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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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First City Recovery Center

First City Recovery Center located in Kokomo, IN, delivers extensive treatment options for adults and seniors battling addiction. The center is known for its hospital inpatient detox services and comprehensive care for substance use disorders alongside co-occurring mental health issues. Emphasizing 12-step methodologies, anger management strategies, and short-term interventions, the facility tailors its programs to meet individual recovery needs. Special offerings are available for adult men and women, as well as those who have faced intimate partner violence or domestic abuse. The center is dedicated to fostering a secure and nurturing atmosphere for individuals on their path to recovery and enhanced well-being.

First Step Home Inc
Cincinnati, OH

First Step Home Inc in Cincinnati, OH, is dedicated to providing specialized care for adult women battling substance use disorders within a secure and nurturing setting. This center is equipped to handle complex cases involving co-occurring substance use and significant mental health challenges. Through proven methods like 12-step integration, emotional regulation techniques, and cognitive behavioral approaches, their program supports adults, older individuals, and younger adults. They place particular emphasis on assisting clients who have endured intimate partner violence, domestic abuse, and sexual trauma, offering both short-term and round-the-clock residential services. Discover empathetic support and scientifically backed therapies at this esteemed recovery facility.

First Step Recovery of Warren

First Step Recovery of Warren, located in Warren, OH, provides a wide range of addiction treatment services that encompass detox programs, therapy for substance use disorders, and transitional housing arrangements such as halfway houses and sober living environments. The facility offers inpatient detoxification alongside specialized treatment programs tailored for adult men and women. Utilizing evidence-based methodologies, the center incorporates strategies such as 12-step recovery, anger management, and cognitive-behavioral therapy. Committed to delivering exceptional care, First Step Recovery of Warren supports adults and young adults of all genders in their journey to overcome addiction and attain sustainable recovery.

First Step Services

First Step Services in Raleigh, NC, delivers thorough addiction recovery care for adults and adolescents. The facility offers structured outpatient, standard outpatient, and partial hospitalization programs designed for each person's unique situation. Utilizing methods like brief counseling, cognitive behavioral techniques, and motivational engagement, this establishment guarantees treatment grounded in proven strategies. Focusing particularly on individuals within the legal system, First Step Services supports both male and female patients. Their dedication to high-quality support and customized recovery paths establishes it as a premier option for effective healing in Raleigh.

Five Towns CC/CODA
Lawrence, NY

Five Towns CC/CODA, located in Lawrence, NY, provides outpatient care for adults, both male and female, dealing with substance use disorders and co-occurring mental health conditions. Their treatment strategies include 12-step facilitation, anger management techniques, and brief intervention methods, offering focused support to young adults and adults on their path to recovery. The center specializes in outpatient treatments involving methadone, buprenorphine, or naltrexone, ensuring clients receive all-encompassing assistance within a disciplined setting. Five Towns CC/CODA customizes its programs for men and women, guaranteeing individualized attention. This dedication to superior care positions Five Towns CC/CODA as a significant provider of effective and empathetic addiction treatment.

Flagstaff Medical Center

Flagstaff Medical Center in Flagstaff, AZ, delivers complete recovery support for addiction and co-occurring mental health conditions in individuals of all ages. They provide inpatient medical detox and intensive outpatient programs, utilizing proven methods such as CBT and motivational interviewing. Their commitment to personalized, gender-affirming treatment ensures that both adults and children receive the highest caliber of care tailored to their distinct needs and journeys toward wellness.

Flatirons Recovery
Lafayette, CO

Flatirons Recovery located in Lafayette, CO, is dedicated to providing targeted treatment for adults and young adults facing substance use disorders alongside significant mental health challenges. The center features a variety of treatment modalities, including intensive outpatient, outpatient, and day programs that utilize proven techniques such as 12-step facilitation, cognitive behavioral therapy, and motivational interviewing. Emphasizing trauma-informed care, Flatirons Recovery serves both men and women aiming for holistic support throughout their recovery process. What sets this facility apart is its focus on delivering high-quality care and personalized programs that meet the intricate needs of those confronting addiction and mental illness.

Flandreau Santee Sioux Tribe

Situated in Flandreau, SD, the Flandreau Santee Sioux Tribe rehabilitation center specializes in treating substance use disorders along with co-existing mental health conditions in both adults and children. The center offers a variety of outpatient services, such as methadone or buprenorphine therapies, naltrexone treatment, anger management sessions, brief interventions, and cognitive behavioral therapy. It features customized programs for adult men, women, and clients facing dual diagnoses, addressing a wide spectrum of needs. Catering to adults and seniors of all genders, the Flandreau Santee Sioux Tribe center emphasizes high-quality care to foster long-term recovery and overall wellness.

First Hospital Panamericano

First Hospital Panamericano in Cidra, PR, delivers expert inpatient detoxification and recovery services for substance use disorders and co-occurring mental health challenges. This institution offers thorough support for adults experiencing severe mental health conditions and children with emotional difficulties. The center employs proven therapeutic methods, including 12-step program integration, emotional regulation techniques, and concise therapeutic interventions to foster healing. Featuring distinct programs designed for active military personnel, teenagers, and adult men, the facility accommodates a broad range of individuals. Serving male and female patients of all ages, this center is committed to high-quality care and personalized treatment plans aimed at achieving enduring recovery and overall well-being.

Five Star Medical Services

Five Star Medical Services in Ambridge, PA, delivers a full spectrum of outpatient care for individuals struggling with substance use. Their services include medication-assisted treatment utilizing methadone, buprenorphine, or naltrexone, alongside standard outpatient therapy and remote counseling options via telemedicine. The facility is equipped to support specific populations, including active military members, adult men, and adult women, demonstrating a commitment to inclusive care. Catering to adults and seniors across all genders, Five Star Medical Services focuses on personalized treatment plans designed to address the distinct requirements of each patient. They are dedicated to providing high-quality recovery services and support, establishing themselves as a leading provider of addiction rehabilitation.

First Choice Community Healthcare

First Choice Community Healthcare in Albuquerque, NM provides extensive outpatient care for addiction, recovery, and dual diagnoses. Their services include outpatient detox, medication-assisted treatment (methadone, buprenorphine, naltrexone), and dedicated programs for adults and older adults facing substance abuse and mental health challenges. Utilizing methods such as anger management, brief intervention, and cognitive behavioral therapy, the center delivers customized support. They prioritize personalized treatment strategies for both men and women seeking effective rehabilitation within a nurturing setting.

First Step Counseling and Medical

First Step Counseling and Medical, situated in Kodak, TN, delivers outpatient substance abuse services for individuals of all ages. Their programs are tailored to meet the specific needs of adult men, adult women, and those impacted by intimate partner or domestic violence. Utilizing evidence-based methods such as 12-step facilitation, brief intervention, and cognitive behavioral therapy, they offer comprehensive care. For those requiring medication-assisted treatment, options like outpatient methadone, buprenorphine, or naltrexone are available. This facility is dedicated to providing individualized support and a nurturing atmosphere for anyone embarking on their journey to recovery.

First Step Recovery Centers

First Step Recovery Centers in Memphis, TN, focuses on providing tailored addiction treatment services specifically for adult men. The center offers various levels of care, including intensive outpatient, outpatient, and standard outpatient programs. They utilize proven methods, including brief interventions, cognitive behavioral therapy, and motivational incentives, to effectively tackle substance use disorders. The center also features specialized programs designed for individuals with a history of trauma and those who have interacted with the criminal justice system. Catering to a diverse clientele, including adults, seniors, and young adults, this facility is dedicated to delivering comprehensive support for those pursuing recovery from substance use and related mental health challenges.

First Choice Community Healthcare

First Choice Community Healthcare in Albuquerque, NM, provides extensive outpatient care for individuals needing help with detoxification, overcoming substance abuse, and managing intertwined mental health challenges. They specialize in personalized treatment, offering outpatient detox alongside medication-assisted options like methadone, buprenorphine, or naltrexone. Their therapeutic strategies include anger management, brief intervention, and cognitive behavioral therapy, designed to meet a wide spectrum of client needs. Serving adult and senior populations regardless of gender, First Choice Community Healthcare is distinguished by its customized treatment pathways and dedication to excellent service.

First Choice Community Healthcare

First Choice Community Healthcare in Albuquerque, NM, provides outpatient services including detoxification and treatment for substance use disorders. They specialize in addressing co-occurring conditions, where substance use intersects with serious mental health challenges in adults or emotional disturbances in children. The center prioritizes personalized recovery plans, utilizing interventions such as anger management, brief counseling, and cognitive behavioral therapy. Designed to serve adults and seniors of any gender, their comprehensive approach to addiction recovery is a hallmark of their care. The facility’s commitment to high-quality treatment is evident in its outpatient medication-assisted treatment options (methadone, buprenorphine, naltrexone), supporting a complete recovery process for every individual.

First Choice Community Healthcare

First Choice Community Healthcare, situated in Los Lunas, NM, delivers extensive outpatient programs for those pursuing recovery from addiction. Their services encompass detoxification, substance abuse treatment, and targeted support for co-occurring mental health issues in adults, as well as emotional challenges in youth. Therapy modalities employed include anger management, brief intervention, and cognitive behavioral therapy. Emphasizing personalized recovery plans, this center serves adults and older adults of any gender. From outpatient detox to methadone/buprenorphine-assisted treatment, individuals will find dedicated, customized care to foster their path to wellness.

First Step Services

First Step Services, located in Cary, NC, specializes in treating substance use disorders in both adults and young adults. The facility offers a range of programs, including intensive outpatient treatment, outpatient services, and regular outpatient options. Emphasizing tailored approaches such as brief intervention, cognitive behavioral therapy, and motivational interviewing, they cater to the distinct needs of each individual. Additionally, there are specialized programs designed for clients involved in the criminal justice system. First Step Services provides care for both men and women, creating a nurturing atmosphere for recovery. If you or someone you know needs reliable addiction treatment, this center stands out for its exceptional care and wide variety of treatment alternatives.

First Step Counseling Inc

First Step Counseling Inc in Parker, CO, provides outpatient treatment for adults and young adults struggling with substance use disorders. They emphasize a personalized approach, focusing on programs like 12-step facilitation, anger management, and brief interventions. This center offers tailored care for both male and female clients, ensuring a supportive setting for those pursuing addiction recovery through their flexible yet comprehensive outpatient services.

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First Step Counseling, situated in Kingsport, TN, delivers extensive treatment options for substance use disorders via its outpatient services. The center features outpatient therapies that include methadone/buprenorphine or naltrexone treatment alongside standard outpatient care. It utilizes various strategies, such as 12-step programs, brief intervention techniques, and relapse prevention methods. Additionally, the facility has specialized programs designed for adult men and women, as well as individuals who have faced intimate partner or domestic violence. Catering to both adults and young adults from all backgrounds, this center provides personalized care, establishing itself as a crucial support system for those in need of effective addiction recovery solutions.

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First Steps to Recovery Inc. in Brooklyn, NY, delivers thorough addiction treatment and specialized support for those facing simultaneous severe mental health issues or emotional challenges. The center's outpatient programs incorporate medication-assisted treatment (methadone, buprenorphine, or naltrexone) and are customized for adult men and women affected by domestic or intimate partner abuse. Emphasizing anger management, brief intervention, and cognitive behavioral therapy, this establishment serves adults and young adults looking for effective care within a nurturing setting. Services are provided to both male and female clients, guaranteeing a personalized recovery journey.

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First Steps to Recovery Inc., located in New York, NY, provides outpatient services for individuals of all ages struggling with substance abuse, particularly those with concurrent serious mental health disorders. Their therapeutic offerings encompass anger management, cognitive behavioral therapy, and brief intervention strategies. The center is dedicated to assisting adult men and women, as well as survivors of intimate partner or domestic violence. By offering customized treatment plans for adults and young adults, and serving both male and female populations, First Steps to Recovery Inc. delivers thorough and individualized support for those addressing addiction and mental health concerns.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)