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Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Sage Neuroscience Center

Sage Neuroscience Center in Albuquerque, NM, delivers a complete suite of rehabilitative programs designed for your unique situation. They offer detox services, address substance abuse, and provide focused support for individuals facing both addiction and significant mental health challenges. Treatment options include robust outpatient programs and a day treatment setting. Their methods are grounded in proven techniques like cognitive behavioral therapy and anger resolution. Sage Neuroscience Center also features dedicated programs for adult men and women, and those affected by intimate partner or domestic violence. Serving all age groups from children to adults, they provide gender-tailored care for both men and women. You can anticipate caring and successful support at this location.

Sage Recovery and Wellness Center

Sage Recovery and Wellness Center, located in Austin, TX, presents a variety of thorough addiction recovery programs designed for both adults and minors. The center focuses on dual diagnosis treatment for individuals facing both substance use and mental health challenges. Offering intensive outpatient, outpatient, and standard outpatient services, the facility employs customized methods that feature 12-step support, anger management strategies, and brief intervention methods. With dedicated programs aimed at teenagers and young adults, Sage Recovery and Wellness Center addresses the needs of a wide array of age groups. The center prioritizes individualized care, welcoming clients of all genders and promoting a nurturing atmosphere for those on their path to recovery.

Safe Harbor Recovery LLC

Safe Harbor Recovery LLC, located in Warren, OH, provides a thorough selection of long-term residential treatment options for adult men dealing with substance use issues. This facility is particularly equipped to support clients who have faced sexual trauma or abuse, fostering a nurturing atmosphere conducive to healing. Employing methods such as 12-step facilitation, anger management, and cognitive behavioral therapy, Safe Harbor ensures a comprehensive approach to recovery. Participants benefit from continuous support and care, including residential detoxification and around-the-clock residential services. Targeted towards adults and young adults in need of tailored addiction treatment, Safe Harbor Recovery LLC is recognized for its dedication to high-quality care and personalized assistance.

Safe Refuge
Long Beach, CA

In Long Beach, California, Safe Refuge provides complete care for adults and adolescents struggling with addiction. They are experts in addressing dual diagnoses, simultaneously treating substance use issues and severe mental health conditions in adults, or significant emotional challenges in children. Safe Refuge offers flexibility in its treatment durations with options for extended stays, brief interventions, and around-the-clock residential care. Their therapeutic methods incorporate 12-step principles, anger management techniques, and cognitive behavioral therapy. Specialized programs are also offered for active military members, adult men, and adult women. Safe Refuge is dedicated to delivering high-quality support for all clients, regardless of gender, on their path to recovery.

Safe Refuge
Long Beach, CA

Safe Refuge, located in Long Beach, CA, delivers a wide array of treatment options for individuals dealing with substance use issues, including both adults and young adults. The center specializes in addressing co-occurring mental health conditions alongside substance use disorders, offering various treatment durations, such as long-term, short-term, and 24-hour residential care. By employing evidence-informed strategies like 12-step programs, anger management, and cognitive behavioral therapy, Safe Refuge promotes a comprehensive approach to healing. The center features specific programs for active military, as well as services tailored for adult men and women. It provides a nurturing and secure atmosphere for clients of all genders who are pursuing a path toward recovery.

Safe Refuge
Long Beach, CA

Safe Refuge, situated in Long Beach, CA, provides an array of premium rehabilitation services. This center offers various treatment options including long-term, residential, and short-term care for individuals facing substance use issues and coexisting mental health disorders, for both adults and children. The treatment methods used encompass 12-step support, anger management strategies, and cognitive behavioral therapy. Safe Refuge serves active duty military members, adult men and women, as well as young adults. With tailored programs designed for various age brackets and genders, Safe Refuge is dedicated to offering thorough and effective care for those pursuing recovery from addiction and mental health struggles.

Safe Refuge
Long Beach, CA

Safe Refuge, located in Long Beach, CA, provides a wide array of treatment options for substance use issues and co-occurring mental health disorders. This center caters to both adults and young adults with its long-term, short-term, and around-the-clock residential programs. Emphasizing personalized care, Safe Refuge employs evidence-based strategies including 12-step support, anger management techniques, and cognitive behavioral therapy. The facility also features specialized services for active military members, men, and women. Committed to delivering high-quality care, Safe Refuge serves as a secure environment for those in need of compassionate and effective addiction recovery support.

Safe Refuge
Long Beach, CA

Situated in Long Beach, CA, Safe Refuge delivers an extensive array of rehabilitation options for adults and young adults facing challenges with substance use disorders alongside severe mental health issues. The center offers various treatment programs, including long-term, short-term, and around-the-clock residential care, employing proven methods such as 12-step facilitation, anger management, and cognitive behavioral therapy. Safe Refuge also incorporates specialized programs designed for active duty military members, adult men, and adult women, guaranteeing customized support for different demographics. Committed to providing high-quality and personalized care, Safe Refuge aims to assist clients in achieving sustainable recovery and enhanced mental well-being.

Safe Refuge
Long Beach, CA

Safe Refuge, situated in Long Beach, CA, delivers extensive substance abuse treatment designed for adults and adolescents. The facility excels in addressing dual diagnoses, combining addiction with significant mental health or emotional challenges. Their offerings encompass intensive outpatient, extended residential stays, and outpatient services, all grounded in proven methods like 12-step encouragement, emotional regulation training, and cognitive restructuring. Safe Refuge also features distinct programs for active military members, men, and women, guaranteeing personalized support. The center is committed to providing superior, gender-tailored care to guide individuals toward lasting recovery.

Safe Refuge
Long Beach, CA

Situated in Long Beach, California, Safe Refuge delivers an all-encompassing strategy for the treatment of substance use disorders in both adults and young adults grappling with significant co-occurring mental health problems. The center offers a variety of program lengths, including long-stay, short-stay, and around-the-clock residential options, addressing the unique needs of individuals in search of effective treatment. Safe Refuge also features dedicated programs for active duty service members, as well as specific tracks for men and women, fostering an inclusive and nurturing atmosphere. Emphasizing holistic healing, this facility is committed to facilitating enduring recovery and overall wellness for its clients.

Safe Refuge
Long Beach, CA

Safe Refuge, situated in Long Beach, CA, delivers extensive addiction recovery programs for adults and young adults. The center is equipped to provide specialized support for those facing both addiction and significant mental health challenges. Offering a variety of residential options, including long-term, short-term, and 24-hour care, Safe Refuge customizes treatment plans for each client. Their therapeutic methods are grounded in proven techniques like 12-step support, emotional regulation training, and cognitive behavioral strategies. Safe Refuge also features distinct programs designed for active military members, adult men, and women. The facility is committed to high standards of care and provides separate treatment tracks for men and women, fostering a secure and conducive atmosphere for healing.

Saginaw Odyssey House Inc

Saginaw Odyssey House Inc, situated in Saginaw, MI, delivers extensive recovery support for adult women facing challenges with substance abuse and concurrent severe mental health conditions. Their array of services includes long-term residential stays, intensive outpatient care, and standard outpatient treatment. The center is particularly adept at assisting those who have endured intimate partner violence, domestic abuse, and sexual assault. Employing therapeutic methods like anger management, motivational interviewing, and cognitive behavioral therapy, Saginaw Odyssey House Inc serves adults, older adults, and younger adults. This facility offers a secure and nurturing setting strictly for women, ensuring individualized, top-tier care designed to address each resident's specific requirements.

Safe Point Lighthouse

Safe Point Lighthouse, located in Dunkirk, NY, provides a variety of outpatient treatment options for substance use, including methadone/buprenorphine and naltrexone therapies, as well as traditional outpatient services. The center is particularly adept in areas such as anger management, brief interventions, and cognitive behavioral therapy. It features distinct programs designed for active military personnel, teenagers, and adult males. Care is accessible for adults and youths of all genders. With a commitment to quality care, Safe Point Lighthouse emphasizes personalized treatment plans that cater to the unique needs of each individual. Its comprehensive approach and tailored programs position it as an essential resource for those in search of effective addiction recovery support.

Safe Point Lighthouse

Situated in Dunkirk, NY, Safe Point Lighthouse provides outpatient treatment options for individuals dealing with substance use issues, including programs for both adults and young adults. The center offers a range of specialized services such as outpatient care using methadone, buprenorphine, or naltrexone, as well as anger management, brief intervention sessions, and cognitive behavioral therapy. Catering to active military members, adolescents, and adult males, it emphasizes personalized treatment plans that address the specific requirements of different demographics. Safe Point Lighthouse is recognized for its holistic approach to addiction recovery, concentrating on delivering high-quality care that is customized for each client's distinct circumstances. If you are in search of targeted substance use treatment with an emphasis on personalized attention, this facility may be ideal for you.

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Safe Harbor Treatment Center in Costa Mesa, CA, offers a complete spectrum of recovery services. Their expertise lies in medically supervised detox and ongoing substance use disorder therapy. Patients receive care within an inpatient hospital setting, with round-the-clock professional assistance. The center employs a range of therapeutic strategies, such as 12-step integration, emotional regulation training, and concise counseling, tailored to the distinct requirements of adult men and women, and young adults. A distinctive feature of Safe Harbor Treatment Center is its tailored programs for individuals who have endured intimate partner violence, domestic abuse, and sexual trauma. Emphasizing excellence in care and personalized recovery plans, this institution provides a nurturing atmosphere for individuals on their journey to wellness.

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Situated in Costa Mesa, California, Safe Harbor Treatment Center provides an extensive range of detoxification and addiction recovery services. This facility is equipped with hospital-based inpatient detox and treatment options, ensuring round-the-clock care for patients. Safe Harbor Treatment Center focuses on various therapeutic methods, including 12-step programs, anger management, and brief intervention techniques. The center offers specialized programs designed for adult women, as well as those affected by intimate partner violence, domestic abuse, and sexual trauma. Available to both adults and young adults of all genders, the center prioritizes personalized care with an emphasis on compassion and quality. Safe Harbor Treatment Center is a reliable option for individuals looking for effective and nurturing support in their journey toward recovery.

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Safe Harbor Treatment Center, located in Costa Mesa, California, provides an extensive range of detox and substance abuse treatment options. The center features hospital-based inpatient detox services alongside therapeutic programs that emphasize 12-step methods, anger management, and brief interventions. It also offers specialized programs designed for adult women and individuals affected by intimate partner violence, domestic abuse, and sexual trauma. Catering to both adult men and women, Safe Harbor Treatment Center is dedicated to offering exceptional care in a nurturing setting. If you or someone close to you is looking for personalized addiction recovery support, this facility is well-prepared to assist in your healing process.

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Safe Harbor Treatment Center, located in Costa Mesa, CA, provides extensive inpatient hospital services for adults and young adults undergoing detoxification and substance use treatment. Their approach emphasizes 12-step facilitation, anger management, and brief intervention strategies. The center offers specialized care for adult women and those who have faced intimate partner violence, domestic violence, or sexual abuse. Personalized treatment programs are designed to meet the specific requirements of all clients, both male and female. Safe Harbor Treatment Center is committed to delivering exceptional care within a nurturing setting, empowering individuals on their journey to sustained recovery and enhanced health.

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Long Beach, CA

Situated in Long Beach, CA, Safe Refuge provides an extensive range of rehabilitation services tailored for adults and young adults facing challenges with substance use disorders and concurrent serious mental health conditions. The center offers various treatment options, including long-term, short-term, and residential programs, all designed to promote a nurturing recovery environment. Safe Refuge employs diverse methods, like 12-step guidance, anger management techniques, and cognitive behavioral therapy, to meet the specific needs of each client. There are specialized programs for active duty service members, as well as distinct services for both adult men and women. Committed to delivering high-quality care and custom treatment strategies, Safe Refuge aims to support individuals on their journey to sustainable recovery.

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Long Beach, CA

Situated in Long Beach, California, Safe Refuge presents an array of detailed rehabilitation services designed for individuals aiming to conquer substance abuse issues and related mental health conditions. The center offers various treatment lengths including long-term, short-term, and around-the-clock residential options, utilizing proven methodologies like 12-step programs, anger management classes, and cognitive behavioral therapy. Tailored programs for active military members, as well as adult males and females, guarantee customized support for individuals of different ages and genders. Safe Refuge is dedicated to delivering high-quality, personalized care, establishing itself as a reliable option for those embarking on their recovery journey.

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Saint Paul, MN

Nestled in Saint Paul, MN, Sage Prairie Eagan stands as a dedicated provider of extensive addiction recovery solutions. This establishment features transitional living, halfway house accommodations, and sober living environments, specifically designed for adults contending with both addiction and significant mental health challenges. Employing treatment modalities like inpatient hospital care and robust outpatient programs, Sage Prairie Eagan employs proven therapeutic strategies including 12-step integration, cognitive behavioral therapy, and the Matrix Model. The center boasts specialized offerings for active military members, adult men, and adult women, welcoming individuals across young adult and adult age groups. Sage Prairie Eagan delivers customized support for both male and female individuals in pursuit of effective rehabilitation.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)