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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Pinnacle Treatment Centers

Pinnacle Treatment Centers, situated in Hazleton, PA, delivers a full spectrum of substance use recovery services for adults and adolescents. Their offerings include various levels of outpatient care, such as medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient programming. Employing evidence-based practices like cognitive behavioral therapy, the Matrix Model, and motivational interviewing, the center customizes treatment plans to suit individual requirements. Specialized support is provided for women, individuals facing dual diagnoses of mental health and substance use conditions, and those who are pregnant or have recently given birth. Pinnacle Treatment Centers serves both men and women, committed to providing high-quality assistance to everyone on their journey to sobriety.

Pinnacle Treatment Centers OH XII LLC

Pinnacle Treatment Centers OH XII LLC, situated in Sandusky, OH, provides outpatient services aimed at adults and young adults dealing with substance use issues. This center emphasizes individualized care with a variety of treatment options, including outpatient programs utilizing methadone, buprenorphine, or naltrexone, along with standard outpatient services. Employing evidence-based strategies such as brief interventions, cognitive behavioral therapy, and the Matrix Model, the facility is committed to delivering high-quality support to both men and women. For those in search of a thorough rehabilitation solution that focuses on customized treatment plans and validated methods, this center is devoted to assisting you on your path to recovery.

Pinnacle Wellness Group
Port Saint Lucie, FL

Pinnacle Wellness Group, situated in Port Saint Lucie, FL, provides outpatient detox and programs for substance use treatment. This center focuses on 12-step facilitation, anger management, and brief intervention strategies to tackle addiction challenges. With specialized programs designed for adult males, adult females, and clients involved in the criminal justice system, Pinnacle Wellness Group meets the needs of a varied clientele. Catering to both adults and young adults of all genders, the facility emphasizes high-quality care customized to every individual’s specific requirements. For those in search of effective and tailored addiction treatment options, Pinnacle Wellness Group is a valuable ally on the path to recovery.

Pioneer Recovery Center

Pioneer Recovery Center, situated in Cloquet, MN, provides comprehensive long-term residential support for individuals battling substance use disorders. The center also offers transitional living arrangements and dedicated therapeutic services for those managing co-occurring mental health and addiction challenges. Their program includes structured approaches like 12-step facilitation, anger management techniques, and brief intervention strategies. Specifically designed to support adult women who have experienced intimate partner violence and sexual trauma, Pioneer Recovery Center welcomes adults, seniors, and young adults. This facility ensures a secure and nurturing space exclusively for women, committed to delivering high-quality care that fosters lasting recovery.

Places for People
Saint Louis, MO

"Places for People," situated in Saint Louis, MO, delivers a wide array of rehabilitation services for both adults and young adults facing challenges related to substance use and concurrent mental health issues. The center features intensive outpatient therapy, outpatient detox programs, and personalized outpatient services designed to meet individual requirements. Catering to adult men, adult women, and individuals with trauma histories, this facility fosters a nurturing atmosphere conducive to recovery. Employing methods such as 12-step support, anger management, and brief counseling, the center emphasizes comprehensive healing. Clients can look forward to high-quality care and customized treatment strategies to aid them on their path to sobriety and enhanced mental health.

Places for People
Saint Louis, MO

"Places for People," located in Saint Louis, MO, delivers an extensive array of rehabilitation services aimed at supporting adults and young adults dealing with substance use issues alongside mental health concerns. The facility offers various programs including intensive outpatient care, outpatient detox, 12-step support, anger management training, and brief intervention sessions. It also features specialized services tailored for adult men, women, and individuals who have faced trauma, addressing a wide spectrum of needs. With its emphasis on personalized care and evidence-based methodologies, the center guarantees effective treatment for those seeking assistance. Regardless of gender, clients can access customized support as they begin their recovery journey at this center.

Pinnacle Treatment Centers OH XIV LLC

Pinnacle Treatment Centers OH XIV LLC, located in Marion, OH, provides focused outpatient services for individuals struggling with substance use disorders, serving both adults and adolescents. Their approach incorporates evidence-based techniques such as cognitive behavioral therapy, motivational interviewing, and relapse prevention strategies to create personalized treatment plans. They also have distinct programs designed for adult men, adult women, and those involved with the criminal justice or forensic systems. Services include outpatient medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient care. Pinnacle Treatment Centers OH XIV LLC is dedicated to delivering effective care within a nurturing setting to support individuals on their path to recovery.

Pinnacle Treatment Ctr OH VIII

Pinnacle Treatment Ctr OH VIII, located in Youngstown, OH, delivers targeted care for individuals aged 18 and over struggling with substance abuse. Their outpatient offerings include medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient therapy and support for 12-step programs. The center emphasizes anger management and brief intervention techniques, serving adult men and women, including active military members. Customized treatment plans are available for both male and female patients, ensuring personalized recovery journeys. Pinnacle Treatment Ctr OH VIII is recognized for its commitment to providing exceptional care through a dedicated team of experts within an encouraging setting, distinguishing itself with a complete strategy for overcoming addiction.

Pinnacle Treatment Centers OH XI LLC

Pinnacle Treatment Centers OH XI LLC, situated in Brilliant, OH, specializes in extensive programs designed for substance use rehabilitation. The center offers a variety of services including outpatient care, methadone/buprenorphine or naltrexone outpatient treatment, and regular outpatient services. With methods like anger management, brief interventions, and cognitive behavioral therapy, this facility supports adult women, individuals recovering from intimate partner violence or sexual abuse, and clients of all genders. Focused on adults and young adults alike, Pinnacle Treatment Centers emphasizes personalized care, ensuring that each individual receives the high-quality support needed for their recovery journey.

Pinnacle Treatment Centers OH XVII LLC

Pinnacle Treatment Centers OH XVII LLC, located in Springfield, OH, specializes in providing effective substance use disorder care for adults and young adults. Their diverse treatment modalities include outpatient services, methadone/buprenorphine or naltrexone-assisted treatment, and regular outpatient programs, ensuring a complete approach to recovery. The curriculum incorporates crucial elements like anger management, brief intervention strategies, and cognitive behavioral therapy to meet each person's specific challenges. The center also offers distinct programs designed for adult men, adult women, and individuals affected by intimate partner or domestic violence. Catering to all genders, Pinnacle Treatment Centers OH XVII LLC delivers personalized support and highly effective interventions.

Pivot Treatment and Wellness Centers

Situated in West Palm Beach, FL, Pivot Treatment and Wellness Centers specializes in extensive treatment for adults dealing with substance use issues, which may include serious mental health conditions. The facility presents a variety of outpatient services, such as intensive outpatient programs and day treatment. Emphasizing approaches like 12-step facilitation, anger management, and brief interventions, the center customizes its programs to suit individual requirements. It also features specialized programs for active duty military members, as well as adult men and women. Catering to both adult and young adult clients of all genders, Pivot Treatment and Wellness Centers is committed to delivering high-quality care that fosters enduring recovery.

Pinnacle Treatment Centers OH X LLC

Pinnacle Treatment Centers OH X LLC, situated in Milford, OH, delivers a wide range of outpatient treatment options for substance use disorders. This facility provides tailored support for both adults and young adults, utilizing methods including anger management, brief interventions, and cognitive behavioral therapy. Committed to high standards of care, the center offers outpatient services that include methadone, buprenorphine, or naltrexone treatments alongside standard outpatient programs. Additionally, it features unique offerings designed specifically for pregnant or postpartum women, addressing their particular needs. Both men and women can find a welcoming and supportive atmosphere here, making it an ideal place for those pursuing recovery from addiction.

Pit River Health Service Inc

Pit River Health Service Inc, situated in Burney, CA, delivers outpatient addiction treatment to individuals and families facing dual mental health challenges. Their dedicated programs cater to adult males, adult females, and survivors of domestic abuse. Therapies offered encompass 12-step support, anger control techniques, and short-term counseling. This center, which welcomes adults and older adults of all genders, also provides outpatient medication-assisted treatment (MAT) using methadone, buprenorphine, or naltrexone, alongside standard outpatient care. Prioritizing excellent service and personalized plans, Pit River Health Service Inc stands as a crucial support system for those pursuing holistic recovery.

Plains Area Mental Health Center

Plains Area Mental Health Center, situated in Spirit Lake, IA, delivers thorough rehabilitation for adults and older adults facing addiction and co-occurring mental health conditions. Their offerings include intensive outpatient care, standard outpatient services, and personalized substance use disorder counseling. The center excels in assisting individuals with dual diagnoses, employing a distinct strategy to manage both substance abuse and psychological well-being. Prioritizing excellent service and customized recovery paths, Plains Area Mental Health Center is committed to fostering sustained healing. This establishment welcomes both male and female individuals seeking encouragement and direction on their path to improved health.

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Pittsburgh, PA

Pittsburgh Mercy, situated in Pittsburgh, PA, stands as a prominent addiction recovery facility dedicated to providing thorough treatment for adults facing concurrent serious mental health conditions. Their specialized services are designed for individuals with multifaceted challenges, encompassing intensive outpatient, outpatient day treatment, and partial hospitalization programs. Pittsburgh Mercy utilizes proven methods like anger management, brief intervention, and cognitive behavioral therapy for optimal patient outcomes. Prioritizing clients with co-occurring disorders, this institution offers customized care for adults and young people alike, accepting all genders for superior treatment and assistance.

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Baltimore, MD

Situated in Baltimore, MD, Pixie Cares presents a variety of specialized rehabilitation services. The center offers intensive outpatient programs, outpatient day treatments, and partial hospitalization designed for both adults and children facing substance use and co-occurring mental health challenges. Emphasizing brief intervention, cognitive behavioral therapy, and motivational incentives, Pixie Cares customizes its treatment plans to meet individual requirements. Unique programs are available for active duty military members, adult males, and those who have experienced intimate partner violence. Catering to adults and young adults of all genders, Pixie Cares commits to providing compassionate care to support clients in achieving sustainable recovery.

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The Plains Area Mental Health Center located in Storm Lake, Iowa, provides a range of treatment options including intensive outpatient and outpatient services for those facing substance use challenges. This center excels in addressing both substance use disorders and serious mental health issues, ensuring customized counseling for both adults and children. Concentrating on clients with dual diagnoses, it serves a diverse population including adults and seniors, delivering personalized care for all genders. The facility prioritizes a holistic treatment philosophy, focusing on comprehensive support tailored to each person's specific requirements. Plains Area Mental Health Center is committed to delivering compassionate and quality care to aid individuals on their recovery path.

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Plains Area Mental Health Center in Cherokee, IA, provides thorough care for substance use issues and expert support for those facing dual mental health challenges. Adults and seniors can access tailored intensive outpatient, outpatient, and regular outpatient services. The center emphasizes counseling for substance use disorders, promoting a complete recovery journey. A dedicated program addresses co-occurring mental and substance use disorders, with gender-specific treatment available for men and women. The facility is committed to offering excellent care for sustained recovery and improved health.

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Plains Area Mental Health Center, located in Ida Grove, IA, delivers targeted addiction recovery services for individuals of all ages facing concurrent severe mental health challenges. The center features comprehensive programs including intensive outpatient, standard outpatient, and regular outpatient care, all centered on addressing addiction. They are equipped to support those with dual diagnoses, managing both mental health and substance dependence. Plains Area Mental Health Center is dedicated to providing effective care and assistance to adults and older adults, irrespective of gender, who are pursuing complete recovery.

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Situated in Denison, IA, the Plains Area Mental Health Center provides focused treatment for individuals facing substance use issues as well as concurrent mental health disorders in both adults and youth. Their all-inclusive programs encompass intensive outpatient, outpatient, and standard outpatient treatment options, with an emphasis on counseling for substance use problems. This facility is adept at catering to those with dual diagnoses, delivering customized support for clients addressing both mental health and substance-related difficulties. The center serves adults and seniors of varied genders, committed to delivering exceptional, individualized care that fosters enduring recovery and overall wellness.

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Plains Area Mental Health Center in Orange City, IA, provides a range of services including intensive outpatient, outpatient, and standard outpatient care for individuals of all ages struggling with substance abuse and co-occurring mental health conditions. The center is particularly adept at addressing substance use disorders and offers customized treatment for those with dual diagnoses. Catering to adults and seniors across all gender identities, this institution delivers high-quality care founded on proven therapeutic methods. Clients can anticipate thorough assistance, whether they opt for individual or group therapy, designed to meet their specific requirements. Plains Area Mental Health Center distinguishes itself through its dedication to comprehensive recovery and individualized care strategies, positioning it as a premier option for effective rehabilitation.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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