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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Mandala Healing Center
West Palm Beach, FL

Located in West Palm Beach, Florida, Mandala Healing Center delivers extensive substance abuse treatment for adults and adolescents. This facility features extended stay residential options, inpatient detoxification services, and continuous supervision. Employing scientifically validated methods such as cognitive behavioral therapy and emotional regulation techniques, the center customizes care plans to manage dual diagnoses in adults and emotional challenges in youth. Offering distinct programs for adult men, adult women, and individuals facing co-occurring conditions, Mandala Healing Center guarantees personalized recovery journeys. Their dedication to excellence and integrated wellness establishes it as a reliable destination for individuals pursuing sobriety.

Mann Grandstaff VA Medical Center

Mann Grandstaff VA Medical Center in Spokane, WA, is a leading facility providing a full spectrum of addiction recovery programs. They offer detox services, comprehensive substance abuse treatment, and specialized support for those facing dual diagnoses of addiction and severe mental health conditions. Patients can access treatment through intensive outpatient, standard outpatient, and outpatient detoxification programs. The center emphasizes approaches like 12-step facilitation, anger management techniques, and brief intervention strategies. Mann Grandstaff VA Medical Center is equipped to serve adult men and women, including survivors of domestic or intimate partner violence, and provides personalized care for adults and young adults.

Manning Regional Healthcare Center

Manning Regional Healthcare Center, situated in Manning, IA, provides extensive support for individuals battling addiction. This institution is dedicated to adults and young adults, focusing on crucial steps like detoxification and comprehensive substance use therapy. They offer a structured hospital inpatient detoxification process, continuous 24-hour hospital inpatient monitoring, and rigorous intensive outpatient programs. Employing proven therapeutic methods, including 12-step facilitation, brief intervention, and cognitive behavioral therapy, the center is committed to effective recovery. Manning Regional Healthcare Center also features targeted programs for active military personnel, adult men, and adult women, demonstrating a commitment to serving various client groups. Their approach emphasizes tailored treatment plans and gender-specific care, ensuring a high standard of rehabilitation for all clients on their journey to sobriety.

Mansfield Comprehensive Treatment Ctr

Situated in Mansfield, OH, the Mansfield Comprehensive Treatment Ctr delivers targeted outpatient programs for substance use issues. This center offers treatments utilizing methadone/buprenorphine or naltrexone, alongside standard outpatient care and various methodologies such as 12-step support, relapse prevention strategies, and substance use disorder counseling. Tailored programs are available for active military members, as well as adult men and women, catering to both adults and young adults. Prioritizing personalized treatment and evidence-based techniques, this facility guarantees effective care for individuals seeking thorough addiction rehabilitation solutions.

Map to Health
Fort Lauderdale, FL

Map to Health, located in Fort Lauderdale, FL, delivers a wide range of personalized addiction treatment services. The center specializes in detox, treatment for substance use disorders, and transitional housing within a nurturing atmosphere. Emphasizing both intensive outpatient and outpatient programs, which encompass day treatment and partial hospitalization, the center employs methods like 12-step facilitation, brief intervention, and cognitive behavioral therapy. It offers tailored programs specifically for active duty military members, as well as adult men and women. Catering to both adults and young adults of all genders, this facility is committed to providing exceptional care to assist individuals on their path to recovery.

Maple Mountain Recovery

Maple Mountain Recovery in Mapleton, UT, provides extensive treatment for substance abuse in adults and young adults. Their offerings include extended stays in a residential setting, detox services, and continuous round-the-clock care. Emphasizing principles like the 12-step program, emotional regulation, and short-term support strategies, the center addresses individuals facing both addiction and significant mental health challenges. Dedicated programs are also designed for current military members, adult males, and adult females. Maple Mountain Recovery is committed to offering excellent, gender-tailored treatment for both sexes, establishing itself as a premier option for those pursuing successful and individualized recovery.

Marimn Health
Plummer, ID

Marimn Health, located in Plummer, ID, delivers a wide array of treatment options for substance use issues, addressing the needs of both adults and children who also face mental health challenges. The center provides various treatment modalities, including intensive outpatient therapy and standard outpatient services, along with specialized programs utilizing methadone, buprenorphine, or naltrexone. Emphasizing 12-step principles, anger management strategies, and focused interventions, Marimn Health customizes its approach to fit the unique needs of each client. Additionally, they offer targeted programs for different demographics, such as adolescents, adult men, and women. This center serves adults and seniors from all backgrounds, ensuring compassionate and professional care for those seeking support in their recovery journey.

Mark Twain Behavioral Health

Mark Twain Behavioral Health located in Hannibal, MO, specializes in delivering thorough outpatient rehabilitation services for those struggling with substance use disorders alongside concurrent mental health issues. Their targeted programs are designed for adults grappling with significant mental health conditions or emotional challenges, featuring customized treatment strategies that incorporate anger management, cognitive behavioral therapy, and short-term interventions. The center provides outpatient treatment with methadone, buprenorphine, or naltrexone, emphasizing high-quality care for adult men, adult women, and teenagers. Devoted to personalized treatment, Mark Twain Behavioral Health fosters a nurturing atmosphere for both male and female clients as they work towards recovery.

Mark Twain Behavioral Health

Mark Twain Behavioral Health, situated in Bowling Green, MO, delivers a full spectrum of addiction recovery solutions. Their services encompass outpatient detox, comprehensive substance use therapy, and distinct tracks for teens, adult men, and adult women. Employing therapeutic modalities such as 12-step support, anger management techniques, and brief intervention strategies, the center serves individuals of all ages and genders. Mark Twain Behavioral Health is recognized for its high standard of care and customized treatment plans, establishing it as a leading option for those pursuing impactful and individualized addiction care locally.

Marthas Vineyard Community Servs

Marthas Vineyard Community Servs in Vineyard Haven, MA, delivers thorough outpatient care for individuals grappling with substance use disorders, particularly those also experiencing significant mental health challenges or emotional distress. Utilizing proven methods like cognitive behavioral therapy and motivational incentives, this center offers tailored support. They provide distinct services for active military members, adult men, and women. Clients seeking outpatient care involving methadone, buprenorphine, or naltrexone will find dedicated attention here. Marthas Vineyard Community Servs is committed to providing individualized and impactful addiction treatment, guiding each person toward a successful recovery journey.

Martinsville Treatment Services

Martinsville Treatment Services, located in Martinsville, VA, delivers personalized outpatient addiction recovery services. Their offerings include medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside general outpatient care. Clients benefit from various therapeutic modalities such as anger management, brief intervention, and cognitive behavioral therapy. The center is dedicated to serving diverse populations with specific programs for adult men, adult women, and the LGBTQ+ community. Catering to adults and young adults across all gender identities, Martinsville Treatment Services is committed to providing high-quality, empathetic, and holistic support for individuals seeking sobriety.

Mary Hall Freedom Village Inc

Situated in Atlanta, GA, Mary Hall Freedom Village Inc delivers targeted support for substance use issues and transitional housing aimed at adult women and senior citizens. This center features a range of programs including intensive outpatient, long-term residential, and outpatient options, employing methods such as 12-step facilitation and anger management techniques. With a dedication to helping clients who have faced challenges like intimate partner violence, domestic abuse, and sexual trauma, this facility creates a secure and nurturing atmosphere conducive to healing. Its tailored approach to the needs of adult women, along with a strong focus on trauma-informed care, distinguishes this center as a key provider of thorough rehabilitation services.

Mark Twain Behavioral Health

Mark Twain Behavioral Health, located in Hannibal, MO, delivers a wide variety of outpatient services for those aiming to overcome substance use issues and related mental health challenges. This center specializes in treatment for adults dealing with significant mental health disorders and children experiencing serious emotional difficulties. Emphasizing techniques like 12-step support, anger management, and short-term interventions, the facility customizes its services to address the individual needs of each client. Specific programs designed for adolescents, adult males, and adult females ensure that care is appropriately directed toward different groups. Mark Twain Behavioral Health is committed to offering high-quality, gender-sensitive support for both adults and youth in a nurturing and understanding atmosphere.

Map to Health
Lake Worth, FL

Map to Health, situated in Lake Worth, FL, provides an extensive array of inpatient detoxification and treatment services for both adults and young adults dealing with substance abuse as well as co-occurring mental health issues. The center focuses on methods such as 12-step assistance, brief interventions, and cognitive behavioral therapy. With dedicated programs designed for adult males and females, alongside those who have suffered from intimate partner violence, the facility delivers personalized care that meets individual requirements. Serving clients of all genders, Map to Health prioritizes high-quality, evidence-driven treatment to aid individuals in their recovery journey.

Many Rivers Whole Health

Many Rivers Whole Health in Great Falls, MT, provides extensive outpatient care for substance use disorders, serving both adults and young people. Their expertise lies in methadone, buprenorphine, and naltrexone treatments administered on an outpatient basis. Each person receives a customized plan, reflecting the center's commitment to high-quality, individualized recovery programs. Many Rivers Whole Health is recognized for its comprehensive and supportive environment, welcoming all individuals in their pursuit of effective addiction treatment.

Marana Health Center Inc

Marana Health Center Inc, situated in Marana, AZ, delivers extensive outpatient care for individuals struggling with substance use disorders and co-occurring mental health challenges, serving both adults and younger populations. They feature dedicated treatment tracks for active military members, teenagers, and adult males. Employing proven therapeutic methods including anger management, cognitive behavioral therapy, and brief interventions, this establishment supports recovery for adults and seniors across all gender identities. Providing outpatient medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient services, Marana Health Center Inc prioritizes delivering excellent, personalized support for those on their journey to healing and rebuilding their lives.

Mark Twain Behavioral Health

At Mark Twain Behavioral Health in Kirksville, MO, we provide comprehensive outpatient services designed to address substance use challenges and dual diagnoses. Our specialized programs are structured to support adults, children, and adolescents navigating the complexities of co-occurring substance use and serious mental health conditions. We offer evidence-based interventions, including anger management, brief intervention strategies, and cognitive behavioral therapy, all delivered within a supportive and professional setting. Our dedicated team is committed to delivering high-quality, individualized care for both male and female clients, ensuring a personalized approach to recovery and well-being.

Marinette County Hlth and Human Servs

Marinette County Hlth and Human Servs, located in Marinette, WI, provides outpatient services for adults and youth experiencing substance use challenges alongside mental health conditions. This center employs therapeutic strategies including anger management, cognitive behavioral therapy, and the Matrix Model to deliver personalized, high-quality care. They are equipped to assist individuals with dual diagnoses, serving adults and older adults across all gender identities. Marinette County Hlth and Human Servs is committed to delivering thorough, evidence-based support to guide individuals toward lasting recovery.

Mark Twain Behavioral Health

Mark Twain Behavioral Health in Moberly, MO, delivers a full spectrum of outpatient care for addiction and withdrawal management. The facility features distinct programs designed for teenagers, adult men, and adult women, serving individuals of all ages. Utilizing therapeutic methods such as 12-step integration, emotional regulation training, and short-term counseling, this location guarantees personalized support for everyone. Whether an individual needs outpatient detox or a day program, they will receive effective treatment suited to their personal journey. Mark Twain Behavioral Health supports recovery for both genders in a nurturing setting conducive to healing.

Marquette Family Health Center

The Marquette Family Health Center in Marquette, MI, delivers extensive outpatient services for individuals facing substance use challenges, co-occurring mental health conditions, and other psychological concerns. They feature tailored treatment paths for active military personnel, adult men, and women. Their approach incorporates key therapeutic elements such as 12-step recovery facilitation, anger management techniques, and brief intervention strategies, serving a diverse adult and senior clientele. Treatment options include medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient counseling. The Marquette Family Health Center is committed to delivering effective support and care for those on their path to healing.

Maryhaven Addiction Stabilization Ctr

Maryhaven Addiction Stabilization Ctr located in Columbus, Ohio, delivers extensive addiction recovery services designed for both adults and young adults. This center specializes in hospital inpatient detoxification and treatment, offering unique programs aimed at assisting pregnant or postpartum women and clients involved with the criminal justice system. The facility implements proven methods such as 12-step programs, cognitive behavioral therapy, and brief interventions to facilitate healing. By prioritizing personalized care, Maryhaven provides effective treatment options for both men and women pursuing recovery from substance use disorders. If you seek a nurturing atmosphere to embark on your recovery journey, this center presents a variety of services customized to your specific requirements.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)