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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Regional Health Systems
East Chicago, IN

Regional Health Systems, situated in East Chicago, Indiana, delivers extensive care for adults and older adults facing challenges with substance abuse and co-occurring psychological issues. They offer robust outpatient treatment, detox programs, and individualized outpatient support. The center features distinct programs for expectant/new mothers and those with dual diagnoses, utilizing proven methods like 12-step guidance and emotional regulation techniques. Regional Health Systems is dedicated to providing high-quality services to all patients, men and women alike, prioritizing sustainable recovery through customized plans.

Rego Park Counseling LLC

Situated in Rego Park, NY, Rego Park Counseling LLC delivers extensive substance use rehabilitation services aimed at both adults and children facing significant mental health challenges. The center features options like intensive outpatient programs, outpatient care, and treatments involving methadone, buprenorphine, or naltrexone. Emphasizing anger management, brief interventions, and cognitive behavioral therapy, this facility serves adult men and women, as well as those who have endured domestic or intimate partner violence. Catering to adults and seniors of all genders, Rego Park Counseling LLC prioritizes exceptional care and tailored treatment strategies to aid individuals on their recovery journey.

Rehabilitative Health Services

Rehabilitative Health Services in Idaho Falls, ID, provides an extensive assortment of treatment programs for substance use issues as well as co-occurring mental health disorders, designed for both adults and younger individuals. The center features various options such as intensive outpatient care, outpatient treatment, and methadone/buprenorphine or naltrexone therapies. Employing evidence-based methodologies including anger management, cognitive behavioral therapy, and short-term interventions, this facility addresses the specific requirements of adult men, women, and teenagers. With dedicated programs for distinct age groups and genders, Rehabilitative Health Services delivers effective care and assistance for those pursuing recovery from addiction and mental health difficulties.

Relentless Recovery

Situated in Columbus, OH, Relentless Recovery delivers a wide range of services for adults and young adults struggling with addiction. This center features detoxification and substance abuse treatments through both intensive outpatient and regular outpatient programs, including outpatient detox options. Emphasizing 12-step support, anger management techniques, and brief intervention strategies, the facility serves both men and women, including those who have faced sexual abuse. With tailored programs designed to meet the specific requirements of each person, the center provides exceptional care and support for all clients on their journey to recovery from addiction.

Relevance LLC
Freehold, NJ

Relevance LLC, situated in Freehold, NJ, delivers extensive recovery support for those overcoming addiction. Their programs include intensive outpatient care, day treatment, and partial hospitalization, incorporating methods like 12-step facilitation, anger management, and brief intervention. They offer specialized tracks for active military personnel, young people, and adult males. Addressing dual diagnoses of addiction and mental health issues, the center serves all ages, from children to adults, and provides options for sober living and transitional housing. Relevance LLC welcomes both male and female individuals, committed to providing excellent assistance throughout their healing journey.

Remedy Therapy
Stuart, FL

Remedy Therapy, situated in Stuart, FL, delivers thorough addiction treatment for adults and young adults. This facility offers inpatient hospital detoxification and care for substance use disorders, encompassing co-occurring serious mental health conditions and emotional difficulties. Emphasizing 12-step facilitation, anger management, and cognitive behavioral therapy, Remedy Therapy customizes programs for each client's specific requirements. Dedicated to trauma-informed practices, the center accommodates both male and female individuals, aiming to provide effective, research-backed treatment. For those looking for assistance on the path to recovery, Remedy Therapy's specialized offerings are worth considering.

ReMind Health Group
Louisville, KY

ReMind Health Group, situated in Louisville, KY, delivers a wide array of addiction recovery services tailored for both adults and young adults. The center excels in detoxification, treatment for substance use disorders, and addressing co-occurring mental health issues. Offering various treatment modalities including intensive outpatient, outpatient care, and options involving methadone, buprenorphine, or naltrexone, ReMind Health Group emphasizes 12-step programs, anger management strategies, and short intervention techniques. This facility serves a diverse clientele, including active duty military personnel, teenagers, and adult males, ensuring that both men and women receive high-quality care as they work toward overcoming addiction and restoring their health and wellness.

Renaissance Ranch
Riverton, UT

Renaissance Ranch, situated in Riverton, UT, delivers extensive addiction recovery programs specifically designed for adult men dealing with substance use challenges and accompanying mental health conditions. This center excels in offering long-term residential care with customized services that include 12-step programs, anger management support, and short-term interventions. By concentrating on individuals who have faced trauma, Renaissance Ranch fosters a nurturing recovery atmosphere. The facility provides residential detoxification along with round-the-clock care for adults, seniors, and young adults. For males in need of personalized, research-backed rehabilitation in a supportive environment, Renaissance Ranch stands out as a reliable option.

Rehab After Work
Jenkintown, PA

Rehab After Work, situated in Jenkintown, PA, provides various treatment options for adults and young adults facing substance use challenges. This center is dedicated to supporting those who experience both substance use disorders and significant mental health issues or emotional challenges. Treatment modalities available here include intensive outpatient programs, general outpatient services, and day treatment or partial hospitalization. Utilizing methods such as 12-step programs, anger management, and brief interventions, the facility delivers personalized care aimed at addressing the specific needs of each individual. Rehab After Work also features specialized programs designed for adult men and women, as well as clients who have dealt with intimate partner violence or domestic abuse. Committed to delivering high-quality care for all clients, this center emphasizes a holistic approach to rehabilitation.

Relief Integrated Healthcare

Relief Integrated Healthcare, located in Louisburg, NC, specializes in substance use treatment for adults experiencing co-occurring serious mental health disorders. The center provides various levels of care, including intensive outpatient, outpatient, and treatment options using methadone, buprenorphine, or naltrexone. Employing strategies such as anger management, brief interventions, and cognitive behavioral therapy, this facility serves active duty military personnel, adolescents, and adult males. Relief Integrated Healthcare is dedicated to supporting both adult and child/adolescent patients, regardless of gender. With a commitment to delivering high-quality care and diverse specialized programs, individuals seeking thorough addiction recovery will find personalized assistance at this center.

Reid Outpatient Behavioral Health

Reid Outpatient Behavioral Health in Connersville, IN, delivers targeted outpatient care for addiction and intertwined mental health challenges affecting individuals of all ages. The facility employs a variety of proven therapeutic methods such as anger control, cognitive restructuring, and incentive-based motivation. Their offerings are designed for specific groups including military personnel, adult men, and adult women, demonstrating a commitment to serving varied needs. Catering to both younger and adult individuals regardless of gender, Reid Outpatient Behavioral Health prioritizes effective treatment through outpatient medication options like methadone, buprenorphine, or naltrexone, alongside consistent outpatient care.

Renaissance House

Renaissance House, situated in Bisbee, AZ, provides a wide array of rehabilitation services focusing on substance abuse recovery and transitional living arrangements. The center offers various programs including outpatient services, residential care, and short-term stays, employing techniques such as 12-step facilitation, cognitive behavioral therapy, and community reinforcement alongside vouchers. With an emphasis on addressing co-occurring substance use disorders and severe mental health conditions in adults, as well as emotional disturbances in children, Renaissance House serves adult women, active military members, seniors, and young adults affected by intimate partner or domestic violence. The facility's gender-sensitive approach ensures that female clients receive personalized support, fostering a secure and compassionate atmosphere for healing.

Regional Medical Center at Lubec

The Regional Medical Center at Lubec, situated in Lubec, ME, provides extensive outpatient services for adults managing substance use disorders alongside significant mental health conditions or emotional challenges. Their expertise includes anger management, brief intervention techniques, and cognitive behavioral therapy. The center caters to specific groups such as active duty military, teenagers, and adult men. They offer high-quality care to adults and older adults of all genders, utilizing outpatient medication-assisted treatments like methadone, buprenorphine, or naltrexone. The Regional Medical Center at Lubec is committed to personalized care plans and specialized interventions to support individuals on their journey to sustained wellness.

Relax Behavioral Health
West Palm Beach, FL

At Relax Behavioral Health, situated in West Palm Beach, Florida, we provide a complete spectrum of care for substance use disorders. Our services encompass detoxification, intensive outpatient care, and outpatient detox, designed for adults and seniors. Emphasizing 12-step facilitation, anger management, and brief interventions, we customize treatment plans for each client. Specialized programs are available for active duty military personnel, teenagers, and adult men, ensuring targeted support. Relax Behavioral Health also offers housing solutions, such as halfway houses and sober living environments, to assist both men and women in their recovery process.

Remedies Renewing Lives

Remedies Renewing Lives, located in Rockford, IL, provides an extensive range of treatment options for substance use disorders and offers tailored support for adults facing co-occurring mental health challenges or emotional issues in children. The center specializes in intensive outpatient programs, standard outpatient services, and medication-assisted treatments using methadone, buprenorphine, and naltrexone. Utilizing evidence-based methodologies such as cognitive behavioral therapy and the Matrix Model, the facility serves both men and women, including those with dual diagnoses. Catering to individuals of all genders, Remedies Renewing Lives prioritizes quality care within a nurturing environment to facilitate enduring recovery.

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Region XV Warren Yazoo Chem Dep Ctr, located in Vicksburg, MS, provides detox and treatment for substance use through a variety of programs, including intensive outpatient, long-term residential, and standard outpatient care. The center employs methods such as 12-step strategies, brief interventions, and cognitive behavioral therapy to assist both adult men and women, including those dealing with concurrent mental health and substance use challenges. Catering to adults and young adults from all backgrounds, the facility offers customized care designed to meet the unique needs of each individual. Committed to delivering high-quality, comprehensive services, Region XV Warren Yazoo Chem Dep Ctr is focused on guiding individuals on their recovery journey.

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Merrillville, IN

Regional Health Systems in Merrillville, IN, provides extensive rehabilitation for adults and older adults. Their expertise lies in treating addiction and concurrent mental health issues through intensive and standard outpatient care, including detox. They utilize methods like 12-step facilitation, anger management, and brief intervention to address individual needs. Specific programs are available for expectant and new mothers, as well as those facing dual diagnoses. Serving all genders, this center prioritizes well-rounded recovery and effective treatment for individuals struggling with addiction.

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Rek Advanced Therapeutic Solutions, located in Baltimore, MD, provides a wide array of programs aimed at addressing substance use disorders, concurrent mental health challenges, and significant emotional issues. The center specializes in services for active duty military personnel as well as adult men and women, offering both intensive outpatient and traditional outpatient therapies, which include methadone and buprenorphine treatments. The facility employs proven methods such as cognitive behavioral therapy and 12-step facilitation, with an emphasis on anger management strategies. Serving adults and young adults of all genders, Rek Advanced Therapeutic Solutions is committed to delivering personalized care, positioning itself as a reliable option for individuals in need of effective rehabilitation services.

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Situated in Durham, NC, Reliable Health Services delivers extensive treatment for substance use disorders in both adults and children facing significant mental health challenges. The center offers a range of services, including intensive outpatient programs, outpatient day therapy, and partial hospitalization, employing methods such as 12-step facilitation, anger management, and brief intervention strategies. Tailored programs are available for adult men, adult women, and individuals who have undergone traumatic experiences. Catering to adults and seniors of all genders, this facility prioritizes high-quality care through personalized treatment plans grounded in evidence-based approaches.

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Renaissance Ranch, situated in Draper, UT, provides exceptional treatment for substance abuse and individualized support for individuals facing significant mental health issues. The center primarily serves adult males who have experienced trauma and offers various treatment options, including intensive outpatient programs, outpatient services, and day treatment. Utilizing evidence-based practices such as 12-step programs, anger management techniques, and brief interventions, Renaissance Ranch caters to adults, seniors, and young adults in a male-exclusive environment. For those in search of complete rehabilitation in a nurturing atmosphere, this center is committed to helping individuals achieve enduring recovery and enhanced mental health.

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Renaissance Rehabilitation Services, situated in Buffalo, NY, delivers extensive addiction recovery and targeted support for those experiencing dual diagnoses of substance abuse and significant mental health conditions. The facility offers acute inpatient, extended residential, and round-the-clock residential services designed for adults, emphasizing 12-step principles, emotional regulation techniques, and short-term counseling strategies. Featuring distinct programs for young people, adult men, and adult women, Renaissance Rehabilitation Services accommodates diverse age demographics and genders, delivering personalized care and assistance. Patients can anticipate superior treatment within a nurturing setting, positioning this center as an excellent option for comprehensive recovery.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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