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Medically Reviewed Content
Updated: July 2026
Sources: SAMHSA, NIDA

Suboxone Clinic Near You: Buprenorphine Treatment for Opioid Addiction

Find a Suboxone clinic near you. Buprenorphine — sold under brand names Suboxone, Sublocade, Subutex, Zubsolv, and Brixadi — is the most-prescribed MAT for opioid use disorder. It is a partial mu-opioid agonist with a ceiling effect that dramatically reduces overdose risk vs. methadone. After the MAT Act of 2023 eliminated the X-waiver requirement, any licensed prescriber can prescribe buprenorphine in office-based settings (OBOT), via telehealth, or at retail pharmacies. Buprenorphine is a Schedule III controlled substance and is covered by Medicaid in all 50 states.

Found 7,145 treatment centers offering buprenorphine (suboxone) across the United States.

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ARS of Ephrata
Ephrata, PA

Situated in Ephrata, Pennsylvania, ARS of Ephrata delivers extensive treatment for substance use through outpatient services and medication-assisted options such as methadone, buprenorphine, or naltrexone. The center focuses on remedies for anger management, provides brief interventions, and employs cognitive behavioral therapy. It offers distinct programs designed for those affected by trauma, members of the LGBTQ community, as well as expectant and new mothers. Catering to adults and young adults of all identities, ARS of Ephrata ensures high-quality support in a nurturing atmosphere. If you or someone you care about is in need of substance use assistance featuring specialized programs and proven methodologies, this center is well-prepared to aid in the recovery process.

ARS Treatment Centers of New Jersey

Situated in Rio Grande, NJ, ARS Treatment Centers of New Jersey specializes in outpatient treatment for substance use disorders, emphasizing high-quality care tailored to individual needs. The center provides treatments that include methadone, buprenorphine, and naltrexone, along with counseling services for those dealing with substance use issues. For added accessibility, telehealth options are also offered. The facility has unique programs designed for pregnant and postpartum women, and it serves adults and young adults of all genders. With a strong focus on personalized treatment and specialized programs, ARS Treatment Centers of New Jersey is committed to aiding individuals in their recovery journey from substance use challenges.

Asana Recovery
Costa Mesa, CA

Asana Recovery, situated in Costa Mesa, California, delivers extensive addiction treatment options for both adults and young adults. The center features long-term residential programs, detoxification services, and round-the-clock support. Prioritizing 12-step methodologies, anger management techniques, and cognitive behavioral therapy, Asana Recovery customizes its services to cater to the unique needs of each individual. The facility is proficient in addressing co-occurring substance use disorders along with significant mental health conditions in adults, and it also caters to serious emotional challenges in children. With a strong emphasis on personalized care, Asana Recovery ensures quality treatment for male and female clients aiming to overcome addiction.

Asana Recovery
Huntington Beach, CA

In Huntington Beach, California, Asana Recovery provides extensive substance abuse treatment for adults and young adults. This establishment offers extended stays in residence, detox services while residing on-site, and round-the-clock residential care for those confronting substance dependence and concurrent significant mental health challenges. Asana Recovery utilizes proven therapeutic methods including 12-step program support, emotional regulation training, and cognitive-behavioral techniques. A key feature of this center is its custom treatment strategies designed for each person's unique circumstances. Featuring distinct offerings for males and females, Asana Recovery is committed to delivering excellent support for individuals embarking on their journey to wellness.

Asana Recovery Center
Costa Mesa, CA

Asana Recovery Center, located in Costa Mesa, CA, delivers a wide array of addiction treatment options tailored for both adults and young adults. This center features long-term residential treatment, detox services, and round-the-clock care. It is particularly adept at addressing co-occurring substance use disorders alongside severe mental health issues in adults and significant emotional challenges in children. Emphasizing personalized treatment plans, Asana Recovery Center employs various methods such as 12-step programs, anger management techniques, and cognitive behavioral therapy. The center is designed to accommodate both men and women, fostering a welcoming and inclusive atmosphere for all individuals pursuing recovery.

Ascend Clinical Services

Ascend Clinical Services, located in Rehrersburg, PA, specializes in a wide range of addiction treatment options for both adults and young adults. The facility offers services such as detox, intensive outpatient programs, and outpatient treatments involving methadone, buprenorphine, or naltrexone. By employing techniques like 12-step facilitation, brief intervention, and cognitive behavioral therapy, Ascend Clinical Services addresses the needs of men and women dealing with both mental health issues and substance use disorders. Committed to delivering high-quality care, the center customizes treatment plans to suit each individual's needs. It provides a nurturing atmosphere for both male and female clients seeking to overcome their substance use challenges.

Ascend Healthcare

Ascend Healthcare in Encino, CA, provides dedicated recovery programs for individuals struggling with addiction and underlying mental health conditions. Their services are structured to support adults with substance use and co-occurring disorders, as well as children experiencing emotional difficulties. Clients can choose from various care settings, including hospital-level inpatient treatment, continuous 24-hour support, and extended residential stays. The center employs personalized therapeutic strategies like 12-step integration, anger management techniques, and brief intervention methods. Ascend Healthcare distinguishes itself by offering specialized care for adolescents, survivors of domestic violence, and those who have endured sexual trauma. Serving men, women, and young people, the facility is committed to delivering thorough and empathetic assistance to all who are on their journey to wellness.

ARS Of Lancaster LP
Lancaster, PA

ARS Of Lancaster LP, located in Lancaster, PA, provides a wide range of addiction rehabilitation services for both adults and young adults. The center focuses on detoxification and treatment for substance use, offering intensive outpatient and standard outpatient programs, inclusive of outpatient detox services. ARS Of Lancaster LP employs evidence-based methods like cognitive behavioral therapy and contingency management, customizing treatment plans to meet the unique needs of each individual. With specialized programs available for active duty military personnel, adult men, and adult women, the center is committed to delivering tailored care. Serving clients of all genders, ARS Of Lancaster LP is dedicated to facilitating recovery journeys with high-quality support.

ARS Treatment Centers of New Jersey

ARS Treatment Centers of New Jersey, located in Stanhope, NJ, offers outpatient services for individuals grappling with substance use challenges. Their programs include options for methadone, buprenorphine, and naltrexone treatment. The center provides counseling for substance use disorders, along with telehealth therapy services. Targeting the unique needs of pregnant and postpartum women, ARS Treatment Centers of New Jersey serves adults and young adults across all gender identities. With a commitment to personalized care, the center strives to deliver effective support for those in pursuit of recovery from addiction. For individuals seeking well-rounded substance use treatment in a nurturing setting, this center provides tailored programs designed to address diverse requirements.

ARS of Virginia LLC
Winchester, VA

ARS of Virginia LLC in Winchester, VA, provides thorough addiction recovery services, employing diverse treatment modalities such as intensive outpatient care and standard outpatient medication-assisted treatment with methadone, buprenorphine, or naltrexone. The facility employs scientifically validated methods like motivational interviewing, cognitive behavioral therapy, and reward-based motivation strategies to foster lasting sobriety. Tailored support is available through specific programs designed for adult men, adult women, and individuals with trauma histories. Catering to a broad demographic of adult and young adult clients, ARS of Virginia LLC delivers high-caliber, individualized treatment. For those in search of effective addiction treatment focused on bespoke care and specialized interventions, ARS of Virginia LLC stands ready to assist.

ARS of Aberdeen
Aberdeen, MD

Situated in Aberdeen, MD, ARS of Aberdeen specializes in extensive treatment for substance use disorders targeting both adults and young adults. The center provides various levels of care including intensive outpatient programs, regular outpatient services, and treatments that utilize methadone/buprenorphine or naltrexone. Implementing research-backed methods such as cognitive behavioral therapy, motivational incentives, and the Matrix Model, ARS of Aberdeen serves both men and women, as well as individuals facing co-occurring mental health and substance use challenges. With tailored programs designed for diverse populations and a commitment to high-quality treatment, ARS of Aberdeen is focused on aiding individuals in their recovery journey.

ARS of Aberdeen LLC

ARS of Aberdeen LLC in Aberdeen, MD, provides a full spectrum of substance abuse treatment, including intensive outpatient, standard outpatient, and medication-assisted treatment options with methadone, buprenorphine, or naltrexone. Their therapeutic approach integrates cognitive behavioral therapy, motivational interviewing, and relapse prevention strategies, all delivered within a personalized framework designed to meet individual needs. The center welcomes adults and young adults of all genders, offering tailored support for a wide range of recovery journeys. ARS of Aberdeen LLC is dedicated to delivering high-quality, evidence-based care in a nurturing setting for individuals pursuing recovery. Discover individualized support and proven rehabilitation strategies at this location.

ARS New Castle
New Castle, DE

ARS New Castle, located in New Castle, DE, specializes in a wide range of substance use treatment and provides particular attention to adults facing both substance use disorders and significant mental health challenges, as well as addressing emotional issues in children. The center offers various treatment formats, including intensive outpatient care, outpatient programs, and options involving methadone, buprenorphine, or naltrexone. Utilizing research-backed methods like cognitive behavioral therapy and contingency management, ARS New Castle tailors its services to meet the unique needs of active duty military members and both men and women. With a focus on delivering exceptional care, the facility is recognized for its array of treatment options and personalized recovery paths.

ASCEND Csl and Recovery Services

ASCEND Csl and Recovery Services located in Portsmouth, OH, provides comprehensive treatment for individuals dealing with substance abuse and concurrent mental health issues, catering to both adults and children. The center offers a variety of services including intensive outpatient programs, outpatient care, and day treatment, employing tailored strategies such as 12-step facilitation, anger management, and cognitive behavioral therapy. Distinct programs are available for adult men, adult women, and those who have faced trauma. This facility is dedicated to serving individuals of all genders, including seniors, and emphasizes personalized care to facilitate clients' journeys toward recovery.

ARS Treatment Centers of New Jersey

ARS Treatment Centers of New Jersey, situated in Hamburg, NJ, delivers outpatient addiction rehabilitation services for adults and young adults. They feature distinct programs for expectant and new mothers, employing thorough substance use disorder counseling via methods such as telemedicine and remote therapy. Personalized outpatient plans incorporating methadone, buprenorphine, or naltrexone are offered. This facility serves both male and female individuals, prioritizing bespoke support for everyone pursuing sobriety. Their dedication to high-quality treatment and a variety of therapeutic options establishes them as a crucial support system for individuals in recovery.

ARS Treatment Centers of New Jersey

ARS Treatment Centers of New Jersey, located in Absecon, NJ, provides outpatient programs for substance use treatment, which include methadone, buprenorphine, and naltrexone options. The center also offers counseling for substance use disorders alongside telemedicine and telehealth services. With a specialization in supporting pregnant and postpartum women, the facility serves both adults and young adults of all genders. Emphasizing high-quality care and individualized treatment strategies, ARS Treatment Centers of New Jersey creates a nurturing setting for those on their path to recovery from addiction. Their holistic methodology focuses on addressing the specific needs of each individual, fostering lasting healing and enduring sobriety.

ARS Treatment Centers of New Jersey

In Lanoka Harbor, NJ, ARS Treatment Centers of New Jersey provides comprehensive outpatient care for substance use disorders, serving adults and young adults. The center features unique programs designed for women who are pregnant or have recently given birth. Their approach includes specialized counseling for addiction, alongside the convenience of telemedicine and telehealth services. Clients can receive individualized outpatient treatment plans incorporating methadone, buprenorphine, or naltrexone, available to both men and women. ARS Treatment Centers of New Jersey is committed to delivering effective support and high-quality recovery services, establishing itself as a key provider of detailed and gender-sensitive treatment options within the region.

Arvada Counseling Center Inc

Arvada Counseling Center Inc, located in Arvada, CO, specializes in the treatment of substance use issues for individuals ranging from adults to young adults and adolescents. The facility offers a variety of programs including intensive outpatient, outpatient, and standard outpatient options. Emphasizing methods such as anger management, cognitive behavioral therapy, and community reinforcement with vouchers, the center customizes its approach to meet the specific needs of each client. Unique offerings are available for active duty military members, adolescents, and adult men. Catering to both women and men, Arvada Counseling Center Inc provides a holistic and thorough rehabilitation experience, ensuring clients receive high-quality and individualized support throughout their recovery journey.

Arthur Center Community Health

The Arthur Center Community Health, situated in Montgomery City, MO, provides extensive outpatient care for adults and seniors battling substance use disorders. This center offers personalized programs in a nurturing setting for both men and women on their journey to recovery. Their treatment model integrates outpatient medication-assisted treatment, including methadone, buprenorphine, or naltrexone, with ongoing outpatient services, promoting a complete and successful recovery. The Arthur Center Community Health is recognized for its high standards of care and tailored strategies, making it a dependable option for individuals aiming to conquer addiction and rebuild their lives.

ARTS Potomac Street Center

Nestled in Aurora, Colorado, the ARTS Potomac Street Center delivers complete care for individuals struggling with substance use disorders, serving both adults and younger adults. Their offerings include intensive outpatient, standard outpatient, and medication-assisted treatment options using methadone, buprenorphine, or naltrexone. Addressing key areas such as anger management, brief interventions, and cognitive behavioral therapy, the center is equipped to support adult men and women, as well as those who have faced trauma. Tailored programs are a hallmark, ensuring each person receives personalized support. The ARTS Potomac Street Center is committed to high standards and proven methods, guiding individuals toward lasting recovery.

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Situated in Fulton, MO, the Arthur Center Behavioral Health delivers targeted outpatient treatment for substance use disorders among adults and seniors. Emphasizing personalized care, the center offers treatments including outpatient methadone/buprenorphine or naltrexone options, regular outpatient services, and customized programs designed for individual needs. The facility employs various methods such as 12-step facilitation, anger management, and brief interventions to provide thorough care for all clients, regardless of gender. Patients can look forward to receiving exceptional treatment within a nurturing environment that fosters long-term recovery. For those in search of effective addiction recovery solutions with a customized approach, the Arthur Center Behavioral Health is an ideal choice.

Frequently Asked Questions

What is buprenorphine and how does it treat opioid addiction?
Buprenorphine is a partial opioid agonist medication approved by the FDA for treating opioid use disorder. It binds to the same receptors as heroin and fentanyl but produces a much weaker effect, reducing cravings and withdrawal symptoms without causing intense euphoria. Buprenorphine has a ceiling effect, meaning its opioid effects plateau at moderate doses, making it safer than methadone in terms of overdose risk.
What is the difference between Suboxone and Subutex?
Suboxone contains two active ingredients — buprenorphine and naloxone — while Subutex contains only buprenorphine without naloxone. The naloxone in Suboxone is included as an abuse deterrent; it remains inactive when taken sublingually as prescribed but triggers withdrawal if the medication is injected. Subutex is generally reserved for patients who cannot tolerate naloxone, such as pregnant women.
What is a Sublocade injection and how does it work?
Sublocade is a once-monthly injectable form of buprenorphine administered as a subcutaneous injection in the abdominal area. After injection, the medication forms a solid deposit under the skin that slowly releases buprenorphine over the course of a month. This eliminates daily dosing and removes the possibility of missed doses or medication diversion.
What are the common side effects of Suboxone?
Common Suboxone side effects include headache, nausea, constipation, insomnia, sweating, and mouth numbness or pain from sublingual administration. Some patients also experience dizziness, drowsiness, and blurred vision, particularly when starting treatment. Most side effects diminish within the first few weeks as the body adjusts. Patients should report difficulty breathing or signs of allergic reaction immediately.
What happens during Suboxone withdrawal?
Suboxone withdrawal occurs when a patient stops taking the medication abruptly after prolonged use, with symptoms including muscle aches, anxiety, insomnia, nausea, and irritability. A medically supervised taper is strongly recommended, typically reducing the dose by small increments over weeks or months. The risk of opioid relapse is significantly higher during unsupervised discontinuation.
How does Suboxone compare to methadone?
Suboxone and methadone are both effective for opioid use disorder but differ in key ways. Methadone is a full opioid agonist dispensed daily at licensed clinics, while Suboxone is a partial agonist that can be prescribed by qualified physicians and taken at home. Suboxone carries a lower overdose risk due to its ceiling effect and offers greater convenience, though methadone may be more appropriate for patients with severe, long-standing dependence.
How can I find a Suboxone clinic or doctor near me?
The most reliable way to find a Suboxone provider is through SAMHSA's online treatment locator at findtreatment.gov, which allows you to search by location and filter for buprenorphine providers. Many primary care offices, addiction treatment centers, and telehealth platforms now offer Suboxone prescriptions following the elimination of the federal X-waiver requirement in early 2023.
What is Zubsolv and how is it different from Suboxone?
Zubsolv is a brand-name buprenorphine and naloxone sublingual tablet that features a mint flavor and dissolves faster under the tongue than other options. Due to its higher bioavailability, Zubsolv uses different dosing strengths — a Zubsolv 5.7 mg/1.4 mg tablet is considered equivalent to a Suboxone 8 mg/2 mg dose. Patients switching between products should work closely with their prescriber for correct dose conversion.
Does Medicaid cover Suboxone treatment?
Yes — Medicaid covers buprenorphine (including Suboxone, Sublocade, Subutex, Zubsolv, and Brixadi) for opioid use disorder in all 50 states, as required by the SUPPORT Act of 2018. Medicaid is the largest single payer for MAT in the US. Coverage details vary by state — some require prior authorization or limit certain formulations. Many OBOT clinics accept Medicaid directly; telehealth Suboxone providers also bill Medicaid in most states. Bring your Medicaid card to your intake appointment.
Can I get Suboxone through telehealth?
Yes. After the MAT Act of 2023 permanently eliminated the X-waiver requirement, any licensed prescriber can prescribe Suboxone via telehealth in most states. The DEA also extended COVID-era telehealth flexibilities through at least 2025, allowing virtual Suboxone induction without a prior in-person visit. Several specialty platforms — Bicycle Health, Ophelia, Workit Health, Boulder Care — offer Medicaid-accepting telehealth Suboxone treatment. Telehealth has dramatically expanded access in rural and underserved areas with no nearby OBOT physicians.

About Buprenorphine (Suboxone)

Buprenorphine is classified as a partial opioid agonist, meaning it activates opioid receptors in the brain but to a much lesser degree than full agonists such as heroin, fentanyl, or oxycodone. This partial activation suppresses withdrawal symptoms and reduces cravings without producing dangerous respiratory depression or intense euphoria. Buprenorphine also has an unusually high binding affinity for the mu-opioid receptor, effectively blocking other opioids from attaching — providing a protective effect against relapse-related overdose.

How Buprenorphine Works

One of the defining features of buprenorphine is its ceiling effect — after a certain dose threshold, increasing the amount does not produce additional opioid effects. This dramatically reduces the risk of fatal overdose compared to methadone or illicit opioids. The ceiling effect, combined with its long duration of action (24 to 72 hours), makes buprenorphine one of the safest and most effective tools in medication-assisted treatment (MAT). Approved by the FDA in 2002, buprenorphine was a breakthrough because it could be prescribed in outpatient settings rather than requiring daily clinic visits.

Buprenorphine Brand Comparison: Suboxone, Subutex, Sublocade, Zubsolv, Brixadi

Buprenorphine is available under several FDA-approved brand names, each with distinct formulations, dosing schedules, and clinical use cases. The comparison below highlights the key differences:

BrandActive ingredientFormFrequencySettingFDA yearBest for
SuboxoneBuprenorphine + naloxoneSublingual film / tabletDailyOBOT, telehealth, retail pharmacy2002Most prescribed; naloxone deters injection misuse
SubutexBuprenorphine (alone)Sublingual tabletDailyOBOT2002Pregnancy; documented naloxone sensitivity
SublocadeBuprenorphine extended-releaseSubcutaneous injection (ATRIGEL depot)MonthlyClinic-administered2017No daily dosing; eliminates diversion risk
ZubsolvBuprenorphine + naloxoneSublingual tablet (higher bioavailability)DailyOBOT2013Faster dissolution; mint flavor; lower mg/dose
BrixadiBuprenorphine extended-releaseSubcutaneous injectionWeekly or monthlyClinic2023Newer alternative to Sublocade; weekly option for induction

All five medications are Schedule III controlled substances and equivalent in clinical efficacy at appropriate doses. The choice depends on adherence patterns, lifestyle, insurance coverage, and clinical context (e.g., pregnancy, prior injection use, daily-dosing burden). Many patients begin on sublingual Suboxone for stabilization and transition to monthly Sublocade or weekly Brixadi after sustained recovery.

Buprenorphine Side Effects

Common buprenorphine side effects include:

  • Headache and dizziness
  • Nausea and vomiting, especially during induction
  • Constipation and insomnia
  • Excessive sweating
  • Mouth numbness or oral discomfort from sublingual formulations

More serious side effects may include respiratory depression (particularly when combined with benzodiazepines or alcohol), liver problems, and allergic reactions. For most patients, side effects are mild and resolve within one to two weeks. The benefits in preventing relapse and overdose death significantly outweigh the risks.

Buprenorphine Dosage and Induction

Treatment begins with an induction phase where the patient must be in mild to moderate opioid withdrawal. Common induction doses range from 2 mg to 8 mg on the first day, with increases over the following days. Most patients stabilize on 8 mg to 24 mg per day, with 16 mg being the most commonly prescribed dose. Research suggests doses of 16 mg or higher are associated with better retention and outcomes. Dosage should always be adjusted under medical supervision.

Buprenorphine/Naloxone Combination

Many buprenorphine formulations include naloxone as an abuse deterrent. When taken sublingually as directed, naloxone has very low bioavailability and produces no clinical effect. However, if someone attempts to inject the medication, the naloxone component becomes fully active and triggers severe withdrawal. This design discourages injection misuse while having no impact on patients who take the medication correctly. The combination is the standard first-line formulation for opioid addiction treatment.

Suboxone: Sublingual Buprenorphine

Suboxone is the most recognized brand name for buprenorphine-naloxone and is most commonly dispensed as a sublingual film (Suboxone strips) that dissolves under the tongue. Suboxone has transformed opioid treatment by enabling millions of patients to receive effective pharmacotherapy in outpatient settings without the daily clinic visits required by methadone programs.

Suboxone Side Effects

Commonly reported Suboxone side effects include headache, nausea, tongue or mouth irritation, constipation, insomnia, sweating, and decreased libido. The sublingual film can cause irritation or small sores inside the mouth — rotating placement between under the tongue and against the cheek helps minimize this. Patients should not eat, drink, or smoke while the film is dissolving.

Suboxone Strips: Film vs. Tablet

Suboxone strips (sublingual film) have largely replaced the original tablet form. The film dissolves more quickly (two to four minutes), provides more consistent absorption, and is harder to divert due to individual foil packaging. Generic buprenorphine-naloxone tablets are often less expensive and may be preferred for cost reasons. Both are therapeutically equivalent when taken as prescribed.

Suboxone Treatment Programs

Comprehensive Suboxone treatment typically includes three phases:

  • Induction: Initial dosing under medical supervision, requiring the patient to be in early withdrawal
  • Stabilization: Dose adjustment until cravings and withdrawal are minimal, usually one to two months
  • Maintenance: Stable dosing for an extended period — often a year or longer — combined with counseling and behavioral therapy

Evidence consistently shows that longer treatment durations are associated with better outcomes. Most addiction medicine experts recommend a minimum of one to two years of maintenance therapy.

Find a Suboxone Clinic Near You — OBOT & Telehealth Options

Finding a Suboxone clinic has become significantly easier since the federal government eliminated the X-waiver requirement in January 2023, meaning any provider with a standard DEA license can now prescribe Suboxone. Patients can search SAMHSA's treatment locator at findtreatment.gov or use our directory to locate nearby facilities that offer buprenorphine-based treatment.

Suboxone Doctors Near Me

Beyond SAMHSA's locator, many state health departments maintain directories of addiction treatment providers. Telehealth has dramatically expanded access — several platforms now offer virtual Suboxone consultations, which is especially valuable for patients in rural areas. When selecting a provider, look for those offering comprehensive treatment including counseling, not just medication prescriptions.

Suboxone Withdrawal and Tapering

Suboxone withdrawal can include muscle aches, anxiety, insomnia, nausea, sweating, and intense opioid cravings. A gradual, medically supervised taper is recommended — typically reducing the dose by 10 to 25 percent every one to four weeks. Slower tapers over several months produce fewer symptoms and lower relapse rates. There is no medically mandated time limit for Suboxone treatment, and many patients benefit from indefinite maintenance.

Suboxone vs Methadone

Suboxone can be prescribed in office settings and taken at home, carries lower overdose risk due to its ceiling effect, and offers greater scheduling flexibility. Methadone is a full agonist that may be more effective for severe, long-standing dependence but must be dispensed at licensed clinics with daily visits. Neither is inherently superior — the best choice keeps the patient in treatment. Some patients may also benefit from naltrexone, a non-opioid alternative.

Sublocade: Monthly Buprenorphine Injection

Sublocade delivers buprenorphine as a once-monthly subcutaneous injection in the abdominal area using the ATRIGEL delivery system, which forms a solid biodegradable depot that slowly releases medication. Patients must first stabilize on sublingual buprenorphine (8 mg+ daily) for at least seven days. Treatment typically begins with two 300 mg injections, followed by maintenance on 300 mg or 100 mg. Sublocade eliminates concerns about daily adherence, missed doses, and medication diversion.

Sublocade Side Effects

The most common Sublocade side effects are injection-site reactions (pain, itching, redness, or a noticeable lump), nausea, constipation, headache, and fatigue. The injection-site lump is normal and gradually diminishes as medication is absorbed. Patients should avoid rubbing or massaging the site. Elevated liver enzymes may also occur but are usually mild and transient.

Subutex: Buprenorphine Without Naloxone

Subutex was the original brand-name buprenorphine product. While the brand has been discontinued, generic buprenorphine-only tablets remain available. Buprenorphine monotherapy is typically reserved for pregnant patients (to avoid naloxone exposure to the fetus), patients with documented naloxone sensitivity, or sometimes during the induction phase before transitioning to the combination product.

Subutex vs Suboxone

The primary difference is the absence of naloxone in Subutex. Because Subutex lacks the abuse-deterrent naloxone component, it may carry slightly higher diversion risk, and many insurance formularies prioritize the combination as the default. Current clinical guidelines favor buprenorphine-only formulations primarily for pregnancy and naloxone sensitivity.

Zubsolv: Alternative Buprenorphine Brand

Zubsolv is a buprenorphine-naloxone sublingual tablet featuring a mint flavor and faster dissolution (under two minutes). Due to enhanced bioavailability, Zubsolv uses different dose strengths — a 5.7 mg/1.4 mg tablet equals a Suboxone 8 mg/2 mg dose. Zubsolv is available in multiple strengths for flexible dosing during both induction and maintenance.

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Medically Reviewed Updated July 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)