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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Rappahannock Area Comm Servs Board

Situated in Fredericksburg, VA, the Rappahannock Area Comm Servs Board delivers a wide array of addiction recovery services for both adults and seniors. The facility is dedicated to addressing substance use issues alongside co-occurring mental health disorders, offering outpatient options that include methadone and buprenorphine therapies. Emphasizing anger management, relapse prevention, and counseling for substance use disorders, the center provides customized programs designed for adult men, adult women, and clients involved with the criminal justice system. With options for transitional housing, halfway facilities, or sober living environments, clients are assured of receiving high-quality care and support. Opt for this center for proven treatment methods and a focus on facilitating enduring recovery.

Ray Recovery
Hudson, OH

Situated in Hudson, OH, Ray Recovery delivers extensive substance abuse treatment for both adults and young adults who also struggle with significant mental health issues. The center offers a range of services, including intensive outpatient care, day treatment, and partial hospitalization, utilizing proven methods such as 12-step programs, anger management, and brief interventions. Ray Recovery features specialized programs designed for active duty service members, as well as tailored support for adult men and women, providing personalized care for individuals of all gender identities. Their commitment to high-quality care and customized treatment plans positions this center as a leading option for those in search of effective rehabilitation in a nurturing atmosphere.

ReMind Health Group
Louisville, KY

ReMind Health Group, situated in Louisville, KY, delivers a wide array of addiction recovery services tailored for both adults and young adults. The center excels in detoxification, treatment for substance use disorders, and addressing co-occurring mental health issues. Offering various treatment modalities including intensive outpatient, outpatient care, and options involving methadone, buprenorphine, or naltrexone, ReMind Health Group emphasizes 12-step programs, anger management strategies, and short intervention techniques. This facility serves a diverse clientele, including active duty military personnel, teenagers, and adult males, ensuring that both men and women receive high-quality care as they work toward overcoming addiction and restoring their health and wellness.

ReVIDA Recovery Centers
Johnson City, TN

ReVIDA Recovery Centers located in Johnson City, TN, specializes in outpatient treatment for adults and young adults dealing with substance use issues. This center offers targeted outpatient services including methadone/buprenorphine or naltrexone therapy, in addition to standard outpatient care. Emphasizing personalized treatment, the facility employs techniques such as 12-step programs, anger management strategies, and brief interventions. Catering to both men and women, ReVIDA Recovery Centers customizes its programs to address the distinct needs of each client. For those in search of a thorough and supportive addiction treatment option in Johnson City, the center’s dedication to high-quality care and individualized plans may provide the help you need.

ReDiscover
Kansas City, MO

Situated in Kansas City, MO, ReDiscover provides an extensive array of outpatient support tailored for adults and young adults facing challenges with addiction alongside co-existing mental health disorders. This center features detox services, treatment for substance use, and targeted care for those dealing with significant emotional or mental struggles. The therapeutic options at ReDiscover encompass anger management, cognitive behavioral therapy, and short intervention strategies to meet each person's unique requirements. With customized programs designed for adult men, women, and those who have endured trauma, the center fosters a nurturing atmosphere conducive to healing. Prioritizing outpatient detoxification and medication-assisted therapies using methadone, buprenorphine, or naltrexone, ReDiscover is committed to providing exceptional care for individuals aiming to overcome addiction and regain control of their lives.

Real Recovery by Pyramid Healthcare

Real Recovery by Pyramid Healthcare in Asheville, NC, delivers thorough programs for addiction and specific support for those facing dual diagnoses of substance abuse and severe mental health conditions. The facility features intensive outpatient care, standard outpatient services, and day treatment/partial hospitalization. Emphasizing anger management, brief intervention, and cognitive behavioral therapy techniques, Real Recovery is equipped to assist adult men, active duty military members, individuals affected by intimate partner violence, and those with a history of domestic abuse. The center provides dedicated, high-quality care for adult men, seniors, and young adults in their journey toward recovery and wellness.

Ravenwood Health
Chardon, OH

Ravenwood Health, situated in Chardon, OH, provides an extensive array of treatment services for substance use issues affecting both adults and youth. This center is dedicated to addressing co-occurring substance use challenges alongside significant mental health conditions in adults or serious emotional issues in younger clients. Their offerings include intensive outpatient programs, standard outpatient care, and medications like methadone, buprenorphine, or naltrexone for treatment. By employing techniques such as anger management, brief interventions, and cognitive behavioral therapy, Ravenwood Health serves both men and women. Additionally, the facility features tailored programs for teenagers, individuals with a history of sexual abuse, and patients facing both mental health and substance use issues.

Reach for Recovery

Situated in Holland, MI, "Reach for Recovery" delivers dedicated residential treatment for individuals dealing with substance use disorders, associated mental health challenges, and emotional issues in children. The center features long-term and round-the-clock residential options designed specifically for adult women who have faced trauma, as well as those with co-occurring disorders. Prioritizing 12-step techniques, anger management strategies, and focused interventions, the facility provides holistic care for adults, seniors, and young adults. Its distinct methods and tailored programs position it as an excellent resource for female clients in need of personalized and effective rehabilitation services.

Reach for Recovery

Situated in Holland, MI, Reach for Recovery provides extended residential care for adults and children facing challenges related to substance abuse and concurrent mental health disorders. The facility emphasizes methods such as 12-step facilitation, anger management, and brief intervention strategies. Specialized programs are available for adult men, those with a history of trauma, and individuals experiencing dual diagnoses. Reach for Recovery is open to adults, seniors, and young adults, ensuring high-quality care specifically designed for male clients. With a commitment to individualized treatment and thorough support, this center creates a secure and nurturing atmosphere for those on their journey to overcome addiction and mental health issues.

Reach for Recovery
Grand Haven, MI

"Reach for Recovery" in Grand Haven, MI, delivers thorough addiction recovery programs and expert support for those navigating simultaneous substance use and significant mental health challenges or emotional distress. They offer robust intensive outpatient and outpatient programs, incorporating medication-assisted treatment options such as methadone, buprenorphine, or naltrexone. The facility emphasizes approaches like 12-step integration, strategies for managing anger, and brief counseling techniques. "Reach for Recovery" welcomes adult men and women, including those with a history of trauma. Their services are available to adults and seniors across all gender identities, with a commitment to personalized, high-quality care designed for each person's specific journey.

Reach for Recovery

Nestled in Holland, MI, Reach for Recovery provides extensive addiction recovery care for adults and young individuals facing concurrent severe mental health conditions. The facility features robust outpatient programs, general outpatient care, and tailored medication-assisted treatments including methadone, buprenorphine, or naltrexone. Their approach incorporates 12-step support, anger control strategies, and concise intervention methods. Reach for Recovery is equipped to assist adult men and women, and those with histories of trauma. Serving a broad demographic from adults to seniors across all genders, Reach for Recovery is committed to delivering top-tier treatment and encouragement to those pursuing successful recovery.

Reality House Inc

Reality House Inc, situated in Astoria, NY, delivers a full spectrum of dedicated recovery services. This establishment provides cleansing from substances, help for addiction, and customized plans for those facing both addiction and significant mental health challenges or emotional distress. With options for hospital inpatient care, round-the-clock hospital inpatient services, and intensive outpatient support, Reality House Inc employs proven methods such as 12-step guidance, anger management techniques, and concise therapeutic interventions. Featuring specific programs for adult males, adult females, and individuals dealing with both pain and substance use issues, this center serves adults and young adults regardless of gender. Discover high-quality support and individualized care at Reality House Inc.

Realization Center Inc

Realization Center Inc, located in Brooklyn, NY, provides an extensive array of treatment options for substance use issues in both adults and youth, including those facing dual mental health challenges. The center offers various programs such as intensive outpatient care, standard outpatient services, and targeted treatments involving methadone, buprenorphine, or naltrexone. It emphasizes 12-step support, anger management strategies, and short-term interventions specifically designed for active duty military members, teenagers, and adult males. Regardless of their gender, patients receive personalized attention aimed at aiding their recovery process. Realization Center Inc distinguishes itself through its eclectic treatment methods, customized plans, and dedication to offering exceptional care to individuals seeking help with addiction challenges.

Realization Center Inc

Realization Center Inc, located in New York, NY, delivers tailored programs for adults battling addiction alongside significant mental health challenges, and for children experiencing severe emotional difficulties. Their offerings include structured intensive outpatient and standard outpatient services, incorporating medication-assisted treatment options such as methadone, buprenorphine, or naltrexone. Employing therapeutic methods like 12-step facilitation, anger management, and brief intervention strategies, this establishment supports active military personnel, teenagers, and adult males. Realization Center Inc is committed to offering thorough care for adults and young people of any gender, prioritizing personalized attention and effective therapeutic practices.

Rebel New Life Treatment Center LLC

Situated in Anaheim, California, Rebel New Life Treatment Center LLC specializes in detoxification as well as treatment for substance use disorders. This center offers comprehensive inpatient detox services, alongside round-the-clock care. Emphasizing techniques such as 12-step facilitation, anger management, and brief intervention, the facility accommodates adult men and women, especially individuals with a history of trauma. Rebel New Life Treatment Center LLC aims to provide exceptional care and assistance to adults and young adults of all genders who are in pursuit of meaningful rehabilitation in a secure and organized setting.

ReDiscover
Kansas City, MO

ReDiscover, situated in Kansas City, MO, delivers a wide array of outpatient services tailored for those seeking help with substance use disorders alongside concurrent mental health issues. The center places an emphasis on detoxification, substance abuse therapy, and support for individuals facing significant emotional challenges. Its programs include anger management, cognitive behavioral therapy, and short-term interventions. ReDiscover caters to both male and female adults, as well as young adults, including those who have experienced trauma. By prioritizing personalized care and effective treatment, this facility offers outpatient detox services and options such as methadone/buprenorphine or naltrexone for all clients.

ReDiscover
Lees Summit, MO

Situated in Lees Summit, MO, ReDiscover provides all-encompassing care for individuals battling substance use disorders, including those experiencing concurrent severe mental health challenges. The center's offerings include intensive outpatient, standard outpatient, and day treatment services, employing methodologies like 12-step support, emotional regulation techniques, and brief therapeutic interventions. ReDiscover features tailored programs designed for active military members, adult men, and adult women, demonstrating a commitment to serving varied demographics. This facility welcomes adults and young adults of any gender, prioritizing the delivery of exceptional care to support individuals in their journey toward lasting recovery.

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Situated in Ruther Glen, VA, the Rappahannock Area Comm Servs Board specializes in outpatient treatment for substance use in both adults and children experiencing significant mental health issues concurrently. Their ongoing outpatient initiatives emphasize managing anger, preventing relapse, and counseling for substance use disorders. This center offers targeted services for adult males, adult females, and clients involved with the criminal justice system. Serving both adults and seniors from all backgrounds, the facility prioritizes personalized care that meets each individual's requirements. Through a holistic approach and focused programs, this center is committed to supporting individuals in overcoming addiction and mental health obstacles.

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The Rappahannock Area Comm Servs Board, situated in King George, VA, provides thorough outpatient treatment for adults and seniors struggling with substance use. This facility focuses on individuals experiencing co-occurring substance use and significant mental health challenges, offering individualized regular outpatient programs. Their treatment methods are grounded in scientific evidence and include support for anger management, preventing relapse, and counseling for substance use disorders. The center is equipped to serve adult men, adult women, and clients involved with the criminal justice system, ensuring that care is adapted to the specific needs of all genders. The Rappahannock Area Comm Servs Board is committed to delivering high-quality restorative services to guide patients toward lasting recovery.

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The Rappahannock Area Comm Servs Board, situated in Spotsylvania, VA, provides outpatient support for individuals of all ages dealing with addiction, particularly those also managing significant mental health challenges. Their specialized services include guidance on controlling anger, strategies for avoiding relapse, and counseling for substance use disorders. They have tailored offerings for adult men, adult women, and those involved with the legal system. This center welcomes adults and older adults, fostering a nurturing space for anyone pursuing recovery and enhanced mental health through professional, evidence-based care.

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Rea Clinic Benton, situated in Benton, IL, provides extensive outpatient treatment for adults grappling with substance use issues alongside mental health concerns. This center is dedicated to serving various groups, including active duty service members, teenagers, and adult males, with programs specifically designed for both men and women. By employing a holistic treatment strategy, the clinic aims to effectively tackle substance use disorders. With an emphasis on high-quality care, it accommodates adults and older individuals who require ongoing outpatient support. If you seek a nurturing setting with evidence-based treatment options, Rea Clinic Benton may be an excellent fit for your path to recovery.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)