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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Pine Lake Behavioral Health/Medical

Pine Lake Behavioral Health/Medical, situated in Lincoln, NE, delivers extensive addiction recovery programs tailored for adults and seniors. The center features intensive outpatient treatment, outpatient detox services, and other outpatient offerings, prioritizing detoxification, substance use support, and co-occurring conditions. Emphasizing techniques such as anger management, brief intervention, and cognitive behavioral therapy, the facility serves both men and women, including individuals with trauma backgrounds. Pine Lake Behavioral Health/Medical is committed to providing personalized care and fostering a comprehensive path to recovery for every client.

Pine Rest Christian Mental Hlth Servs

Pine Rest Christian Mental Health Services, located in Grand Rapids, MI, delivers extensive care for detoxification, substance abuse, and co-occurring psychological disorders in adults, alongside addressing serious emotional challenges in children. Their inpatient hospital and round-the-clock care programs feature distinct services like 12-step guidance, anger management strategies, and short-term interventions. This center accommodates both adult men and women, including individuals who have faced trauma, guaranteeing personalized treatment plans. Catering to adults and young adults of all genders, Pine Rest Christian Mental Health Services combines empathy with effectiveness, establishing itself as a premier facility for those in need of quality rehabilitation from addiction.

Pine Tree Recovery Center

Pine Tree Recovery Center, situated in Portland, ME, delivers thorough care for addiction in adults and young adults. Services include detox and substance abuse treatment via intensive outpatient, standard outpatient, and regular outpatient programs. The center employs diverse therapeutic methods such as 12-step facilitation, anger management, and brief intervention to address each person's unique journey. Specialized support is offered for adult men, adult women, and individuals affected by intimate partner or domestic violence. Committed to high-quality support, this facility serves both men and women looking for tailored and successful recovery programs.

Pinehurst Comprehensive Treatment Ctr

Pinehurst Comprehensive Treatment Ctr located in Pinehurst, NC, provides outpatient programs designed for substance use recovery that cater to the unique needs of each individual. The center specializes in treatments involving methadone, buprenorphine, and naltrexone, and serves adult men, women, and active-duty military members. Employing evidence-based methods such as brief interventions, motivational interviewing, and strategies for relapse prevention, the facility is dedicated to empowering both adults and younger individuals in their recovery process. With a strong focus on delivering high-quality care and customized treatment plans, Pinehurst Comprehensive Treatment Ctr is recognized as a reliable and caring option for those seeking assistance with addiction.

Pinelands Recovery Center of Medford

Pinelands Recovery Center of Medford, located in New Jersey, provides a wide variety of addiction treatment options catering to both adults and young adults. The facility is well-known for its residential detox services, round-the-clock supervision, and short-term residential treatment plans. It employs evidence-based methodologies such as 12-step programs, anger management strategies, and short intervention techniques. The center is particularly distinguished by its unique offerings for young adults and its attention to addressing co-occurring substance use disorders along with significant mental health challenges. By offering distinct programs for male and female participants, the center is committed to delivering personalized care and attention for each client. Discover exceptional treatment and customized care plans at Pinelands Recovery Center of Medford.

Pinnacle Recovery Services

Pinnacle Recovery Services, situated in Lansing, MI, delivers tailored addiction treatment within a nurturing setting. This establishment provides outpatient care, standard outpatient programs, and temporary housing solutions for adult men and women. Emphasizing 12-step integration, emotional regulation techniques, and concise intervention strategies, Pinnacle supports active military members, adult males, and females. Catering to adults and young adults of all gender identities, this center guarantees personalized attention and well-crafted recovery strategies. For those in search of a thorough rehabilitation program featuring diverse specialized offerings, Pinnacle Recovery Services is committed to guiding you toward sustained abstinence.

Pine Rest Christian Mental Hlth Servs

Pine Rest Christian Mental Hlth Servs, situated in Kalamazoo, MI, offers dedicated treatment for addiction and co-occurring mental health conditions in individuals of all ages. Their services encompass intensive outpatient and traditional outpatient options, featuring medication-assisted treatment with methadone and buprenorphine. Key therapeutic approaches include support for 12-step programs, strategies for managing anger, and brief intervention techniques. The center provides distinct pathways for adult men, adult women, and young adults, ensuring a personalized approach to recovery. Pine Rest Christian Mental Hlth Servs is committed to delivering high-quality, impactful rehabilitation for all genders.

Pinnacle Recovery
Salt Lake City, UT

Pinnacle Recovery, situated in Salt Lake City, UT, delivers an extensive array of rehabilitation services designed for those struggling with substance use disorders and associated mental health issues. This center features hospital inpatient, outpatient, and round-the-clock inpatient programs that employ evidence-based strategies, including 12-step facilitation, cognitive behavioral therapy, and brief interventions. With tailored programs for active duty military members, as well as adult men and women, Pinnacle Recovery addresses a variety of needs among its clients. Their commitment to high-quality care and personalized treatment plans positions them as a leading option for adults and young adults seeking effective support for addiction recovery in a nurturing atmosphere.

Piedmont Community Services

Piedmont Community Services, located in Rocky Mount, VA, delivers a wide array of treatment solutions for individuals dealing with substance use disorders and simultaneous mental health challenges, catering to both adults and children. The center offers various treatment options, including intensive outpatient programs, outpatient services, and medications like methadone, buprenorphine, or naltrexone. Emphasizing approaches such as 12-step facilitation, anger management, and cognitive behavioral therapy, personalized treatment plans are created to meet the specific needs of each client. The facility also features specialized programs designed for adult men, adult women, and clients involved in the criminal justice system. Piedmont Community Services is dedicated to providing excellent care and assistance to adults and seniors of all genders who are on their path to recovery.

Pine Grove BH and Addiction Servs

Pine Grove BH and Addiction Servs, situated in Hattiesburg, MS, provides a wide range of addiction recovery services for both adults and youth. The facility specializes in inpatient detoxification and treatment for substance use issues alongside co-occurring mental health disorders. Emphasizing a 12-step approach, the program also incorporates elements like anger management and cognitive behavioral therapy. It is designed to serve adult males and females, as well as young people. Pine Grove BH and Addiction Servs is committed to offering high-quality care through personalized programs that address the specific needs of each client, positioning it as a premier option for those in need of supportive and effective rehabilitation services.

Pine Rest Christian Mental Hlth Servs

Situated in Holland, MI, Pine Rest Christian Mental Hlth Servs is dedicated to providing various targeted treatment options for adults and young adults facing challenges related to substance abuse and concurrent mental health conditions. The center features outpatient offerings, such as methadone and buprenorphine therapies, customized to suit individual requirements. Emphasizing 12-step support, anger management techniques, and brief intervention strategies, Pine Rest serves a diverse clientele, including individuals who have gone through traumatic experiences. The facility’s specialized programs for adult males, adult females, and individuals recovering from trauma create an all-encompassing and nurturing atmosphere for healing.

Piedmont Community Services

In Stuart, VA, Piedmont Community Services delivers extensive care for adults battling substance use disorders, particularly those with co-occurring severe mental health conditions or challenges in children's emotional development. Their offerings encompass intensive outpatient, standard outpatient, and medication-assisted treatment options utilizing methadone, buprenorphine, or naltrexone. Employing proven methods such as 12-step facilitation, anger management, and cognitive behavioral therapy, the center serves adults of all ages and genders, providing specialized programming. Piedmont Community Services is committed to high-quality, individualized recovery plans within a nurturing setting, promoting both sobriety and enhanced mental well-being.

Pine Street Inn
Jamaica Plain, MA

Pine Street Inn, situated in Jamaica Plain, MA, focuses on providing treatment for adult men dealing with substance use issues alongside mental health disorders. The center features both intensive outpatient and outpatient programs that utilize 12-step methods, anger management strategies, and brief intervention techniques. Pine Street Inn is dedicated to offering specialized support for individuals who have faced trauma. Aiming to assist clients with co-occurring disorders, including severe mental health conditions, the facility is designed for adults and seniors who are in need of comprehensive, personalized care. Pine Street Inn is recognized for its customized treatment plans and unwavering commitment to providing exceptional care to aid clients in their recovery process.

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Pike County Recovery Council, situated in Chillicothe, OH, provides extensive treatment options for substance use disorders in both adults and children dealing with concurrent mental health issues. The facility offers various levels of care, including intensive outpatient, outpatient, and standard outpatient services, employing a variety of methods such as 12-step programs, anger management, and short-term interventions. It features specialized programs aimed at adolescents, as well as adult men and women, accommodating a diverse clientele. Dedicated to delivering superior support, the center aims to assist individuals of all genders and ages in their recovery process.

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Pike County Recovery Council, situated in Waverly, OH, specializes in providing tailored treatment for adult women dealing with substance use issues. This center emphasizes holistic care for those facing both substance use disorders and significant mental health challenges. It offers various programs, including long-term residential, 24-hour residential, and short-term residential options, employing evidence-based practices such as 12-step programs, anger management techniques, and cognitive behavioral therapy. Additionally, the center is recognized for its unique programs aimed at supporting clients who have undergone sexual abuse or trauma. Committed to serving women of all ages, Pike County Recovery Council prioritizes the well-being and recovery of its clients.

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Pike County Recovery Council, located in Chillicothe, OH, provides complete care for women struggling with substance use, offering both treatment and temporary housing. The center is particularly equipped to support those facing dual diagnoses of substance use disorders and significant mental health issues, including individuals with a history of trauma or sexual abuse. Clients can access intensive outpatient, standard outpatient, and regular outpatient programs. Treatment strategies employed include proven methods like 12-step facilitation, anger management techniques, and cognitive behavioral therapy. The facility also offers specific programs designed for adult women, older adults, and young adults, ensuring personalized support. For effective rehabilitation that addresses addiction and mental well-being, Pike County Recovery Council stands as a reliable resource for achieving recovery.

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Situated in Waverly, OH, Pike County Recovery Council provides diverse, tailored recovery services. This establishment features extended, live-in, and brief treatment plans for adult women and older individuals grappling with addiction and related mental health challenges. Their methodology incorporates 12-step support, emotional regulation techniques, and cognitive-behavioral interventions. Specialized tracks are designed for adult females, survivors of sexual assault, and individuals with a history of trauma. Emphasizing excellent support and personalized care, Pike County Recovery Council is committed to aiding individuals in their path toward healing.

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Pike County Recovery Council, situated in Waverly, OH, provides focused substance use disorder care for adult women experiencing co-occurring mental health challenges. This center delivers intensive outpatient, outpatient, and standard outpatient care, employing scientifically validated methods like 12-step facilitation, anger management techniques, and brief intervention strategies. Their programs are also adapted for adolescents and individuals with dual diagnoses, emphasizing high-quality services for adults and older adults. For those in need of thorough and impactful treatment within a nurturing setting, explore the distinct offerings at Pike County Recovery Council.

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Pine Manor Inc, situated in Nevis, MN, provides specialized detoxification and addiction treatment services for adults and young adults. The center prioritizes personalized care through its residential detox, 24-hour residential, and short-term residential offerings. Employing methods such as 12-step facilitation, brief intervention, and cognitive behavioral therapy, Pine Manor Inc delivers a thorough and impactful recovery journey. Open to both male and female patients, the facility's tailored programs address the distinct requirements of every individual. Pine Manor Inc stands out as an excellent option for those pursuing sobriety in a nurturing setting.

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Pines and Cady Hill in Columbus, MS, delivers a full spectrum of addiction recovery care. They offer structured intensive outpatient programs, extended residential stays, and regular outpatient services for adults and adolescents. Their expertise includes treating substance abuse, offering supportive transitional living, and addressing dual diagnoses of addiction and significant mental health conditions. The center employs therapeutic methods like 12-step integration, anger management, and cognitive behavioral therapy. With dedicated tracks for adult men, adult women, and survivors of domestic abuse, Pines and Cady Hill prioritizes personalized treatment plans. Their commitment to high standards and proven methods establishes them as a reliable resource for individuals pursuing sobriety.

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Pines Behavioral Health in Coldwater, MI, delivers a full spectrum of services for adults grappling with substance use disorders and co-occurring mental health challenges. Their offerings include intensive outpatient services, general outpatient care, and medication-assisted treatment with methadone, buprenorphine, or naltrexone. Employing proven therapeutic methods such as cognitive behavioral therapy and anger management, Pines Behavioral Health delivers separate, tailored programs for adult men, women, and adolescents. This center is dedicated to providing high-quality, individualized support to adults and seniors of any gender pursuing recovery from addiction and dual diagnoses.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)