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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Samaritan Medical Center

Samaritan Medical Center in Watertown, NY, provides dedicated rehabilitation for individuals battling substance use disorders, with a focus on also addressing any co-occurring mental health challenges. They offer a range of treatment modalities designed for both adults and younger individuals, including intensive outpatient services, standard outpatient care, and medication-assisted treatment options such as methadone, buprenorphine, and naltrexone. Employing proven methods like cognitive behavioral therapy, motivational interviewing, and brief intervention, the center guides patients toward sustained recovery. Samaritan Medical Center has developed specific programs catering to adolescents, adult men, and women, ensuring inclusive support across different demographics. Their commitment lies in delivering high-quality, personalized care to facilitate enduring recovery for everyone they serve.

Samba Recovery
Peachtree Corners, GA

Samba Recovery in Peachtree Corners, GA, delivers targeted therapies for individuals, both young and adult, grappling with substance abuse and co-occurring mental health challenges. The facility offers various levels of care, including intensive outpatient, outpatient, and day treatment programs. Their therapeutic approach emphasizes strategies like anger management, brief intervention, and cognitive behavioral therapy. Samba Recovery also provides specialized pathways for active duty military personnel, as well as distinct programs for adult men and women. This comprehensive center is dedicated to providing excellent care and support to all individuals pursuing recovery.

San Diego American Indian Health Ctr

San Diego American Indian Health Ctr, located in San Diego, CA, provides outpatient services for those dealing with substance use issues and co-occurring mental health disorders in adults, as well as emotional challenges in children. The center emphasizes strategies such as 12-step programs, brief interventions, and cognitive behavioral therapy, offering specialized care for adult men, adult women, and trauma survivors. Catering to both adults and children/adolescents across all genders, this center is committed to delivering effective treatment in a culturally respectful setting. If you are looking for all-encompassing support that tackles both addiction and mental health difficulties, this facility is here to assist you on your path to recovery.

San Francisco AIDS Foundation

San Francisco AIDS Foundation, situated in San Francisco, CA, provides outpatient services for adults struggling with substance use. Their approach integrates Cognitive Behavioral Therapy, Motivational Interviewing, and Contingency Management. This center is particularly skilled in addressing concurrent substance use disorders and significant mental health concerns in adults, as well as profound emotional challenges in children. They offer specialized programs for adult men and women, including those affected by intimate partner or domestic violence, ensuring high-quality support within an inclusive setting. Committed to assisting adults and young adults in their recovery path, this facility welcomes all clients.

Samaritas
Belding, MI

Samaritas in Belding, MI provides extensive recovery support for adults and seniors facing addiction and co-occurring mental health challenges. Their offerings encompass robust outpatient treatment, supervised detox services, and flexible outpatient plans designed to meet individual requirements. The center features distinct programs for adolescents, adult men, and adult women, facilitating highly individualized care. Their therapeutic methods include anger management techniques, targeted brief interventions, and cognitive behavioral therapy, all geared toward achieving sustainable healing. Samaritas is recognized for its dedication to high-quality support and its emphasis on catering to the specific requirements of different genders and age demographics.

Samaritas
Troy, MI

Samaritas, situated in Troy, MI, stands out as a premier rehabilitation center that offers an extensive variety of treatment services for those grappling with substance use disorders. This facility is adept at addressing both substance use issues and significant mental health conditions in adults, alongside severe emotional challenges in children. Emphasizing intensive outpatient and outpatient services, Samaritas employs specialized strategies including anger management, brief intervention, and cognitive behavioral therapy. Their unique programs are designed for individuals across different age groups, including adolescents, adults, and seniors, ensuring personalized treatment approaches for each gender. Samaritas is committed to delivering exceptional care and assistance to those on their journey to overcome addiction.

San Francisco AIDS Foundation

The San Francisco AIDS Foundation, situated in San Francisco, CA, provides outpatient support for individuals grappling with substance use disorders. Their services extend to adults facing co-occurring serious mental health challenges or emotional distress. Employing evidence-based techniques such as cognitive behavioral therapy, motivational interviewing, and contingency management, this establishment delivers targeted interventions for adult men and women, including those who have endured intimate partner violence. Committed to excellence and personalized care, the center serves adult men, women, and young adults looking for holistic addiction recovery within a nurturing setting.

Samaritan Daytop Village Inc

Samaritan Daytop Village Inc, located in Staten Island, NY, provides a wide variety of treatment options for both adults and children. This center focuses on detoxification, treatment for substance use, and addressing co-occurring conditions. It offers both intensive outpatient and standard outpatient services, including detox programs. Emphasizing approaches like 12-step facilitation, anger management, and brief interventions, the facility is dedicated to customizing care for each person. Distinctive programs for active duty military members, adolescents, and adult men highlight its unique offerings. Serving clients of all genders, Samaritan Daytop Village Inc is committed to delivering high-quality, evidence-based support to individuals on their recovery journey.

Samaritan Daytop Village Inc

Samaritan Daytop Village Inc, situated in Blauvelt, NY, offers extensive treatment options for substance use disorders alongside specialized services for individuals experiencing significant mental health challenges. The center provides various treatment modalities, including intensive outpatient, outpatient, and day programs. Their therapeutic approach features techniques such as anger management, brief intervention strategies, and cognitive behavioral therapy. Additionally, Samaritan Daytop Village has programs specifically designed for active duty military personnel, as well as tailored support for adult men and women. This center serves a wide array of clients, including adults, seniors, and young adults of all genders, ensuring a high standard of care and evidence-informed practices in rehabilitation.

Samaritan Daytop Village/Harlem

Samaritan Daytop Village/Harlem, located in New York, NY, provides extensive support for individuals and families facing addiction challenges. Their programs are designed to address a spectrum of needs, including initial withdrawal management, ongoing substance use disorder treatment, and specialized care for those with co-occurring mental health conditions in adults and emotional difficulties in young people. The center offers various levels of outpatient care, including intensive programs and detoxification services, to accommodate different recovery journeys. Their therapeutic methodologies encompass techniques such as anger management, brief intervention strategies, and cognitive behavioral therapy. Additionally, Samaritan Daytop Village/Harlem features distinct services for active-duty military personnel, adolescents, and adult men. They are committed to delivering personalized, high-quality treatment to adults and young individuals of all genders.

Samaritan Inns
Washington, DC

Samaritan Inns, located in Washington, DC, provides an extensive array of long-term residential treatment services aimed at addressing substance abuse and co-occurring serious mental health conditions in adults, alongside emotional issues in children. Emphasizing 12-step methodologies, anger management techniques, and brief intervention strategies, this center is designed primarily for adult men who have faced intimate partner violence, domestic abuse, and sexual trauma. With a focus on personalized care for adults, seniors, and young adults, Samaritan Inns is recognized for its specialized programs and gender-focused treatment for male individuals. The center's dedication to high-quality care and personalized support establishes it as an essential option for those pursuing recovery from addiction and mental health challenges.

Samaritan Inns Inc
Washington, DC

Samaritan Inns Inc, located in Washington, DC, provides extensive addiction recovery programs within a nurturing residential environment designed for adult women. The center's expertise lies in addressing substance abuse, offering supportive transitional living, and treating individuals with both addiction and significant mental health challenges. Emphasizing extended residential stays, the facility incorporates methods like 12-step support, emotional regulation techniques, and short-term counseling. Targeted assistance is available for women impacted by domestic abuse, intimate partner violence, or sexual trauma. Samaritan Inns Inc serves adults and older adults, delivering specialized, gender-affirming care to foster enduring sobriety and overall well-being.

Samaritas
Grand Rapids, MI

Samaritas, situated in Grand Rapids, MI, provides a wide range of rehabilitation services for adults and seniors facing challenges related to substance use and co-occurring mental health disorders. This center features intensive outpatient programs, general outpatient services, and tailored initiatives for adolescents and those who have experienced trauma. With an emphasis on research-backed methods such as cognitive behavioral therapy and anger management, Samaritas supports both men and women in their recovery journeys. Their outpatient options for methadone/buprenorphine or naltrexone treatment are designed to meet the unique needs of each individual. Samaritas is recognized for its exceptional care and dedication to aiding individuals as they navigate their pathways to recovery.

Samaritas
Charlotte, MI

Samaritas, situated in Charlotte, MI, stands as a premier recovery facility providing a full spectrum of care for adults and seniors facing addiction and co-occurring mental health challenges. They offer robust outpatient detoxification, intensive outpatient programs, and general outpatient services. Their treatment model integrates proven methods like cognitive behavioral therapy, anger management, and brief intervention. Samaritas serves a broad client base, including teenagers, adult males, and adult females, with distinct programs designed for each demographic. Prioritizing high-quality support and personalized treatment strategies, Samaritas is dedicated to guiding individuals toward lasting recovery.

San Bernardino Cnty Dept Behav Health

San Bernardino Cnty Dept Behav Health, located in Barstow, CA, delivers extensive addiction recovery services aimed at both adults and young adults. The facility specializes in detoxification, treatment for substance abuse, and offers dedicated support for those facing dual diagnoses that include both substance use issues and significant mental health disorders. Emphasizing intensive outpatient and outpatient treatment options, the center employs research-based techniques such as cognitive-behavioral therapy, anger management, and brief interventions. It serves both men and women, along with individuals who have undergone traumatic experiences, providing personalized care to meet varied needs. The center's dedication to high-quality treatment and a wide array of programs underscores its importance as a resource for individuals on their path to recovery.

San Diego Freedom Ranch Inc

San Diego Freedom Ranch Inc, located in Campo, CA, offers long-term residential programs focusing on detoxification, substance use treatment, and treating co-occurring substance use with serious mental health issues in adults or serious emotional disturbances in children. The facility provides specialized care for adult men, active duty military personnel, and adolescents. With a focus on 12-step facilitation, anger management, and brief intervention approaches, this center ensures quality and comprehensive care for male clients. Serving adults, seniors, and young adults, San Diego Freedom Ranch Inc is a reliable choice for individuals seeking effective and tailored rehabilitation services.

San Luis Valley
La Jara, CO

Situated in La Jara, Colorado, the San Luis Valley rehabilitation center provides outpatient treatment options for substance use disorders, catering to both adults and children who may also face mental health issues concurrently. This center specializes in various therapeutic approaches, including anger management, cognitive behavioral therapy, and trauma-informed care, offering customized programs designed to assist individuals dealing with substance abuse and mental health problems. Committed to delivering high-quality care, the facility includes outpatient methods such as methadone/buprenorphine and naltrexone treatments, along with standard outpatient services. The San Luis Valley center supports adults and seniors of every gender, establishing itself as a reliable provider of thorough and impactful rehabilitation solutions.

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Samaritan Daytop Village Inc, located in Richmond Hill, NY, delivers thorough addiction recovery services via extended-stay residential, round-the-clock residential, and brief residential treatment options. This establishment emphasizes anger management, concise intervention strategies, and cognitive behavioral therapy, delivering customized support to adults and young adults. Serving both men and women, the center employs a distinctive method to create individualized recovery roadmaps. Samaritan Daytop Village Inc distinguishes itself through its dedication to high-standard treatment and personal engagement, positioning it as a dependable resource for individuals pursuing impactful and encouraging substance use disorder care.

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Holland, MI

Situated in Holland, Michigan, Samaritas offers a complete spectrum of rehabilitative services, including detox, addiction treatment, and expert support for individuals facing both substance abuse and significant mental health challenges. This center delivers intensive outpatient, standard outpatient, and outpatient detox programs within a nurturing setting. Emphasizing techniques such as anger management, brief intervention, and cognitive behavioral therapy, Samaritas personalizes treatment plans. Dedicated programs are available for teenagers, adult men, and adult women, and the facility serves adults and seniors of all gender identities. Samaritas is committed to providing excellent care with empathy to guide individuals toward lasting recovery.

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San Bernardino County, situated in Rialto, CA, delivers extensive treatment options for substance use for both adults and young adults. This center features outpatient programs that include methadone/buprenorphine or naltrexone therapies, standard outpatient care, brief intervention sessions, the Matrix Model, and motivational interviewing techniques. The facility adopts a personalized approach, providing customized support for every client. With dedicated programs for males and females, San Bernardino County emphasizes high-quality care to assist individuals as they move towards recovery from addiction.

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Situated in Blanding, UT, the San Juan Counseling Center provides targeted outpatient services for adults facing substance abuse as well as concurrent serious mental health challenges, alongside support for emotional difficulties in children. Their extensive offerings include outpatient treatments with methadone/buprenorphine or naltrexone, 12-step programs, anger management sessions, and brief interventions. The center is designed to serve adults and seniors across all genders, focusing on personalized care for trauma survivors and those engaged with the criminal justice system. Committed to delivering quality and customized treatment, the San Juan Counseling Center strives to assist clients in attaining sustainable recovery and enhanced well-being.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)