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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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HopeHealth Inc
Florence, SC

HopeHealth Inc, located in Florence, SC, provides a wide range of substance use rehabilitation services through different outpatient methods, including methadone and buprenorphine therapy, along with cognitive behavioral therapy. The center is dedicated to tackling issues like anger management and implementing brief interventions, serving both adult males and females, as well as individuals who have faced intimate partner violence. Additionally, HopeHealth Inc places an emphasis on adolescents, offering personalized treatment strategies for all clients. With its focus on evidence-driven practices and specialized offerings, the center guarantees top-notch assistance for individuals on their path to overcoming substance use challenges.

Hopes Horizon
Nottingham, MD

Situated in Nottingham, MD, Hopes Horizon delivers an extensive selection of addiction recovery services. The facility offers detox and a variety of substance use treatment options, including intensive outpatient, long-term residential, and standard outpatient programs. Emphasizing methods such as 12-step facilitation, brief intervention, and cognitive behavioral therapy, the center customizes treatment plans to address the unique needs of each individual. Hopes Horizon also features specialized programs catering to adult men, adult women, as well as those dealing with co-occurring mental health and substance use challenges. This center serves both adults and young adults, fostering a nurturing and healing environment for individuals of all genders.

HopeWorks
Albuquerque, NM

HopeWorks, situated in Albuquerque, NM, delivers extensive substance abuse recovery services for both adults and young adults facing serious mental health challenges or emotional issues. The center features long-term residential options, outpatient care, and treatments involving methadone/buprenorphine or naltrexone. HopeWorks emphasizes personalized support for those on their recovery journey. By employing methods such as 12-step facilitation, anger management, and brief interventions, this facility serves adult men and women, including those who have undergone trauma. The center is dedicated to providing specialized programs tailored to various age groups and genders, ensuring high-quality, individualized care for each person seeking assistance with addiction.

Horizon Health and Wellness

Horizon Health and Wellness, located in Globe, AZ, specializes in treating substance use disorders while also tackling serious co-occurring mental health conditions in adults and emotional challenges in children. The center provides both intensive outpatient and outpatient services, incorporating methadone and buprenorphine therapies. It emphasizes the 12-step approach, anger management techniques, and brief interventions. Featuring a distinct personalized method, the services are designed for adults and seniors, regardless of gender. Horizon Health and Wellness is dedicated to delivering high-quality, customized care, making it an excellent option for individuals in need of thorough and individualized rehabilitation support.

Horizon Health and Wellness

Horizon Health and Wellness, located in Casa Grande, AZ, provides targeted substance use rehabilitation for adults who are also dealing with significant mental health challenges. The center features both residential and short-term residential treatment options, delivering extensive care that includes 12-step support, anger management, and focused intervention strategies. It offers specialized programs designed specifically for adult men to provide customized assistance throughout their recovery process. Catering to both men and women, as well as young adults, Horizon Health and Wellness is dedicated to offering a comprehensive and personalized recovery experience. Emphasizing top-notch care and reliance on evidence-based methodologies, this facility serves as a guiding light for individuals striving to overcome addiction and related mental health struggles.

Horizon Health and Wellness

Horizon Health and Wellness, situated in Yuma, AZ, specializes in extensive treatment for substance use and co-occurring disorders for both adults and children. Emphasizing personalized care, the center offers a range of services including intensive outpatient programs, regular outpatient treatment, and day programs. By incorporating methods such as 12-step support, anger management strategies, and brief interventions, the facility customizes treatment plans to suit the distinct requirements of each individual. Catering to adults and seniors of all genders, Horizon Health and Wellness creates a nurturing atmosphere for those aiming to tackle addiction and mental health issues. Discover exceptional care and customized treatment at this premier rehabilitation center.

Horizon Health and Wellness

Horizon Health and Wellness, located in Casa Grande, AZ, provides a wide array of treatment services for individuals dealing with substance use challenges, specifically designed for both adults and young adults. The center has a particular focus on addressing co-occurring disorders in adults, as well as serious emotional issues in children. Treatment options available at this facility include intensive outpatient programs and outpatient services, along with medication-assisted therapies such as methadone, buprenorphine, and naltrexone. Horizon Health and Wellness emphasizes personalized care, utilizing various therapeutic methods, including anger management, brief interventions, and cognitive behavioral therapy. Furthermore, the center features specialized programs for those who have faced trauma. Committed to delivering high-quality care, the facility accommodates both men and women in pursuit of effective rehabilitation options.

Horizon Health and Wellness

Horizon Health and Wellness, situated in Florence, AZ, specializes in treating substance use and co-occurring disorders for adults facing significant mental health challenges, as well as children dealing with severe emotional issues. The center offers a range of treatment opportunities, including intensive outpatient programs, regular outpatient services, and options for methadone, buprenorphine, or naltrexone. Emphasizing anger management, cognitive behavioral therapy, and the Matrix Model, the facility customizes its programs to meet each individual's needs. Horizon Health and Wellness serves adults and seniors across all genders, fostering a nurturing atmosphere conducive to recovery. Discover individualized care and research-backed methods at this esteemed rehabilitation facility.

Horizon Health and Wellness

Horizon Health and Wellness in Casa Grande, AZ, is dedicated to providing effective substance use disorder therapy within a compassionate setting. They offer both residential and extended care options designed for adults and adolescents, catering to diverse gender identities. Their distinctive therapeutic framework incorporates 12-step support, strategies for managing anger, and brief counseling techniques. Horizon Health and Wellness is committed to delivering high-caliber support, assisting individuals in their path to sustained wellness through customized recovery strategies. For those seeking a treatment center that respects and adapts to each person's unique road to abstinence, this center could be an excellent fit.

Horizon Health Services Inc

Horizon Health Services Inc, located in Buffalo, NY, delivers extensive outpatient care for individuals struggling with substance abuse and concurrent mental health issues, serving both adults and children. The facility features tailored programs for various demographics, including active military personnel, teenagers, and adult males, accommodating a range of ages and gender identities. Their treatment methods incorporate 12-step guidance, anger management strategies, and brief therapeutic interventions, all designed to ensure individualized support for each patient. Offering outpatient services along with methadone, buprenorphine, and naltrexone treatment options, the center is dedicated to providing high-quality care and assistance for those on their road to recovery. Horizon Health Services Inc stands as a reputable provider of effective and empathetic addiction treatment solutions.

Horizon Health Services Inc

Horizon Health Services Inc, located in Buffalo, NY, offers extensive outpatient care for individuals of all ages struggling with addiction and co-occurring mental health issues. The center features tailored programs for active military personnel, young people, and adult men, addressing a wide range of requirements. By employing methods like 12-step support, emotional regulation techniques, and short-term counseling, the facility guarantees personalized support. Horizon Health Services Inc delivers services such as outpatient medication-assisted treatment (MAT) with methadone, buprenorphine, or naltrexone, alongside general outpatient services, emphasizing effective and high-quality treatment for everyone. This organization stands as a symbol of optimism for those embarking on a journey of recovery and wellness.

Horizon Village Inc

Horizon Village Inc, located in Sanborn, NY, is a dedicated rehabilitation facility that provides long-term residential support and around-the-clock care for adult males dealing with substance abuse issues. The program integrates 12-step methodologies, techniques for managing anger, and concise intervention strategies to effectively tackle addiction challenges. This center serves adult men, including seniors and younger adults, fostering a nurturing atmosphere specifically oriented towards male clientele. With an emphasis on individualized care and specialized programs, Horizon Village Inc distinguishes itself as a well-rounded rehabilitation center committed to assisting individuals in their recovery journey from addiction.

Hotel California by the Sea

Hotel California by the Sea, located in Kirkland, WA, provides a wide array of rehabilitation options for both adults and young adults dealing with substance use challenges and concurrent mental health conditions. The facility features tailored programs for adult men, women, and those who have faced intimate partner violence. It offers various services including long-term residential programs, detoxification, and round-the-clock treatment support. By employing proven methods such as 12-step guidance, anger management, and cognitive behavioral therapy, the center prioritizes customized care for each individual. Committed to high standards and personalized recovery paths, Hotel California by the Sea strives to aid clients in their healing process.

Hotel California By The Sea

Located in Cincinnati, OH, Hotel California By The Sea specializes in extensive substance abuse rehabilitation for adults, including individuals facing significant mental health challenges alongside addiction. The center offers various treatment options such as intensive outpatient programs, partial hospitalization, and outpatient day therapy, all rooted in methods like 12-step support, anger management, and cognitive behavioral therapy. Catering to both men and women, as well as those who have encountered intimate partner violence, this facility addresses a wide range of needs. With services tailored for both adults and younger individuals, Hotel California By The Sea is committed to providing top-notch, individualized care in the rehabilitation process.

Hotel California By The Sea

Hotel California By The Sea in Cincinnati, OH, provides comprehensive treatment for addiction and co-occurring mental health issues for individuals of all ages. They offer flexible program lengths, including extended, brief, and round-the-clock residential care, all personalized through methods like 12-step integration, emotional regulation techniques, and cognitive restructuring. Specialized tracks are available for adult men, women, those affected by intimate partner abuse, and survivors of domestic violence. Catering to both adults and young adults, this center is dedicated to delivering customized, high-standard support for sustained healing and mental wellness.

Hopewell Health Centers Inc

Hopewell Health Centers Inc., located in Athens, OH, provides outpatient care for individuals struggling with substance abuse, co-occurring mental health and substance use disorders in adults, and significant emotional challenges in children. They offer targeted interventions for active-duty military personnel, teenagers, and adult males. Their therapeutic methods encompass approaches like 12-step facilitation, anger control strategies, and brief intervention techniques. Serving both male and female adults, including older adults, this center delivers well-rounded support. Hopewell Health Centers Inc. distinguishes itself with its outpatient medication-assisted treatment (methadone/buprenorphine or naltrexone) and a dedication to high-quality, personalized recovery plans, making it a leading facility for effective substance use disorder treatment.

Horizon Health Services Inc

Horizon Health Services Inc, situated in Lockport, NY, provides a variety of outpatient services aimed at treating substance use issues and co-existing mental health challenges in both adults and youth. The center is adept in 12-step approaches, anger management techniques, and short-term interventions, ensuring that each patient receives customized support. Additionally, Horizon Health Services Inc features specific programs designed for active military personnel, adolescents, and adult males, addressing the needs of various groups. Patients can access outpatient treatments including methadone, buprenorphine, or naltrexone, as the facility emphasizes the importance of high-quality care for all individuals pursuing recovery.

Horizons Mental Health Center Inc

Horizons Mental Health Center Inc, located in Hutchinson, KS, provides outpatient services aimed at addressing substance use and co-occurring mental health issues for both adults and children. This center features customized programs specifically designed for adolescents, women, and individuals who have faced traumatic experiences, ensuring that care meets diverse needs. Among the therapeutic methods utilized are anger management, brief interventions, and cognitive behavioral therapy. Catering to adults and elderly clients regardless of gender, the center also offers outpatient options for methadone/buprenorphine or naltrexone treatment in addition to standard outpatient programs. Clients can anticipate exceptional care within a nurturing setting that emphasizes comprehensive healing and recovery.

Horizon Health Services Inc

Horizon Health Services Inc, situated in Buffalo, NY, delivers thorough addiction treatment and targeted support for those facing combined substance use and significant mental health challenges. The center features intensive outpatient programs, general outpatient services, and medication-assisted treatment options including methadone, buprenorphine, and naltrexone. Emphasis is placed on 12-step encouragement, strategies for managing anger, and brief therapeutic interventions, ensuring each person's treatment plan is personalized. Services are available for active military members, young people, and adult men, accommodating adults and children/adolescents across all genders. Horizon Health Services Inc is committed to offering superior care and assistance to guide individuals toward lasting recovery.

Horizon Health Services Inc

Horizon Health Services Inc, located in Niagara Falls, NY, provides a wide range of treatment options for substance use issues, with a particular focus on treating dual diagnoses that involve both substance use disorders and significant mental health challenges in adults, as well as addressing severe emotional issues in children. The center offers extensive outpatient programs, including methadone, buprenorphine, or naltrexone treatments. Their therapeutic methods encompass 12-step support, anger management, and brief intervention techniques. They have specifically designed programs for active military personnel, teenagers, and adult males, ensuring that services are accessible to individuals of all genders, including seniors. Horizon Health Services Inc is committed to delivering high-quality care and assistance to those pursuing a path to recovery.

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In Albany, NY, Hospitality House TC Inc specializes in delivering comprehensive substance use therapies for both adults and children facing complex mental health challenges. The center offers both long-term and short-term residential programs, incorporating strategies such as 12-step facilitation, anger management, and brief intervention techniques. This facility is designed to support adult men, active military members, and those who have gone through intimate partner violence. It provides targeted care for seniors, young adults, and adults, ensuring a nurturing atmosphere for recovery in a male-only setting at Hospitality House TC Inc.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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