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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 7,994 treatment centers offering naltrexone (vivitrol) across the United States.

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Under Angels Wings Recovery Center

At Under Angels Wings Recovery Center in Brooklyn, NY, we provide extensive outpatient services for addiction and dependency, including detoxification and medication-assisted treatment options such as methadone, buprenorphine, and naltrexone. Our approach incorporates evidence-based practices like 12-step facilitation, anger management, and brief intervention strategies. We are committed to serving a wide range of individuals, from active military members and adolescents to adult men and women, ensuring personalized care for patients of all ages and genders to guide them toward lasting wellness.

Unison Behavioral Health

Unison Behavioral Health, situated in Waycross, GA, delivers dedicated long-term residential care aimed at treating substance use disorders and co-occurring severe mental health issues in adults, as well as emotional disturbances in children. This facility offers round-the-clock support and personalized treatment strategies, including cognitive behavioral therapy, brief interventions, and anger management. Special programs are designed for adult women, particularly those who have experienced intimate partner violence, domestic violence, and sexual abuse. The center prioritizes the needs of female clients but also accommodates seniors and young adults. With a commitment to high-quality care and targeted programs, Unison Behavioral Health serves as a vital support system for individuals in need of tailored rehabilitation solutions.

UPMC Chautauqua WCA
Jamestown, NY

UPMC Chautauqua WCA in Jamestown, NY, provides extensive support for individuals of all ages struggling with addiction and accompanying mental health challenges. They cater to specific needs with distinct programs for adult men, adult women, and those with trauma histories. Their hospital-based inpatient detoxification and treatment employ proven methods such as 12-step support, managing anger, and cognitive behavioral therapy. By offering gender-specific pathways, UPMC Chautauqua WCA fosters a welcoming atmosphere. Their dedication to high-quality, personalized recovery plans establishes them as a premier option for effective rehabilitation in the Jamestown region.

UPMC Mercy Hospital
Pittsburgh, PA

UPMC Mercy Hospital, situated in Pittsburgh, PA, delivers thorough detoxification for adults and young adults. Committed to excellent patient care, this institution features hospital inpatient detoxification and round-the-clock hospital inpatient programs. The center excels in utilizing 12-step facilitation, the Matrix Model, and Motivational Interviewing. UPMC Mercy Hospital distinguishes itself with customized programs for adult men, adult women, and individuals with a history of trauma. Providing specialized support for both male and female patients, this facility creates a nurturing setting for those on their journey to addiction recovery.

UPMC Western Maryland
Cumberland, MD

Nestled in Cumberland, MD, UPMC Western Maryland provides dedicated support for individuals battling substance use issues, as well as those facing dual diagnoses of addiction and significant mental health challenges in adults or developmental concerns in youth. Their outpatient offerings, which include methadone and buprenorphine therapies, are grounded in proven methods like cognitive behavioral therapy and motivational interviewing. The facility crafts unique recovery paths for adults and young adults across the gender spectrum, emphasizing a personal journey toward healing. UPMC Western Maryland is recognized for its high standards of care and customized treatment strategies, positioning it as a reliable option for those desiring thorough recovery assistance.

Ultimate Treatment Center

At Ashland, KY's Ultimate Treatment Center, we provide thorough addiction rehabilitation. Our services include detox and drug/alcohol treatment via intensive outpatient, standard outpatient, and outpatient detox options. We employ methods such as anger management, brief intervention, and cognitive behavioral therapy, serving adults and young adults of any gender. Specialized support is available for pregnant/postpartum individuals and veterans. Prioritizing personalized attention and proven techniques, our center is dedicated to aiding each person's path to lasting sobriety.

UPMC Mckeesport Hosptial

Situated in McKeesport, PA, UPMC McKeesport Hospital delivers an extensive range of detoxification and substance abuse treatment options. This center features inpatient detox and therapeutic services, tailored programs specifically for active military personnel, as well as distinct offerings for adult men and women. Emphasizing 12-step support, anger management, and concise intervention strategies, this facility serves adults and young adults across all genders. UPMC McKeesport Hospital is dedicated to providing exceptional care and assistance for those on their path to recovery from addiction, establishing itself as a reliable choice for specialized treatment assistance.

Umass Harrington Healthcare at Webster

Umass Harrington Healthcare at Webster, situated in Webster, MA, provides targeted outpatient services for adults dealing with substance use issues and severe mental health disorders, as well as emotional challenges in children. The center delivers extensive support through programs such as anger management, cognitive behavioral therapy, and customized treatment plans designed for individual needs. Aiming to support both young adults and mature individuals, the facility serves clients of all genders. Offered services encompass outpatient treatments with methadone/buprenorphine or naltrexone, standard outpatient care, and brief intervention tactics. Committed to high-quality, personalized treatment, this center strives to assist individuals on their journey toward recovery.

Unbound Horizon Outpatient service

Unbound Horizon Outpatient Service in Carthage, Missouri, offers regular and intensive outpatient care with buprenorphine and naltrexone, treating adolescents through seniors. Programs serve pregnant and postpartum women, veterans, and clients with trauma or co-occurring disorders. Medicare, Medicaid, and a sliding fee scale are accepted.

URP Lake Worth LLC
Lake Worth, FL

URP Lake Worth in Lake Worth, Florida provides residential detoxification and short-term residential substance use treatment for adults. Buprenorphine and naltrexone are used in treatment, and programs serve clients with co-occurring mental or pain disorders and those who have experienced trauma. Private health insurance and self-payment are accepted.

UPMC Western Behav Hlth at Safe Harbor

UPMC Western Behav Hlth at Safe Harbor, located in Erie, PA, provides extensive treatment options for substance use challenges among both adults and children facing concurrent mental health disorders. The facility features various programs including intensive outpatient care, outpatient services, and medication-assisted treatments with methadone, buprenorphine, or naltrexone. Emphasizing personalized approaches such as anger management, cognitive behavioral therapy, and motivational interviewing, they craft specialized treatment plans for each individual. The center also includes dedicated programs for adult men and women, as well as those managing combined mental health and substance use issues. Services are designed for individuals across all ages and genders, ensuring access to exceptional care and focused therapies at UPMC Western Behav Hlth at Safe Harbor.

Union Losson Recovery Center

Nestled in Buffalo, NY, Union Losson Recovery Center delivers outpatient care for adults grappling with substance use disorders and co-occurring serious mental health conditions. The center facilitates outpatient treatment using methadone, buprenorphine, and naltrexone, integrated with therapeutic modalities such as 12-step facilitation, anger management, and brief interventions. Tailored programs are available for active duty military, adolescents, and adult men, demonstrating the center's dedication to serving a varied client base. Union Losson Recovery Center provides support to adult men and women, as well as children and adolescents, aiming to offer effective, complete support for those pursuing lasting recovery.

Unison Health
Toledo, OH

Unison Health, situated in Toledo, OH, delivers an extensive variety of services for addiction recovery aimed at both adults and seniors. It features specialized programs catering to adolescents as well as separating options for adult men and women. The center offers detox services, treatment for substance use, transitional housing, and sober living environments. Employing techniques like cognitive behavioral therapy, anger management, and brief interventions, Unison Health provides multiple treatment formats, including intensive outpatient, long-term residential care, and outpatient support. Committed to high-quality care and individualized treatment plans, this rehabilitation center strives to aid individuals on their recovery paths while fostering a nurturing atmosphere for all clients.

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Unified Community Services, located in Dodgeville, WI, provides extensive treatment for substance use issues impacting both adults and children who also face significant mental health challenges. The center features various treatment methods, including intensive outpatient programs, outpatient services, and options for methadone, buprenorphine, or naltrexone. Emphasizing techniques such as anger management, brief interventions, and cognitive behavioral therapy, this facility is designed for individuals who have undergone trauma, including experiences of intimate partner or domestic violence. Unified Community Services is dedicated to delivering exceptional care to adults and seniors across all genders grappling with both mental health and substance use disorders.

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Unified Community Services, located in Lancaster, WI, delivers comprehensive outpatient services for individuals dealing with substance use issues alongside mental health challenges, catering to both adults and children. The center provides tailored treatment options that include anger management, cognitive behavioral therapy, and programs that address trauma. It specifically supports clients affected by intimate partner violence and those experiencing dual diagnoses. The facility serves adults and seniors of all genders, offering outpatient treatments such as methadone and buprenorphine. Committed to evidence-based practices, the center prioritizes delivering exceptional care for anyone pursuing assistance with addiction and mental health concerns.

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Situated in Jamestown, NY, the UPMC Behavioral Health Wellness Center delivers extensive services for addiction recovery. The center offers detoxification and treatment for substance use through various programs, including hospital inpatient care, 24-hour hospital services, and long-term residential options. The facility employs methodologies such as 12-step facilitation, cognitive behavioral therapy, and motivational interviewing to customize treatment for each client. Focusing on care for adults and young adults of all genders, this center is distinguished by its individualized recovery plans. Clients can anticipate top-notch, evidence-driven care in a nurturing atmosphere at the UPMC Behavioral Health Wellness Center.

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Situated in Dunkirk, NY, the UPMC Chautauqua Dunkirk Health Center specializes in thorough treatment for substance use disorders among both adults and children who also face mental health challenges. This center offers a range of outpatient services, including treatments with methadone and buprenorphine, alongside cognitive behavioral therapy. Tailored programs are designed for adult men and women, as well as for individuals who have undergone trauma. Emphasizing 12-step approaches and brief interventions, this facility accommodates adults and seniors of any gender. The UPMC Chautauqua Dunkirk Health Center is committed to providing top-tier, evidence-based support to assist clients in their recovery journey.

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Jamestown, NY

Situated in Jamestown, NY, UPMC Chautauqua WCA delivers high-caliber treatment for substance use issues in both adults and children grappling with complex mental health disorders. The center offers outpatient options, including therapies with methadone, buprenorphine, or naltrexone. Their treatment methodology incorporates scientifically supported techniques such as 12-step facilitation, brief interventions, and cognitive behavioral therapy. Tailored programs are available for adult men, adult women, and those who have faced trauma. With a focus on providing thorough support for adults and seniors from all backgrounds, this center is dedicated to helping individuals navigate the challenges of addiction and mental wellness.

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Situated in Franklin, PA, UPMC Western Behav Hlth at Safe Harbor delivers focused outpatient services for adults dealing with substance use, as well as serious mental health conditions, and offers support for children experiencing serious emotional challenges. This center employs customized treatment approaches, including cognitive behavioral therapy, motivational interviewing, and techniques aimed at preventing relapse. It features specialized programs for active military personnel, adolescents, and adult women, addressing the distinct requirements of each client. UPMC Western Behav Hlth at Safe Harbor provides a nurturing and inclusive atmosphere for both adult and senior women on their journey to recovery.

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UPMC Western Behavioral Health, located in Somerset, PA, specializes in providing targeted substance use rehabilitation for both adults and older adults. This facility features a range of treatment options, including intensive outpatient programs, standard outpatient services, and day treatment or partial hospitalization. Emphasizing techniques such as anger management, brief interventions, and cognitive behavioral therapy, the center customizes its offerings to fit the needs of each person. UPMC Western Behavioral Health is recognized for its dedication to individualized care, accommodating both men and women. For those looking for a thorough addiction treatment solution in a nurturing setting, this center delivers high-quality services tailored to your specific requirements.

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UPMC Western Behavioral Health in Somerset, PA, delivers extensive programs for substance abuse recovery, emphasizing detox and ongoing treatment. They provide extended stay residential options, immediate detox services, and round-the-clock residential support. The center has dedicated pathways for adult males, adult females, and individuals affected by domestic or intimate partner violence, addressing a spectrum of specific requirements. Through methods like 12-step support, emotional regulation training, and rapid assessment, UPMC Western Behavioral Health guarantees personalized assistance for adults and young adults regardless of gender. Discover exceptional treatment and customized aid at this esteemed recovery facility.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)