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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Public Health of Dayton and

Public Health of Dayton and in Dayton, OH, provides extensive care for substance use issues. They offer several treatment paths, including intensive outpatient, standard outpatient, and specific methadone/buprenorphine programs. Their methods are grounded in proven techniques like cognitive behavioral therapy, anger control, and 12-step support. Designed for adult men, adult women, and those affected by intimate partner violence, the center ensures a secure and encouraging setting for healing. Catering to adults and young adults across all gender identities, Public Health of Dayton and is committed to delivering high-quality, personalized support for every individual's journey.

Purpose Healing Center

Purpose Healing Center, situated in Scottsdale, AZ, focuses on integrated care for adults facing addiction and co-occurring serious mental health conditions. The center offers flexible outpatient programs, such as intensive outpatient and partial hospitalization, employing strategies like 12-step facilitation and anger management. This facility is equipped to support adult men and women, including those with histories of trauma. Their tailored programs for adults and young adults of all genders emphasize personalized recovery journeys.

PursueCare
East Providence, RI

PursueCare, situated in East Providence, RI, provides outpatient care for adults and young adults dealing with substance use disorders alongside significant mental health challenges. This center offers various treatment options, including outpatient services with methadone, buprenorphine, or naltrexone, complemented by standard outpatient programs. Specializations include anger management, brief intervention strategies, and cognitive behavioral therapy. Additionally, PursueCare offers tailored programs specifically designed for adult men, adult women, and those who have undergone trauma. Committed to delivering high-quality care, PursueCare supports both men and women in their journey toward effective rehabilitation in an encouraging setting.

Pyramid Healthcare
Newport News, VA

Pyramid Healthcare, situated in Newport News, VA, delivers thorough substance abuse rehabilitation for adults and adolescents. This institution offers hospital-based inpatient detox and care, alongside options for supportive living accommodations. Featuring tailored programs for active military personnel, adult males, and adult females, Pyramid Healthcare addresses a range of specific requirements. The center employs scientifically validated methods, including 12-step facilitation, emotional regulation training, and concise counseling techniques, to deliver individualized support. Providing care for both male and female individuals, Pyramid Healthcare is dedicated to delivering excellent, gender-focused treatment to aid people in their path to sobriety.

Psychological Addiction Services LLC

Psychological Addiction Services LLC, located in Madison, WI, delivers focused outpatient care designed for adults and young adults struggling with substance use. The clinic administers medication-assisted treatment using methadone, buprenorphine, or naltrexone, incorporating proven techniques like contingency management, motivational interviewing, and strategies for preventing relapse. They feature distinct programs for men, women, and individuals managing co-occurring mental health and substance use conditions, demonstrating a commitment to individual circumstances. By offering tailored support to both male and female patients, the center prioritizes individualized attention. For those in Madison looking for impactful addiction recovery solutions, Psychological Addiction Services LLC presents a complete range of services and dedicated support.

Pyramid Healthcare Inc

Pyramid Healthcare Inc, located in Pittsburgh, PA, delivers extensive addiction rehabilitation for adults and adolescents. Their services encompass hospital-based inpatient detox and treatment for substance use disorders, alongside care for co-occurring mental health challenges. Tailored programs are available for active military personnel, adult men, and women, addressing specific demographic needs. The center employs methods such as 12-step facilitation, anger management techniques, and brief interventions to provide personalized support. Catering to both male and female individuals, this establishment is dedicated to offering superior care to aid those pursuing recovery.

Pyramid Healthcare Inc

Pyramid Healthcare Inc located in Pittsburgh, PA, provides targeted substance use rehabilitation programs that are designed for adults and seniors. The center features various treatment options, including intensive outpatient and outpatient day programs. Employing proven methods like cognitive behavioral therapy, the Matrix Model, and motivational interviewing, this facility guarantees thorough support. Special initiatives for active duty military personnel, adolescents, and adult males further enhance its ability to meet various needs. The facility offers accessible quality care for both men and women, establishing it as a comprehensive choice for individuals in search of effective recovery services.

PursueCare
Allentown, PA

PursueCare, situated in Allentown, PA, delivers a wide-ranging outpatient program for those struggling with substance use issues, targeting both adults and young adults. The center specializes in addressing concurrent substance use and mental health disorders, as well as emotional challenges faced by children. Treatment options include anger management, short-term interventions, and cognitive behavioral therapy. PursueCare also offers personalized outpatient treatments with methadone, buprenorphine, or naltrexone, designed to meet individual requirements. The facility provides distinct programs for adult men, adult women, and individuals with trauma histories. Prioritizing quality care, PursueCare serves both male and female clients in search of effective rehabilitation solutions.

Pyramid Healthcare Inc

Pyramid Healthcare Inc in Waynesboro, PA, provides a full spectrum of addiction treatment for individuals of all ages, including those with concurrent mental health conditions. Employing intensive outpatient methods and proven techniques such as cognitive behavioral therapy, the facility delivers focused support for teenagers, people with dual diagnoses, and those dealing with pain alongside substance dependency. Customized interventions are available for adult men, adult women, and seniors, fostering a welcoming and inclusive atmosphere. Pyramid Healthcare Inc is recognized for its dedication to high standards of care and individualized recovery strategies.

PursueCare LLC
Concord, NH

PursueCare LLC, situated in Concord, NH, delivers extensive outpatient treatment for substance use disorders in both adults and young adults who also face mental health challenges. The center is proficient in administering treatments such as methadone, buprenorphine, or naltrexone, utilizing methodologies that include cognitive behavioral therapy, anger management, and brief interventions. With customized programs designed for adult men and women, as well as those who have gone through traumatic experiences, PursueCare LLC is dedicated to addressing unique individual requirements. Their commitment to high-quality and personalized care establishes them as an excellent option for individuals in search of effective rehabilitation support. The facility embraces a welcoming atmosphere for all clients, promoting inclusivity and support.

Pyramid Healthcare Inc

Pyramid Healthcare Inc, situated in Belleville, PA, provides focused treatment for adult males dealing with substance use issues. The center offers a variety of therapeutic options, such as long-term residential, 24-hour residential, and short-term residential programs. Emphasizing 12-step facilitation, anger management, and brief intervention strategies, it supports individuals impacted by intimate partner violence, domestic violence, and sexual abuse. Catering to adults, seniors, and young adults, Pyramid Healthcare Inc is distinguished by its customized programs that meet the specific recovery needs of men facing addiction challenges.

Pyramid Healthcare Inc
Bartonsville, PA

Pyramid Healthcare Inc in Bartonsville, PA, provides a full spectrum of substance abuse care, including intensive outpatient, outpatient, and day treatment options. Employing proven methods such as cognitive behavioral therapy, the Matrix Model, and motivational interviewing, this establishment features dedicated programs for young people and individuals facing both mental health and substance use challenges simultaneously. Open to adults and youth of all genders, Pyramid Healthcare Inc commits to personalized care and assistance for everyone. Driven by a commitment to excellence and successful treatment, this facility aims to guide clients toward sustained recovery and enhanced overall health.

Psychiatric Hope
North Platte, NE

Situated in North Platte, NE, Psychiatric Hope provides an extensive array of treatment options for those facing challenges related to substance abuse and concurrent mental health disorders. The center offers various services, including intensive outpatient care, long-term residential support, and outpatient programs, catering to both adults and children/adolescents of any gender. Emphasizing short-term interventions, relapse prevention strategies, and counseling for substance use disorders, Psychiatric Hope adopts a personalized approach to ensure that every client receives tailored care. Its dedication to high-quality treatment and specialized programming addresses the distinct needs of individuals, establishing it as a reliable option for effective rehabilitation services.

PursueCare Connecticut PC

PursueCare Connecticut PC, located in Middletown, CT, specializes in providing outpatient services for adults and young adults dealing with substance use issues alongside significant mental health challenges or emotional difficulties. This center offers treatment options such as methadone, buprenorphine, or naltrexone, along with typical outpatient services. Emphasizing strategies like anger management, brief interventions, and cognitive-behavioral therapy, the facility serves both men and women, including those who have faced traumatic experiences. The program is designed to address the specific needs of individuals seeking effective care in a nurturing setting.

Pursuit of Hope Group LLC

Pursuit of Hope Group LLC, situated in Pearland, TX, specializes in outpatient services for adults dealing with substance use disorders and serious mental health issues, in addition to addressing emotional challenges in children. The center employs various evidence-supported methods, such as cognitive behavioral therapy and motivational interviewing, aimed at facilitating recovery. It offers customized programs for active duty military personnel, as well as adult men and women, accommodating a wide range of individual requirements. Catering to both adult and young adult clients, the center prioritizes high-quality care through focused interventions and consistent outpatient services, including treatments with methadone/buprenorphine or naltrexone.

Pyramid Healthcare Inc

Pyramid Healthcare Inc, located in Altoona, PA, delivers high-quality treatment for substance use and offers transitional housing specifically for adult men. The center features long-term residential options that emphasize 12-step programs, anger management techniques, and brief intervention strategies. Pyramid Healthcare Inc is particularly focused on supporting clients who have faced issues related to intimate partner violence, domestic violence, and sexual abuse. With customized programs for adult men, seniors, and young adults, this facility ensures personalized attention and support. For those in search of a secure and organized setting to tackle substance use challenges, Pyramid Healthcare Inc in Altoona is committed to offering thorough and empathetic care.

Pyramid Healthcare Inc

Pyramid Healthcare Inc, located in Altoona, PA, provides extended residential treatment for adult women dealing with substance use issues in a nurturing and secure setting. The facility is known for its transitional housing and sober living arrangements, specifically aimed at individuals who have faced challenges such as intimate partner violence, domestic abuse, and sexual trauma. Emphasizing 12-step programs, anger management, and brief intervention techniques, Pyramid Healthcare Inc delivers specialized support for adults, seniors, and young adults on their recovery journey. With a strong focus on personalized care and effective treatment strategies, the center is committed to guiding clients towards enduring sobriety and emotional restoration.

PursueCare LLC
Newark, DE

PursueCare LLC, situated in Newark, DE, specializes in outpatient treatment for substance use disorders, particularly addressing serious mental health challenges in adults and emotional issues in children. The facility offers a range of outpatient services, including methadone, buprenorphine, or naltrexone therapies, alongside standard outpatient care and targeted programs for men and women as well as trauma survivors. Customized interventions such as anger management, brief counseling, and cognitive behavioral therapy are part of the treatment repertoire. Catering to adults and young adults across all genders, PursueCare LLC is dedicated to providing effective and empathetic care, making it a prime option for individuals in need of thorough and individualized addiction recovery solutions.

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Situated in Lawrence, MA, the Psychological Center delivers a variety of specialized addiction rehabilitation services designed specifically for adult women. The center features long-term residential, outpatient, and options for outpatient treatment involving methadone, buprenorphine, or naltrexone. Emphasizing techniques such as 12-step facilitation, anger management, and brief interventions, the facility also includes tailored programs for adolescents, adult women, and individuals who have faced intimate partner or domestic violence. Catering to adults of all ages, the center's dedicated approach to supporting female clients distinguishes it in offering comprehensive and empathetic assistance for those on the path to recovery from substance use issues.

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Psychotherapeutic Services Inc, located in Dover, DE, provides an extensive array of targeted therapies for adults and young adults facing challenges related to substance abuse and mental health conditions. This center specializes in long-term residential treatment, detoxification within a residential setting, and around-the-clock support. Emphasizing methods like 12-step facilitation, anger management, and brief interventions, the facility also features a unique program designed specifically for adult women, creating a supportive and gender-sensitive atmosphere. Psychotherapeutic Services Inc distinguishes itself through its dedication to delivering high-quality care that effectively addresses both substance use and mental health disorders in an integrated manner.

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Phoenix, AZ

Push Wellness located in Phoenix, AZ, provides a full range of substance abuse rehabilitation services for adults dealing with mental health disorders, as well as support for children facing emotional challenges. Their programs encompass intensive outpatient and regular outpatient services featuring 12-step guidance, anger management strategies, and short-term intervention techniques. This center is equipped to assist active duty military members, teenagers, and adult males. Emphasizing personalized care, Push Wellness is dedicated to serving clients of all genders and age groups. Their pledge to deliver high-quality, customized programs positions them as a leading option for individuals pursuing compassionate and effective addiction recovery in the Phoenix region.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)