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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Mid State Health Center

Mid State Health Center, based in Plymouth, NH, delivers extensive treatment options for adults and young adults facing substance use challenges. This establishment features programs such as intensive outpatient care, outpatient services, and treatments involving methadone, buprenorphine, or naltrexone. With a focus on specialized methods including 12-step support, anger management, and brief intervention strategies, the center serves both men and women. Furthermore, Mid State Health Center includes dedicated programs for pregnant and postpartum women, ensuring customized care for every client. The center's dedication to high-quality services and a variety of treatment pathways positions it as an essential asset for individuals in search of supportive and effective addiction recovery solutions.

Mid State Health Center

Mid State Health Center, situated in Plymouth, NH, delivers extensive addiction recovery services for adults and young adults. Their offerings encompass outpatient care such as medication-assisted treatment (methadone/buprenorphine or naltrexone), general outpatient programs, brief counseling, cognitive behavioral therapy, and motivational strategies. They also feature a dedicated program for expectant and new mothers. Mid State Health Center is equipped to address the diverse requirements of every patient, serving both male and female individuals with their evidence-based and individualized approach to care. For those in search of impactful and tailored addiction treatment, Mid State Health Center stands ready to assist in your path to wellness.

Middlesex Recovery PC

Middlesex Recovery PC, located in Norton, MA, delivers dedicated treatment for substance use issues among both adults and young adults. The facility offers various outpatient services, such as treatments involving methadone, buprenorphine, and naltrexone, alongside standard outpatient programs and customized care plans. Incorporating techniques like cognitive behavioral therapy, motivational interviewing, and counseling specific to substance use disorders, this center is committed to meeting the unique requirements of each client. With a strong emphasis on personalized strategies, Middlesex Recovery PC serves both men and women in search of thorough and effective solutions for addiction recovery. Discover high-quality care and individualized assistance at this esteemed rehabilitation center.

Middletown Clinic
Middletown, NY

Situated in Middletown, NY, the Middletown Clinic delivers extensive outpatient services for adults and seniors dealing with substance use issues. The center features targeted programs designed for men, women, and individuals who have faced sexual abuse. Treatment modalities encompass 12-step facilitation, brief interventions, and cognitive behavioral therapy, ensuring that care is tailored to each individual's needs. With options for outpatient methadone/buprenorphine or naltrexone treatment, the facility addresses a wide range of client requirements. The Middletown Clinic emphasizes high-quality care and personalized programs, serving as a crucial support system for those pursuing effective addiction recovery.

MidState Health Center

MidState Health Center, located in Bristol, NH, provides a wide range of outpatient services for adults and young adults struggling with substance use disorders. Their offerings encompass outpatient treatments using methadone, buprenorphine, or naltrexone, as well as standard outpatient therapy, brief interventions, cognitive behavioral therapy, and motivational incentives through contingency management. The center particularly excels in supporting pregnant and postpartum women, offering specialized care for both male and female clients. Emphasizing personalized treatment plans and evidence-based methodologies, MidState Health Center is dedicated to delivering effective support for individuals seeking recovery from addiction.

Midwest Center Youngstown

Situated in Youngstown, OH, Midwest Center Youngstown provides extensive care for individuals struggling with addiction, catering to both adults and young adults. Their services encompass detoxification, comprehensive substance use therapy, and individualized treatment plans. The center employs various therapeutic approaches, including 12-step facilitation, anger management techniques, and brief interventions, available through intensive outpatient, outpatient, and standard outpatient programs. Midwest Center Youngstown distinguishes itself with gender-specific tracks for men and women, fostering a secure and welcoming atmosphere. Committed to high standards of care and personalized strategies, the facility is devoted to supporting clients on their journey to sustained recovery.

Midwest Detox
Brookfield, WI

Midwest Detox, situated in Brookfield, WI, delivers expert residential detoxification solutions. This center ensures continuous care for adult men and women, as well as young adults, employing diverse therapeutic methods. Their treatment strategies include 12-step program support, emotional regulation techniques, and cognitive behavioral interventions, all tailored to each person's specific requirements. Midwest Detox distinguishes itself through its dedication to individualized support and fostering long-term sobriety. For a thorough detox experience that acknowledges your specific circumstances, this establishment provides a nurturing space to embark on your path to recovery.

Midwest Detox Center

Midwest Detox Center, situated in Maumee, OH, delivers extensive addiction recovery solutions for adolescents and adults. Their offerings encompass detoxification protocols, comprehensive substance use disorder therapy, and targeted interventions for individuals facing dual diagnoses of substance abuse and significant mental health conditions or severe emotional disturbances in youth. The center provides a range of treatment modalities, including extended residential stays, partial hospitalization programs, and standard outpatient services, accommodating a wide spectrum of recovery requirements. Dedicated programs are also available for active military members, adult men, and adult women. Employing therapeutic strategies like 12-step integration, emotional regulation training, and short-term counseling, Midwest Detox Center is committed to personalized treatment plans. This establishment fosters a nurturing setting conducive to healing and enhances overall wellness.

Midwest Recovery Center

Midwest Recovery Center, based in Toledo, OH, delivers a diverse array of rehabilitation services. This center focuses on treating substance use issues and effectively manages co-occurring disorders related to drug and alcohol abuse as well as mental health challenges. The offerings include intensive outpatient programs, standard outpatient services, and day treatment. Utilizing methods like 12-step programs, anger management strategies, and brief therapeutic interventions, the facility serves both adults and young adults from various backgrounds. Additionally, specialized programs are available for active-duty military personnel, men, and women. Midwest Recovery Center is committed to offering exceptional care and guidance to assist individuals in their recovery process.

Milestone Recovery

Milestone Recovery, situated in Phoenix, AZ, delivers a full spectrum of addiction treatment for adults and adolescents. The center features intensive outpatient, extended residential stays, and outpatient services, emphasizing 12-step principles, emotional regulation techniques, and short-term counseling. Tailored programs are available for military personnel, adult males, and adult females, guaranteeing personalized support. Beyond substance abuse, Milestone Recovery also manages dual-diagnosis conditions affecting adults and youths. Committed to high standards of care, Milestone Recovery is devoted to guiding individuals toward lasting sobriety.

MidMichigan Community Health Services

MidMichigan Community Health Services, located in Houghton Lake, MI, delivers specialized outpatient care focused on substance dependency, detoxification, and the management of co-occurring mental health conditions for individuals of all ages. Their services encompass outpatient detox, medication-assisted treatment using methadone, buprenorphine, and naltrexone. Therapeutic modalities employed include 12-step facilitation, brief intervention, and cognitive behavioral therapy. The center is equipped to assist adult men and women, including survivors of intimate partner violence, and offers gender-specific programming for adults and young adults. A commitment to exceptional care and personalized recovery strategies is central to their mission.

Mile High Treatment and Recovery Inc

Mile High Treatment and Recovery Inc, situated in Denver, CO, provides outpatient detox and treatment for both adults and young adults dealing with substance use issues. The center is dedicated to relapse prevention, offers specialized counseling for substance use disorders, and incorporates telehealth services. Prioritizing personalized care, this facility administers outpatient options, including methadone/buprenorphine or naltrexone treatments, alongside traditional outpatient programs. Catering to a diverse clientele, Mile High Treatment and Recovery Inc is distinguished by its customized strategies for recovery, delivering extensive and quality services that assist individuals in their journey toward health and recovery.

Milestone Addiction Treatment LLC

Milestone Addiction Treatment LLC, located in Merchantville, NJ, delivers a full spectrum of care for individuals struggling with substance use disorders. They offer various levels of outpatient treatment, including intensive, standard, and regular programs, all customized to meet each client's specific requirements. Their treatment methodologies emphasize 12-step principles, anger management techniques, and brief intervention strategies, making them well-equipped to address co-occurring mental health conditions. Additionally, Milestone Addiction Treatment LLC provides targeted support for active military personnel, adult men, and women. The center is open to all genders, fostering a welcoming atmosphere conducive to successful recovery.

Middlesex Recovery PC
Gloucester, MA

Middlesex Recovery PC, located in Gloucester, MA, provides thorough treatment for substance use disorders via outpatient services, which include options for methadone, buprenorphine, or naltrexone. The center employs scientifically-backed methods such as cognitive behavioral therapy, motivational interviewing, and strategies for preventing relapse in order to assist individuals on their recovery path. With a commitment to personalized care, Middlesex Recovery PC serves adults and young adults of any gender. Their customized programs focus on delivering high-quality treatment that meets the distinct needs of each individual, fostering a supportive and effective rehabilitation experience for those seeking assistance with addiction.

Middlesex Recovery PC

Middlesex Recovery PC, located in Stoughton, MA, specializes in providing outpatient treatment options for substance use tailored to both adults and young adults. The center employs a variety of proven methodologies, such as cognitive behavioral therapy, motivational interviewing, and counseling focused on substance use disorders. With a strong emphasis on customized care, Middlesex Recovery PC guarantees that every client receives focused attention. The center offers outpatient treatment alternatives, including methadone, buprenorphine, and naltrexone, to meet a variety of needs. Open to all genders, it serves individuals pursuing meaningful and compassionate recovery from addiction. Middlesex Recovery PC distinguishes itself through its dedication to high-quality care and extensive support for those on their journey to healing.

Mid Plains Center for
Grand Island, NE

Mid Plains Center, located in Grand Island, NE, delivers extensive outpatient care for adults and children needing assistance with withdrawal, addiction, and concurrent mental health conditions. Employing therapeutic methods such as anger control, short-term counseling, and motivational conversation, this establishment offers personalized support designed for each individual's unique requirements. Featuring targeted programs for adult and elderly clients of any gender, the center cultivates a nurturing setting conducive to healing. Its distinctive strength lies in its client-centered philosophy, prioritizing excellent service and proven therapeutic techniques for sustained abstinence and overall mental well-being.

Middle Peninsula/Northern Neck CSB

Middle Peninsula/Northern Neck CSB in Tappahannock, VA, provides a wide array of addiction recovery services for adults and seniors. This center features intensive outpatient programming, regular outpatient services, and detoxification options. Emphasizing 12-step support, anger management, and brief intervention techniques, the facility addresses the needs of individuals facing both mental health challenges and substance use disorders. Moreover, it is experienced in working with adolescents and those dealing with simultaneous pain management issues and substance dependencies, offering personalized programs for both male and female clients. The facility's commitment to quality care and variety of treatment modalities establish it as an essential resource for individuals pursuing effective rehabilitation in Tappahannock.

Middle Peninsula/Northern Neck CSB

Middle Peninsula/Northern Neck CSB in Gloucester, VA, delivers extensive addiction treatment for individuals of all ages facing co-occurring mental health challenges. Their services include robust outpatient options and intensive programs, complemented by detoxification support. Employing methods like 12-step facilitation and anger management, they craft customized recovery plans. Dedicated tracks for teens and older adults, alongside specialized care for those with concurrent pain and substance use issues, underscore their commitment to all-encompassing recovery. Prioritizing excellence and individualized support, this center is devoted to guiding clients toward lasting wellness.

Mile High Behavioral Healthcare

Nestled in Westminster, Colorado, Mile High Behavioral Healthcare is dedicated to providing specialized care for adults struggling with substance use disorders, with a particular emphasis on individuals experiencing co-occurring serious mental health conditions. The center features a range of residential treatment options, including extended stays, continuous 24-hour supervision, and shorter program durations. Employing evidence-based strategies such as 12-step facilitation and anger management techniques, the facility is equipped to support adult women who have experienced intimate partner violence, domestic abuse, or sexual trauma. Mile High Behavioral Healthcare serves a diverse clientele encompassing adults, seniors, and young adults, cultivating a secure and nurturing setting for women pursuing thorough recovery. Discover personalized attention and impactful therapeutic interventions at Mile High Behavioral Healthcare.

Mile High Council on Alcoholism and

The Mile High Council on Alcoholism, situated in Denver, CO, delivers extensive substance abuse services for individuals of all ages, addressing co-occurring mental health conditions. They offer various levels of care, including intensive outpatient, outpatient, and medication-assisted treatment with methadone or buprenorphine. Employing proven methods such as cognitive behavioral therapy and community reinforcement, the center has distinct programs for teenagers, adult men, and women, welcoming diverse populations. Support extends to transitional housing and halfway house arrangements, fostering a nurturing atmosphere for recovery. Committed to serving adults and seniors across all gender identities, this facility is dedicated to providing personalized, high-quality care.

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The Midwestern CT Council of Alcoholism, located in Torrington, CT, provides tailored programs for substance use recovery in a supportive atmosphere. Emphasizing intensive outpatient treatment as well as various outpatient options, this center offers thorough assistance for both adults and young adults. It employs methods such as anger management, brief interventions, and cognitive behavioral therapy, accommodating clients of all genders. Distinct programs are designed for adult men, adult women, and those who have undergone intimate partner or domestic violence. The center's dedication to personalized care and proven treatment strategies guarantees effective support for individuals on their path to overcoming substance use challenges.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)