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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Northeast Ohio VA Healthcare System

Situated in Cleveland, OH, the Northeast Ohio VA Healthcare System delivers a wide range of rehabilitation services for adults and young adults dealing with substance abuse issues and associated mental health challenges. The center offers intensive outpatient care, outpatient detoxification, and various outpatient programs that incorporate methods such as 12-step facilitation, anger management, and brief intervention strategies. Customized programs are designed specifically for adult men, adult women, and veterans. Emphasizing personalized care, this facility guarantees high-quality treatment for both genders, serving as an essential resource for individuals pursuing specialized addiction recovery options in Northeast Ohio.

Northeast Treatment Centers

Northeast Treatment Centers, located in Philadelphia, PA, provides a wide array of substance abuse treatment options for adults dealing with severe mental health issues alongside those of children facing significant emotional challenges. The center specializes in intensive outpatient services, general outpatient care, and targeted outpatient medication-assisted treatments with methadone, buprenorphine, or naltrexone. Utilizing evidence-based methods like brief interventions, cognitive behavioral therapy, and motivational interviewing, the center caters to specific needs through customized programs for adolescents, men, and women. Prioritizing both gender and age-specific care, Northeast Treatment Centers is committed to delivering high-quality support and rehabilitation for those in need.

Northeastern Health System

Northeastern Health System, situated in Tahlequah, OK, delivers a complete spectrum of addiction recovery programs. The facility offers detox, addiction treatment, and tailored support for adults facing dual diagnoses of substance use and significant mental health conditions, alongside children experiencing severe emotional distress. Northeastern Health System employs proven strategies like anger management, brief intervention, and cognitive behavioral therapy within its treatment modalities, which include intensive outpatient, general outpatient, and outpatient detox. The center welcomes diverse groups, such as active military, teenagers, adult males, adults in general, and older adults, providing focused interventions to address their distinct requirements. Northeastern Health System is committed to providing excellent care for all individuals, regardless of gender, seeking impactful recovery services.

Northern Arizona VA Healthcare System

The Northern Arizona VA Healthcare System, situated in Prescott, AZ, provides dedicated programs for adults grappling with substance abuse issues alongside significant mental health conditions. Their comprehensive services encompass intensive outpatient and outpatient care, featuring medication-assisted treatments like methadone, buprenorphine, or naltrexone, available to both adults and young adults. Employing strategies such as 12-step facilitation, anger management techniques, and brief intervention methods, the center delivers personalized support to active duty military personnel, adult men, and adult women. Prioritizing high standards and personalized care, this facility fosters a nurturing atmosphere for individuals striving to recover from addiction and mental health difficulties.

Northeastern Counseling Center

Northeastern Counseling Center, situated in Roosevelt, UT, delivers a full spectrum of recovery support for adults and older individuals facing addiction and related mental health challenges. Their offerings include robust outpatient programs, standard outpatient services, and tailored interventions for young people, adult men, and women. Utilizing therapeutic methods such as 12-step integration, cognitive behavioral therapy, and brief counseling, the center supports both male and female patients. Furthermore, Northeastern Counseling Center provides transitional housing and sober living environments to assist with sustained recovery. Clients can anticipate empathetic guidance and proven therapeutic strategies at this respected recovery facility.

Northeast Ohio VA Healthcare System

Situated in Youngstown, OH, the Northeast Ohio VA Healthcare System delivers focused treatment for substance use disorders in adults dealing with concurrent mental health challenges. This facility features intensive outpatient programs and customized services for individuals impacted by intimate partner violence, offering thorough care for adult men and women alike. Their treatment methodology incorporates 12-step support, anger management techniques, and short-term interventions, promoting an all-encompassing recovery journey. Catering to both younger and older adults, the center prioritizes personalized care to foster healing and enhance overall health.

Northeast Ohio VA Healthcare System

The Northeast Ohio VA Healthcare System in Elyria, OH, delivers extensive substance use disorder services for adults and young adults. This institution features robust intensive outpatient programs, outpatient medication-assisted treatment options (methadone, buprenorphine, naltrexone), and dedicated support for individuals facing concurrent serious mental health conditions or emotional disruptions. Emphasizing approaches such as 12-step facilitation, anger management, and brief intervention strategies, the center supports adult men and women, including survivors of intimate partner violence. The Northeast Ohio VA Healthcare System is committed to providing high-quality, individualized care to address the unique requirements of each patient.

Northeast Ohio VA Healthcare System

The Northeast Ohio VA Healthcare System, situated in Willoughby, OH, provides comprehensive rehabilitative programs designed for adults and young adults confronting substance use disorders and co-occurring severe mental health challenges. Their services encompass intensive outpatient programs, general outpatient support, and medication-assisted treatment options such as methadone, buprenorphine, or naltrexone. Emphasizing approaches like 12-step facilitation, anger management, and brief intervention, the center is equipped to support adult men, women, and individuals affected by intimate partner or domestic violence. By offering individualized care plans tailored to diverse age demographics and genders, this facility is dedicated to delivering exceptional support for those pursuing recovery from addiction.

Northeastern Counseling Center

Situated in Vernal, UT, the Northeastern Counseling Center delivers a wide range of substance abuse treatment and tailored support for those facing significant mental health challenges or emotional issues. Emphasizing intensive outpatient and outpatient programs, the center employs proven methods like 12-step facilitation, brief interventions, and cognitive behavioral therapy. They have specialized initiatives for teenagers, women, and individuals affected by trauma. The center is dedicated to serving adults and seniors of every gender and aims to provide high-quality, personalized care to foster enduring recovery and enhance overall wellness.

Northeast Ohio VA Healthcare System

Situated in New Philadelphia, OH, the Northeast Ohio VA Healthcare System provides comprehensive services for individuals dealing with substance use issues alongside co-existing mental health challenges, catering to both adults and children. This facility features intensive outpatient programs as well as outpatient treatment options with methadone, buprenorphine, or naltrexone therapies. It employs a variety of therapeutic techniques, including 12-step facilitation, anger management, and brief intervention strategies. The center offers specialized programs designed for adult men, women, and those who have faced intimate partner violence. Committed to delivering high-quality care, the center focuses on custom treatment plans to assist individuals in their recovery journey, serving people of all genders across different age groups.

Northeast Ohio VA Healthcare System

Northeast Ohio VA Healthcare System in Akron, OH, provides targeted rehabilitation for adults and young adults grappling with addiction and concurrent serious mental health challenges. Their structured outpatient services incorporate medication-assisted treatment, including methadone/buprenorphine or naltrexone. Core therapeutic elements comprise 12-step support, emotional regulation techniques, and concise counseling strategies, all adapted to individual requirements. Specialized care is available for adult men, adult women, and survivors of intimate partner abuse, offering distinct support pathways. Northeast Ohio VA Healthcare System is dedicated to delivering effective, research-backed treatment for all genders seeking recovery.

Northeastern Center Inc
Kendallville, IN

Situated in Kendallville, IN, Northeastern Center Inc delivers targeted outpatient care for those dealing with substance use issues, alongside treatment for co-existing substance use disorders and severe mental health challenges in adults, as well as serious emotional disturbances in children. The center offers a range of outpatient options, including methadone/buprenorphine or naltrexone therapy, traditional outpatient care, and incorporates several methodologies such as anger management, brief intervention techniques, and cognitive behavioral therapy. With a commitment to assisting clients facing both mental health and substance use disorders, Northeastern Center Inc provides its services to adults and seniors of all genders, ensuring a high standard of care and support for those in need of extensive rehabilitation services.

Northeastern Center Inc

Situated in Auburn, IN, Northeastern Center Inc delivers extensive addiction recovery services for both adults and young adults. The center is renowned for its expertise in detoxification, treatment for substance use, and addressing co-occurring mental health conditions. Emphasizing short-term interventions, Northeastern Center Inc offers inpatient detox and around-the-clock medical support. They serve a diverse clientele, including both men and women dealing with simultaneous mental health and substance use challenges. Recognized for their high standards of care and tailored programs, this facility is an excellent option for those pursuing combined treatment for addiction and mental health concerns.

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The Northeast Ohio VA Healthcare System located in Ravenna, OH provides extensive substance abuse rehabilitation for adults facing significant mental health challenges, as well as emotional issues in children. Their offerings encompass intensive outpatient programs, outpatient care, and treatments involving methadone/buprenorphine or naltrexone. The center employs methods such as 12-step programs, anger management strategies, and brief intervention techniques. It serves a diverse clientele, including adult men and women, as well as individuals who have undergone domestic or intimate partner violence. This facility is dedicated to delivering tailored care in a nurturing setting, facilitating the healing and recovery process for adults and young adults of all backgrounds.

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The Northeast Ohio VA Healthcare System, situated in East Liverpool, OH, provides extensive care for substance use issues affecting adults and younger individuals. This center excels in addressing dual diagnoses, specifically substance use disorders alongside significant mental health conditions in adults, and severe emotional challenges in children. Their treatment modalities include intensive outpatient, standard outpatient, and outpatient medication-assisted treatment (methadone/buprenorphine or naltrexone), incorporating strategies like 12-step facilitation, anger management, and brief intervention techniques. Tailored services are available for adult men, adult women, and individuals who have faced intimate partner or domestic violence. The facility welcomes both male and female patients, committed to delivering high-quality support for those on their path to recovery.

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Situated in Wilmington, DE, Northeast Treatment Center delivers extensive addiction recovery services for adults and young adults. This establishment features inpatient detoxification and treatment programs, complemented by around-the-clock support. The center employs proven methodologies, including 12-step facilitation, cognitive behavioral therapy, and brief intervention techniques. Northeast Treatment Center is adept at addressing clients with dual diagnoses of mental health and substance use disorders, providing customized programs for both adult men and women. With an emphasis on superior care and personalized treatment strategies, this center is committed to assisting clients in attaining enduring recovery from addiction.

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Northeast Treatment Centers, situated in Philadelphia, PA, provides a wide range of outpatient services designed for those grappling with substance abuse and related mental health concerns. This facility is dedicated to delivering focused care for adults facing significant mental health challenges as well as for children experiencing emotional difficulties. Utilizing methods such as cognitive behavioral therapy, contingency management, and the Matrix Model, their treatment plans are customized to suit the unique needs of each patient. Specific initiatives are available for adult men, adult women, and those with co-occurring disorders. Catering to individuals of all ages and backgrounds, Northeast Treatment Centers strives to offer exceptional support on the journey to recovery.

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Situated in LaGrange, IN, Northeastern Center Inc delivers focused outpatient services for individuals dealing with substance abuse and concurrent mental health issues, addressing both adults and children. The center employs a variety of evidence-supported methods such as anger management, cognitive behavioral therapy, and short-term interventions. Customized programs are designed for clients facing dual diagnoses. Northeastern Center Inc serves adults and seniors of all genders, providing outpatient services that include methadone/buprenorphine or naltrexone treatments alongside standard outpatient support. Committed to high-quality care and personalized treatment strategies, this center is resolute in guiding individuals towards their recovery journey.

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Northeastern Center Inc, situated in Auburn, IN, delivers a wide array of outpatient services aimed at treating substance use issues and co-occurring disorders in both adults and children. The center offers treatment options that include outpatient methadone, buprenorphine, and naltrexone therapies, alongside standard outpatient care. Utilizing evidence-based methodologies like cognitive behavioral therapy, anger management, and brief interventions, the facility ensures a well-rounded approach. There are specialized programs designed for adolescents as well as adult men and women, providing tailored support for individuals of all ages and genders. With a reputation for exceptional care and personalized treatment plans, Northeastern Center Inc is a leading option for those in search of effective rehabilitation services in the area.

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Northeastern Center Inc, situated in Angola, IN, provides targeted outpatient services for individuals of all ages grappling with substance use and co-occurring mental health conditions. The center employs diverse therapeutic strategies such as anger management, brief intervention, and motivational interviewing to foster healing and sustained recovery. This facility is equipped to support adult women and those experiencing both mental health and substance use challenges. Northeastern Center Inc is dedicated to delivering thorough care and personalized treatment plans for adults and seniors across all genders. Patients can anticipate excellent and empathetic assistance, whether they require standard outpatient services or specialized medication-assisted treatment like methadone or buprenorphine, as they pursue a path to improved well-being.

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Northern Erie Clinical Services, situated in Buffalo, NY, provides extensive care for individuals struggling with substance use disorders via its outpatient services for adults and young adults. Their expertise encompasses medication-assisted treatment (methadone/buprenorphine or naltrexone), 12-step facilitation, brief intervention techniques, and cognitive behavioral therapy. The center is dedicated to offering personalized support to adult men and women, including those facing dual diagnoses of mental health and substance use conditions. Committed to excellence, Northern Erie Clinical Services develops distinct treatment strategies for each patient to foster successful recovery for all clients pursuing addiction treatment.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)