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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Mental Health Partners

Situated in Lafayette, CO, Mental Health Partners provides outpatient treatment for substance use aimed at adults dealing with significant mental health disorders and children facing serious emotional issues. Their standard outpatient services include anger management, brief intervention, and cognitive behavioral therapies. The center also offers specialized assistance for teenagers, adult males, and those who have encountered intimate partner violence or domestic abuse. Serving adults and seniors of all genders, Mental Health Partners emphasizes personalized care that meets the distinct requirements of each individual, ensuring thorough support and successful treatment for individuals pursuing recovery from addiction and associated mental health problems.

Mental Health Partners

Situated in Boulder, Colorado, Mental Health Partners delivers a wide array of services for addiction recovery. This center specializes in detox services, treatment for substance use disorders, and focused care for those suffering from both substance use issues and significant mental health disorders in adults, as well as severe emotional challenges in children. Their treatment options feature programs like intensive outpatient care and outpatient detoxification, employing methodologies such as 12-step principles, anger management techniques, and short-term interventions. Mental Health Partners serves a diverse clientele, including adolescents, adult men, and women, with customized programs designed to meet the specific needs of each group. By offering support to both adults and younger patients, this center prioritizes effective treatment for individuals across all demographics who are on the path to recovery from addiction.

Mercy Hospital Unity Campus

Mercy Hospital Unity Campus, located in Minneapolis, MN, specializes in addressing addiction issues for both adults and young adults affected by substance use disorders and related mental health complications. The center features a variety of treatment options, including intensive outpatient programs, standard outpatient services, and medication-assisted treatments with methadone, buprenorphine, or naltrexone. To meet diverse patient needs, they integrate strategies such as 12-step programs, anger management training, and brief intervention techniques. Notably, Mercy Hospital Unity Campus emphasizes support for individuals facing both mental health challenges and substance use issues, providing customized care for male and female clients alike. Committed to delivering high-quality treatment, the center ensures extensive assistance for those on their path to recovery.

Mercy Hospital Unity Campus

Mercy Hospital Unity Campus, located in Minneapolis, MN, delivers a wide range of addiction recovery services aimed at both adults and young adults. This center features inpatient detoxification and treatment solutions for substance use disorders, along with support for co-occurring severe mental health conditions in adults and significant emotional challenges in children. Their offerings include 12-step programs, anger management strategies, and brief intervention methods. They also have specialized programs designed for active duty military members, as well as separate tracks for adult men and women. Emphasizing individualized care, Mercy Hospital Unity Campus is committed to providing high-quality treatment for those looking to overcome addiction, with tailored options available for both male and female participants.

Meridian Behavioral Health

Meridian Behavioral Health, located in Saint Paul, MN, provides an extensive array of targeted addiction treatment options. This center features residential detox programs and short-term residential care specifically designed for adult women facing co-occurring mental health issues. By implementing evidence-based methods such as 12-step support and anger management techniques, the facility prioritizes personalized treatment to tackle both substance abuse and significant emotional challenges in children and adults. With a commitment to excellence and empathy, Meridian Behavioral Health serves as an exceptional resource for women in need of professional guidance within a nurturing setting.

Meridian Behavioral Health

Meridian Behavioral Health in Pine City, MN, delivers focused care for addiction within a live-in environment. This location features round-the-clock support via its short-term residential offerings. Emphasizing 12-step principles, emotional regulation techniques, and concise therapeutic methods, the center is designed for adult women impacted by domestic and relationship violence. Their services are structured for adults, older adults, and younger adults. Meridian Behavioral Health distinguishes itself through its complete assistance for its female clientele, guaranteeing individualized attention and successful paths to healing.

Meridian Behavioral Health

Meridian Behavioral Health in Stillwater, MN, provides targeted support for adult men grappling with both addiction and concurrent mental health challenges within a residential environment. This facility offers continuous around-the-clock care, emphasizing techniques such as anger management, brief intervention strategies, and cognitive behavioral therapy. Customized treatment plans are available for adult individuals, seniors, and younger adults, ensuring personalized recovery journeys. Meridian Behavioral Health distinguishes itself through its holistic methodology, simultaneously tackling substance abuse and significant mental health conditions. Dedicated to high-quality services and bespoke treatment strategies, this center fosters a nurturing atmosphere for individuals pursuing short-term residential recovery.

Meridian Behavioral Health

Meridian Behavioral Health, located in Saint Paul, MN, provides a wide array of services designed to tackle substance use issues alongside accompanying mental health challenges for both adults and children. The center features specialized programs aimed at LGBTQ individuals and those experiencing dual diagnoses. Treatment options include long-term residential care, detox services, and 24-hour inpatient therapies. By employing proven methods such as 12-step programs, cognitive behavioral techniques, and brief intervention strategies, this facility guarantees high-quality support for clients across different demographics. Whether addressing substance use or mental wellness, Meridian Behavioral Health delivers personalized programs to accommodate varied therapeutic requirements.

Meridian Behavioral Health

Meridian Behavioral Health in Saint Paul, MN, provides extensive support for individuals struggling with substance use disorders, utilizing diverse program structures like intensive outpatient, standard outpatient, and ongoing outpatient care. Employing proven methods such as 12-step facilitation, brief intervention, and cognitive behavioral therapy, they deliver customized recovery plans. This center features dedicated services for active military personnel, adult men, adult women, and supports both adult and young adult populations of all genders. Known for its commitment to high-quality, individualized treatment, Meridian Behavioral Health stands as a reliable resource for effective and nurturing addiction recovery services in the Saint Paul vicinity.

Merakey
Sharon Hill, PA

Situated in Sharon Hill, PA, Merakey is a leading rehabilitation facility that delivers intensive outpatient services for individuals dealing with substance use disorders alongside co-occurring mental health challenges in both adults and children. The center employs a variety of evidence-supported methods, such as cognitive behavioral therapy and the Matrix Model. Customized programs are designed for adult men and women, as well as individuals facing dual diagnoses. Merakey provides outpatient options for medication-assisted recovery, including methadone/buprenorphine and naltrexone therapies. With a focus on delivering specialized care for adults and seniors of all genders, this facility is dedicated to offering exceptional, personalized treatment aimed at fostering sustainable recovery.

Mental Health Services for

"Mental Health Services for" located in Springfield, OH, offers a wide array of treatment alternatives aimed at empowering individuals on their journey to recovery from mental health and substance use disorders. The facility features hospital inpatient detox programs, round-the-clock inpatient care, and specialized outpatient services designed for adults and the elderly. Emphasizing evidence-based practices such as cognitive behavioral therapy and anger management, the center prioritizes high-quality support for clients facing co-occurring conditions. Tailored programs are also available for those who have undergone trauma and for individuals grappling with both mental health challenges and substance dependency. Catering to both men and women, this rehabilitation center fosters a nurturing atmosphere aimed at facilitating comprehensive healing and recovery.

Merakey Parkside Recovery

Merakey Parkside Recovery, situated in Philadelphia, PA, delivers a well-rounded approach to treating adults grappling with substance use and accompanying mental health disorders. The center features a variety of programs including intensive outpatient, outpatient services, and options that utilize methadone, buprenorphine, or naltrexone. Emphasizing techniques such as anger management, brief interventions, and cognitive behavioral therapy, it serves both men and women, including those affected by domestic or intimate partner violence. There are specialized programs for young adults, with services tailored to meet the needs of both genders. At Merakey Parkside Recovery, the commitment to personalized care and high-quality support is central to fostering effective recovery outcomes.

Merakey Parkside Recovery

Nestled in Philadelphia, PA, Merakey Parkside Recovery delivers thorough addiction treatment for adults and adolescents facing concurrent significant mental health conditions. This location offers outpatient care, featuring methadone/buprenorphine therapy, cognitive behavioral interventions, and anger management strategies. Dedicated programs for active military personnel, adult males, and females ensure Merakey Parkside Recovery serves a wide array of individuals. The center's commitment to high-quality care emphasizes personalized treatment strategies to foster healing. For those needing support with addiction or combined mental health concerns, this center employs research-supported methods to guide individuals toward sustained recovery and emotional well-being.

Mercy Hall
Freeport, NY

Mercy Hall, located in Freeport, NY, provides extensive long-term residential rehabilitation for adults grappling with substance abuse and concurrent mental health challenges. This center emphasizes a nurturing atmosphere specifically designed for adult women, older adults, and young individuals who have faced intimate partner abuse. Additionally, it serves active military members. Prioritizing methods such as 12-step facilitation, anger management, and brief intervention strategies, Mercy Hall is committed to offering exceptional care within a secure and supportive environment. Clients have access to transitional housing and programs customized to address their specific requirements.

MercyOne House Mercy
Des Moines, IA

MercyOne House Mercy in Des Moines, IA, is dedicated to providing extensive support for individuals facing substance use challenges. This includes offering a safe place to live during recovery and specialized care for those experiencing co-occurring substance use and significant mental health concerns in adults or emotional difficulties in children. Their treatment options encompass intensive outpatient, extended residential stays, and general outpatient services. Therapeutic methods employed at the center include facilitating engagement with 12-step principles, teaching anger management techniques, and utilizing brief intervention strategies. The facility also extends its services to active military personnel, teenagers, and adult men through targeted programs. MercyOne House Mercy is committed to serving adults and older adults of all genders, ensuring that each person receives personalized, high-quality care designed to foster enduring sobriety and well-being.

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Situated in San Diego, CA, Mental Health Systems Inc delivers an extensive variety of substance abuse treatment options for adults, particularly those also facing significant mental health challenges. The center features intensive outpatient, outpatient, and standard outpatient programs, employing methods like 12-step facilitation, anger management, and brief interventions. With distinct programs available for adult men, adult women, and trauma survivors, Mental Health Systems Inc addresses a wide spectrum of client needs. Regardless of whether you are an adult or a young adult looking for help, this center offers personalized care designed to fit each individual's specific requirements, guaranteeing high-quality and effective rehabilitation services.

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Nestled in Santee, California, Mental Health Systems Inc is dedicated to providing a spectrum of focused therapeutic interventions. This institution offers robust outpatient care for individuals struggling with addiction, alongside customized treatment plans for adults facing combined substance use and severe mental health challenges, and for children experiencing emotional distress. Their therapeutic toolkit includes methodologies like 12-step program integration, techniques for managing anger, and brief intervention strategies. Recognizing diverse needs, Mental Health Systems Inc also features specialized support for adult men, women, and survivors of trauma, extending its outpatient services to adults and young adults. The center is distinguished by its commitment to high-standard care and all-encompassing offerings, aiming to equip individuals with the essential resources for healing.

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Situated in Mentor, OH, Mentor Outpatient and Admin Office delivers a range of addiction recovery services tailored for both adults and young adults. This center specializes in intensive outpatient therapies, outpatient detox, and various outpatient programs aimed at detoxification and substance use management. By employing strategies such as 12-step methods, anger management, and brief intervention techniques, the facility effectively addresses the needs of clients experiencing co-occurring mental health and substance use disorders. The center also offers specialized programs for adult women, male and female individuals, as well as those engaged with the criminal justice system. Mentor Outpatient and Admin Office is committed to providing exceptional care and guiding individuals towards their recovery paths.

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Philadelphia, PA

Situated in Philadelphia, PA, Merakey provides extensive treatment services for substance use through various outpatient programs, which include options such as methadone, buprenorphine, and naltrexone therapies. This center is known for its expertise in 12-step facilitation, cognitive behavioral therapy, and motivational interviewing techniques. It features specialized programs designed for adult men and women, along with support for those who have encountered intimate partner or domestic violence. Merakey caters to adults and young adults of any gender, offering customized care that addresses a wide range of needs. With a strong emphasis on high-quality, individualized treatment, the facility is distinguished by its dedication to assisting individuals throughout their recovery process.

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Coal Township, PA

Situated in Coal Township, PA, Merakey Behavioral Health delivers a wide range of rehabilitation services tailored for both adults and children facing substance use issues and concurrent mental health disorders. The center features intensive outpatient care, outpatient programs, and tailored treatment options like methadone/buprenorphine or naltrexone. By employing evidence-based methods such as anger management, brief interventions, and cognitive behavioral therapy, this facility supports male and female clients alike. With a particular emphasis on adult women, Merakey Behavioral Health is dedicated to providing exceptional care and assistance for those striving to conquer addiction and mental health difficulties.

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Springfield, OH

Mercy Health in Springfield, OH, delivers complete substance abuse recovery services for adults. Their offerings include intensive outpatient programs, standard outpatient services, and medication-assisted treatment utilizing methadone, buprenorphine, or naltrexone. Emphasizing approaches like 12-step facilitation, anger management, and brief intervention, this center customizes its treatment plans to address each person's unique requirements. Specialized programs are available for young people, adult men, and adult women. Mercy Health is dedicated to delivering excellent care for all clients, regardless of gender, who are pursuing freedom from substance use disorders. For individualized treatment within a nurturing setting, this establishment provides a variety of options to support your path to lasting sobriety.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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