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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Mayo Clinic
Rochester, MN

Mayo Clinic, situated in Rochester, MN, provides a wide range of substance use treatment options for both adults and young adults. The facility offers intensive outpatient programs, standard outpatient services, and specific treatments using methadone, buprenorphine, or naltrexone. Mayo Clinic employs proven methodologies such as 12-step facilitation, cognitive behavioral therapy, and the Matrix Model to guide their recovery processes. There are special initiatives aimed at those dealing with co-occurring mental health and substance abuse issues. With its commitment to personalized treatment, the center serves both men and women, fostering an encouraging and welcoming atmosphere for everyone on their journey to overcoming addiction.

Mayo Clinic Health System

Mayo Clinic Health System in La Crosse, WI, provides targeted outpatient care for individuals struggling with substance use disorders alongside co-existing mental health issues, catering to both adults and children. The center utilizes a variety of therapeutic strategies, including brief intervention, cognitive behavioral therapy, and the Matrix Model, to meet diverse client needs. With customized programs for adolescents and those facing dual diagnoses, comprehensive care is prioritized. Serving a diverse clientele, including seniors and individuals of all genders, Mayo Clinic Health System is dedicated to delivering high-quality support throughout the recovery process. Whether patients are looking for standard outpatient services or specific therapies like methadone, buprenorphine, or naltrexone, this facility is focused on guiding individuals toward sustained wellness.

Mazzoni Center
Philadelphia, PA

Philadelphia's Mazzoni Center provides targeted recovery support for individuals struggling with addiction and related mental health issues. They offer a range of treatment modalities, including intensive outpatient, standard outpatient, and medication-assisted treatment with methadone, buprenorphine, or naltrexone. Their therapeutic strategies incorporate 12-step facilitation, brief intervention, and cognitive behavioral therapy, with special attention given to those living with HIV/AIDS and members of the LGBTQ+ community. The center is dedicated to delivering thorough and effective care for adults and young people of all gender identities, guiding them toward lasting wellness.

McCall Behavioral Health Network

McCall Behavioral Health Network, located in Torrington, CT, provides a wide range of substance abuse treatment options, including intensive outpatient programs, standard outpatient services, and outpatient care with methadone or buprenorphine and naltrexone. Emphasizing evidence-based methodologies such as anger management, brief intervention strategies, and cognitive behavioral therapy, this center offers tailored programs for adolescents and adults, regardless of gender. With a commitment to delivering high-quality care, McCall Behavioral Health Network is dedicated to helping individuals of all ages navigate their journey to recovery from addiction.

McCall Behavioral Health Network

McCall Behavioral Health Network, located in Danbury, CT, specializes in treating substance use issues and co-existing mental health conditions for both adults and children. The center offers various programs, including both intensive outpatient and regular outpatient services, utilizing treatments such as methadone/buprenorphine and naltrexone. Emphasizing 12-step strategies, anger management, and cognitive behavioral therapy, McCall tailors its approach to suit the uniqueness of each individual. There are specialized programs available for adult men and women, as well as clients facing dual diagnoses. This center extends its comprehensive services to all adults and young adults, fostering a compassionate environment to support individuals on their journey to sustainable recovery.

McCall Behavioral Health Network

Located in Torrington, CT, McCall Behavioral Health Network delivers tailored substance use rehabilitation in a nurturing residential atmosphere. The facility offers an extensive range of services, including anger management, cognitive behavioral therapy, and the Matrix Model methodology. Aiming to assist adult men, adult women, and individuals with trauma histories, the program is designed to address various needs. This center welcomes adults and young adults of all identities, providing personalized care to ensure each client’s needs are met. With a dedication to high-quality, evidence-based treatment, McCall Behavioral Health Network is a reliable choice for those pursuing effective addiction recovery in a caring setting.

Mayflower Recovery Center

Mayflower Recovery Center, situated in Wilmington, MA, delivers extensive detox and substance use treatment services for both adults and young adults. The center features inpatient hospital detox programs and 24/7 care. It offers tailored programs for different groups, including active duty military members, men, and women, addressing a wide range of needs. Various methodologies are implemented, such as 12-step facilitation, anger management, and brief intervention, to assist individuals in their recovery journey. Visitors can anticipate personalized care designed to meet their unique requirements, fostering a nurturing and efficient rehabilitation process.

Mayflower Recovery Center

Mayflower Recovery Center, located in Wilmington, MA, delivers a complete suite of care for addiction and dual diagnosis conditions. This institution offers inpatient hospital stays, residential living, and brief residential stays for adults and young adults, serving both men and women. With dedicated services for individuals facing HIV/AIDS, the LGBTQ community, and those involved with the legal system, Mayflower Recovery Center prioritizes tailored support. Employing methods like 12-step encouragement, emotional regulation training, and quick intervention techniques, the center is committed to providing excellent, scientifically-backed treatment to guide individuals toward lasting sobriety.

McAlister Institute for Trt and Educ

The McAlister Institute for Trt and Educ, located in El Cajon, CA, delivers thorough substance abuse care for adults and adolescents facing co-occurring severe mental health conditions or emotional challenges. They offer intensive outpatient, outpatient, and standard outpatient services, employing methods like anger management, brief intervention, and cognitive behavioral therapy. The facility also features specialized tracks for active duty military personnel, adult men, and adult women, addressing a wide range of requirements. Catering to both male and female individuals, this institute prioritizes personalized, high-quality treatment, establishing itself as a vital provider of effective recovery solutions in the area.

Mayrx LLC
Asheville, NC

Mayrx LLC, situated in Asheville, NC, delivers outpatient care for adults and young adults struggling with substance dependency. The center is particularly adept at addressing concurrent addiction and significant mental health concerns in adults, or emotional disturbances in minors. They craft personalized relapse prevention strategies. Offering methadone/buprenorphine or naltrexone as outpatient medication-assisted treatment, Mayrx LLC serves both men and women. Their distinctive methodology prioritizes customized support for every client, delivering excellent care for individuals aiming to conquer addiction and mental health issues within a nurturing setting.

McCall Behavioral Health Network

McCall Behavioral Health Network in Waterbury, CT, provides dedicated long-term residential care for adult males struggling with addiction and accompanying mental health conditions. The center employs scientifically supported therapeutic methods, including 12-step programs, emotional regulation techniques, and cognitive behavioral interventions, to meet the distinct requirements of its residents. Focusing on dual diagnoses of substance abuse and severe mental health disorders, McCall Behavioral Health Network supports adults, older adults, and younger adults within a gender-specific setting. This institution is recognized for its thorough treatment plans designed for those facing multifaceted difficulties.

McDermott Center/Haymarket Ctr

Situated in Chicago, IL, the McDermott Center/Haymarket Ctr delivers an extensive range of addiction recovery services for both adults and young adults. This center features various programs, including hospital inpatient care, intensive outpatient options, and long-term residential support, all aimed at detoxification, addressing substance use issues, and treating co-occurring mental health disorders. It offers tailored programs for different groups, such as active military members, men, and women. Employing strategies such as the 12-step model, anger management techniques, and brief intervention methods, the facility guarantees personalized treatment. The McDermott Center/Haymarket Ctr is committed to providing exceptional support for those pursuing recovery from substance use and mental health difficulties.

McDermott Center/Haymarket Ctr

McDermott Center/Haymarket Ctr located in Chicago, IL, delivers extensive programs for addiction recovery for both adults and young adults. The center specializes in detox services, treatment for substance abuse, and managing co-occurring conditions, offering around-the-clock inpatient care as well as rigorous outpatient options. Emphasizing a personalized approach, the facility incorporates 12-step support, anger management techniques, and short intervention strategies to meet the distinct needs of each client. They also feature specific programs designed for active military personnel, as well as tailored services for adult men and women. Committed to providing effective care for all individuals, McDermott Center aims to support those in their journey towards overcoming addiction and mental health issues.

McDermott Center/Haymarket Ctr

The McDermott Center/Haymarket Ctr, situated in Chicago, IL, delivers expert inpatient hospital and residential detoxification programs. Their approach emphasizes 12-step facilitation, anger management techniques, and brief intervention strategies. This center is designed to support adult men, encompassing active military service members and individuals who have faced domestic abuse. They offer focused care for adults, seniors, and young adults, ensuring treatment is customized for the specific recovery requirements of male patients. For those seeking thorough detox with personalized attention and specialized recovery paths, this establishment offers robust assistance for achieving sobriety.

McDermott Center/Haymarket Ctr

The McDermott Center/Haymarket Ctr, situated in Chicago, IL, provides extensive detoxification services designed for adults, older adults, and younger adults. This institution excels in providing inpatient hospital detoxification and residential detoxification, offering continuous care for individuals pursuing recovery. Emphasizing 12-step facilitation, anger management, and brief intervention techniques, the center serves female patients, including active military members and adult women affected by domestic abuse. Known for its high standards of care and specialized offerings, McDermott Center/Haymarket Ctr is a premier destination for individuals requiring focused and successful substance abuse treatment.

McKay Family Practice
West Jordan, UT

McKay Family Practice, located in West Jordan, UT, provides outpatient detox programs and treatment for substance use disorders. This center focuses on brief interventions, cognitive behavioral therapy, and strategies for preventing relapse. It offers customized programs for youth, men, and women, addressing the needs of a diverse clientele. Catering to adults and older adults of all genders, the facility ensures high-quality care within a compassionate atmosphere. With options for outpatient treatment using methadone, buprenorphine, or naltrexone, McKay Family Practice presents a thorough approach to recovery from addiction. It is a reputable option for individuals seeking tailored rehabilitation services in West Jordan.

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McCall Behavioral Health Network, located in Waterbury, CT, provides an extensive array of targeted therapies for both substance abuse and interconnected mental health disorders affecting adults and youth. Offering intensive outpatient services, outpatient programs, and medication-assisted treatments, the center focuses on tailored care through proven methodologies like 12-step facilitation, anger management, and cognitive behavioral therapy. Dedicated programs are designed for adult males, females, and those facing dual diagnoses. The facility caters to a diverse clientele of all genders, emphasizing high-quality care and customized treatment to foster enduring recovery.

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McCall Behavioral Health Network, situated in Winsted, CT, specializes in outpatient treatment for substance use and offers targeted support for individuals dealing with co-occurring mental health issues. This center presents various therapeutic options, including outpatient services utilizing methadone, buprenorphine, or naltrexone, alongside routine outpatient counseling. Emphasizing anger management, quick intervention strategies, and cognitive behavioral therapy, the facility serves adult men and women, as well as young adults, in need of holistic care. Clients receive customized programs specifically aimed at addressing both mental health and substance use challenges, ensuring a high standard of individualized treatment for everyone.

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Albany, NY

McCarty Avenue, situated in Albany, NY, provides extensive substance abuse treatment for adult males within a secure and nurturing setting. The center's expertise lies in extended residential stays, inpatient detoxification services, and round-the-clock residential care. Employing scientifically validated methods like anger management, cognitive behavioral therapy, and motivational interviewing, the facility delivers personalized interventions for addiction and co-occurring psychological health issues. Specialized services are available for those who have endured intimate partner violence, domestic abuse, and sexual trauma. Catering specifically to adult, senior, and young adult men, McCarty Avenue is dedicated to offering superior treatment and assistance for individuals pursuing freedom from addiction.

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McIntosh Trail Community Servs Board in Griffin, GA, specializes in integrated care for individuals of all ages struggling with substance abuse and co-occurring mental health challenges. The facility offers various levels of support, including intensive outpatient, outpatient, and day treatment, employing evidence-based methods like anger management, cognitive behavioral therapy, and brief interventions. Dedicated services are available for adult men, those with dual diagnoses, and individuals involved with the criminal justice system. McIntosh Trail Community Servs Board is committed to providing tailored, high-quality rehabilitation and recovery support to all who seek it.

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Cleveland, OH

Situated in Cleveland, OH, McIntyre Center Inc provides an all-encompassing approach to substance use recovery, offering transitional housing and sober living arrangements. The center features both intensive outpatient and outpatient services, incorporating 12-step methodologies, brief interventions, and cognitive behavioral therapy. Designed for a wide range of clients, McIntyre Center Inc caters to adults, children, and teenagers across all genders. Known for its personalized treatment strategies, the center is committed to ensuring that each client receives care tailored to their individual needs. If you or someone you know is looking for a nurturing setting to embark on the journey of addiction recovery, this center's well-rounded programs and varied treatment methods can offer the essential support needed for achieving sobriety.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)