NWVCIL Logo
Medically Reviewed Content
Updated: July 2026
Sources: SAMHSA, NIDA

Suboxone Clinic Near You: Buprenorphine Treatment for Opioid Addiction

Find a Suboxone clinic near you. Buprenorphine — sold under brand names Suboxone, Sublocade, Subutex, Zubsolv, and Brixadi — is the most-prescribed MAT for opioid use disorder. It is a partial mu-opioid agonist with a ceiling effect that dramatically reduces overdose risk vs. methadone. After the MAT Act of 2023 eliminated the X-waiver requirement, any licensed prescriber can prescribe buprenorphine in office-based settings (OBOT), via telehealth, or at retail pharmacies. Buprenorphine is a Schedule III controlled substance and is covered by Medicaid in all 50 states.

Found 7,145 treatment centers offering buprenorphine (suboxone) across the United States.

Need Help Finding the Right Treatment Center?

Speak with a compassionate specialist now - 100% free & confidential

Call +1 (833) 244-3031
Available 24/7
All 50 States
Filters:

Showing 21 of 7145 results

S2L Recovery
Woodbury, TN

S2L Recovery in Woodbury, TN, is a dedicated facility providing extensive addiction treatment solutions. They offer services including medical detox, comprehensive substance abuse therapy, and tailored support for those facing dual diagnoses of addiction and significant mental health conditions in adults, or serious emotional distress in youth. Their diverse treatment modalities encompass intensive outpatient, extended residential stays, and standard outpatient care, accommodating a wide spectrum of recovery requirements. The center employs therapeutic strategies such as anger management, motivational interviewing, and cognitive behavioral techniques. Distinctive programs are available for active military service members, adult males, and survivors of domestic or intimate partner abuse. S2L Recovery is committed to delivering high-quality, supportive care for adults, older adults, and young adults within a male-oriented setting, empowering individuals on their journey to lasting sobriety.

Sacramento Comprehensive Treatment Ctr

Sacramento Comprehensive Treatment Ctr in Sacramento, CA, provides a structured outpatient approach to addiction recovery for adults and adolescents. Their treatment plans integrate proven therapeutic modalities, including cognitive behavioral therapy, motivational interviewing, and contingency management, ensuring a personalized experience for every individual. This facility is dedicated to offering tailored support for both male and female clients navigating the complexities of substance use disorders. Sacramento Comprehensive Treatment Ctr emphasizes a high standard of care and employs scientifically validated methods, positioning it as a supportive environment for those pursuing lasting sobriety.

Sacramento Native American

Situated in Sacramento, CA, the Sacramento Native American rehabilitation center delivers focused care for substance abuse and co-occurring disorders in both adults and children. This facility offers outpatient options such as methadone/buprenorphine therapy and standard outpatient programs. Emphasizing 12-step support, anger management, and concise interventions, the center serves active duty military members, adolescents, and adult males. Accommodating clients of all genders, the center is dedicated to providing personalized treatment for diverse age demographics. Discover customized care and high-quality programs at the Sacramento Native American rehabilitation center.

Sacramento Recovery Homes Inc

Sacramento Recovery Homes Inc, situated in Sacramento, California, delivers targeted addiction recovery services within a secure and nurturing atmosphere. The center features extensive long-term residential, around-the-clock residential, and brief residential options designed for adult women facing challenges with substance dependence. Their methodology incorporates 12-step engagement, emotional regulation strategies, and cognitive behavioral interventions. The facility offers distinct programming for adult women, individuals with a history of trauma, and those dealing with dual diagnoses of mental health and substance use conditions. Emphasizing high-standard support, Sacramento Recovery Homes Inc serves adults, older adults, and younger adults pursuing sobriety in an exclusive women's environment.

Sacopee Valley Health Center

Sacopee Valley Health Center, situated in Porter, ME, delivers expert outpatient services for adults and children grappling with substance abuse and co-occurring mental health issues. This establishment prioritizes personalized treatment plans, employing various proven methods such as cognitive behavioral therapy and the Matrix Model. Their thorough programs are designed for adults and older adults of any gender, guaranteeing a customized experience for everyone. From standard outpatient care to specialized medication-assisted treatment (methadone/buprenorphine/naltrexone), individuals receive top-tier support from seasoned practitioners. Opt for Sacopee Valley Health Center for recovery that is both unique to you and demonstrably successful.

Sacred Oaks Healing Center

Situated in Davis, CA, Sacred Oaks Healing Center provides extended residential treatment for substance use targeting children and teens. This establishment focuses on various therapeutic techniques, including anger management, cognitive behavioral strategies, and motivational incentives through contingency management. With dedicated programs for both young men and women, the center fosters a nurturing and secure atmosphere for adolescents battling addiction. Their holistic treatment approach guarantees that each individual enjoys high-quality care and guidance as they navigate their recovery process. Sacred Oaks Healing Center is distinguished by its emphasis on young people and its dedication to delivering effective and empathetic addiction recovery services.

Safe Harbor Recovery LLC

Safe Harbor Recovery LLC, located in Warren, OH, provides a thorough selection of long-term residential treatment options for adult men dealing with substance use issues. This facility is particularly equipped to support clients who have faced sexual trauma or abuse, fostering a nurturing atmosphere conducive to healing. Employing methods such as 12-step facilitation, anger management, and cognitive behavioral therapy, Safe Harbor ensures a comprehensive approach to recovery. Participants benefit from continuous support and care, including residential detoxification and around-the-clock residential services. Targeted towards adults and young adults in need of tailored addiction treatment, Safe Harbor Recovery LLC is recognized for its dedication to high-quality care and personalized assistance.

Sacramento Recovery House Inc

Situated in Sacramento, California, Sacramento Recovery House Inc delivers an extensive range of treatment options for those dealing with substance use challenges in a nurturing atmosphere. This center offers both long-term and short-term rehabilitation as well as round-the-clock residential services specifically designed for adult males on their path to recovery. It emphasizes a variety of therapeutic approaches, including 12-step programs, anger management techniques, and cognitive behavioral therapy. Customized plans are developed for individuals who have experienced trauma and those facing dual diagnoses involving mental health and substance use issues. Sacramento Recovery House Inc serves adults, seniors, and young adults, prioritizing personalized treatment and effective reintegration into the community. This facility is a reliable option for men seeking high-quality rehabilitation services.

SAFE Foundation Inc
Eatontown, NJ

SAFE Foundation Inc, located in Eatontown, NJ, delivers extensive outpatient treatment for adults and seniors dealing with substance use issues. The center features targeted programs for adult men, adult women, and young adults, recognizing the distinct needs of each demographic. Emphasizing methods such as 12-step facilitation, brief interventions, and cognitive behavioral therapy, the facility guarantees personalized care and support for individuals on their path to recovery. It offers outpatient services that include methadone/buprenorphine or naltrexone treatment, along with standard outpatient care, focusing on providing high-quality assistance to both male and female participants. For evidence-based treatment within a nurturing atmosphere, look to SAFE Foundation Inc for your rehabilitation journey.

SAFE Foundation Inc

SAFE Foundation Inc, located in Brooklyn, NY, provides outpatient programs aimed at helping adults and seniors tackle substance use issues. This center is dedicated to meeting the unique needs of adult men, adult women, and young adults, addressing a range of demographics and genders. With a variety of treatment modalities including 12-step support, brief interventions, and cognitive behavioral therapy, the center focuses on personalized care for every individual. Their availability of outpatient options with methadone/buprenorphine or naltrexone, alongside traditional outpatient services, enhances access to recovery solutions. SAFE Foundation Inc stands out in the Brooklyn community for its high-quality care and comprehensive range of treatment programs for those in need of addiction support.

Safe Refuge
Long Beach, CA

Safe Refuge, located in Long Beach, CA, delivers a wide array of treatment options for individuals dealing with substance use issues, including both adults and young adults. The center specializes in addressing co-occurring mental health conditions alongside substance use disorders, offering various treatment durations, such as long-term, short-term, and 24-hour residential care. By employing evidence-informed strategies like 12-step programs, anger management, and cognitive behavioral therapy, Safe Refuge promotes a comprehensive approach to healing. The center features specific programs for active military, as well as services tailored for adult men and women. It provides a nurturing and secure atmosphere for clients of all genders who are pursuing a path toward recovery.

Safe Refuge
Long Beach, CA

Nestled in Long Beach, CA, Safe Refuge delivers a full spectrum of recovery solutions. Their offerings encompass addiction treatment, temporary accommodations, and supportive sober living environments. They also address dual diagnoses of substance abuse and significant mental health challenges in adults, as well as emotional difficulties in children. Clients can choose from intensive outpatient, extended residential stays, and standard outpatient programs. Safe Refuge utilizes proven therapeutic methods including 12-step integration, emotional regulation techniques, and cognitive restructuring. Tailored services are available for active military personnel, adult males, and adult females, demonstrating their commitment to varied client populations. Safe Refuge serves adult and young adult individuals across the gender spectrum, dedicated to offering excellent care and assistance to all on their path to wellness.

Safe Refuge
Long Beach, CA

Safe Refuge, situated in Long Beach, CA, provides an array of premium rehabilitation services. This center offers various treatment options including long-term, residential, and short-term care for individuals facing substance use issues and coexisting mental health disorders, for both adults and children. The treatment methods used encompass 12-step support, anger management strategies, and cognitive behavioral therapy. Safe Refuge serves active duty military members, adult men and women, as well as young adults. With tailored programs designed for various age brackets and genders, Safe Refuge is dedicated to offering thorough and effective care for those pursuing recovery from addiction and mental health struggles.

Safe Point Lighthouse

Safe Point Lighthouse, located in Dunkirk, NY, provides a variety of outpatient treatment options for substance use, including methadone/buprenorphine and naltrexone therapies, as well as traditional outpatient services. The center is particularly adept in areas such as anger management, brief interventions, and cognitive behavioral therapy. It features distinct programs designed for active military personnel, teenagers, and adult males. Care is accessible for adults and youths of all genders. With a commitment to quality care, Safe Point Lighthouse emphasizes personalized treatment plans that cater to the unique needs of each individual. Its comprehensive approach and tailored programs position it as an essential resource for those in search of effective addiction recovery support.

Safe Point Lighthouse

Situated in Dunkirk, NY, Safe Point Lighthouse provides outpatient treatment options for individuals dealing with substance use issues, including programs for both adults and young adults. The center offers a range of specialized services such as outpatient care using methadone, buprenorphine, or naltrexone, as well as anger management, brief intervention sessions, and cognitive behavioral therapy. Catering to active military members, adolescents, and adult males, it emphasizes personalized treatment plans that address the specific requirements of different demographics. Safe Point Lighthouse is recognized for its holistic approach to addiction recovery, concentrating on delivering high-quality care that is customized for each client's distinct circumstances. If you are in search of targeted substance use treatment with an emphasis on personalized attention, this facility may be ideal for you.

Placeholder image

SA Treatment Unit of Central Iowa located in Marshalltown, IA, delivers extensive substance use recovery services for both adults and children who are also experiencing mental health challenges. The center features multiple outpatient treatment options, including intensive and standard outpatient programs. Emphasizing techniques such as anger management, brief interventions, and cognitive behavioral therapy, the facility customizes its approach to meet the specific requirements of each individual. Unique programs are available for active military members, teenagers, and adult males. This facility serves a diverse clientele, offering high-quality care for those in need of successful rehabilitation in a nurturing atmosphere.

Placeholder image

Sacred Heart Rehabilitation Center Inc in Saint Ignace, MI provides all-encompassing assistance for those battling addiction. The center delivers outpatient services, featuring distinct programs for adults with co-occurring substance use and mental health challenges, and for children experiencing emotional difficulties. Utilizing methods like 12-step facilitation, anger management, and cognitive behavioral therapy, they personalize treatment for every patient. Catering to adults and young adults of any gender, Sacred Heart Rehabilitation Center Inc is dedicated to offering excellent care and encouragement throughout the recovery journey.

Placeholder image

Situated in Costa Mesa, California, Safe Harbor Treatment Center provides an extensive range of detoxification and addiction recovery services. This facility is equipped with hospital-based inpatient detox and treatment options, ensuring round-the-clock care for patients. Safe Harbor Treatment Center focuses on various therapeutic methods, including 12-step programs, anger management, and brief intervention techniques. The center offers specialized programs designed for adult women, as well as those affected by intimate partner violence, domestic abuse, and sexual trauma. Available to both adults and young adults of all genders, the center prioritizes personalized care with an emphasis on compassion and quality. Safe Harbor Treatment Center is a reliable option for individuals looking for effective and nurturing support in their journey toward recovery.

Placeholder image

Safe Harbor Treatment Center, located in Costa Mesa, California, provides an extensive range of detox and substance abuse treatment options. The center features hospital-based inpatient detox services alongside therapeutic programs that emphasize 12-step methods, anger management, and brief interventions. It also offers specialized programs designed for adult women and individuals affected by intimate partner violence, domestic abuse, and sexual trauma. Catering to both adult men and women, Safe Harbor Treatment Center is dedicated to offering exceptional care in a nurturing setting. If you or someone close to you is looking for personalized addiction recovery support, this facility is well-prepared to assist in your healing process.

Placeholder image

Safe Harbor Treatment Center in Costa Mesa, CA, offers a complete spectrum of recovery services. Their expertise lies in medically supervised detox and ongoing substance use disorder therapy. Patients receive care within an inpatient hospital setting, with round-the-clock professional assistance. The center employs a range of therapeutic strategies, such as 12-step integration, emotional regulation training, and concise counseling, tailored to the distinct requirements of adult men and women, and young adults. A distinctive feature of Safe Harbor Treatment Center is its tailored programs for individuals who have endured intimate partner violence, domestic abuse, and sexual trauma. Emphasizing excellence in care and personalized recovery plans, this institution provides a nurturing atmosphere for individuals on their journey to wellness.

Placeholder image

Safe Harbor Treatment Center, located in Costa Mesa, CA, provides extensive inpatient hospital services for adults and young adults undergoing detoxification and substance use treatment. Their approach emphasizes 12-step facilitation, anger management, and brief intervention strategies. The center offers specialized care for adult women and those who have faced intimate partner violence, domestic violence, or sexual abuse. Personalized treatment programs are designed to meet the specific requirements of all clients, both male and female. Safe Harbor Treatment Center is committed to delivering exceptional care within a nurturing setting, empowering individuals on their journey to sustained recovery and enhanced health.

Frequently Asked Questions

What is buprenorphine and how does it treat opioid addiction?
Buprenorphine is a partial opioid agonist medication approved by the FDA for treating opioid use disorder. It binds to the same receptors as heroin and fentanyl but produces a much weaker effect, reducing cravings and withdrawal symptoms without causing intense euphoria. Buprenorphine has a ceiling effect, meaning its opioid effects plateau at moderate doses, making it safer than methadone in terms of overdose risk.
What is the difference between Suboxone and Subutex?
Suboxone contains two active ingredients — buprenorphine and naloxone — while Subutex contains only buprenorphine without naloxone. The naloxone in Suboxone is included as an abuse deterrent; it remains inactive when taken sublingually as prescribed but triggers withdrawal if the medication is injected. Subutex is generally reserved for patients who cannot tolerate naloxone, such as pregnant women.
What is a Sublocade injection and how does it work?
Sublocade is a once-monthly injectable form of buprenorphine administered as a subcutaneous injection in the abdominal area. After injection, the medication forms a solid deposit under the skin that slowly releases buprenorphine over the course of a month. This eliminates daily dosing and removes the possibility of missed doses or medication diversion.
What are the common side effects of Suboxone?
Common Suboxone side effects include headache, nausea, constipation, insomnia, sweating, and mouth numbness or pain from sublingual administration. Some patients also experience dizziness, drowsiness, and blurred vision, particularly when starting treatment. Most side effects diminish within the first few weeks as the body adjusts. Patients should report difficulty breathing or signs of allergic reaction immediately.
What happens during Suboxone withdrawal?
Suboxone withdrawal occurs when a patient stops taking the medication abruptly after prolonged use, with symptoms including muscle aches, anxiety, insomnia, nausea, and irritability. A medically supervised taper is strongly recommended, typically reducing the dose by small increments over weeks or months. The risk of opioid relapse is significantly higher during unsupervised discontinuation.
How does Suboxone compare to methadone?
Suboxone and methadone are both effective for opioid use disorder but differ in key ways. Methadone is a full opioid agonist dispensed daily at licensed clinics, while Suboxone is a partial agonist that can be prescribed by qualified physicians and taken at home. Suboxone carries a lower overdose risk due to its ceiling effect and offers greater convenience, though methadone may be more appropriate for patients with severe, long-standing dependence.
How can I find a Suboxone clinic or doctor near me?
The most reliable way to find a Suboxone provider is through SAMHSA's online treatment locator at findtreatment.gov, which allows you to search by location and filter for buprenorphine providers. Many primary care offices, addiction treatment centers, and telehealth platforms now offer Suboxone prescriptions following the elimination of the federal X-waiver requirement in early 2023.
What is Zubsolv and how is it different from Suboxone?
Zubsolv is a brand-name buprenorphine and naloxone sublingual tablet that features a mint flavor and dissolves faster under the tongue than other options. Due to its higher bioavailability, Zubsolv uses different dosing strengths — a Zubsolv 5.7 mg/1.4 mg tablet is considered equivalent to a Suboxone 8 mg/2 mg dose. Patients switching between products should work closely with their prescriber for correct dose conversion.
Does Medicaid cover Suboxone treatment?
Yes — Medicaid covers buprenorphine (including Suboxone, Sublocade, Subutex, Zubsolv, and Brixadi) for opioid use disorder in all 50 states, as required by the SUPPORT Act of 2018. Medicaid is the largest single payer for MAT in the US. Coverage details vary by state — some require prior authorization or limit certain formulations. Many OBOT clinics accept Medicaid directly; telehealth Suboxone providers also bill Medicaid in most states. Bring your Medicaid card to your intake appointment.
Can I get Suboxone through telehealth?
Yes. After the MAT Act of 2023 permanently eliminated the X-waiver requirement, any licensed prescriber can prescribe Suboxone via telehealth in most states. The DEA also extended COVID-era telehealth flexibilities through at least 2025, allowing virtual Suboxone induction without a prior in-person visit. Several specialty platforms — Bicycle Health, Ophelia, Workit Health, Boulder Care — offer Medicaid-accepting telehealth Suboxone treatment. Telehealth has dramatically expanded access in rural and underserved areas with no nearby OBOT physicians.

About Buprenorphine (Suboxone)

Buprenorphine is classified as a partial opioid agonist, meaning it activates opioid receptors in the brain but to a much lesser degree than full agonists such as heroin, fentanyl, or oxycodone. This partial activation suppresses withdrawal symptoms and reduces cravings without producing dangerous respiratory depression or intense euphoria. Buprenorphine also has an unusually high binding affinity for the mu-opioid receptor, effectively blocking other opioids from attaching — providing a protective effect against relapse-related overdose.

How Buprenorphine Works

One of the defining features of buprenorphine is its ceiling effect — after a certain dose threshold, increasing the amount does not produce additional opioid effects. This dramatically reduces the risk of fatal overdose compared to methadone or illicit opioids. The ceiling effect, combined with its long duration of action (24 to 72 hours), makes buprenorphine one of the safest and most effective tools in medication-assisted treatment (MAT). Approved by the FDA in 2002, buprenorphine was a breakthrough because it could be prescribed in outpatient settings rather than requiring daily clinic visits.

Buprenorphine Brand Comparison: Suboxone, Subutex, Sublocade, Zubsolv, Brixadi

Buprenorphine is available under several FDA-approved brand names, each with distinct formulations, dosing schedules, and clinical use cases. The comparison below highlights the key differences:

BrandActive ingredientFormFrequencySettingFDA yearBest for
SuboxoneBuprenorphine + naloxoneSublingual film / tabletDailyOBOT, telehealth, retail pharmacy2002Most prescribed; naloxone deters injection misuse
SubutexBuprenorphine (alone)Sublingual tabletDailyOBOT2002Pregnancy; documented naloxone sensitivity
SublocadeBuprenorphine extended-releaseSubcutaneous injection (ATRIGEL depot)MonthlyClinic-administered2017No daily dosing; eliminates diversion risk
ZubsolvBuprenorphine + naloxoneSublingual tablet (higher bioavailability)DailyOBOT2013Faster dissolution; mint flavor; lower mg/dose
BrixadiBuprenorphine extended-releaseSubcutaneous injectionWeekly or monthlyClinic2023Newer alternative to Sublocade; weekly option for induction

All five medications are Schedule III controlled substances and equivalent in clinical efficacy at appropriate doses. The choice depends on adherence patterns, lifestyle, insurance coverage, and clinical context (e.g., pregnancy, prior injection use, daily-dosing burden). Many patients begin on sublingual Suboxone for stabilization and transition to monthly Sublocade or weekly Brixadi after sustained recovery.

Buprenorphine Side Effects

Common buprenorphine side effects include:

  • Headache and dizziness
  • Nausea and vomiting, especially during induction
  • Constipation and insomnia
  • Excessive sweating
  • Mouth numbness or oral discomfort from sublingual formulations

More serious side effects may include respiratory depression (particularly when combined with benzodiazepines or alcohol), liver problems, and allergic reactions. For most patients, side effects are mild and resolve within one to two weeks. The benefits in preventing relapse and overdose death significantly outweigh the risks.

Buprenorphine Dosage and Induction

Treatment begins with an induction phase where the patient must be in mild to moderate opioid withdrawal. Common induction doses range from 2 mg to 8 mg on the first day, with increases over the following days. Most patients stabilize on 8 mg to 24 mg per day, with 16 mg being the most commonly prescribed dose. Research suggests doses of 16 mg or higher are associated with better retention and outcomes. Dosage should always be adjusted under medical supervision.

Buprenorphine/Naloxone Combination

Many buprenorphine formulations include naloxone as an abuse deterrent. When taken sublingually as directed, naloxone has very low bioavailability and produces no clinical effect. However, if someone attempts to inject the medication, the naloxone component becomes fully active and triggers severe withdrawal. This design discourages injection misuse while having no impact on patients who take the medication correctly. The combination is the standard first-line formulation for opioid addiction treatment.

Suboxone: Sublingual Buprenorphine

Suboxone is the most recognized brand name for buprenorphine-naloxone and is most commonly dispensed as a sublingual film (Suboxone strips) that dissolves under the tongue. Suboxone has transformed opioid treatment by enabling millions of patients to receive effective pharmacotherapy in outpatient settings without the daily clinic visits required by methadone programs.

Suboxone Side Effects

Commonly reported Suboxone side effects include headache, nausea, tongue or mouth irritation, constipation, insomnia, sweating, and decreased libido. The sublingual film can cause irritation or small sores inside the mouth — rotating placement between under the tongue and against the cheek helps minimize this. Patients should not eat, drink, or smoke while the film is dissolving.

Suboxone Strips: Film vs. Tablet

Suboxone strips (sublingual film) have largely replaced the original tablet form. The film dissolves more quickly (two to four minutes), provides more consistent absorption, and is harder to divert due to individual foil packaging. Generic buprenorphine-naloxone tablets are often less expensive and may be preferred for cost reasons. Both are therapeutically equivalent when taken as prescribed.

Suboxone Treatment Programs

Comprehensive Suboxone treatment typically includes three phases:

  • Induction: Initial dosing under medical supervision, requiring the patient to be in early withdrawal
  • Stabilization: Dose adjustment until cravings and withdrawal are minimal, usually one to two months
  • Maintenance: Stable dosing for an extended period — often a year or longer — combined with counseling and behavioral therapy

Evidence consistently shows that longer treatment durations are associated with better outcomes. Most addiction medicine experts recommend a minimum of one to two years of maintenance therapy.

Find a Suboxone Clinic Near You — OBOT & Telehealth Options

Finding a Suboxone clinic has become significantly easier since the federal government eliminated the X-waiver requirement in January 2023, meaning any provider with a standard DEA license can now prescribe Suboxone. Patients can search SAMHSA's treatment locator at findtreatment.gov or use our directory to locate nearby facilities that offer buprenorphine-based treatment.

Suboxone Doctors Near Me

Beyond SAMHSA's locator, many state health departments maintain directories of addiction treatment providers. Telehealth has dramatically expanded access — several platforms now offer virtual Suboxone consultations, which is especially valuable for patients in rural areas. When selecting a provider, look for those offering comprehensive treatment including counseling, not just medication prescriptions.

Suboxone Withdrawal and Tapering

Suboxone withdrawal can include muscle aches, anxiety, insomnia, nausea, sweating, and intense opioid cravings. A gradual, medically supervised taper is recommended — typically reducing the dose by 10 to 25 percent every one to four weeks. Slower tapers over several months produce fewer symptoms and lower relapse rates. There is no medically mandated time limit for Suboxone treatment, and many patients benefit from indefinite maintenance.

Suboxone vs Methadone

Suboxone can be prescribed in office settings and taken at home, carries lower overdose risk due to its ceiling effect, and offers greater scheduling flexibility. Methadone is a full agonist that may be more effective for severe, long-standing dependence but must be dispensed at licensed clinics with daily visits. Neither is inherently superior — the best choice keeps the patient in treatment. Some patients may also benefit from naltrexone, a non-opioid alternative.

Sublocade: Monthly Buprenorphine Injection

Sublocade delivers buprenorphine as a once-monthly subcutaneous injection in the abdominal area using the ATRIGEL delivery system, which forms a solid biodegradable depot that slowly releases medication. Patients must first stabilize on sublingual buprenorphine (8 mg+ daily) for at least seven days. Treatment typically begins with two 300 mg injections, followed by maintenance on 300 mg or 100 mg. Sublocade eliminates concerns about daily adherence, missed doses, and medication diversion.

Sublocade Side Effects

The most common Sublocade side effects are injection-site reactions (pain, itching, redness, or a noticeable lump), nausea, constipation, headache, and fatigue. The injection-site lump is normal and gradually diminishes as medication is absorbed. Patients should avoid rubbing or massaging the site. Elevated liver enzymes may also occur but are usually mild and transient.

Subutex: Buprenorphine Without Naloxone

Subutex was the original brand-name buprenorphine product. While the brand has been discontinued, generic buprenorphine-only tablets remain available. Buprenorphine monotherapy is typically reserved for pregnant patients (to avoid naloxone exposure to the fetus), patients with documented naloxone sensitivity, or sometimes during the induction phase before transitioning to the combination product.

Subutex vs Suboxone

The primary difference is the absence of naloxone in Subutex. Because Subutex lacks the abuse-deterrent naloxone component, it may carry slightly higher diversion risk, and many insurance formularies prioritize the combination as the default. Current clinical guidelines favor buprenorphine-only formulations primarily for pregnancy and naloxone sensitivity.

Zubsolv: Alternative Buprenorphine Brand

Zubsolv is a buprenorphine-naloxone sublingual tablet featuring a mint flavor and faster dissolution (under two minutes). Due to enhanced bioavailability, Zubsolv uses different dose strengths — a 5.7 mg/1.4 mg tablet equals a Suboxone 8 mg/2 mg dose. Zubsolv is available in multiple strengths for flexible dosing during both induction and maintenance.

Buprenorphine resources:

Find Buprenorphine (Suboxone) by State

Browse buprenorphine (suboxone) programs in states with the most treatment options.

Explore Related Options

Related conditions, treatment approaches, and levels of care.

Medically Reviewed Updated July 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)