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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 7,994 treatment centers offering naltrexone (vivitrol) across the United States.

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Syracuse Community Health Center

Syracuse Community Health Center located in Syracuse, NY, offers focused treatment for adults who are dealing with substance use issues alongside significant mental health disorders, as well as support for children experiencing serious emotional challenges. The center provides both intensive outpatient and standard outpatient programs, with options for methadone and buprenorphine therapies. Emphasizing 12-step processes, anger management techniques, and short interventions, the facility adopts a personalized care strategy for individuals across all age groups and genders. Syracuse Community Health Center is recognized for its holistic approach and dedication to meeting the distinct needs of each patient within a nurturing setting.

Syracuse VAMC
Syracuse, NY

Syracuse VAMC, situated in Syracuse, NY, delivers extensive rehabilitation programs. Their expertise lies in helping individuals overcome addiction, providing treatment for substance use issues, and addressing dual diagnoses involving serious mental health conditions in adults or emotional challenges in children. The facility provides intensive outpatient care, standard outpatient services, and outpatient detoxification. Focusing on techniques like anger management, brief intervention, and cognitive behavioral therapy, the center welcomes active-duty military personnel, adult men, and adult women. Syracuse VAMC is committed to offering excellent care in a nurturing setting to adults and young adults, irrespective of gender.

TLC Treatment Center

TLC Treatment Center, situated in Mesa, Arizona, provides an extensive range of services for individuals dealing with substance use issues, including options for transitional housing and sober living. The center features intensive outpatient care alongside outpatient and partial hospitalization programs. Emphasizing 12-step support, anger management, and brief therapeutic interventions, it serves both adult men and women, as well as those who have faced sexual abuse. TLC Treatment Center focuses on adults and young adults, offering gender-specific programming tailored for both sexes. With a strong dedication to delivering high-quality care and personalized treatment plans, this center is committed to assisting clients throughout their recovery process.

Syracuse Recovery Services

Syracuse Recovery Services in Cortland, NY, delivers customized outpatient substance use disorder services. The facility specializes in supporting adult men, adult women, and individuals with trauma histories. Their therapeutic methods encompass brief interventions, cognitive behavioral therapy, and contingency management/motivational incentives. Catering to a broad demographic, they offer programs for adults and young people. The center provides outpatient medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient care, prioritizing effective and individualized recovery journeys.

Syracuse VA
Rome, NY

The Rome Outpatient VA Clinic, part of Syracuse VA in Rome, New York, treats veterans for substance use and co-occurring serious mental illness on an outpatient basis, using buprenorphine and naltrexone. Programs also address veterans who have experienced trauma. Sign language services for the deaf and hard of hearing are available.

Syracuse VA
Auburn, NY

Veterans in the Auburn, New York area can receive outpatient substance use treatment at this VA clinic, which also runs programs for clients who have experienced trauma. Buprenorphine and naltrexone are used in treatment, and care covers co-occurring serious mental illness in adults. Sign language services are available.

THRIVE Wellness and Recovery Inc

THRIVE Wellness and Recovery Inc provides outpatient and intensive outpatient treatment in Lowville, New York, with buprenorphine and naltrexone available. Programs serve adolescents, pregnant and postpartum women, veterans, military families, and criminal justice clients. Medicaid, Medicare, TRICARE, SAMHSA block grants, and a sliding fee scale are accepted.

TPC Substance Use Outpatient Services

Situated in Amarillo, TX, TPC Substance Use Outpatient Services delivers focused outpatient care for individuals dealing with substance use issues and overlapping mental health conditions in both adults and children. The center employs strategies such as brief intervention, cognitive behavioral therapy, and community reinforcement in conjunction with vouchers to offer customized assistance to its clients, regardless of gender. Prioritizing individualized care, TPC Substance Use Outpatient Services is designed for adults and young adults who are in search of thorough support in an outpatient setting. If you or someone you know is in need of effective substance use treatment that emphasizes a tailored approach, this center is committed to facilitating a successful recovery journey.

TCN Behavioral Health Services Inc

TCN Behavioral Health Services Inc, located in Fairborn, OH, provides extensive support for individuals battling substance use disorders, along with targeted interventions for those managing co-occurring severe mental health challenges. Their diverse treatment offerings are designed for both young people and adults, encompassing intensive outpatient, day treatment, and partial hospitalization programs. Emphasizing methodologies such as 12-step support, anger resolution, and short-term counseling, the center delivers personalized care plans. Dedicated services are provided for teenagers, adult men, and adult women. TCN Behavioral Health Services Inc serves a broad spectrum of clients, including males and females of all ages, from adults to seniors, who are pursuing a path to recovery and improved mental well-being.

THRIVE Wellness and Recover Inc

Intensive and regular outpatient care in Watertown, New York, with buprenorphine and naltrexone for opioid use disorder. This THRIVE Wellness and Recovery clinic treats co-occurring disorders in adults and children and runs programs for adolescents, pregnant women, veterans, and forensic clients. Medicaid, Medicare, SAMHSA block grants, and sliding fee payment are accepted.

Syracuse Recovery Services

Syracuse Recovery Services located in Auburn, NY, specializes in outpatient care for substance use disorders, emphasizing personalized treatment plans. The facility offers services such as outpatient methadone/buprenorphine and naltrexone therapies, along with standard outpatient programs. By employing proven methodologies including cognitive behavioral therapy and contingency management, the center serves adults of all genders and ages, including those who have faced traumatic experiences. Catering to both adults and youth, the center adopts a holistic approach to recovery. Syracuse Recovery Services in Auburn, NY, is committed to delivering effective addiction treatment that recognizes and responds to the distinct needs of every individual.

TCN Behavioral Health Services Inc

TCN Behavioral Health Services Inc, located in Xenia, OH, delivers an extensive array of rehabilitation services with a focus on substance abuse treatment, transitional living arrangements, and support for individuals dealing with both substance use disorders and severe mental health issues. This center provides various program options, including long-term, short-term, and round-the-clock residential care, employing customized strategies such as 12-step programs, anger management sessions, and brief intervention tactics. TCN Behavioral Health Services Inc also offers specialized programs designed for adolescents, adult males, and individuals who have faced intimate partner violence, addressing the specific needs of men and older adults. Clients can expect high-quality care and assistance in a secure and organized setting at this rehabilitation center.

TCN Behavioral Health Services Inc

TCN Behavioral Health Services Inc in Xenia, OH, provides an extensive array of rehabilitation treatments. This center specializes in detoxification, addressing substance use disorders, and offering tailored support for those with both substance use problems and severe mental health conditions. Treatment options include intensive outpatient care, standard outpatient services, and partial hospitalization. The facility employs research-backed methods such as 12-step programs, anger management, and brief therapeutic interventions. TCN Behavioral Health Services also offers dedicated programs for teens, as well as adult men and women, ensuring a wide breadth of support. Aiming to assist adults and seniors of all genders, this center is committed to offering exceptional care to help individuals progress on their recovery journey.

TPC Wellness
Jackson, OH

TPC Wellness, located in Jackson, OH, is dedicated to providing targeted substance use treatment specifically for adult males. This center features a variety of programs including intensive outpatient, outpatient, and day treatment formats. Emphasizing methods like 12-step facilitation, anger management, and cognitive behavioral therapy, TPC Wellness ensures that clients receive the attention they need. While primarily serving adult men, the facility also accommodates adult women and individuals living with HIV or AIDS, offering customized care to meet different requirements. Catering to adults, seniors, and young adults alike, this center focuses on delivering high-quality, personalized treatment strategies. For those in search of an inclusive addiction recovery program with an emphasis on male participants, TPC Wellness provides a nurturing space for healing and growth.

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Syracuse Recovery Services LLC, based in Syracuse, NY, provides a wide range of treatment options for individuals struggling with substance use issues, targeting both adults and teens. The facility specializes in outpatient care that includes medications like methadone, buprenorphine, or naltrexone, as well as cognitive behavioral therapy and brief intervention strategies. Additionally, there are specific programs designed for adult men, adult women, and individuals who have faced trauma. Committed to delivering high-quality support, the center caters to both males and females on their path to recovery. Syracuse Recovery Services LLC is distinguished by its personalized treatment plans, ensuring that every client receives the specific assistance they need to achieve lasting sobriety.

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Situated in Tok, AK, TCC Upper Tanana Behavioral Health is dedicated to addressing substance use challenges for adults dealing with concurrent mental health conditions and for children facing significant emotional difficulties. The center offers both intensive outpatient and outpatient treatment options, including the use of methadone, buprenorphine, or naltrexone as part of its program. Utilizing methods such as 12-step support, anger management techniques, and short-term interventions, the facility serves clients of all genders. TCC Upper Tanana Behavioral Health is particularly recognized for its commitment to those with dual diagnoses, providing thorough assistance for individuals of all ages as they navigate their path to recovery.

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TCN Behavioral Health Services Inc, located in Dayton, OH, provides a wide range of services aimed at treating addiction. The center offers detox services, treatment for substance use disorders, and targeted programs for adults facing both substance use and severe mental health challenges. Their treatment options include intensive outpatient care, outpatient services, and day treatment. Employing evidence-based methods, TCN incorporates strategies such as 12-step facilitation, anger management, and short interventions in their programs. Additionally, there are specialized services for adolescents, as well as tailored programs for adult men and women. TCN Behavioral Health Services is committed to delivering exceptional care to adults and seniors, ensuring effective support for all individuals on their recovery journey.

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TCN Behavioral Health Services Inc. in Bellefontaine, OH, delivers extensive care for adults struggling with substance misuse, particularly those with co-occurring serious mental health conditions or children experiencing emotional distress. The facility offers a range of therapeutic services, including intensive outpatient programs, standard outpatient services, and day treatment. TCN addresses the needs of specific demographics with tailored programs for adolescents, adult men, and adult women. Employing strategies such as 12-step facilitation, anger management techniques, and brief intervention methods, the center prioritizes personalized treatment plans. Seniors and adults looking for effective, customized addiction recovery will find dedicated support and high-quality care at TCN Behavioral Health Services Inc.

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TCN Behavioral Health Services Inc, located in Urbana, OH, delivers a full spectrum of therapeutic interventions for individuals battling addiction and dual diagnoses. The center features intensive outpatient, outpatient, and day treatment modalities, serving adults and older adults. TCN Behavioral Health Services Inc provides distinct programs for young people, adult males, and adult females, emphasizing personalized care plans. Their recovery strategies incorporate 12-step facilitation, anger management techniques, and concise interventions. Through dedicated tracks for men and women, TCN Behavioral Health Services Inc is committed to gender-informed care that enhances treatment effectiveness.

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Ironton, OH

Situated in Ironton, OH, TPC Wellness is a prominent rehabilitation facility focused on providing substance use treatment specifically for adult women. The center offers various programs, including intensive outpatient, outpatient, and day treatment services, employing proven methods like 12-step facilitation, cognitive behavioral therapy, and anger management. TPC Wellness is distinguished by its targeted programs for adult women, as well as individuals living with HIV or AIDS and those facing dual diagnoses involving mental health and substance use issues. Catering to adults, seniors, and young adults, the center delivers holistic care designed to meet the distinct needs of female clients, ensuring effective treatment and support.

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Mount Orab, OH

TPC Wellness, situated in Mount Orab, OH, stands out as a leading rehabilitation facility focused on substance use recovery for adult males. The center offers a variety of programs including intensive outpatient treatment, traditional outpatient services, and daytime treatment options, all designed to foster a nurturing recovery atmosphere. Their approach integrates 12-step principles, anger management techniques, and cognitive behavioral therapy to meet the diverse needs of clients. TPC Wellness serves adult men, seniors, and young adults, with specialized programs available for those living with HIV or AIDS, as well as individuals facing dual mental health challenges. Renowned for its exceptional care and personalized treatment strategies, this center is committed to guiding individuals on their journey toward enduring sobriety.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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