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Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Royal Life Centers
Prescott, AZ

Located in Prescott, AZ, Royal Life Centers provides extensive addiction rehabilitation services through multiple formats such as intensive outpatient programs, outpatient care, and day treatment options. The center focuses on 12-step facilitation, along with anger management and brief intervention strategies. With specialized programs designed for active military members, as well as adult men and women, Royal Life Centers serves a variety of individuals. The facility is committed to delivering exceptional care in a nurturing atmosphere to both adults and young adults of all genders. Individuals in search of personalized addiction treatment in a friendly environment will discover programs that cater to their specific requirements at Royal Life Centers.

Royal Life Centers
Prescott, AZ

Situated in Prescott, AZ, Royal Life Centers provides extensive treatment for substance use in a residential format. The program covers various therapeutic modalities, including 12-step facilitation, strategies for anger management, and brief intervention techniques. This center serves adult women, current military members, and those who have faced intimate partner violence. Emphasizing care for adults, seniors, and young adults, Royal Life Centers offers focused support for female patients. With its short-term and round-the-clock residential options, the facility creates a nurturing environment conducive to recovery. Clients can anticipate personalized care and customized treatment plans to support their path to sobriety.

Royal Life Centers

Royal Life Centers, situated in Olympia, WA, delivers all-encompassing addiction recovery services for adults and young adults. The facility offers a spectrum of care, encompassing intensive outpatient, outpatient, and partial hospitalization programs. Employing strategies like 12-step facilitation, anger management, and brief intervention, Royal Life Centers customizes treatment plans for each person. Dedicated programs are provided for active military members, adult males, and adult females. Catering to both genders, this establishment prioritizes effective care and assistance for individuals pursuing sobriety.

Royal Life Centers

Royal Life Centers in Spokane, WA, delivers thorough addiction recovery services. This establishment offers detox and addiction therapy within residential accommodations, featuring round-the-clock support and shorter-term stays. Their approach includes the 12-step program, strategies for managing anger, and concise intervention techniques. They serve adult men and women, as well as active military members. Customized treatment plans are provided for both younger and older adults, guaranteeing personalized attention. Royal Life Centers distinguishes itself by offering distinct programs for male and female patients, underscoring their commitment to high-caliber treatment and successful rehabilitation for sustained sobriety.

Royal Life Centers

Situated in Mead, WA, Royal Life Centers delivers thorough addiction recovery services for adults and younger individuals. The facility offers intensive outpatient, standard outpatient, and day treatment (partial hospitalization) programs. Emphasizing 12-step facilitation, anger management, and brief intervention techniques, this center serves adult men and women, as well as active duty military members. Specialized programs for both genders guarantee personalized recovery plans. Royal Life Centers is committed to high-quality care and assistance for individuals striving to conquer addiction, establishing itself as a leading option for effective rehabilitation.

Royal Life Centers

Situated in Olympia, Washington, Royal Life Centers provides complete care for addiction, encompassing both detox and ongoing treatment. They offer various residential options, including immediate detox, round-the-clock residential support, and shorter residential stays, serving adults and young adults of all genders. The facility employs tailored therapeutic methods like 12-step support, emotional regulation training, and immediate intervention strategies. Special programs are available for active military members, adult men, and adult women. Royal Life Centers is dedicated to offering excellent care and assistance to those battling substance abuse, positioning itself as a leading facility for individuals aiming for a sober life.

Royal Life Centers
Prescott, AZ

Royal Life Centers, located in Prescott, Arizona, provides focused detox and substance abuse treatment in a tranquil residential environment. The center employs customized methods including 12-step support, anger management, and brief intervention to ensure thorough care for both adults and young adults. Programs are specifically designed for active military members, men, and women, allowing for personalized assistance. Clients can access residential detox services, round-the-clock care, and short-term residential treatments available for both genders. Committed to delivering high-quality care and individualized therapies, Royal Life Centers aims to support individuals on their journey to long-term recovery.

Royal Life Centers
Prescott, AZ

Royal Life Centers located in Prescott, AZ, provides exceptional treatment for substance use within a calm residential environment. This center emphasizes 12-step facilitation, anger management, and brief intervention strategies to tackle addiction. It offers customized programs specifically designed for active duty military members, adult males, and those who have endured intimate partner violence, ensuring focused support. Catering to adults, seniors, and young adults, this facility is dedicated to male clients in need of thorough rehabilitation services. Discover quality care and individualized treatment plans at Royal Life Centers to promote effective recovery and sustained sobriety.

Royal Life Centers

At Royal Life Centers in Sumner, WA, we provide extensive addiction recovery solutions for individuals and younger adults. Our services include detox and comprehensive substance abuse care via our intensive outpatient, outpatient, and day treatment options. We offer tailored programs for active duty military personnel, adult men, and adult women, recognizing the unique challenges each group faces. Royal Life Centers employs proven therapeutic methods including 12-step facilitation, anger management strategies, and brief intervention techniques to foster healing. Our dedication to personalized attention and a nurturing atmosphere ensures clients are empowered for lasting abstinence.

RUHS/Behavioral Health
Palm Springs, CA

RUHS/Behavioral Health, located in Palm Springs, CA, provides an extensive array of treatment options for individuals dealing with substance abuse and concurrent mental health disorders. The center features intensive outpatient services, outpatient day care, and partial hospitalization programs, all employing proven methods like cognitive behavioral therapy and the Matrix Model. Specialized programs are designed for active-duty military members, teenagers, and adult males. With an emphasis on adults and young adults of all genders, this facility is dedicated to offering effective care that aids individuals on their path to recovery.

Rural Health Inc

Rural Health Inc, situated in Anna, IL, delivers extensive outpatient services for individuals battling substance use disorders. This facility is particularly adept at addressing co-occurring substance use and severe mental health challenges, employing customized therapeutic approaches such as cognitive behavioral therapy and motivational interviewing. Their specialized care extends to trauma survivors and those with dual diagnoses, accommodating both male and female patients. Available treatment modalities encompass outpatient medication management (methadone, buprenorphine, naltrexone) and standard outpatient counseling. Rural Health Inc is committed to providing superior and individualized rehabilitation solutions.

Rural Health Inc
Goreville, IL

Rural Health Inc, situated in Goreville, IL, provides extensive outpatient care for adults and young adults struggling with substance use. This center is particularly adept at addressing dual diagnoses, managing co-occurring substance use disorders and significant mental health conditions in adults, and emotional challenges in children. Employing approaches like cognitive behavioral therapy, motivational interviewing, and brief interventions, they deliver tailored support to both male and female patients. Rural Health Inc also offers specialized assistance to those with a history of trauma and individuals facing concurrent mental health concerns. Their comprehensive services include outpatient treatment with methadone/buprenorphine or naltrexone, integrated with ongoing outpatient support, promoting a well-rounded path to recovery.

Rural Health Inc
Dongola, IL

Rural Health Inc, situated in Dongola, IL, provides extensive support for individuals battling substance use disorders and those facing complex challenges with co-occurring mental health conditions. Their specialized programs cater to both adults and young people, offering outpatient options such as methadone and buprenorphine treatment alongside standard outpatient care. Employing proven methods like cognitive behavioral therapy and motivational interviewing, the center is distinguished by its dedicated approach to individuals with trauma histories and dual diagnoses. Rural Health Inc is committed to delivering high-quality, personalized care to foster sustained recovery for all clients, regardless of gender.

Rural Nevada Counseling

Situated in Fernley, NV, Rural Nevada Counseling delivers extensive treatment for substance use disorders alongside targeted care for those facing both substance use and significant mental health challenges. The center offers a variety of treatment modalities, including intensive outpatient, outpatient services, and medication-assisted options such as methadone, buprenorphine, or naltrexone. Emphasizing methods like 12-step facilitation, brief intervention, and cognitive behavioral therapy, this center customizes its programs to meet the needs of active military personnel, teenagers, and adult males. Catering to men and women of all ages, Rural Nevada Counseling provides high-quality, personalized care to assist individuals as they work towards recovery.

Rural Nevada Counseling
Silver Springs, NV

At its Silver Springs, NV location, Rural Nevada Counseling is dedicated to providing extensive support for substance abuse and tailored services for individuals facing the complexities of both substance use disorders and significant mental health challenges. They also address serious emotional disturbances in young people. The facility's treatment offerings include intensive outpatient, standard outpatient, and medication-assisted treatment options utilizing methadone, buprenorphine, or naltrexone. Employing therapeutic modalities such as 12-step facilitation, brief intervention, and cognitive behavioral therapy, this center is equipped to assist active military members, teenagers, and adult males. Rural Nevada Counseling extends its high-quality, individualized care to adults and older adults of any gender.

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Roxbury Outpatient Services, situated in Chambersburg, PA, focuses on delivering specialized treatment for women dealing with substance use issues alongside significant mental health conditions. The center features both intensive outpatient and standard outpatient options, incorporating treatments such as methadone/buprenorphine and naltrexone. Roxbury Outpatient Services prioritizes personalized treatment plans and employs various methods, including 12-step programs, anger management, and brief interventions. This facility is dedicated to providing adults, seniors, and younger individuals with thorough and customized rehabilitation support. Clients can expect quality care in an encouraging atmosphere tailored to meet their specific needs.

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Baltimore, MD

Located in Baltimore, MD, Royal Minds provides a complete spectrum of substance abuse treatment options, customized to each person's unique requirements. The center excels in providing intensive outpatient services, extended residential stays, and standard outpatient care, employing proven methodologies such as anger management techniques, cognitive behavioral therapy, and brief intervention strategies. Royal Minds is dedicated to delivering high-quality support and offers distinct programs for active military members, adult men, and women. Catering to both older and younger adults, this establishment is open to individuals of any gender looking for a structured journey toward healing within a nurturing setting.

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Staten Island, NY

The RUMC Silberstein Clinic, situated in Staten Island, New York, specializes in offering extensive treatment for substance use disorders for both adults and young adults who also experience mental health issues. This center delivers outpatient care, which includes options like methadone, buprenorphine, or naltrexone treatment. The program employs a variety of therapeutic techniques encompassing anger management, brief interventions, and cognitive behavioral therapy to provide comprehensive support. There are specialized programs designed for adult men, adult women, and individuals with concurrent mental health and substance use challenges. Committed to delivering personalized care, this clinic aids clients of all genders in their paths to recovery.

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Situated in Vienna, IL, Rural Health Inc provides targeted outpatient services for individuals dealing with substance abuse, concurrent mental health issues, and those who have experienced trauma. Catering to both adults and young adults across all genders, this center utilizes a variety of evidence-supported methods such as cognitive behavioral therapy and motivational interviewing. Emphasizing personalized treatment, the facility is equipped to support clients needing consistent outpatient care, as well as those pursuing methadone, buprenorphine, or naltrexone therapies. Patients receive customized support and interventions aimed at addressing significant emotional challenges. Rural Health Inc is recognized for its exceptional, all-encompassing services that foster sustainable recovery and overall wellness.

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Metropolis, IL

Situated in Metropolis, IL, Rural Health Inc delivers an extensive variety of outpatient treatment services for individuals struggling with substance use, including both adults and young adults. The center specializes in addressing both substance use disorders and severe mental health conditions, employing evidence-based techniques such as cognitive behavioral therapy and motivational interviewing. Emphasizing trauma-informed care, Rural Health Inc is dedicated to assisting clients who have experienced trauma and those facing both mental health challenges and substance use issues. With programs designed separately for males and females, the center ensures that each individual receives a personalized treatment strategy. Clients looking for standard outpatient care or methadone/buprenorphine therapy can anticipate receiving exceptional support and quality care at Rural Health Inc.

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Located in Dayton, NV, Rural Nevada Counseling offers comprehensive substance use treatment and specialized care for co-occurring substance use and serious mental health illnesses in adults or serious emotional disturbances in children. With intensive outpatient, outpatient, and methadone/buprenorphine or naltrexone treatment options, the center utilizes 12-step facilitation, brief intervention, and cognitive behavioral therapy approaches. Tailored programs are available for active duty military, adolescents, and adult men. Serving adults and seniors of all genders, this facility provides quality care and support to help individuals on their path to recovery.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)