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Medically Reviewed Content
Updated: April 2026
Sources: SAMHSA, NIDA

Medication-Assisted Treatment (MAT) Centers in California

Medically reviewed by Sarah Mitchell, LCSWLast reviewed: April 2026

Our directory lists 713 MAT programs across California, with the largest concentrations in Los Angeles (44), Long Beach (25) and Costa Mesa (22).

Medication-Assisted Treatment (MAT) combines FDA-approved medications — methadone, buprenorphine, and naltrexone — with counseling and behavioral therapies for comprehensive addiction care. MAT is the evidence-based gold standard for opioid and alcohol use disorders.

Treatment landscape in California:

  • Comprehensive Medi-Cal coverage for substance abuse treatment
  • Luxury coastal rehabilitation centers in Malibu and Newport
  • Specialized programs for dual diagnosis and mental health
  • Evidence-based treatment with cutting-edge therapies
  • DMC-ODS providing enhanced outpatient services

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Coverage & Regulations in California

Medi-Cal

Medi-Cal covers methadone, buprenorphine, and naltrexone under the Drug Medi-Cal Organized Delivery System (DMC-ODS) in most counties, including counseling and care coordination.

State regulations

California permits Narcotic Treatment Programs (NTPs) to admit patients the same day and offers one of the nation’s largest OTP networks under California Code of Regulations Title 9.

SAMHSA National Helpline: 1-800-662-4357Crisis: 988
Top Cities for Medication-Assisted Treatment in California
Los Angeles
44 centers
Long Beach
25 centers
Costa Mesa
22 centers
San Diego
22 centers
San Francisco
21 centers
Malibu
17 centers
Huntington Beach
15 centers
Sacramento
13 centers
Commonly Accepted Insurance
  • Cash or self-payment632
  • Private health insurance547
  • Medicaid327
  • Federal military insurance (e.g., TRICARE)296
  • Federal, or any government funding for substance use treatment programs289
  • State-financed health insurance plan other than Medicaid255
Available Settings
  • Outpatient388
  • Residential/24-hour residential366
  • Regular outpatient treatment347
  • Short-term residential334
  • Long-term residential296

MAT programs in California

Mission Viejo, CA

855-449-4490

Situated in Mission Viejo, California, 449 Recovery is dedicated to providing tailored substance abuse treatment for adults facing significant mental health challenges or emotional issues in children. This center features intensive outpatient programs, day treatment services, and partial hospitalization options. Emphasizing approaches such as 12-step support, anger management, and brief interventions, it serves both men and women, including clients who have undergone intimate partner or domestic violence. With a commitment to delivering personalized care, this facility offers a supportive atmosphere for adults and adolescents pursuing holistic rehabilitation solutions.

Malibu, CA

310-589-2880

6390 Meadows Court LLC, situated in Malibu, California, specializes in extensive detox and treatment services for substance use issues. This center features residential detox programs, round-the-clock care, and short-term residential options for adult men and women, including those who have faced traumatic experiences. Emphasizing cognitive behavioral therapy, strategies for relapse prevention, and counseling for substance use disorders, the facility serves both adults and young adults. With tailored services available for male and female participants, 6390 Meadows Court LLC is committed to delivering exceptional care and support for those in need of effective rehabilitation in a peaceful environment.

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Indio, CA

760-342-6616

At ABC Recovery Center Inc, located in Indio, CA, we provide extensive support for those battling addiction. Our services encompass the full spectrum of care, from initial detox to ongoing substance use treatment and stable transitional housing. Residents benefit from a secure, long-term residential environment offering continuous 24-hour assistance. We utilize proven therapeutic methods, including cognitive behavioral therapy and 12-step program integration. Our tailored programs are designed for adult men and women, with special considerations for individuals who have faced intimate partner violence. We also address anger management and offer highly personalized care plans for adults and young adults of all gender identities as they embark on their recovery journey. ABC Recovery Center Inc is dedicated to delivering exceptional, customized treatment to facilitate enduring sobriety.

Indio, CA

760-342-6616

ABC Recovery Center Inc, located in Indio, CA, provides a full spectrum of substance abuse treatment options. This establishment is particularly adept at long-term residential rehabilitation and inpatient detox for adult women. Their approach emphasizes 12-step facilitation, anger management, and cognitive-behavioral therapy, designed for individuals facing co-occurring mental health and substance use issues, including those living with HIV or AIDS. Catering to a diverse age range from young adults to seniors, the center fosters a nurturing setting for women to begin their path to wellness. Known for its dedication to high-quality, evidence-based care, ABC Recovery Center Inc stands as a reliable choice for effective addiction treatment.

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San Diego, CA

866-314-3222

ABC Sober Living LLC, located in San Diego, CA, specializes in providing extensive treatment for substance use as well as transitional housing specifically for adult women. The center employs intensive outpatient services that leverage proven methods, including 12-step facilitation, cognitive behavioral therapy, and contingency management. This program is particularly beneficial for individuals who have faced trauma or sexual abuse. With an emphasis on females spanning various age groups, including adults, seniors, and young adults, the center guarantees personalized attention in a nurturing atmosphere. ABC Sober Living LLC is recognized for its dedication to high-quality care and customized treatment plans that meet the distinct requirements of each person on their path to recovery.

San Juan Capistrano, CA

866-225-3260

Able to Change Recovery Inc, situated in San Juan Capistrano, CA, delivers targeted substance abuse rehabilitation for adults and adolescents. Their services include intensive outpatient programs, standard outpatient care, and day treatment or partial hospitalization options. The center emphasizes 12-step facilitation, anger management techniques, and brief intervention strategies, specifically addressing the needs of those with co-occurring mental health challenges. Able to Change Recovery Inc serves both men and women, fostering a welcoming and inclusive atmosphere. This institution is committed to providing high-quality, individualized care to support enduring recovery and overall well-being.

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Los Angeles, CA

323-223-6298

Addiction Research and Treatment Inc in Los Angeles, CA, provides extensive outpatient care for withdrawal management and recovery from substance dependence. They have distinct programs for active service members, adult males, and adult females, addressing varied requirements. Employing methods such as guided 12-step work, emotional regulation training, and concise counseling techniques, this establishment delivers customized support for adults and young adults across all gender identities. Their outpatient detox and medication-assisted treatment options, including methadone, buprenorphine, or naltrexone, offer adaptable and successful pathways to healing. Prioritizing excellent service and personal attention, Addiction Research and Treatment Inc is a dependable option for individuals pursuing freedom from addiction.

Rancho Mirage, CA

760-322-1777

Nestled in Rancho Mirage, CA, Addiction Therapeutic Services is dedicated to providing a full spectrum of care for those facing addiction and accompanying mental health challenges. They offer essential detox services and personalized care strategies for adults managing severe mental health conditions, as well as children experiencing significant emotional distress. Their treatment offerings include robust intensive outpatient and day treatment options, ensuring a flexible approach to recovery. Employing methods like 12-step guidance and anger management techniques, their programs aim to foster enduring sobriety. Specialized support is available for active military personnel, teenagers, and adult men. Catering to individuals of all ages and genders, this center is committed to delivering exceptional care within a nurturing setting.

Roseville, CA

916-774-6647

Aegis Treatment Centers LLC, located in Roseville, CA, provides outpatient detox and programs for substance use recovery for both adults and young adults. The facility is known for its expertise in brief intervention, cognitive behavioral therapy, and the use of motivational incentives. Catering to a variety of patients, including adult men, adult women, and pregnant or postpartum women, the center delivers personalized services for all genders. Aegis Treatment Centers LLC is dedicated to offering high-quality, compassionate care, making it a suitable option for those looking for effective addiction treatment solutions in the Roseville region.

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Marysville, CA

530-742-7747

Aegis Treatment Centers LLC, located in Marysville, CA, delivers outpatient services for chemical dependency and substance abuse, serving adults and adolescents. The center features targeted interventions for expectant and new mothers, with distinct care plans for male and female patients. Employing therapeutic modalities such as cognitive behavioral therapy, motivational incentives, and the Matrix Model, Aegis Treatment Centers LLC prioritizes scientifically supported methods for successful rehabilitation. The facility also provides outpatient medication-assisted treatment using methadone, buprenorphine, or naltrexone, addressing a broad spectrum of recovery requirements. For those in Marysville requiring thorough and individualized addiction recovery support, Aegis Treatment Centers LLC is committed to guiding individuals toward sustained wellness.

Bakersfield, CA

661-218-2108

Aegis Treatment Centers LLC in Bakersfield, CA, delivers outpatient services for individuals struggling with substance use disorders. Their offerings include medication-assisted treatment utilizing methadone, buprenorphine, or naltrexone. The center employs evidence-based therapeutic modalities such as 12-step program support, anger management techniques, and brief intervention strategies. Aegis Treatment Centers LLC is dedicated to serving specific populations, including active military personnel, adult men, and adult women, with tailored programs. They welcome adults and young adults of all genders seeking effective recovery solutions. The facility is committed to providing excellent care and robust support for those on their journey to sobriety.

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Los Angeles, CA

213-353-1140

Addiction Research and Treatment Inc, situated in Los Angeles, CA, provides comprehensive outpatient services including medical detoxification, comprehensive substance use disorder therapy, and medication-assisted treatment with methadone, buprenorphine, or naltrexone. This facility is dedicated to serving adults and young adults, employing therapeutic modalities such as cognitive behavioral therapy, the Matrix Model, and motivational interviewing. Recognizing the unique needs of women, particularly those who are pregnant or postpartum, Addiction Research and Treatment Inc offers tailored, gender-specific programs for both men and women. Their commitment lies in delivering effective, scientifically-backed care to guide individuals toward lasting recovery.

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Oakland, CA

510-533-0800

Addiction Research and Treatment in Oakland, CA, delivers thorough outpatient care for individuals pursuing sobriety from substance use disorders. This establishment features distinct programs tailored for active service members, adult males, and adult females. Employing scientifically supported methods like 12-step integration, emotional regulation skills, and concise intervention strategies, the facility supports adults and younger adults of all genders. Patients have access to outpatient services involving methadone, buprenorphine, or naltrexone, alongside standard outpatient care. The center's dedication to high-standard treatment and personalized plans establishes it as a crucial support system for those in need of effective addiction recovery solutions.

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Burbank, CA

626-792-8797

Situated in Burbank, CA, Absolute Control Transitional specializes in a wide array of addiction recovery services. The center offers detoxification, treatment for substance use disorders, and transitional housing with a variety of options including intensive outpatient, long-term residential, and outpatient programs. It employs targeted strategies such as 12-step facilitation, anger management, and brief intervention, catering to adult men and women, including those affected by intimate partner violence. Absolute Control Transitional is dedicated to providing exceptional care to adults and young adults of all genders, guiding them through their recovery process.

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La Puente, CA

626-855-5090

Addiction Research and Treatment Inc, situated in La Puente, CA, provides extensive support for individuals facing addiction. This center is dedicated to outpatient detoxification, addressing substance use disorders, and offering medication-assisted treatment with methadone, buprenorphine, or naltrexone on an outpatient basis. They employ proven therapeutic methods such as cognitive behavioral therapy, the Matrix Model, and motivational interviewing to deliver personalized care plans for adults and young adults. Addiction Research and Treatment Inc places a special emphasis on supporting pregnant and postpartum women, ensuring that every client receives unique assistance. Catering to both male and female patients, the facility is committed to delivering high-quality services that facilitate recovery.

Concord, CA

925-690-5710

Addiction Research and Treatment Inc, located in Concord, CA, provides comprehensive outpatient services for individuals struggling with substance use disorders. Their treatment modalities encompass anger management techniques, cognitive behavioral therapy (CBT), and contingency management strategies, also known as motivational incentives. The center serves a diverse clientele, including adult men and women, and extends its services to active duty military members. Addiction Research and Treatment Inc offers specialized recovery programs designed for both adults and young adults. They are committed to delivering high-quality care, featuring outpatient treatment options that may include methadone, buprenorphine, or naltrexone, alongside standard outpatient services. Furthermore, the facility recognizes the importance of tailored support through its gender-specific programs for men and women navigating their journey toward sobriety.

Antioch, CA

925-522-0124

Addiction Research and Treatment Inc, situated in Antioch, CA, delivers targeted programs for adults and young adults overcoming substance use disorders. Their offerings include outpatient care, featuring medication-assisted treatment with methadone, buprenorphine, or naltrexone. The center emphasizes 12-step integration, individual counseling for addiction, and remote therapy options. Specialized support is provided for active military members, adult men, and adult women, catering to diverse client populations. Addiction Research and Treatment Inc ensures comprehensive and personalized care to aid clients in their recovery journey.

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Porterville, CA

559-853-6222

Addiction Research and Treatment Inc, situated in Porterville, CA, provides extensive outpatient support for those pursuing freedom from addiction. The facility excels in offering detoxification, substance abuse therapy, and care for dual-diagnosis mental health issues, catering to both adults and younger individuals. Through approaches like cognitive behavioral therapy, motivational interviewing, and strategies for avoiding relapse, they craft personalized care paths aimed at sustained sobriety. Specialized offerings exist for active military members, adult men, and women. Addressing adults and young adults across all gender identities, this center delivers exceptional care and encouragement to those embarking on their healing path.

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Richmond, CA

510-232-0874

Addiction Research and Treatment Inc, situated in Richmond, CA, delivers extensive programs for individuals grappling with substance dependency, serving both adults and adolescents. Their offerings include outpatient detox, comprehensive substance use therapy, and medication-assisted treatment with methadone, buprenorphine, or naltrexone. The facility is dedicated to personalized recovery plans, employing therapeutic strategies like anger management, cognitive behavioral therapy, and motivational interviewing. Welcoming both men and women, the center prioritizes high-quality support and a nurturing atmosphere throughout the healing journey. For those requiring expert addiction care, this establishment provides customized solutions designed to meet diverse challenges within a professional and empathetic framework.

Thousand Oaks, CA

805-493-5741

Wildwood Recovery in Thousand Oaks, CA, provides extensive addiction rehabilitation for adults and young adults. This center delivers hospital-based inpatient detox and care for substance abuse issues and accompanying mental health challenges. Emphasizing 12-step guidance, emotional regulation, and concise therapeutic strategies, Wildwood Recovery features distinct tracks for adult men, adult women, and individuals with dual diagnoses. Customizing treatment to address individual requirements, the program guarantees high-quality support and care for all clients embarking on their path to sobriety.

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San Francisco, CA

415-928-7800 x2150

Situated in San Francisco, CA, Addiction Research and Treatment Inc delivers focused programs for substance use rehabilitation. This center offers a range of outpatient options, which include choices such as methadone/buprenorphine or naltrexone treatments alongside standard outpatient care. Employing research-backed techniques like brief interventions, motivational interviewing, and contingency management/motivational incentives, the facility serves a diverse clientele, including young people, and both adult men and women. Committed to quality and individualized treatment, Addiction Research and Treatment Inc is devoted to assisting individuals as they navigate their recovery journeys.

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Showing 21 of 713 MAT programs in California. Browse all centers in California

Frequently Asked Questions About MAT in California

Do I need a formal OUD diagnosis before starting mat?

Yes. Providers in California must document a current OUD diagnosis to prescribe mat as part of medication-assisted treatment. The intake assessment typically takes 60–90 minutes and includes a physical exam, drug screen, and psychiatric history — results are used to confirm eligibility.

What is the cheapest way to get mat in California?

For most California residents, Medi-Cal is the lowest-cost option — co-pays are usually $0–$3. Without Medicaid, federally qualified health centers with sliding-scale fees are next cheapest, followed by State Opioid Response–funded clinics.

What’s the difference between Medi-Cal managed-care plans for MAT?

Medi-Cal managed-care organizations (MCOs) in California all cover MAT, but formulary details, prior-authorization rules, and in-network provider lists vary. Choose the MCO whose network includes your preferred MAT programs; you can usually switch plans once a year.

Does Blue Cross Blue Shield cover mat in California?

Yes. Blue Cross Blue Shield plans in California cover all three FDA-approved MAT medications. BCBS typically requires the provider to be in-network; most major MAT programs in Los Angeles and across California accept BCBS.

Is mat covered under California’s Good Samaritan law?

California’s Good Samaritan law provides immunity from low-level drug-possession prosecution when someone seeks help for an overdose. MAT enrollment is not penalized; California specifically prohibits probation or family court from forcing patients to stop mat.

What are the most common reasons patients stop mat?

Common reasons include lifestyle stabilization (patient and clinician agree to taper), cost barriers, side effects, travel or employment disruption, and desire to try naltrexone after tapering. Many patients resume treatment later — clinics welcome return visits without judgment.

What should I avoid before my first mat visit?

Avoid benzodiazepines, alcohol, and long-acting opioids for 6–12 hours before induction to reduce sedation risk. For buprenorphine, let the clinician know your last opioid use time so they can time the first dose to avoid precipitated withdrawal.

Can I drive myself home from the first mat dose in California?

California programs generally recommend arranging a ride for the first induction visit, since initial drowsiness is common. After the first 1–2 weeks at a stable dose, patients typically resume driving and most daily activities without restriction.

Will mat show on a standard drug test?

Buprenorphine and methadone do not test positive on standard 5-panel drug tests — specialty panels are needed. Naltrexone and its metabolites are not screened on standard panels. Share an MAT provider letter with any employer or court drug-testing program to avoid confusion.

Does California have perinatal-MAT programs?

Yes. Most California regions have perinatal-addiction programs coordinating OB care, MAT, and social support. Call 988 or SAMHSA 1-800-662-4357 for California-specific referral. Los Angeles-area hospitals typically have dedicated perinatal-addiction coordinators.

Does Medi-Cal cover counseling along with mat?

Yes. Medi-Cal covers individual therapy, group sessions, and care coordination at California MAT clinics without separate deductibles in most plans. Peer-recovery support services are also covered in California.

Can my family get information about my mat treatment without my consent?

No. Your California clinic cannot share any information with family members without a signed release specifying who, what information, and for how long. Patients under 18 may have parental involvement requirements — rules vary.

Other Treatment Options in California

Medication-Assisted Treatment in Other States

Medically ReviewedUpdated: April 2026
Sources:SAMHSANIDACDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)