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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Ona Treatment Center
Browns Valley, CA

Ona Treatment Center, situated in Browns Valley, CA, delivers extensive care for adults and adolescents facing addiction and co-occurring mental health challenges. The center provides a range of program lengths, including extended, live-in, and brief durations, utilizing specialized therapeutic methods such as 12-step support, emotion regulation training, and brief counseling. Distinctive offerings are available for individuals with a history of trauma or dual diagnoses. Catering to both men and women, this institution is dedicated to offering high-caliber support and a secure, organized setting for those pursuing sobriety.

Onward Behavioral Health

Onward Behavioral Health, situated in Hammonton, NJ, provides a wide array of addiction recovery services tailored for both adults and young adults. The center specializes in inpatient detoxification and treatment targeting substance use disorders alongside overlapping mental health issues. Onward Behavioral Health creates customized programs for various demographics, including active military personnel, men, and women. Utilizing evidence-based methods like 12-step facilitation, anger management strategies, and brief therapeutic interventions, the center prioritizes effective treatment. With an emphasis on personalized care and high-quality service, this facility stands out as an excellent option for individuals on their journey to recovery from addiction.

OneEighty
Wooster, OH

OneEighty, situated in Wooster, OH, delivers a full spectrum of addiction recovery options for individuals of all ages. The facility offers detox, substance abuse therapy, and tailored interventions for those affected by domestic abuse, past traumas, or legal system involvement. Employing intensive outpatient, standard outpatient, and day treatment models, OneEighty incorporates proven methods like 12-step support, anger control techniques, and brief therapeutic strategies. Catering to both men and women, this center is committed to delivering effective treatment and assistance for anyone navigating addiction and its associated difficulties.

OnTrack Inc
Medford, OR

OnTrack Inc in Medford, OR, is dedicated to assisting individuals in their journey toward overcoming addiction and concurrent mental health challenges. The center delivers robust outpatient care, including intensive, day treatment, and partial hospitalization options. Utilizing proven therapeutic methods like cognitive behavioral therapy, anger management techniques, and brief intervention strategies, OnTrack Inc supports both adults and young people. Specialized initiatives are available for teenagers, adult men, and adult women, providing customized support. OnTrack Inc distinguishes itself through its commitment to high-quality, personalized treatment plans, offering a reliable haven for those pursuing lasting recovery.

Operation PAR Inc
North Fort Myers, FL

Operation PAR Inc, located in North Fort Myers, FL, specializes in outpatient treatment for substance use, emphasizing high-quality care and research-backed methodologies. This facility offers outpatient services including methadone, buprenorphine, or naltrexone therapy, and incorporates 12-step facilitation, brief interventions, and cognitive behavioral therapy into its programs. The center features specialized services for individuals who have faced trauma, those dealing with both pain and substance use challenges, as well as support for pregnant and postpartum women. Treatment plans are customized for adults and seniors of all genders. Operation PAR Inc is recognized for its comprehensive approach and dedication to assisting individuals in their journey to overcome addiction through tailored care and efficient methods.

Operation PAR Inc
Sarasota, FL

Operation PAR Inc, located in Sarasota, FL, specializes in outpatient treatment for substance use, prioritizing high-quality care and evidence-driven methods. The center offers outpatient services for managing methadone/buprenorphine or naltrexone, while also implementing 12-step support, brief intervention techniques, and cognitive behavioral therapy. There are specialized programs designed for individuals who have faced trauma, those with concurrent pain and substance use issues, as well as pregnant and postpartum women. Catering to adults and seniors of all genders, this center focuses on customized treatment to aid each person's recovery. For those in search of empathetic and effective addiction support, Operation PAR Inc is committed to guiding you towards enduring sobriety.

Operation PAR Inc
Clearwater, FL

Operation PAR Inc, located in Clearwater, FL, provides a range of outpatient programs designed for substance use treatment, including options for methadone, buprenorphine, or naltrexone. The center utilizes evidence-based methodologies such as 12-step programs, brief interventions, and cognitive behavioral therapy. Additionally, it offers specialized services for those who have faced trauma, individuals dealing with both chronic pain and substance use challenges, and pregnant or postpartum women. Catering to adults and seniors of all genders, this facility is committed to delivering high-quality care with personalized treatment plans to assist individuals in their recovery journey.

OnCall Healthy Living Program

OnCall Healthy Living Program located in Indian Orchard, MA, provides outpatient services for detoxification and treatment of substance use for both adults and young adults. This center is dedicated to delivering tailored care for pregnant and postpartum women within a nurturing setting. The methods of treatment encompass brief interventions, cognitive behavioral therapy, and motivational incentives. Prioritizing high standards of care, this facility also offers outpatient treatment options including methadone, buprenorphine, or naltrexone. It serves a diverse clientele, both male and female, and focuses on personalized treatment strategies to enhance recovery and promote a healthy lifestyle. Discover thorough addiction recovery solutions at OnCall Healthy Living Program.

One Promise Behavioral health

One Promise Behavioral Health, located in Baltimore, MD, specializes in addiction recovery services designed for adults and young adults. This facility offers detoxification and substance use treatment across various programs, including intensive outpatient, outpatient, and day treatment options. Emphasizing approaches such as 12-step facilitation, anger management, and brief interventions, One Promise Behavioral Health customizes care to meet each person's unique requirements. The center features distinctive programs tailored for adult men, adult women, and individuals who have faced intimate partner or domestic violence. Catering to both male and female clients, One Promise Behavioral Health is committed to delivering effective treatment with genuine compassion.

One Promise Counseling and Education

One Promise Counseling and Education in Baltimore, MD, delivers targeted substance abuse recovery services for adults and young adults. Their offerings include intensive outpatient, standard outpatient, and partial hospitalization programs. Utilizing methods like 12-step facilitation, anger management, and brief intervention, the center is equipped to address the specific challenges faced by individuals affected by intimate partner and domestic violence. Dedicated programs for adult men and women promote a gender-affirming and encouraging path to healing. One Promise Counseling and Education is committed to providing superior addiction treatment.

Operation PAR Inc

Operation PAR Inc, located in Largo, FL, delivers extensive treatment options for substance use within a nurturing setting. This center features a variety of programs, including long-term and short-term solutions, alongside round-the-clock residential care for adult clients, including those who have faced trauma. Emphasizing 12-step support, brief intervention strategies, and cognitive behavioral therapy, the facility assists both men and women, as well as young adults. Operation PAR Inc is distinguished by its specialized offerings that address the unique needs of different populations. The center prioritizes high-quality care and utilizes evidence-based practices, making it an excellent option for those in need of effective and empathetic addiction recovery services.

Operation PAR Inc

Operation PAR Inc. in Largo, FL, delivers extensive detox and addiction recovery services. Focusing on inpatient treatment, this center offers continuous assistance for adults and young adults. Employing methods like 12-step encouragement, brief counseling, and cognitive behavioral therapy, the facility customizes care plans. Their specialized tracks for those in the legal system, LGBTQ+ individuals, and older adults demonstrate a commitment to accessible and individualized support. Operation PAR Inc. caters to both men and women, prioritizing effective and proven strategies for sustained sobriety.

Operation PAR Inc

Operation PAR Inc, situated in Largo, FL, delivers exceptional addiction recovery services for adult women within a secure and encouraging setting. This institution features a range of treatment durations, encompassing extended stays, shorter programs, and round-the-clock residential care. Prioritizing personalized attention, the center employs scientifically validated methods including 12-step program integration, brief counseling, and cognitive behavioral techniques. Operation PAR Inc also extends its specialized services to diverse groups, such as LGBTQ individuals, expectant and new mothers, and older adults. For those pursuing substance abuse treatment with a customized plan and complete assistance, this center is committed to guiding you toward wellness.

Operation PAR Inc
Spring Hill, FL

Operation PAR Inc, located in Spring Hill, Florida, provides outpatient treatment for substance use, including programs utilizing methadone, buprenorphine, or naltrexone. The center emphasizes various therapeutic methods such as 12-step facilitation, brief intervention, and cognitive behavioral therapy. It offers specialized programs for individuals dealing with trauma, those with concurrent pain and substance use issues, and expectant or postpartum women. Services are designed for adults and seniors of all genders. Committed to delivering high-quality care, this facility fosters a nurturing atmosphere for individuals looking for effective rehabilitation solutions in a professional context.

Operation PAR Inc
Bradenton, FL

Operation PAR Inc. in Bradenton, FL provides comprehensive outpatient services for substance use disorders, incorporating medication-assisted treatment with methadone, buprenorphine, or naltrexone. Their therapeutic approach includes 12-step facilitation, brief intervention, and cognitive behavioral therapy. The center has specialized programs designed for individuals who have experienced trauma, those managing co-occurring pain and addiction, and women who are pregnant or have recently given birth. These services are accessible to adult clients and seniors of any gender. Operation PAR Inc. is dedicated to delivering high-quality, evidence-based care in a nurturing setting for those in the Bradenton region pursuing recovery from addiction.

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Wooster, OH

OneEighty, situated in Wooster, OH, provides a wide range of addiction treatment options specifically designed for adult women. The center is known for its emphasis on long-term residential programs, detoxification services, and round-the-clock support for residents. Prioritizing methods such as 12-step work, anger management, and brief intervention strategies, OneEighty tailors its approach for clients who have faced trauma, domestic abuse, or intimate partner violence. Catering to women of all ages—including adults, seniors, and younger adults—the facility creates a welcoming and nurturing atmosphere for those seeking help with substance use issues. The center's exceptional programs and focused services position it as an outstanding choice for individuals in need of compassionate and effective rehabilitation.

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Medford, OR

OnTrack Inc, situated in Medford, OR, provides extended residential treatment services for adult males aiming for recovery from substance use. This center features options such as transitional housing, halfway houses, and sober living environments. Emphasizing cognitive behavioral therapy, anger management strategies, and short-term interventions, OnTrack Inc supports individuals dealing with co-occurring mental health and substance use issues, as well as those with a history of trauma. Focused on the care of adults, seniors, and younger adults, this facility prioritizes high-quality treatment specifically for male clients. For thorough and individualized programs for overcoming addiction, OnTrack Inc stands out as a reliable option in Medford, OR.

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Grants Pass, OR

OnTrack Inc located in Grants Pass, Oregon, specializes in thorough programs for substance use recovery. The center presents various treatment formats, including intensive outpatient and regular outpatient options. Emphasizing techniques such as anger management, cognitive behavioral therapy, and brief intervention, this facility personalizes care to meet the unique requirements of each client. There are specific programs designed for adult men, adult women, and those who have experienced trauma. Catering to both adults and younger individuals, OnTrack Inc is dedicated to providing tailored support for every client. With an unwavering commitment to quality rehabilitation services, the center creates a nurturing and understanding atmosphere for all who seek help.

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Grants Pass, OR

Situated in Grants Pass, OR, OnTrack Inc delivers focused treatment for substance use in a serene residential environment. The center provides long-term residential care along with round-the-clock support programs specifically designed for both adults and young adults. OnTrack Inc distinguishes itself through a variety of treatment methodologies, including 12-step facilitation, anger management, and brief intervention. It serves adult men and women, as well as individuals who have faced trauma, ensuring each person receives individualized attention. By emphasizing quality care and compassion, this facility creates a nurturing space for individuals aiming to conquer addiction and reclaim their lives.

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Medford, OR

OnTrack Inc, located in Medford, OR, is dedicated to providing tailored substance use therapy and temporary living arrangements specifically for adult females. This establishment offers extended residential support, emphasizing strategies for managing anger, immediate counseling, and cognitive behavioral techniques. Designed to assist individuals with past trauma and those facing intertwined mental health and substance use challenges, OnTrack Inc delivers complete services for adults, older adults, and younger adults. The center's dedication to high standards and personalized care positions it as a premier option for women looking for a nurturing setting to conquer addiction and attain sustained well-being.

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Opelousas Behavioral Health Clinic, located in Opelousas, Louisiana, specializes in providing outpatient services for substance abuse and tailored support for adults dealing with severe mental health challenges alongside treatment for children experiencing significant emotional difficulties. The clinic’s offerings include twelve-step programming, anger management strategies, and short-term interventions aimed at fostering recovery. With a commitment to serving adolescents, as well as male and female adults, the center addresses the needs of diverse age groups. This facility strives to deliver exceptional care in a nurturing atmosphere, focused on assisting individuals in attaining enduring recovery and enhanced mental health.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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