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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Grant Street Partnership

Grant Street Partnership, located in West Haven, CT, provides an extensive array of research-supported treatment options for individuals dealing with substance abuse and related mental health issues. The center specializes in intensive outpatient care, daytime outpatient programs, and partial hospitalization for both adults and young adults. Emphasizing 12-step methodologies, anger management strategies, and cognitive behavioral therapy, the facility caters to clients with a history of trauma, those with dual diagnoses, and individuals connected to the criminal justice system. Grant Street Partnership fosters an inclusive and supportive atmosphere, welcoming clients of all genders who are on their journey to recovery.

Grasshopper House LLC

Grasshopper House LLC, situated in Malibu, CA, provides thorough addiction treatment for adults facing substance use challenges. This facility is equipped to handle detoxification and general substance use care for both men and women, with a particular focus on individuals with a history of trauma. Offering residential and short-term residential stays, Grasshouse House LLC ensures constant care for adults and young adults. Their therapeutic approach integrates cognitive behavioral therapy, relapse prevention strategies, and dedicated counseling for substance use disorders, all personalized to each client's unique recovery journey. At Grasshopper House LLC, individuals will find a nurturing atmosphere designed to meet their particular requirements, promising excellent treatment and a clear route to sustained abstinence.

Gratitude Lodge
Newport Beach, CA

Gratitude Lodge, situated in Newport Beach, California, provides extended residential programs dedicated to detoxification and treating substance use disorders. This establishment offers around-the-clock support in a nurturing setting for both adults and young adults, regardless of gender. Emphasizing 12-step guidance, anger management, and short-term interventions, Gratitude Lodge customizes its services to fit the unique requirements of each client. Specialized programs for active-duty military personnel, as well as for men and women, are also offered. The center’s commitment to high-quality care and its holistic approach make it an excellent option for individuals in search of effective and personalized addiction recovery solutions.

Gratitude Lodge
Newport Beach, CA

Situated in Newport Beach, CA, Gratitude Lodge stands out as a leading rehabilitation facility that provides extended residential detox and around-the-clock substance use treatment services. With a strong emphasis on the 12-step process, anger management, and short intervention strategies, this center serves adult men and women, including those in active military service. Catering to both adults and young adults, Gratitude Lodge offers tailored support for clients of all genders. Renowned for its thorough and efficient treatment options, this center is committed to delivering exceptional care for individuals on their journey to overcome addiction.

Gratitude Lodge
Long Beach, CA

Situated in Long Beach, California, Gratitude Lodge provides extended residential treatment and round-the-clock support for those in need of detox and addiction recovery services. The facility is focused on 12-step programs, anger management techniques, and short-term intervention methods. Gratitude Lodge also features specialized programs for active military members, as well as for adult men and women, addressing a wide spectrum of needs. This center supports both adult and young adult clients, creating a nurturing and organized atmosphere for individuals committed to their recovery journey. With its high standard of care and personalized treatment plans, this facility stands out as an excellent option for those in search of complete rehabilitation solutions.

Great Lakes Recovery Centers Inc
Sault Sainte Marie, MI

Great Lakes Recovery Centers Inc in Sault Sainte Marie, MI, delivers extensive addiction recovery services for adult men, older adults, and young men. The center features extended residential stays, detox services within a residential setting, and constant on-site assistance. They are proficient in 12-step approaches, short-term counseling, and cognitive behavioral strategies, customized for individuals facing dual diagnoses of mental health and substance abuse issues. Recognizing the impact of trauma, they foster a nurturing atmosphere conducive to healing and sustained sobriety. For men needing structured living environments, including transitional housing or sober living arrangements, this establishment provides expert treatment with a gender-specific focus.

Great Heights OTP
Calumet City, IL

Great Heights OTP, located in Calumet City, IL, provides a wide array of services aimed at treating addiction. The center specializes in detoxification, as well as offering treatment for substance use disorders and addressing complex cases involving co-occurring mental health issues. Their diverse treatment modalities include intensive outpatient programs, outpatient treatment, and outpatient detox services, all designed to cater to individual needs. The center emphasizes anger management, short-term interventions, and cognitive behavioral therapy to create a well-rounded therapeutic environment. Additionally, Great Heights OTP differentiates itself with programs tailored for clients involved in the criminal justice system. This facility serves adults, children, and adolescents of all genders, ensuring accessible, high-quality support for those on their journey to recovery.

Great Heights OTP

Great Heights OTP, located in Ottawa, IL, delivers a wide array of services aimed at treating addiction. This center specializes in detoxification, therapy for substance use, and tailored programs addressing co-occurring disorders affecting adults, as well as emotional challenges in children. With options for intensive outpatient care and traditional outpatient treatment, including outpatient detox services, Great Heights OTP meets a variety of treatment needs. Their methodologies encompass anger management, brief interventions, and cognitive behavioral strategies. Additionally, there are specific programs designed for clients involved in the criminal justice system. The facility is dedicated to providing individualized support for both adult and youth clients, ensuring that all receive high-quality, evidence-based care regardless of gender.

Great Lakes Recovery Centers Inc

Great Lakes Recovery Centers Inc, located in Marquette, MI, provides tailored treatment programs for substance use in outpatient environments. Emphasizing techniques such as 12-step facilitation, cognitive behavioral therapy, and brief interventions, this center ensures high-quality care for adults, as well as children and adolescents of all genders. The facility also features specialized programs for individuals facing both mental health and substance use challenges, veterans, and those connected to the criminal justice system. Whether patients need routine outpatient services or methadone/buprenorphine treatment, this center offers a broad range of services designed to meet varied requirements through a caring framework.

Great Lakes Recovery Centers Inc

Great Lakes Recovery Centers Inc, located in Marquette, MI, provides an extensive array of services for addiction recovery. This center offers detox programs, treatment for substance use disorders, transitional living options, halfway houses, and sober living accommodations. With options for long-term stays, residential detox, and around-the-clock care, the facility serves both adults and young adults, regardless of gender. The treatment methodologies implemented include 12-step programs, brief interventions, and cognitive behavioral therapy, focusing particularly on clients dealing with trauma. Customized care plans are available for adult men, women, and individuals requiring trauma-sensitive support. The center's dedication to high-quality care positions it as a reputable choice for those seeking recovery from addiction.

Grace House on Stratford

Grace House on Stratford, located in New Orleans, LA, provides a wide array of both long-term and short-term residential treatment options specifically designed for adult women facing substance use challenges and related emotional issues. The center employs various therapeutic methods, including 12-step programs, anger management, and cognitive behavioral therapy. What sets Grace House on Stratford apart is its commitment to supporting individuals who have undergone trauma, fostering a nurturing and secure atmosphere conducive to recovery. Catering to adults, seniors, and young adults, this facility ensures that all care is customized for women, promoting an effective and personalized approach to rehabilitation.

Grand Lake Mental Health Center Inc

Situated in Colcord, OK, Grand Lake Mental Health Center Inc provides a wide array of outpatient services aimed at those pursuing recovery from addiction. The facility is known for its expertise in detoxification, treatment for substance use disorders, and handling dual diagnoses that involve both substance abuse and significant mental health issues in adults, as well as emotional challenges in children. Emphasizing brief interventions, cognitive behavioral therapy, and the Matrix Model, the center delivers personalized care designed to meet the unique needs of each client. There are also specialized programs tailored for active duty military members, teenagers, and adult males. This center is committed to assisting adults and seniors of all backgrounds on their journey towards healing.

Grandview Foundation Inc

Grandview Foundation Inc. in Pasadena, California, is dedicated to offering targeted recovery support for adult men facing challenges with addiction and co-occurring mental health conditions. Their treatment offerings include intensive outpatient, extended residential stays, and outpatient services, drawing on proven methods like 12-step integration, anger management, and cognitive behavioral therapy. The foundation distinguishes itself with specialized programs designed for active military members, adult men, and survivors of intimate partner violence. Prioritizing adult, senior, and young adult males, this institution is distinguished by its thorough approach and personalized strategies to foster sustained healing and a higher quality of life.

Great Lakes Recovery Centers Inc
Sault Sainte Marie, MI

Situated in Sault Sainte Marie, MI, Great Lakes Recovery Centers Inc delivers a wide range of addiction treatment options specifically designed for adult women. The center features long-term residential programs, residential detox services, and round-the-clock care, employing methods such as 12-step facilitation and cognitive behavioral therapy. They have a particular emphasis on supporting women, as well as clients who have encountered intimate partner violence or sexual trauma. By prioritizing high-quality care, the facility serves adults, seniors, and young adults who are on the path to recovery from substance use issues. Great Lakes Recovery Centers Inc is a reputable resource for individuals seeking compassionate and effective rehabilitation support.

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Grand Lake Mental Health Center Inc, located in Cleveland, OK, provides an extensive array of outpatient services aimed at detoxification, treating substance use disorders, and addressing co-occurring conditions for both adults and children. The center employs methods like Cognitive Behavioral Therapy and the Matrix Model to deliver tailored programs for active military personnel, youth, and adult males. Committed to high-quality care, the center serves adults and seniors regardless of gender. Those in need of outpatient detox services or methadone/buprenorphine treatments can anticipate receiving evidence-informed interventions customized to meet their unique requirements at this respected rehabilitation facility.

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Chicago Heights, IL

Situated in Chicago Heights, IL, Grand Prairie Services delivers an extensive array of rehabilitation solutions for those facing challenges with substance use and related mental health issues. This center offers various treatment options, including intensive outpatient, outpatient, and standard outpatient programs, employing proven methods such as 12-step facilitation, anger management, and cognitive behavioral therapy. Grand Prairie Services is designed to serve particular groups, including active duty military members, as well as adult men and women. By concentrating on adults and young adults of all genders, this facility provides personalized care that addresses the distinct requirements of each individual, fostering a nurturing setting for recovery and personal growth.

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Grant Blackford Mental Health Inc, located in Hartford City, IN, provides targeted outpatient care for individuals facing substance abuse issues alongside mental health challenges, catering to both adults and children. The center emphasizes a range of treatments such as 12-step principles, anger management strategies, and short-term interventions, ensuring personalized support for each client. Their distinctive programs are designed to meet the needs of adult men and women, including those affected by intimate partner violence. By offering customized services that address different genders and age brackets, the facility aims to deliver thorough assistance. With outpatient options that include methadone/buprenorphine or naltrexone therapies and regular outpatient sessions, Grant Blackford Mental Health Inc demonstrates its dedication to various therapeutic methods. The center is committed to providing high-quality care that empowers individuals on their journey to sustainable recovery.

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Situated in Malibu, California, Grasshopper House LLC delivers extensive addiction recovery services for both adults and young adults. The facility offers residential detoxification alongside round-the-clock residential support within a nurturing setting. By incorporating cognitive behavioral therapy, strategies for relapse prevention, and counseling focused on substance use disorders, the center customizes its approach to align with each person's unique requirements. Specialized programs are available for adult men, women, and individuals who have gone through traumatic experiences. Committed to high standards of care, Grasshopper House LLC provides a secure and successful path to recovery for all clients pursuing substance use rehabilitation.

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Nestled in Malibu, CA, Grasshopper House LLC delivers extensive addiction recovery solutions. Their expertise encompasses drug and alcohol detox and ongoing treatment, featuring inpatient detox, round-the-clock residential support, and brief residential stays. Employing cognitive behavioral therapy, strategies for preventing relapse, and guidance for substance use disorders, this establishment serves adult men and women, including those with a history of trauma. Targeting adults and young adults, Grasshopper House LLC provides separate treatment tracks for men and women. The facility is dedicated to providing superior, tailored support to guide individuals toward lasting sobriety.

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Nestled in Grayson, KY, Grayson Integrated Clinic delivers a suite of specialized care options for adults confronting addiction and concurrent severe mental health challenges. Their offerings include intensive outpatient, day treatment, and partial hospitalization programs. Employing methods like 12-step guidance, anger control techniques, and brief intervention strategies, the clinic customizes its interventions for each person. Emphasizing a personalized path to healing, Grayson Integrated Clinic provides a nurturing setting for both male and female patients to receive exceptional support. For those in search of thorough and bespoke addiction recovery services, this establishment is committed to supporting your journey toward wellness.

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Great Lakes Recovery Centers Inc located in Negaunee, MI, provides outpatient programs designed for individuals dealing with substance use issues across various age groups, including adults, children, adolescents, and the elderly. Emphasizing high-quality treatment, the center tailors its offerings for those battling co-occurring mental health and substance use disorders, as well as veterans and older adults. The therapeutic methods utilized encompass 12-step facilitation, brief interventions, and cognitive behavioral therapy. Additionally, the center provides outpatient treatment options involving methadone, buprenorphine, or naltrexone. This facility caters to both men and women, fostering a nurturing atmosphere for individuals seeking to overcome addiction.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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