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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Endless Mountains Extended Care LLC

Endless Mountains Extended Care LLC, located in Factoryville, PA, provides comprehensive long-term residential care for adult men struggling with substance use. The center is equipped to address complex cases, including individuals facing dual diagnoses of substance use disorders and significant mental health conditions. Their therapeutic approach integrates 12-step principles, anger management techniques, and brief intervention strategies. They serve a diverse population, including active duty military members, adult males, and those who have endured intimate partner or domestic violence. This facility is dedicated to offering high-quality treatment tailored for adults, seniors, young adults, with a particular emphasis on the needs of male clients.

English Mountain Recovery Center

English Mountain Recovery Center in Sevierville, TN, is a premier facility dedicated to providing extensive support for individuals battling substance use disorders. They also specialize in addressing the complex needs of those managing co-occurring mental health challenges. Their therapeutic offerings include various residential options, from extended stays to more immediate, shorter-term care, all designed to meet individual recovery journeys. Treatment methodologies employed at the center are diverse and evidence-based, incorporating principles of the 12-step model, strategies for managing anger, and cognitive behavioral techniques. English Mountain Recovery Center features distinct programs designed for adult men, adult women, and survivors of sexual trauma, serving a broad demographic of adults and young adults. Their dedication to delivering high-quality, personalized rehabilitation services positions them as a leading resource for effective recovery.

Enlightened Solutions Detox LLC

Enlightened Solutions Detox LLC, located in Atlantic City, NJ, provides thorough residential programs for substance abuse recovery. The center offers distinct treatment pathways for active military personnel, adult men, and adult women, addressing diverse needs. Clients benefit from round-the-clock supervision and brief residential stays, employing methods like 12-step support, emotional regulation techniques, and short-term counseling. Catering to both young adults and adults, with dedicated gender-specific services, the facility ensures personalized care. Discover exceptional treatment and assistance at Enlightened Solutions Detox LLC.

Enlightened Solutions LLC
Egg Harbor City, NJ

Enlightened Solutions LLC, located in Egg Harbor City, NJ, specializes in complete substance abuse treatment for adults, accommodating individuals with co-occurring mental health challenges. This center provides a range of outpatient services, such as intensive outpatient programs and day treatment, designed to meet varied requirements. Distinctive offerings include specialized programs for active duty military personnel, adult men, and women. Their therapeutic methods incorporate 12-step facilitation, anger management techniques, and brief intervention strategies. Enlightened Solutions LLC is dedicated to delivering high-quality care in a nurturing setting, supporting adults and young adults of all genders in their journey toward recovery.

Erie County Detox Unit

Situated in Sandusky, Ohio, the Erie County Detox Unit specializes in outpatient detox and programs for those dealing with substance use issues. This center offers a variety of services, which include outpatient treatment options with methadone, buprenorphine, or naltrexone, as well as standard outpatient care and programs specifically designed for clients within the criminal justice system. The facility serves adults and seniors of all genders. Utilizing methods such as 12-step facilitation, anger management, and brief interventions, the Erie County Detox Unit focuses on delivering comprehensive, individualized care. Committed to high-quality addiction treatment, the center aims to assist individuals on their path to recovery.

Erlanger Behavioral Health Hospital

Erlanger Behavioral Health Hospital, situated in Chattanooga, TN, delivers extensive addiction treatment services catering to both adults and children. This center specializes in hospital-based inpatient detoxification and management of substance use disorders, including those accompanied by mental health issues. The facility employs various methodologies, including anger management, cognitive behavioral therapy, and short-term interventions, to customize treatment strategies that address individual requirements. It also features specialized programs designed for adolescents as well as adult men and women. Committed to providing high-quality care, Erlanger Behavioral Health Hospital strives to support individuals in attaining sustainable recovery and enhanced mental health.

Escondido Comprehensive Treatment Ctr

The Escondido Comprehensive Treatment Ctr, situated in Escondido, CA, delivers comprehensive outpatient care for individuals pursuing sobriety and recovery from substance use disorders. Their offerings include outpatient detox services, medication-assisted treatment with methadone, buprenorphine, or naltrexone, and dedicated programs for expectant and new mothers. Employing therapeutic approaches such as 12-step facilitation, cognitive behavioral therapy, and motivational interviewing, this center supports adults and young adults across all gender identities. Escondido Comprehensive Treatment Ctr is devoted to providing high-quality, individualized treatment, serving as a supportive resource for those on their journey to recovery.

Esperanza
Chicago, IL

Esperanza, situated in Chicago, IL, delivers tailored outpatient care for adults and children dealing with substance use disorders and simultaneous mental health conditions. The center offers outpatient services including methadone, buprenorphine, and naltrexone treatments, employing methods such as cognitive behavioral therapy and contingency management. By prioritizing personalized care, Esperanza accommodates individuals of all genders across different age groups. The program highlights brief interventions and motivational incentives, ensuring a holistic and impactful treatment journey. For those in search of effective addiction support in a nurturing setting, Esperanza is committed to assisting individuals in attaining enduring recovery.

Esperanza
Chicago, IL

Esperanza, situated in Chicago, IL, delivers extensive outpatient services for individuals dealing with substance abuse as well as co-occurring mental health issues, catering to both adults and children. This center offers various treatment options, including outpatient methadone/buprenorphine or naltrexone programs, standard outpatient services, and customized plans that meet the specific requirements of clients. By employing research-backed methods such as cognitive behavioral therapy and contingency management, Esperanza maintains high standards of care for both male and female adults as well as young adults. The facility prioritizes brief interventions and tailored treatment strategies, distinguishing itself through its dedication to fulfilling the distinct needs of every individual on their path to recovery.

Essentials Recovery Delaware

Essentials Recovery Delaware, situated in Wilmington, DE, delivers expert treatment for substance use issues among adults and young adults. The center features various programs, including intensive outpatient, outpatient, and treatments utilizing methadone, buprenorphine, or naltrexone. Emphasizing customized care, this facility incorporates techniques such as 12-step facilitation, anger management, and brief interventions to tackle addiction. Serving both men and women, Essentials Recovery Delaware guarantees an extensive and personalized approach to treatment. Individuals looking for reliable addiction recovery options in a nurturing setting will discover high-quality, tailored programs at this center.

Ethan Crossing Addiction Campus

Ethan Crossing Addiction Campus in Indianapolis, IN, provides extensive substance abuse rehabilitation for adults and adolescents. Their services include hospital-based inpatient detoxification and treatment for addiction, alongside dedicated support for dual-diagnosis mental health issues. The treatment methodology incorporates 12-step principles, anger management techniques, and brief intervention strategies. They also offer distinct programs designed for active military personnel, men, and women, demonstrating a commitment to serving varied populations. Ethan Crossing Addiction Campus delivers high-quality, individualized care for all clients, positioning it as a leading facility for successful addiction recovery.

Ethan Crossing Recovery Center

Ethan Crossing Recovery Center, situated in Springfield, OH, delivers a thorough suite of addiction recovery solutions. They offer detox and substance abuse treatment via intensive outpatient, extended residential, and outpatient options. Emphasizing 12-step facilitation, anger management, and brief intervention, the center serves adult men and women, encompassing young adults. Ethan Crossing Recovery Center prioritizes customized support for every client, addressing their unique requirements and desires. Featuring tailored programs for various age demographics and genders, this institution is dedicated to providing superior, individualized rehabilitation to foster enduring sobriety.

Esperanza
Chicago, IL

Esperanza, situated in Chicago, IL, delivers an extensive range of outpatient services for individuals dealing with substance abuse and concurrent severe mental health issues in adults, as well as significant emotional challenges in children. This center offers outpatient therapy that includes methadone/buprenorphine and naltrexone treatments, alongside general outpatient support. The programs implemented are grounded in research-backed methods, featuring brief interventions, cognitive behavioral therapy, and motivational incentives/contingency management. What sets Esperanza apart is its tailored approach, serving individuals of all genders across different age groups. Committed to delivering high-quality care, this center serves as a crucial resource for those in pursuit of effective and customized addiction recovery solutions.

Espanola Health Services

Espanola Health Services, situated in Espanola, New Mexico, is a leading provider of extensive outpatient rehabilitation services. Their core expertise lies in detoxification and addressing substance use disorders, offering specialized outpatient detox along with medication-assisted treatments such as methadone, buprenorphine, or naltrexone. The therapeutic framework at Espanola Health Services incorporates cognitive behavioral therapy and individualized counseling for substance use disorders. They welcome active duty military members, adult men, and women, as well as young adults of all genders, ensuring personalized care plans. Committed to high standards of treatment and scientifically validated methods, Espanola Health Services is devoted to guiding individuals toward a successful recovery.

Epic Behavioral Healthcare

Epic Behavioral Healthcare, situated in Bunnell, FL, provides extensive outpatient services for individuals of all ages struggling with substance use. Their expertise lies in addressing dual diagnoses, including substance use and significant mental health conditions in adults, alongside severe emotional challenges in children. Employing proven methods like cognitive behavioral therapy and the Matrix Model, the center delivers personalized treatment to both male and female clients. Additional specialized tracks are available for adult men, adult women, and those involved in the criminal justice system. Discover effective treatment and dedicated support at Epic Behavioral Healthcare.

Equinox Inc
Albany, NY

Equinox Inc, located in Albany, NY, provides extensive care for substance use disorders via its outpatient services. These include medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient care. The center employs proven therapeutic methods like anger management, brief intervention, and cognitive behavioral therapy to aid individuals on their path to recovery. Equinox Inc accommodates a wide range of needs with tailored programs for adolescents, adult men, and adult women. The facility is dedicated to offering personalized support in a supportive setting for adults and young people of any gender. Individuals looking for excellent addiction treatment will discover caring and successful programs at this institution.

Esper Treatment Center

Situated in Erie, PA, the Esper Treatment Center specializes in outpatient programs for individuals recovering from substance use disorders. The facility offers various treatment options, such as outpatient services for methadone/buprenorphine or naltrexone, traditional outpatient care, and methods like 12-step facilitation, brief interventions, and cognitive behavioral therapy. The center is equipped to serve both adult men and women, including those who have faced intimate partner violence or domestic abuse, thereby addressing a wide array of needs. Committed to delivering high-quality care, the Esper Treatment Center focuses on tailored support for all adults and young adults seeking to achieve sobriety.

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Epiphany Family Services MD LLC, situated in Baltimore, MD, specializes in holistic treatment for adults facing challenges with substance use alongside mental health disorders. The center offers both intensive outpatient and outpatient options, featuring treatments such as methadone/buprenorphine and naltrexone. Emphasizing approaches like 12-step facilitation, anger management, and focused interventions, this facility addresses the needs of teenagers, adult men, and women. Committed to delivering exceptional care and personalized support, Epiphany Family Services MD LLC aims to assist individuals of all ages in their recovery journey.

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Moncks Corner, SC

Nestled in Moncks Corner, SC, the Ernest E Kennedy Center provides extensive care for substance use disorders, featuring intensive outpatient, outpatient, and medication-assisted treatment options like methadone, buprenorphine, or naltrexone. Their expertise lies in areas such as anger management, cognitive behavioral therapy, and motivational interviewing techniques. The center accommodates diverse needs with specialized programs for adult men, women, and survivors of intimate partner violence, serving adults and young adults regardless of gender. Emphasizing individualized attention and proven therapeutic methods, this institution delivers superior treatment for those on a journey of healing and overcoming addiction.

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Esper Treatment Center, situated in Corry, PA, delivers focused outpatient services for individuals grappling with substance use disorders. The program encompasses various modalities such as medication-assisted treatment (methadone, buprenorphine, naltrexone), standard outpatient care, and evidence-based therapies like 12-step facilitation, brief intervention, and cognitive behavioral therapy. This center is equipped to assist adult men and women, including those who have experienced intimate partner or domestic violence. Esper Treatment Center is dedicated to providing personalized and effective recovery support for all individuals.

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Essential Touchstones, situated in Ridgeland, MS, delivers extensive outpatient services for addiction recovery, designed to address individual client requirements. The center provides varying levels of care, including intensive outpatient, standard outpatient, and general outpatient programs for adults, younger individuals, and older adults facing addiction and mental health challenges. Employing proven methods like cognitive behavioral therapy and anger management, the facility also features unique programs for those dealing with chronic pain and addiction simultaneously. Essential Touchstones is dedicated to providing high-quality support, with customized treatment plans for men, women, and teens on their path to healing.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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