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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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McLean Hospital
Belmont, MA

Located in Belmont, MA, McLean Hospital delivers extensive rehabilitation services aimed at adults and young adults dealing with substance abuse and related mental health issues. The center features inpatient detoxification and treatment options, excelling in methods such as 12-step facilitation, cognitive behavioral therapy, and motivational interviewing. With customized programs designed for active-duty military personnel, as well as adult men and women, individualized care is a key focus. Catering to both male and female clients, the facility emphasizes high-quality care for those on their recovery journey. If you or someone close to you requires expert support for substance use and mental health challenges, McLean Hospital provides a nurturing space for healing and personal development.

Meadows
Wickenburg, AZ

Meadows, situated in Wickenburg, AZ, is a leading rehabilitation facility that specializes in treating substance use disorders along with related mental health challenges. The center features long-term residential care, detoxification services, and round-the-clock support for both adults and young adults. Utilizing targeted modalities like 12-step approaches, cognitive behavioral therapy, and trauma-informed care, Meadows effectively addresses the needs of individuals facing complex issues. Additionally, the center provides tailored programs for those managing both pain and substance use problems. Committed to offering top-notch, evidence-based treatment, Meadows serves clients of all genders within a nurturing and therapeutic atmosphere.

Meadows Integrated Outpatient Services

Meadows Integrated Outpatient Services, situated in Syracuse, NY, delivers extensive care for individuals facing substance abuse issues and accompanying mental health challenges across all age groups. The facility features robust intensive outpatient and standard outpatient programs, alongside dedicated treatments utilizing methadone/buprenorphine and naltrexone. Emphasizing 12-step principles, anger control techniques, and concise therapeutic interventions, the center supports adult women, young people, and those managing dual diagnoses. Open to all genders and age ranges, including seniors, Meadows Integrated Outpatient Services is committed to providing personalized recovery and mental wellness support.

Meadows Malibu
Malibu, CA

Situated in Malibu, California, Meadows Malibu delivers extensive rehabilitation programs for both adults and young adults facing challenges with substance abuse and concurrent mental health issues. The center features tailored initiatives for adult men, women, and those who have dealt with trauma, offering inpatient detox services and treatment within a nurturing atmosphere. Through methods like 12-step support, anger management techniques, and brief interventions, the facility emphasizes personalized care that meets the unique requirements of each client. Meadows Malibu is committed to offering exceptional, gender-focused treatment to support clients in attaining sustainable recovery and enhanced mental health.

Meadows Texas
Princeton, TX

Situated in Princeton, TX, Meadows Texas delivers a wide range of services for the treatment of addiction, catering to both adults and young adults. The facility offers extended residential care, detox programs, and round-the-clock residential assistance. Emphasizing techniques such as 12-step support, cognitive behavioral therapy, and motivational interviewing, the center customizes its approach to meet the unique requirements of each client. Meadows Texas excels in providing support for adult men and women, including those with a history of trauma. Its gender-specific programs foster a nurturing atmosphere for individuals of both sexes who are on their recovery journey. With a strong commitment to high-quality treatment and research-backed methods, Meadows Texas strives to empower individuals in achieving enduring sobriety.

Mechanicsburg Comprehensive Trt Ctr

Mechanicsburg Comprehensive Trt Ctr, situated in Mechanicsburg, PA, delivers extensive substance abuse recovery programs for adults and adolescents. This center features outpatient, methadone/buprenorphine or naltrexone outpatient care, and standard outpatient offerings. Their treatment expertise lies in cognitive behavioral therapy, the Matrix Model, and motivational interviewing. Specialized services are available for individuals with HIV or AIDS and for pregnant or postpartum women. Emphasizing personalized recovery plans, the center supports both male and female patients, cultivating an encouraging and welcoming atmosphere for everyone pursuing sobriety.

MedStar Montgomery Medical Center

MedStar Montgomery Medical Center, located in Olney, MD, provides a wide range of addiction recovery programs designed for both adults and children/adolescents facing substance use challenges and related mental health concerns. Its specialized inpatient offerings include detox services and continuous hospital care, emphasizing the 12-step model, short-term interventions, and cognitive behavioral therapy. The center designs customized programs for adult women, adolescents, and individuals with co-occurring disorders. Committed to delivering high-quality care, this facility serves both male and female patients in need of compassionate and effective rehabilitation support.

MedMark Treatment Centers

Situated in Hayward, CA, MedMark Treatment Centers provides outpatient detox services and treatment for individuals dealing with substance use issues, including both adults and young adults. The center features specialized programs designed for pregnant and postpartum women, addressing their distinct requirements. Emphasizing 12-step programs, anger management, and brief intervention strategies, the facility aims to deliver thorough support for those on their path to recovery. MedMark Treatment Centers also facilitates outpatient treatment options using methadone, buprenorphine, or naltrexone. Their services are available for both men and women, ensuring high-quality care within a supportive and professional setting.

MedMark Treatment Centers

MedMark Treatment Centers located in Sacramento, CA, deliver specialized outpatient services aimed at detoxification and addressing substance use disorders. The center employs methods such as cognitive behavioral therapy, contingency management, and the Matrix Model to furnish personalized treatment for adults, children, and adolescents alike. With options for outpatient detoxification and medications like methadone, buprenorphine, or naltrexone, MedMark meets a variety of treatment needs. Their commitment to individualized care ensures that each treatment plan is customized for the client. Catering to both men and women, the facility emphasizes high-quality, evidence-based care. If you or someone you care about is looking for effective recovery solutions in Sacramento, MedMark Treatment Centers is a commendable choice.

McPike Addiction Treatment Center

The McPike Addiction Treatment Center, situated in Utica, NY, specializes in providing extensive care for adults and young adults struggling with substance use disorders alongside significant mental health challenges. This center features personalized 12-step programs, techniques for managing anger, and cognitive behavioral therapy available in both inpatient and around-the-clock treatment environments. With dedicated programs for adult men, women, and individuals with trauma backgrounds, McPike ensures that each client receives customized support regardless of gender. The center is committed to offering top-notch, evidence-backed therapeutic interventions to aid clients in their recovery journey.

McKinley Hall Inc
Springfield, OH

Located in Springfield, OH, McKinley Hall Inc delivers a wide array of addiction recovery services. The facility features intensive outpatient programs, outpatient services, and treatments utilizing methadone, buprenorphine, or naltrexone. Emphasizing 12-step support, cognitive behavioral therapy, and the Matrix Model, this center serves adult clients, including those who have faced traumatic experiences. With specialized programs for both men and women, McKinley Hall Inc is dedicated to providing high-quality care and a variety of treatment options, making it an essential support for individuals on their path to overcoming substance use issues.

McKinley Hall Inc
Springfield, OH

McKinley Hall Inc, situated in Springfield, Ohio, delivers a wide range of addiction recovery services aimed at both adults and young adults. The center specializes in detoxification and substance abuse treatment through various levels of care, including intensive outpatient, outpatient, and day programs. Emphasizing techniques such as 12-step support, anger management, and brief interventions, the facility serves adult men and women, and it also addresses the needs of clients with a history of sexual trauma. Known for its customized care plans for both genders, McKinley Hall Inc is recognized for its dedication to providing high-quality rehabilitation services.

MedMark Treatment Centers

MedMark Treatment Centers located in Savannah, GA, provide outpatient programs for individuals dealing with substance use issues, incorporating treatments like methadone, buprenorphine, and naltrexone. The center employs scientifically supported methods including cognitive behavioral therapy, the Matrix Model, and motivational interviewing techniques. Specialized programs are designed for active duty service members, as well as adult men and women. The facility addresses the needs of both male and female adults and young adults, delivering personalized care to ensure effective treatment. Committed to high-quality, individualized support, MedMark Treatment Centers in Savannah strive to assist individuals in conquering addiction and attaining sustainable recovery.

MedMark Treatment Centers

MedMark Treatment Centers, located in Fairfield, CA, provides outpatient services for substance use disorders, featuring options such as outpatient methadone, buprenorphine, or naltrexone therapy. Their methodology incorporates techniques like anger management, brief intervention, and cognitive behavioral therapy. This center is distinguished by its customized treatment plans designed for adults and young adults across all genders. Emphasizing high-quality care, MedMark Treatment Centers in Fairfield offers a nurturing atmosphere for individuals aiming for effective and tailored addiction recovery solutions.

Meadow Run
Rhinebeck, NY

Situated in Rhinebeck, NY, Meadow Run is a dedicated rehabilitation center that provides long-term residential options along with round-the-clock care for women facing challenges related to substance use disorders. The center offers customized treatment plans that incorporate 12-step facilitation, anger management techniques, and brief interventions. Meadow Run is particularly notable for its commitment to helping clients who have encountered issues such as intimate partner violence, domestic abuse, and sexual trauma. Catering to adults, seniors, and young adults, this center creates a secure and compassionate atmosphere for female clients. Meadow Run is dedicated to delivering exceptional care and individualized support to facilitate the recovery process.

MedMark Treatment Centers

MedMark Treatment Centers located in Blairsville, GA, specialize in outpatient services for adults and young adults dealing with substance use issues. The facility provides treatment options including methadone/buprenorphine and naltrexone, in addition to standard outpatient programs. Various methods such as 12-step facilitation, anger management, and brief interventions are employed in the rehabilitation process. Tailored programs are available for adult men, adult women, and pregnant or postpartum women, ensuring that both genders receive specific attention to their unique needs. The center prioritizes high-quality care and customized support, making it a crucial option for those in need of effective addiction recovery services.

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McLean Ambulatory and Residential, situated in Petersham, MA, delivers exceptional care for substance use disorders, with specialized expertise in treating individuals facing co-occurring serious mental health conditions or emotional disruptions. The center offers both residential and short-term residential options, serving adults and young adults of all genders. Their recovery approach is rooted in evidence-based practices, including 12-step facilitation, cognitive behavioral therapy, and motivational interviewing. Notably, McLean Ambulatory and Residential provides distinct programs tailored for active duty military members, adult men, and adult women, underscoring their commitment to personalized support for lasting sobriety and improved mental well-being.

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Princeton, MA

McLean Fernside located in Princeton, MA, provides extensive treatment for substance use disorders among adults and young adults facing significant mental health challenges or emotional issues. The center offers a variety of programs, including long-term, short-term, and 24-hour residential options, employing proven methodologies such as 12-step principles, anger management techniques, and cognitive behavioral therapy. With dedicated services designed for adult men, women, and those who have encountered trauma, McLean Fernside customizes its treatment plans to meet the unique needs of each individual. Both male and female participants benefit from high-quality, gender-sensitive care in a nurturing atmosphere aimed at fostering long-term recovery and overall wellness.

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Situated in Harlowton, MT, Meadowlark Counseling provides accessible care for individuals battling substance abuse. They also offer expert support for those managing both addiction and significant mental health challenges. Employing proven therapeutic methods such as cognitive behavioral therapy and motivational interviewing, the facility crafts personalized recovery strategies aimed at preventing future relapse. Their offerings include a dedicated program for adult women, as well as services catering to adults and young adults across all gender identities. Meadowlark Counseling is devoted to delivering high-quality, individualized support, establishing them as a dependable resource for recovery in the region.

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Monroe, NC

Medasic Monroe, situated in Monroe, NC, delivers extensive addiction treatment services for adults and young adults. The center features outpatient care, including methadone/buprenorphine or naltrexone treatments, and standard outpatient programs. Emphasizing relapse prevention and counseling for substance use disorders, Medasic Monroe also provides virtual therapy sessions. The facility serves active duty military members, adult males, and adult females, offering specialized attention to diverse populations. Their individualized approach ensures personalized care and robust support for individuals on their journey to recovery from addiction.

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Goldsboro, NC

Situated in Goldsboro, NC, Medical Care Inc provides extensive outpatient rehabilitation services. The facility is dedicated to detoxification, treatment for substance use issues, and managing co-occurring disorders in both adults and children. Treatment options comprise outpatient services, day treatment, partial hospitalization, and outpatient detox. Emphasizing anger management, brief interventions, and cognitive behavioral therapy, the center ensures personalized care that meets the unique needs of each individual. Catering to adults and seniors of any gender, Medical Care Inc distinguishes itself through its committed approach to tackling substance use and mental health challenges. Experience exceptional care and support at this distinguished rehabilitation facility.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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