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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Lifeline Connections

Lifeline Connections, located in Vancouver, WA, provides a wide range of treatment options for substance use disorders along with dedicated support for individuals facing dual mental health challenges. This center features programs such as intensive outpatient services, regular outpatient care, and options for methadone/buprenorphine or naltrexone treatment. Implementing proven methods like cognitive behavioral therapy and motivational interviewing, Lifeline Connections serves both adults and youth, offering programs specifically designed for those who have underwent trauma or present with co-occurring issues. Committed to delivering high-caliber care, Lifeline Connections invites male and female clients seeking reliable rehabilitation support in a nurturing atmosphere.

Lifeline Professional Counseling Servs

Lifeline Professional Counseling Servs, located in Scottsdale, AZ, specializes in extensive treatment for substance use and provides targeted support for adults facing co-occurring substance use disorders alongside significant mental health issues, as well as children with emotional challenges. The center delivers various programs, including intensive outpatient treatment, outpatient day services, and partial hospitalization, utilizing methods such as 12-step facilitation, anger management, and brief intervention strategies. Lifeline offers customized programs for active military personnel, teenagers, and adult men, serving a diverse clientele that includes adults and seniors of all genders. The center's commitment to high-quality care and personalized treatment plans positions it as a leading option for individuals seeking effective rehabilitation solutions.

Lifeline Professional Counseling Servs

Nestled in Chandler, AZ, Lifeline Professional Counseling Servs is dedicated to providing expert substance abuse treatment for adults experiencing severe mental health challenges and for children facing emotional difficulties. Their wide-ranging programs feature intensive outpatient care, daytime outpatient therapy, and partial hospitalization. Emphasizing 12-step support, anger management, and brief intervention strategies, this center serves active military personnel, teenagers, and adult males. Catering to adults and seniors of all genders, Lifeline is committed to delivering personalized care that meets the unique needs of individuals, establishing itself as an essential option for effective rehabilitation services in the Chandler vicinity.

LifeSpring Health Systems

LifeSpring Health Systems, located in New Albany, IN, specializes in outpatient services that address substance use disorders and co-existing mental health issues in adults, as well as emotional challenges in children. The center provides an array of treatment options, which include outpatient methadone/buprenorphine and naltrexone programs, in addition to standard outpatient services. Utilizing evidence-based methods such as cognitive behavioral therapy and 12-step facilitation, along with personalized treatment plans, LifeSpring Health Systems ensures that each client's needs are met. They offer specialized programs for both adults and children/adolescents, with services tailored for males and females alike. Emphasizing quality and individualized attention, this center is distinguished for its thorough and effective treatment solutions.

LifeStream Behavioral Center

LifeStream Behavioral Center in Clermont, FL, delivers comprehensive addiction treatment services designed for individuals of any age or gender. The center features various levels of care, including hospital inpatient, 24-hour hospital inpatient, and outpatient options, all employing proven therapeutic methods such as cognitive behavioral therapy and the Matrix Model. Prioritizing excellent patient care, LifeStream Behavioral Center has developed targeted programs specifically for adolescents and young adults, recognizing their distinct challenges. Both male and female patients receive specialized support through brief interventions and complete treatment strategies aimed at fostering lasting recovery. LifeStream Behavioral Center distinguishes itself with its all-encompassing strategy to overcoming addiction.

Lifeline Connections

Lifeline Connections, located in Vancouver, WA, provides an array of targeted services for those in need of treatment for substance abuse and mental health challenges. The center features hospital-based detoxification services, intensive outpatient programs, and employs proven strategies like cognitive behavioral therapy and the Matrix Model. Offering customized programs designed for teenagers, adult males, and females, Lifeline Connections serves a wide spectrum of ages and genders. Its emphasis on short-term interventions and high-quality care positions it as an essential support system for individuals beginning their recovery process.

LifeSpring Health Systems
Jeffersonville, IN

LifeSpring Health Systems, located in Jeffersonville, IN, specializes in treating adults and young adults dealing with substance use disorders alongside significant mental health challenges or emotional difficulties. The center offers a range of services, including intensive outpatient treatment, outpatient care, and therapies involving methadone, buprenorphine, and naltrexone. Emphasizing techniques such as 12-step facilitation, cognitive behavioral therapy, and motivational incentives, the facility customizes its approach to meet the unique needs of each individual. LifeSpring Health Systems serves both male and female patients, ensuring a thorough and gender-sensitive method of treatment. With an emphasis on quality and personalized care, this center is recognized for its effective and tailored rehabilitation programs.

Lifeline Connections
Bellingham, WA

At Lifeline Connections in Bellingham, WA, a full spectrum of addiction recovery support is available for all ages. This facility excels in providing services for medically supervised withdrawal, comprehensive addiction counseling, and integrated care for those managing both substance use and mental health challenges. Clients can access structured partial hospitalization programs, less intensive outpatient withdrawal management, and proven therapeutic techniques like cognitive behavioral therapy and motivational interviewing. Specialized assistance is also offered for individuals navigating the legal system. Dedicated to delivering exceptional, personalized care, Lifeline Connections welcomes men and women embarking on their journey to overcome addiction and co-occurring disorders.

LifeSpring Health Systems
Jeffersonville, IN

LifeSpring Health Systems, located in Jeffersonville, IN, provides focused outpatient services for individuals dealing with substance use issues and concurrent mental health challenges, catering to both adults and children. The center emphasizes personalized treatment, utilizing methods like 12-step facilitation, cognitive behavioral therapy, and motivational incentives. LifeSpring offers programs specifically designed for adults and young adults of diverse backgrounds, distinguishing itself through a wide array of services, including methadone and buprenorphine management, as well as standard outpatient programs. The facility is committed to delivering high-quality care, aiming to assist individuals throughout their recovery journeys with tailored treatment approaches.

LifeSpring Health Systems

LifeSpring Health Systems, located in Austin, IN, provides targeted treatment for adults and young adults dealing with substance use disorders alongside serious mental health challenges or emotional issues. Their programs include intensive outpatient and outpatient services, featuring treatment options such as methadone and buprenorphine. By employing proven methodologies like 12-step facilitation, cognitive behavioral therapy, and motivational incentives, they emphasize personalized care for both men and women. LifeSpring Health Systems is committed to creating a nurturing atmosphere for individuals pursuing thorough and impactful rehabilitation solutions in the Austin region.

LifeSkills Inc
Scottsville, KY

LifeSkills Inc, situated in Scottsville, KY, delivers exceptional residential care for individuals battling substance use disorders. Their expertise encompasses 12-step integration, strategies for managing anger, and cognitive behavioral techniques. This establishment is particularly dedicated to assisting adult women who have endured intimate partner violence, domestic abuse, or sexual trauma. Serving adults of all ages, LifeSkills Inc centers its services on female clients, cultivating a secure and nurturing atmosphere for the recovery journey. Through short-term and round-the-clock residential options, the center emphasizes personalized treatment plans and proven methods to foster enduring wellness and abstinence.

LifeSkills Inc
Bowling Green, KY

LifeSkills Inc, located in Bowling Green, KY, provides a full spectrum of outpatient care for adults and young adults navigating substance abuse and co-occurring mental health challenges. Their expertise extends to detoxification, support for the 12-step recovery model, anger resolution, and concise intervention strategies. This establishment delivers customized support for adult men, adult women, and individuals with a history of trauma. Emphasizing gender-informed treatment, LifeSkills Inc guarantees high-quality services, including outpatient options with methadone, buprenorphine, or naltrexone. Those in search of impactful and encouraging recovery pathways can discover individualized programs at this center.

LifeSpring Health Systems

LifeSpring Health Systems, located in English, IN, offers a variety of outpatient services aimed at addressing substance abuse and related mental health challenges for both adults and children. Employing proven methods like cognitive behavioral therapy and 12-step programs, the center creates personalized treatment plans to meet the unique needs of each individual. Committed to delivering high-quality care, LifeSpring Health Systems serves both men and women through outpatient options that include methadone, buprenorphine, and naltrexone therapies. The facility ensures that adults and youth alike receive consistent outpatient support, fostering a nurturing and accepting atmosphere for those on their path to recovery.

LifeSpring Health Systems

LifeSpring Health Systems in Jasper, IN, provides expert therapeutic care for individuals struggling with substance abuse and concurrent mental health challenges, serving both adults and younger individuals. Their approach emphasizes personalized treatment, offering comprehensive outpatient services, such as medication-assisted treatment with methadone or buprenorphine. Core therapeutic strategies include support through 12-step principles, cognitive behavioral techniques, and motivational reinforcement. LifeSpring Health Systems welcomes individuals of all ages and genders seeking a supportive environment for recovery. The center is dedicated to crafting customized recovery pathways, aiming to foster sustained well-being and presenting a nurturing option for effective addiction management.

LifeSpring Health Systems

LifeSpring Health Systems, located in Rockport, IN, specializes in integrated care for adults facing co-occurring substance use and serious mental health conditions, as well as for children experiencing emotional difficulties. The facility offers various levels of care, including intensive outpatient, standard outpatient, and medication-assisted treatment (MAT) with methadone, buprenorphine, or naltrexone. Their therapeutic approaches encompass 12-step facilitation, cognitive behavioral therapy (CBT), and contingency management strategies. LifeSpring Health Systems is committed to providing tailored, high-quality rehabilitation services designed for both adults and children, with gender-specific programming available, to guide individuals toward sustained wellness.

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LifeSpring Health Systems in Paoli, IN, provides outpatient services focused on addiction and co-occurring mental health conditions for adults, as well as emotional challenges for young people. They offer customized support through methods such as 12-step facilitation, cognitive behavioral therapy, and motivational incentives. Programs are designed to meet the needs of adults and children/adolescents regardless of gender. A key feature of LifeSpring Health Systems is their outpatient treatment utilizing methadone/buprenorphine or naltrexone, aiming for a thorough and successful recovery. This facility is committed to high standards and individualized attention, aiding individuals in their process of recovery and well-being.

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LifeSpring Health Systems in New Albany, IN, provides thorough outpatient services for adults struggling with substance abuse and co-occurring severe mental health conditions, as well as for children experiencing emotional disturbances. Their specialized services extend to individuals involved with the criminal justice system or forensic populations. Utilizing methods such as 12-step facilitation, cognitive behavioral therapy, and contingency management, the facility delivers tailored support to adults and young adults regardless of gender. LifeSpring Health Systems is dedicated to delivering high-quality, evidence-based care to assist individuals in their journey toward wellness.

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LifeSpring Health Systems in Tell City, IN, provides targeted interventions for individuals of all ages grappling with addiction and related mental health issues. The center's diverse treatment modalities encompass intensive outpatient, standard outpatient, and medication-assisted options including methadone, buprenorphine, or naltrexone. Employing evidence-based practices such as 12-step facilitation, cognitive behavioral therapy, and contingency management/incentives, their approach is thorough. A hallmark of LifeSpring Health Systems is their commitment to crafting personalized treatment plans to address each client's specific circumstances. They offer dedicated services for both genders, fostering a nurturing setting conducive to recovery from substance abuse and mental health concerns.

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LifeSpring Health Systems in Corydon, IN, provides extensive outpatient care for addiction and accompanying mental health concerns in adults, along with emotional challenges in young people. They feature individualized programs utilizing 12-step support, cognitive behavioral therapy, and motivational rewards to aid the recovery journey. The center also offers outpatient services for opioid use disorder using medications like methadone, buprenorphine, or naltrexone. Catering to adults and youth of all genders, LifeSpring Health Systems emphasizes high-quality, individualized rehabilitation and is a leading provider of compassionate and successful addiction treatment.

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LifeSpring Health Systems, located in Madison, IN, delivers complete addiction recovery services for adults, older adults, and adolescents. The center is dedicated to addressing dual diagnoses of substance abuse and significant mental health conditions in adults, along with severe emotional challenges in children. Services include intensive outpatient care, general outpatient services, and outpatient medication-assisted treatment with methadone, buprenorphine, or naltrexone. Employing proven methods such as 12-step engagement, cognitive behavioral therapy, and motivational strategies, the facility guarantees personalized support for every individual. LifeSpring Health Systems prioritizes gender-informed treatment, offering effective care designed for the distinct requirements of both male and female patients.

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LifeStream Behavioral Center, located in Ocoee, FL, provides targeted outpatient services for individuals dealing with substance use issues and related mental health disorders, serving both adults and children. The center employs a variety of evidence-based techniques such as cognitive behavioral therapy and motivational interviewing, customized to meet the unique needs of each person. Programs specifically designed for adolescents are also offered, addressing the requirements of both young adults and adults. Committed to delivering high-quality care, LifeStream offers outpatient treatments utilizing methadone/buprenorphine or naltrexone, in addition to traditional outpatient services. This facility is open to male and female clients who are in search of compassionate and effective rehabilitation support.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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