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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Pecan Valley Centers for

Pecan Valley Centers located in Cleburne, TX, provides targeted treatment for adults experiencing substance use issues alongside significant mental health disorders, as well as support for children with severe emotional difficulties. Their programs, including intensive outpatient and outpatient options, encompass 12-step facilitation, anger management techniques, and short-term interventions. The center offers customized services designed for active duty military members, adolescents, and men, accommodating both male and female clients. Emphasizing personalized care and tailored treatment strategies, Pecan Valley Centers delivers thorough assistance to adults and children in their journey towards recovery from substance use and mental health struggles.

Peninsula Community Health Services of

Peninsula Community Health Services in Soldotna, AK, delivers outpatient care for addiction and concurrent mental health challenges. They offer individualized medication-assisted treatment with methadone, buprenorphine, or naltrexone. Their approach incorporates 12-step principles, motivational interviewing, and cognitive behavioral techniques to assist adults and older adults. Dedicated programs address trauma and the complexities of dual diagnoses. This center provides gender-inclusive services for everyone on their path to recovery.

Peninsula Community Health Services of

Peninsula Community Health Services in Kenai, AK, provides outpatient care for individuals of all ages struggling with substance use disorders, particularly those with co-occurring serious mental health conditions. They offer specialized medication-assisted treatment options, including methadone, buprenorphine, and naltrexone, in addition to general outpatient services. The center employs evidence-based techniques such as brief intervention, cognitive behavioral therapy, and motivational interviewing, all adapted to meet each person's unique requirements. Their commitment to personalized care extends to adults and seniors across the gender spectrum, ensuring a supportive and effective path toward recovery. Peninsula Community Health Services is recognized for its high standards of treatment and all-encompassing recovery programs.

Pecan Haven Addiction Recovery Center

Pecan Haven Addiction Recovery Center, situated in Monroe, LA, delivers a diverse array of treatment solutions for adults facing challenges with substance use disorders along with related mental health issues. The center features programs such as intensive outpatient care, long-term residential stays, and standard outpatient services, employing techniques like 12-step facilitation, anger management, and brief interventions. Pecan Haven also offers tailored programs for men and women, addressing the needs of various age groups, including young adults. Committed to personalized care and research-supported methods, this facility fosters a nurturing atmosphere for both male and female individuals on their journey to recovery from addiction.

Pennsylvania Recovery Center

The Pennsylvania Recovery Center in Phoenixville, PA, provides extensive care for substance use and co-occurring conditions affecting adults and youth. Their offerings include detoxification, intensive outpatient, outpatient, and partial hospitalization programs. The center emphasizes 12-step facilitation, anger management, and brief intervention, with specialized support for active military, men, and women. Serving a diverse adult and young adult population, the Pennsylvania Recovery Center is committed to delivering individualized, effective treatment solutions.

Penn Medicine Princeton House

At Penn Medicine Princeton House in Moorestown, NJ, we provide dedicated care for adults facing substance use challenges alongside mental health concerns, and for children with significant emotional difficulties. Our programs include intensive outpatient, outpatient, and day treatment formats, all grounded in proven therapeutic methods like cognitive behavioral therapy, motivational interviewing, and relapse prevention techniques. We offer specialized tracks for active military personnel, teenagers, and adult men, ensuring our services are accessible and relevant to various demographics. Renowned for its high standards and all-encompassing support, this center is a leading destination for those desiring personalized and successful recovery from addiction.

Peninsula Behavioral Health

Peninsula Behavioral Health, located in Port Angeles, WA, delivers extensive addiction recovery services for individuals of all ages who also navigate mental health challenges. The facility offers robust intensive outpatient programs, standard outpatient services, and targeted treatments utilizing methadone, buprenorphine, or naltrexone. Their therapeutic methods encompass brief interventions, cognitive behavioral therapy, and motivational interviewing, all designed to meet unique patient requirements. A notable feature of Peninsula Behavioral Health is its dedicated programs for individuals managing both mental health and substance use issues concurrently. Providing care adjusted for adults and older adults across the gender spectrum, the center is committed to delivering excellent support for those on their path to healing in a nurturing setting.

Peekskill Clinic
Peekskill, NY

Situated in Peekskill, NY, Peekskill Clinic specializes in outpatient treatment for substance use and co-occurring disorders for both adults and children. The clinic employs methods such as 12-step facilitation, cognitive behavioral therapy, and brief intervention strategies to deliver effective care for individuals facing significant mental health challenges. Peekskill Clinic also features dedicated programs for various groups, including adult men, women, and clients who are living with HIV or AIDS, ensuring that it meets a wide array of needs. This center focuses on personalized treatment plans for individuals across all genders, emphasizing support throughout the recovery process. If you're in search of a thorough rehabilitation program with tailored services, Peekskill Clinic is prepared to help you on your healing journey.

Peggy Albrecht Friendly House

Situated in Los Angeles, CA, Peggy Albrecht Friendly House provides comprehensive long-term residential care, detoxification services, and round-the-clock support for women facing substance use challenges. The center emphasizes a variety of therapeutic methods, including 12-step programs, short interventions, and cognitive behavioral therapy to tackle concurrent mental health disorders and trauma. Tailored specifically for adult women, encompassing both seniors and younger adults, this facility ensures a nurturing and secure setting for recovery and healing. Committed to evidence-driven practices and personalized treatment, Peggy Albrecht Friendly House strives to empower clients on their journey towards sustainable sobriety and overall wellness.

Pennsylvania Psychiatric Institute

The Pennsylvania Psychiatric Institute, located in Harrisburg, PA, specializes in providing a variety of targeted treatments for individuals dealing with substance use issues and accompanying mental health challenges. This center offers a comprehensive array of services, including intensive outpatient treatment, standard outpatient care, and medication-assisted therapies such as methadone, buprenorphine, or naltrexone. Emphasizing strategies like anger management, cognitive behavioral therapy, and brief interventions, the facility serves adults, children, and adolescents. Additionally, there are specialized programs designed to assist clients who have faced trauma. The Pennsylvania Psychiatric Institute is committed to delivering exceptional care to those in need of personalized support for their mental health and substance use treatment.

Pecan Valley Centers for
Mineral Wells, TX

Pecan Valley Centers in Mineral Wells, TX, delivers extensive support for individuals battling substance abuse and those facing dual diagnoses of addiction and mental health challenges in adults, as well as emotional difficulties in young people. Prioritizing intensive outpatient and standard outpatient care, the center provides medication-assisted treatment such as methadone, buprenorphine, and naltrexone. Their therapeutic approaches include 12-step program integration, anger management techniques, and brief intervention strategies. Pecan Valley Centers distinguishes itself with specialized programs designed for active military service members, teenagers, and adult men, serving individuals of all genders and age groups from children to adults. The dedication to high-quality, individualized treatment plans establishes Pecan Valley Centers as a crucial provider of effective and compassionate recovery services.

Penn Medicine Princeton House

Penn Medicine Princeton House, located in North Brunswick, NJ, specializes in extensive treatment for substance use issues and offers tailored support for those battling both substance use and mental health challenges. The center features a range of treatment options, including intensive outpatient and day treatment services. By implementing research-backed methods such as cognitive behavioral therapy and motivational interviewing, the facility emphasizes the importance of preventing relapse and fostering overall wellness. Unique programs are designed for military personnel, teenagers, and adult men. With services available for both adults and youth, Penn Medicine Princeton House provides care that acknowledges the specific needs of males and females. Discover exceptional treatment at this esteemed center.

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Pecan Valley Centers, situated in Granbury, TX, offers targeted rehabilitation programs for those facing challenges with substance use and concurrent mental health issues. The facility features intensive outpatient treatment alongside outpatient services, including options for methadone/buprenorphine and naltrexone therapies. Emphasizing a 12-step approach, anger management strategies, and brief interventions, the center serves a diverse population including active duty military members, teenagers, and adult males. Pecan Valley Centers is committed to providing exceptional care that is customized to meet the specific requirements of both adults and children/adolescents of any gender.

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Pecan Valley Centers for, situated in Weatherford, TX, delivers extensive addiction recovery programs. They offer targeted support for individuals facing dual diagnoses of substance use disorders and severe mental health conditions in adults, alongside addressing significant emotional challenges in young people. The center's offerings include intensive and standard outpatient care, featuring medication-assisted treatment with methadone, buprenorphine, or naltrexone. Emphasizing 12-step principles, emotional regulation strategies, and concise therapeutic approaches, their services are available to active duty military, teenagers, and adult men. Pecan Valley Centers for is equipped to assist adults and youth of all genders in their journey toward wellness and recovery.

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Peekskill, NY

Situated in Peekskill, NY, Peekskill Clinic provides focused substance use rehabilitation for adults and young adults via its outpatient programs. The center employs consistent outpatient care using proven methods like cognitive behavioral therapy, motivational interviewing, and techniques for preventing relapse. What distinguishes Peekskill Clinic is its customized approach, crafting treatment strategies to align with the distinct needs of every individual. With a commitment to serving both men and women, this facility promotes a holistic and inclusive atmosphere for care. For those in search of effective addiction recovery with a personal approach, Peekskill Clinic stands out as a reliable option.

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Peninsula Addiction Services, situated in Salisbury, MD, delivers complete treatment for substance dependence, encompassing detox and recovery programs. They feature intensive outpatient and standard outpatient services, with specialized support through 12-step guidance, anger control techniques, and brief counseling. This facility supports adult men and women, including survivors of intimate partner or domestic violence. Catering to adults and young adults of any gender, Peninsula Addiction Services prioritizes high-quality, individualized care, positioning it as a leading option for those in Salisbury seeking efficient and customized addiction recovery.

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Colmar, PA

Situated in Colmar, PA, Penn Foundation provides a thorough rehabilitation program for adults and young adults dealing with severe mental health challenges alongside substance use disorders. Their customized treatment plans offer options such as intensive outpatient care and outpatient services using methadone, buprenorphine, or naltrexone. The center features specialized programs that cater to the needs of each individual, including 12-step support, anger management strategies, and cognitive behavioral therapy techniques. Penn Foundation prioritizes high-quality care for both men and women, fostering a nurturing atmosphere conducive to recovery. For those in need of tailored and effective addiction treatment, this center is recognized for its dedication to tackling both substance misuse and mental wellness issues.

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Princeton, NJ

Penn Medicine, situated in Princeton, NJ, delivers extensive detox and substance use treatment services. The facility features inpatient detoxification, treatment options, and around-the-clock care for adults and young adults, regardless of gender. Emphasizing 12-step facilitation, brief intervention, and motivational rewards, this center supports clients with histories of trauma, sexual abuse, and those who have served in the military. With tailored programs and personalized care, Penn Medicine guarantees effective treatment for individuals pursuing recovery from addiction.

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Penndel Mental Health Center, located in Langhorne, PA, delivers targeted therapeutic services for individuals of all ages struggling with addiction and co-occurring mental health conditions. Their comprehensive offerings include intensive outpatient programs, standard outpatient services, and medication-assisted treatment with methadone, buprenorphine, or naltrexone. Emphasis is placed on evidence-based practices such as anger management, brief interventions, and cognitive behavioral therapy, with all care plans customized to meet each person's unique requirements. Specialized support is available for active duty military personnel, adult men, and adult women. The center is dedicated to providing high-quality, individualized care to adults and young adults across the gender spectrum.

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Princeton, KY

Situated in Princeton, KY, Pennyroyal Center delivers outpatient treatment for substance use for both adults and children facing significant mental health challenges or emotional issues. The center employs consistent outpatient services grounded in evidence-based methods, including 12-step programs, brief interventions, and cognitive-behavioral therapy. With a focus on the needs of clients involved in the criminal justice system, Pennyroyal Center serves a diverse range of adults and seniors across all genders. Committed to providing high-quality, personalized care, this facility stands out as an excellent option for individuals looking for thorough rehabilitation support in a nurturing atmosphere.

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Greenville, KY

Pennyroyal Center, situated in Greenville, KY, delivers extensive outpatient services aimed at addressing substance use and co-occurring disorders for both adults and children. The center employs proven methods, including 12-step facilitation, brief interventions, and cognitive behavioral therapy, in its regular outpatient programs. Catering particularly to criminal justice and forensic populations, Pennyroyal Center supports individuals of all genders, including elderly clients. With tailored programs and personalized treatment plans, the center is dedicated to providing effective support for those on the path to recovery from addiction and mental health issues.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)