg to 8 mg on the first day, with increases over the following days. Most patients stabilize on 8 mg to 24 mg per day, with 16 mg being the most commonly prescribed dose. Research suggests doses of 16 mg or higher are associated with better retention and outcomes. Dosage should always be adjusted under medical supervision.

Buprenorphine/Naloxone Combination

Many buprenorphine formulations include naloxone as an abuse deterrent. When taken sublingually as directed, naloxone has very low bioavailability and produces no clinical effect. However, if someone attempts to inject the medication, the naloxone component becomes fully active and triggers severe withdrawal. This design discourages injection misuse while having no impact on patients who take the medication correctly. The combination is the standard first-line formulation for opioid addiction treatment.

Suboxone: Sublingual Buprenorphine

Suboxone is the most recognized brand name for buprenorphine-naloxone and is most commonly dispensed as a sublingual film (Suboxone strips) that dissolves under the tongue. Suboxone has transformed opioid treatment by enabling millions of patients to receive effective pharmacotherapy in outpatient settings without the daily clinic visits required by methadone programs.

Suboxone Side Effects

Commonly reported Suboxone side effects include headache, nausea, tongue or mouth irritation, constipation, insomnia, sweating, and decreased libido. The sublingual film can cause irritation or small sores inside the mouth — rotating placement between under the tongue and against the cheek helps minimize this. Patients should not eat, drink, or smoke while the film is dissolving.

Suboxone Strips: Film vs. Tablet

Suboxone strips (sublingual film) have largely replaced the original tablet form. The film dissolves more quickly (two to four minutes), provides more consistent absorption, and is harder to divert due to individual foil packaging. Generic buprenorphine-naloxone tablets are often less expensive and may be preferred for cost reasons. Both are therapeutically equivalent when taken as prescribed.

Suboxone Treatment Programs

Comprehensive Suboxone treatment typically includes three phases:

  • Induction: Initial dosing under medical supervision, requiring the patient to be in early withdrawal
  • Stabilization: Dose adjustment until cravings and withdrawal are minimal, usually one to two months
  • Maintenance: Stable dosing for an extended period — often a year or longer — combined with counseling and behavioral therapy

Evidence consistently shows that longer treatment durations are associated with better outcomes. Most addiction medicine experts recommend a minimum of one to two years of maintenance therapy.

Find a Suboxone Clinic Near You — OBOT & Telehealth Options

Finding a Suboxone clinic has become significantly easier since the federal government eliminated the X-waiver requirement in January 2023, meaning any provider with a standard DEA license can now prescribe Suboxone. Patients can search SAMHSA's treatment locator at findtreatment.gov or use our directory to locate nearby facilities that offer buprenorphine-based treatment.

Suboxone Doctors Near Me

Beyond SAMHSA's locator, many state health departments maintain directories of addiction treatment providers. Telehealth has dramatically expanded access — several platforms now offer virtual Suboxone consultations, which is especially valuable for patients in rural areas. When selecting a provider, look for those offering comprehensive treatment including counseling, not just medication prescriptions.

Suboxone Withdrawal and Tapering

Suboxone withdrawal can include muscle aches, anxiety, insomnia, nausea, sweating, and intense opioid cravings. A gradual, medically supervised taper is recommended — typically reducing the dose by 10 to 25 percent every one to four weeks. Slower tapers over several months produce fewer symptoms and lower relapse rates. There is no medically mandated time limit for Suboxone treatment, and many patients benefit from indefinite maintenance.

Suboxone vs Methadone

Suboxone can be prescribed in office settings and taken at home, carries lower overdose risk due to its ceiling effect, and offers greater scheduling flexibility. Methadone is a full agonist that may be more effective for severe, long-standing dependence but must be dispensed at licensed clinics with daily visits. Neither is inherently superior — the best choice keeps the patient in treatment. Some patients may also benefit from naltrexone, a non-opioid alternative.

Sublocade: Monthly Buprenorphine Injection

Sublocade delivers buprenorphine as a once-monthly subcutaneous injection in the abdominal area using the ATRIGEL delivery system, which forms a solid biodegradable depot that slowly releases medication. Patients must first stabilize on sublingual buprenorphine (8 mg+ daily) for at least seven days. Treatment typically begins with two 300 mg injections, followed by maintenance on 300 mg or 100 mg. Sublocade eliminates concerns about daily adherence, missed doses, and medication diversion.

Sublocade Side Effects

The most common Sublocade side effects are injection-site reactions (pain, itching, redness, or a noticeable lump), nausea, constipation, headache, and fatigue. The injection-site lump is normal and gradually diminishes as medication is absorbed. Patients should avoid rubbing or massaging the site. Elevated liver enzymes may also occur but are usually mild and transient.

Subutex: Buprenorphine Without Naloxone

Subutex was the original brand-name buprenorphine product. While the brand has been discontinued, generic buprenorphine-only tablets remain available. Buprenorphine monotherapy is typically reserved for pregnant patients (to avoid naloxone exposure to the fetus), patients with documented naloxone sensitivity, or sometimes during the induction phase before transitioning to the combination product.

Subutex vs Suboxone

The primary difference is the absence of naloxone in Subutex. Because Subutex lacks the abuse-deterrent naloxone component, it may carry slightly higher diversion risk, and many insurance formularies prioritize the combination as the default. Current clinical guidelines favor buprenorphine-only formulations primarily for pregnancy and naloxone sensitivity.

Zubsolv: Alternative Buprenorphine Brand

Zubsolv is a buprenorphine-naloxone sublingual tablet featuring a mint flavor and faster dissolution (under two minutes). Due to enhanced bioavailability, Zubsolv uses different dose strengths — a 5.7 mg/1.4 mg tablet equals a Suboxone 8 mg/2 mg dose. Zubsolv is available in multiple strengths for flexible dosing during both induction and maintenance.

Buprenorphine resources:

Find Buprenorphine (Suboxone) by State

Browse buprenorphine (suboxone) programs in states with the most treatment options.

Explore Related Options

Related conditions, treatment approaches, and levels of care.

Medically Reviewed Updated August 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)