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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 7,994 treatment centers offering naltrexone (vivitrol) across the United States.

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Southside Behavioral Health

Southside Behavioral Health, located in South Boston, VA, provides outpatient substance abuse recovery services for individuals of all ages experiencing co-occurring severe mental health issues. Their regular outpatient care utilizes proven therapeutic methods, including anger management techniques, brief strategic interventions, and cognitive behavioral therapy. The center also features specialized tracks for adult men, adult women, and survivors of trauma. Accepting adults and seniors across the gender spectrum, Southside Behavioral Health delivers personalized assistance to address diverse requirements. Committed to excellence in care and holistic support, Southside Behavioral Health aims to empower individuals in their journey to recovery from addiction and enhanced mental wellness.

Southern Iowa Mental Health Center

Southern Iowa Mental Health Center in Ottumwa, IA, provides outpatient services for adults struggling with substance use disorders and co-occurring serious mental health conditions. Their specialized approaches include anger management, brief interventions, and cognitive behavioral therapy. The center caters to a diverse clientele, offering programs for adolescents, adult men and women, and seniors of all genders. Through regular outpatient care, they are committed to delivering excellent support to those addressing both substance use and mental health challenges. Southern Iowa Mental Health Center prioritizes guiding individuals toward healing and enhanced mental wellness.

Southern Peaks RTC
Canon City, CO

Southern Peaks RTC, situated in Canon City, CO, provides extensive long-term residential care for individuals of all ages struggling with substance use and co-occurring mental health conditions. Their approach emphasizes anger management, brief intervention strategies, and cognitive behavioral therapy to address complex needs. The center features dedicated programs for adolescents, survivors of sexual abuse, and those with trauma histories. Serving adults, children, adolescents, and young adults across all genders, Southern Peaks RTC is dedicated to delivering high-quality, supportive care and evidence-based treatments for sustainable recovery.

Southwest Arkansas Counseling and

Southwest Arkansas Counseling and in Hope, AR, provides dedicated rehabilitation programs designed for both adults and young individuals facing challenges with substance dependence and concurrent severe mental health conditions. Their service offerings encompass intensive outpatient services, standard outpatient support, and medication-assisted treatment utilizing methadone, buprenorphine, or naltrexone. The center employs therapeutic strategies such as 12-step program guidance, anger management training, and brief intervention methods. Recognizing the unique requirements of different demographics, they offer specialized, gender-specific programs for adolescents, adult males, and adult females. Southwest Arkansas Counseling and is committed to offering thorough and effective rehabilitation solutions to aid individuals in their path toward lasting recovery.

Southern Indiana Comprehensive

Outpatient medication treatment with buprenorphine or naltrexone is offered at this Charlestown, Indiana center, with regular outpatient substance use care for young adults through seniors. Programs cover pregnant and postpartum women, veterans, military families, and people with HIV or AIDS or histories of abuse or domestic violence. Medicare, Medicaid, TRICARE, and government funding are accepted.

Southern Live Oak Wellness

Partial hospitalization and intensive outpatient treatment for substance use and co-occurring serious mental illness in Atlanta, Georgia, using buprenorphine and naltrexone. Southern Live Oak Wellness runs programs for veterans, military families, pregnant and postpartum women, and criminal justice clients. Private insurance and self-pay are accepted.

Southern Sky Outpatient Detox

Outpatient detoxification and day treatment in Memphis, Tennessee, are the focus of Southern Sky Outpatient Detox, which also uses buprenorphine and naltrexone in treatment. Programs serve veterans, military families, and pregnant women. Payment is limited to private insurance, state-financed plans, and self-pay.

Southern Sky Recovery

Southern Sky Recovery in Bluffton, South Carolina, delivers outpatient detoxification, partial hospitalization, intensive outpatient, and regular outpatient care, with buprenorphine and naltrexone available. The program works with veterans, military families, criminal justice clients, and people with co-occurring pain or mental health disorders. TRICARE, private insurance, and self-payment are accepted.

Southwest Behav and Health Services

Southwest Behav and Health Services provides regular outpatient substance use treatment in Phoenix, Arizona, for adolescents, young adults, and seniors, including co-occurring serious mental illness in adults and serious emotional disturbance in children. Buprenorphine and naltrexone are used. Payment options include Medicaid, SAMHSA block grants, and a sliding fee scale.

Southwest Behavioral Health Services

The Mesa Clinic of Southwest Behavioral Health Services offers regular outpatient substance use treatment in Mesa, Arizona, for adolescents, young adults, and seniors, including co-occurring serious mental illness. Buprenorphine and naltrexone are used for opioid use disorder. Medicaid, Medicare, SAMHSA block grants, and a sliding fee scale are accepted.

Southwest Behavioral Health Services

This Flagstaff, Arizona, clinic of Southwest Behavioral Health Services provides intensive and regular outpatient treatment with methadone, buprenorphine, and naltrexone for opioid use disorder. Programs serve adolescents, pregnant women, veterans, and forensic clients, among others. Medicare, Medicaid, tribal funds, SAMHSA block grants, and a sliding fee scale are accepted.

Southern Family Medicine

Southern Family Medicine, situated in Mocksville, NC, provides extensive outpatient rehabilitation. Their expertise lies in treating substance use disorders and dual diagnoses for individuals of all ages. They employ techniques such as anger management, cognitive behavioral therapy, and brief intervention to create personalized treatment plans. Distinctive offerings include specialized programs for military personnel, adult males, and survivors of domestic abuse. Catering to both adults and children, Southern Family Medicine delivers high-quality care to all. They offer outpatient services, including methadone/buprenorphine treatment, to support those pursuing recovery.

Southwest Arkansas Counseling and

Situated in De Queen, AR, Southwest Arkansas Counseling provides an extensive array of services for substance use treatment. This center focuses on addressing co-occurring substance use disorders and significant mental health conditions in adults, as well as severe emotional disturbances in children. With options for intensive outpatient treatment and standard outpatient care, the center delivers personalized support utilizing strategies like 12-step programs, anger management, and brief interventions. Specialized programs are tailored for adolescents, adult men, and adult women. Southwest Arkansas Counseling accommodates both adults and minors, featuring gender-specific programs designed for women and men. You can expect high-quality care and assistance at this facility.

Southwest Behavioral Health Center

Southwest Behavioral Health Center, situated in Beaver, UT, provides an extensive array of rehabilitation services. This center focuses on treating substance abuse and co-occurring mental health disorders in both adults and children. It offers various levels of care, including intensive outpatient programs, outpatient services, and day treatment. The facility employs methods such as 12-step facilitation, brief intervention, and cognitive behavioral therapy, accommodating individuals of all genders, including seniors. With specialized programs designed for adolescents, adult men, and women, Southwest Behavioral Health Center emphasizes personalized care and support. Opt for this center for effective, evidence-driven treatment and empathetic rehabilitation services.

Southwest Behavioral Health Center

At Southwest Behavioral Health Center located in Panguitch, UT, individuals can access a wide range of services for substance abuse treatment, as well as support for adults facing serious mental health challenges and children with emotional issues. The center provides various programs including intensive outpatient care, outpatient therapy, and day treatment options, employing research-backed methods such as 12-step facilitation, brief intervention strategies, and cognitive behavioral therapies. Designed for different demographics, including adolescents and adults of all genders, the center focuses on meeting the unique requirements of its clients. Southwest Behavioral Health Center is dedicated to offering high-quality, personalized care, establishing itself as a premier destination for rehabilitation services in the area.

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Southern Highlands CMHC Inc, located in Princeton, WV, provides in-depth treatment for substance use issues targeting adult men, seniors, young adults, and other adults. The center focuses on addressing both co-occurring substance use disorders and significant mental health conditions. It offers various treatment options, including long-term, short-term, and round-the-clock residential programs, all designed to ensure personalized care. The therapeutic strategies employed include anger management, brief interventions, and cognitive behavioral therapy. Tailored programs are available specifically for adult men and those facing both mental health and substance use challenges. Committed to delivering exceptional care with specialized approaches for different groups, this facility is focused on empowering individuals to achieve enduring recovery.

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Southern Highlands CMHC Inc, situated in Princeton, WV, provides thorough outpatient care for those requiring detoxification and help with substance use. They are experts in addressing co-occurring substance use disorders alongside significant mental health conditions in adults and severe emotional disturbances in young people. Their therapeutic methods encompass anger management, brief intervention, and cognitive behavioral therapy. Furthermore, they offer tailored programs for teenagers, serving adults and children/adolescents alike. Southern Highlands CMHC Inc prioritizes high-quality service, creating personalized treatment strategies for male and female patients within a nurturing and healing setting.

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Southern Highlands CMHC Inc, located in Welch, WV, provides outpatient substance abuse recovery services for adults, including individuals facing concurrent mental health challenges. Their expertise lies in areas such as anger management techniques, cognitive behavioral therapy, and short-term counseling approaches. The facility is equipped to deliver personalized support to adults and younger individuals alike. For those requiring it, Southern Highlands CMHC Inc also offers outpatient pharmacotherapy for opioid use disorder, utilizing medications like methadone, buprenorphine, or naltrexone. Their commitment to a personalized, gender-inclusive approach ensures that every client receives specialized and effective treatment designed for their distinct circumstances.

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Situated in Kanab, UT, the Southwest Behavioral Health Center provides a wide range of substance use disorder treatments and has a particular focus on addressing co-occurring conditions in both adults and children. The center offers various programs, including intensive outpatient services, outpatient day treatment, and partial hospitalization. With a commitment to utilizing methods such as 12-step facilitation, brief intervention, and cognitive behavioral therapy, the center serves adolescents, as well as adult men and women. Catering to adults and seniors of all genders, Southwest Behavioral Health Center emphasizes high-quality care through personalized treatment strategies and evidence-based practices.

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Southwest Behavioral Health Center, situated in Saint George, UT, is dedicated to offering tailored rehabilitation for individuals grappling with addiction and co-occurring mental health challenges, serving both young and adult populations. The facility features robust treatment modalities including intensive outpatient, general outpatient, and day treatment programs. Employing proven therapeutic strategies such as 12-step facilitation, brief intervention, and cognitive behavioral therapy, the center accommodates adolescents, adult men, and women. Southwest Behavioral Health Center is committed to providing superior, personalized care for adults and seniors, establishing itself as a leading destination for comprehensive recovery services in the area.

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Southwest Behavioral Health Center, situated in Milford, UT, provides extensive programs for individuals of all ages, from youth to seniors, addressing both substance abuse and mental health concerns. The center customizes care through diverse treatment modalities, including intensive outpatient and day treatment options. Employing proven methods like 12-step facilitation and cognitive behavioral therapy, Southwest Behavioral Health Center is committed to fostering healing and sustained recovery for every client.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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