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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Lifeline Professional Counseling Servs

Lifeline Professional Counseling Servs in Glendale, AZ, is dedicated to providing effective, research-backed therapeutic services for individuals of all ages grappling with addiction and co-occurring mental health concerns. Their comprehensive offerings include intensive outpatient, day treatment, and partial hospitalization programs. Treatment modalities emphasize 12-step facilitation, anger management techniques, and brief intervention strategies. Specialized support is available for active duty military, teenagers, and adult men. Lifeline extends its quality, personalized care to adults and seniors across all gender identities, ensuring that each person receives support suited to their unique journey.

Lifestream Health Center

Situated in Bowie, MD, Lifestream Health Center presents a wide range of outpatient services aimed at those in need of detox, substance abuse recovery, and support for intertwined mental health issues. The center offers outpatient detox services, treatments with methadone/buprenorphine or naltrexone, short-term interventions, and counseling for substance use disorders. Lifestream Health Center is committed to serving a varied clientele, providing specialized programs for active military members, as well as adult men and women. Their offerings cater to both adults and younger individuals, with distinct programs available for each gender. The center focuses on providing exceptional care to facilitate the recovery process for all clients.

Lifesync Recovery and Detox LLC

Lifesync Recovery and Detox LLC in Malibu, CA, provides premier inpatient detoxification and addiction treatment for adults and young adults. This facility specializes in 12-step program integration, anger management techniques, and brief intervention strategies. They offer dedicated care for adult men and women, including those affected by intimate partner or domestic violence. Lifesync Recovery and Detox LLC delivers short-term residential stays with continuous support within a secure and supportive setting. Their dedication to individualized treatment and scientifically proven methods makes this Malibu center a leader in complete addiction recovery.

Lifeways
Jackson, MI

Situated in Jackson, MI, Lifeways stands out as a prominent rehabilitation center that specializes in outpatient services for individuals grappling with substance abuse and concurrent mental health issues, catering to both adults and children. The facility features tailored programs designed for active military members, along with distinct offerings for men and women. Lifeways implements proven techniques like cognitive behavioral therapy and motivational interviewing to ensure top-notch care. With options for outpatient treatment including methadone/buprenorphine and naltrexone, the center addresses the unique requirements of all genders among adults and young adults. For those seeking effective support in addiction recovery, Lifeways is committed to guiding you on your journey to healing.

Lifewell
Mesa, AZ

Lifewell, situated in Mesa, AZ, provides comprehensive, evidence-based therapeutic interventions for individuals of all ages grappling with addiction and concurrent mental health challenges. Their offerings include intensive outpatient, outpatient, and standard outpatient programs. The center employs proven methodologies such as anger management, cognitive behavioral therapy, and the Matrix Model. Lifewell's specialized services extend to adult women, individuals with co-occurring mental health and substance use conditions, and those facing co-occurring pain and addiction. With tailored programs designed for adult men and women, as well as young adults, Lifewell is dedicated to offering superior care to foster successful recovery journeys.

Lifeline Professional Counseling Servs

Situated in Mesa, AZ, Lifeline Professional Counseling Servs delivers extensive substance abuse treatment for both adults and children grappling with concurrent mental health challenges. The center features both intensive outpatient and outpatient day programs, utilizing strategies such as 12-step guidance, anger management, and quick intervention techniques. With distinct offerings for active duty military members, teenagers, and adult males, Lifeline addresses a wide range of client needs. It serves adults and seniors of all genders, ensuring personalized treatment plans that align with each individual's requirements. Lifeline Professional Counseling Servs is committed to delivering exceptional and impactful rehabilitation support to aid individuals in their recovery paths.

Lighthouse Behavioral Health

Situated in Columbus, OH, Lighthouse Behavioral Health provides targeted substance use recovery programs for both adults and young adults. The facility offers various treatment methods such as intensive outpatient services, outpatient programs, and day treatment or partial hospitalization options. Emphasizing techniques like cognitive behavioral therapy, motivational interviewing, and contingency management with incentives, this center customizes its services to meet the needs of each person. A standout aspect of Lighthouse Behavioral Health is its commitment to personalized care, guaranteeing that every client benefits from tailored treatment plans. The center is open to both male and female individuals in need of effective addiction recovery services.

Lifespring Health Systems
Jeffersonville, IN

Situated in Jeffersonville, IN, Lifespring Health Systems provides extensive addiction recovery services tailored for both adults and young adults. The facility specializes in hospital inpatient detox and treatment for substance use issues, alongside addressing co-existing mental health disorders. Lifespring Health Systems features dedicated programs for individuals facing dual diagnoses, employing research-supported methods including 12-step facilitation, brief interventions, and cognitive behavioral therapy. Designed for individuals of all genders, this center is committed to delivering exceptional care and assistance for those on the path to recovery from addiction and associated mental health challenges.

Lifeline Treatment Services Inc

Lifeline Treatment Services Inc in Oakland, CA provides outpatient services for adults and young adults struggling with substance use disorders. Their specialized programs address the unique needs of pregnant and postpartum women. Employing methods like 12-step facilitation, motivational interviewing, and contingency management, they create individualized treatment plans. Lifeline Treatment Services Inc is dedicated to offering high-quality, supportive care for all genders pursuing recovery.

Lifeline Professional Counseling Servs

Situated in Avondale, Arizona, Lifeline Professional Counseling Servs specializes in providing rehabilitation services tailored to both adults and children dealing with substance abuse and mental health issues. The center offers a variety of programs including intensive outpatient treatment, regular outpatient services, and day treatment, using techniques such as 12-step support, anger management, and brief intervention methods. Lifeline Professional Counseling Servs is designed to meet the needs of diverse populations, including active military personnel, teenagers, and adult males. The facility is committed to delivering exceptional care and support for individuals of all ages and genders who are on their journey to recovery.

Lifeways
Hillsdale, MI

Situated in Hillsdale, MI, Lifeways stands out as a leading rehabilitation facility that delivers outpatient services for substance abuse and co-occurring issues in both adults and children. The center emphasizes cognitive behavioral therapy and motivational interviewing techniques, offering customized programs specifically designed for active duty military members, as well as adult men and women. Lifeways adapts its treatment to cater to the distinct requirements of adults and young adults, providing outpatient methadone/buprenorphine or naltrexone treatment options. Committed to delivering high-quality care through various methodologies, Lifeways aims to support individuals on their journey to sustainable recovery.

Lighthouse Counseling/Mediation Servs

Lighthouse Counseling/Mediation Servs, located in Steubenville, OH, specializes in treatment for substance use and co-occurring mental health disorders among adults facing significant psychological challenges, as well as children grappling with emotional issues. The center offers various programs, including intensive outpatient services, standard outpatient care, and medication-assisted treatments with methadone, buprenorphine, or naltrexone. Emphasizing techniques like anger management, brief intervention, and cognitive behavioral therapy, this facility accommodates active duty military members, teenagers, and adult males. With a commitment to serving people of all genders, including seniors and adults, Lighthouse Counseling/Mediation Servs provides tailored, comprehensive care aimed at supporting individuals on their path to recovery.

Lighthouse Inc
Cullman, AL

Lighthouse Inc, situated in Cullman, AL, delivers dedicated long-term residential treatment for adult men struggling with substance use disorders. This facility ensures continuous care within a nurturing atmosphere, employing proven therapeutic strategies like 12-step integration, emotional regulation training, and cognitive behavioral interventions. Lighthouse Inc serves distinct demographics, including adult males, survivors of sexual assault, and individuals processing trauma. Emphasizing care for adult, elderly, and younger adult males, the center customizes its services to address each client's specific requirements. Through its unwavering dedication to excellence and specialized treatment plans, Lighthouse Inc stands as a guiding light for individuals pursuing thorough recovery.

Lifespring Health Systems

Situated in Scottsburg, IN, Lifespring Health Systems delivers customized outpatient programs for substance use treatment aimed at both adults and youth dealing with simultaneous mental health challenges. The center emphasizes personalized care, addressing the unique requirements of each individual. Lifespring Health Systems employs proven methods including cognitive behavioral therapy and 12-step facilitation to foster recovery. Catering to both male and female clients, as well as young adults, this facility also provides outpatient therapy using methadone, buprenorphine, or naltrexone. Individuals can anticipate empathetic support and tailored treatment strategies to assist them on their path toward recovery.

Lighthouse Behavioral Health

Situated in Reynoldsburg, OH, Lighthouse Behavioral Health provides extensive treatment for adults and young adults dealing with substance use issues. The center features a variety of programs including intensive outpatient treatment, outpatient care, and partial hospitalization services. Emphasizing evidence-based practices like cognitive behavioral therapy, motivational interviewing, and contingency management, the facility customizes treatment plans to meet the unique needs of each client. Committed to an individualized approach, Lighthouse Behavioral Health serves both male and female clients who are in pursuit of effective support for overcoming addiction.

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Situated in Dallas, TX, Life's Second Chance Treatment Center delivers various outpatient services that emphasize detoxification and treatment for substance use issues. This facility employs specialized methods such as motivational interviewing, strategies for relapse prevention, and counseling specific to substance use disorders. To meet the unique needs of its clients, it offers customized programs for men, women, pregnant or postpartum women, and young adults, ensuring personalized care. Committed to delivering high-quality support, the center provides outpatient options including methadone, buprenorphine, and naltrexone treatments, alongside standard outpatient care. Catering to both male and female participants, the center aims to create a nurturing atmosphere for individuals embarking on their rehabilitation journey and pursuing a new beginning.

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Lifespan Behavioral Health Nevada in Henderson, NV, provides extensive support for recovery, addressing a wide spectrum of addiction and mental health challenges. The facility's offerings encompass detoxification, comprehensive addiction treatment, and specialized care for dual diagnoses in adults, alongside support for childhood emotional issues. Patients can benefit from intensive outpatient, standard outpatient, and outpatient detoxification services. The center employs evidence-based therapeutic modalities such as anger management, brief intervention, and cognitive behavioral therapy, ensuring high-quality care for adult men and women, and young adults. Dedicated programs are also available for active military members.

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Situated in Salem, IN, Lifespring Health Systems delivers extensive treatment for substance use issues for both adults and children/adolescents who also face significant mental health challenges. The center offers various outpatient services, among which are methadone and buprenorphine therapies. Lifespring Health Systems employs proven methods, including cognitive behavioral therapy and contingency management. With an emphasis on personalized care, the facility serves individuals of all genders and ages, including young adults. Clients can look forward to receiving top-notch treatment and tailored programs that address their unique requirements at this distinguished rehabilitation center.

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Ontario, OR

Situated in Ontario, OR, Lifeways provides extensive support for substance use disorders with its long-term and 24-hour residential treatment options. The center is known for its expertise in 12-step facilitation, anger management strategies, and cognitive behavioral therapy. Lifeways serves adult men and women, including individuals who have undergone trauma, ensuring targeted care for these demographics. With a commitment to adults and young adults of all genders, Lifeways develops personalized treatment plans that address each individual's specific circumstances. The facility's high-quality services and varied specialized programs make it a popular option for people seeking compassionate and effective addiction recovery solutions.

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Ontario, OR

Situated in Ontario, OR, Lifeways delivers extensive treatment for substance use disorders in adults, including those facing significant mental health challenges simultaneously. Emphasizing intensive outpatient care, the center also offers outpatient options with methadone, buprenorphine, and naltrexone. Programs are customized, incorporating strategies such as anger management, cognitive behavioral therapy, and brief interventions. Lifeways features specialized programs designed for adolescents as well as adult men and women, serving individuals of all adult age brackets, including seniors. The facility prioritizes high-quality care for both male and female patients, positioning itself as an essential provider of effective, personalized rehabilitation services.

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Lighthouse Behavioral Wellness Centers, situated in Ardmore, OK, provides extensive outpatient care for individuals struggling with substance use, serving both adults and young adults. The center excels in addressing dual diagnoses, managing co-occurring substance use disorders alongside significant mental health conditions in adults or emotional challenges in children. Their treatment methodologies encompass diverse strategies such as anger management techniques, brief intervention strategies, and cognitive behavioral therapy. Lighthouse Behavioral Wellness Centers further distinguishes itself with specialized offerings for adult men, adult women, and survivors of intimate partner violence, ensuring that each person receives tailored support. This facility is dedicated to delivering high-quality, comprehensive care with a focus on overall well-being and recovery for all its clients, irrespective of gender.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)