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Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Serenity Knolls Treatment Center

Serenity Knolls Treatment Center, situated in Forest Knolls, CA, provides extensive treatment options for addiction aimed at both adults and young adults. The center is dedicated to the processes of detoxification and treatment for substance use, offering long-term residential care, residential detox, and round-the-clock support. Their approach combines 12-step principles, brief interventions, and cognitive-behavioral therapy tailored to meet the unique needs of each individual. Serenity Knolls also features targeted programs designed specifically for men, women, and individuals who have faced intimate or domestic violence, ensuring that both male and female clients receive gender-responsive support in their journey to recovery.

Serenity Lane
Eugene, OR

Situated in Eugene, Oregon, Serenity Lane delivers extensive detox and substance abuse services for both adults and young adults. The center features tailored programs for those affected by intimate partner violence, domestic violence, sexual abuse, and various forms of trauma, creating a nurturing space for recovery. By employing methods like 12-step support, anger management, and brief interventions, the facility guarantees individualized attention to meet specific requirements. Serenity Lane provides hospital inpatient detox and treatment options, accommodating clients of all genders. Discover compassionate and impactful care at this esteemed rehabilitation center.

Serenity Lane
Eugene, OR

Situated in Eugene, Oregon, Serenity Lane delivers thorough addiction recovery services for both adults and young adults. This center specializes in hospital-based inpatient detox and employs various methods including 12-step programs, anger management, and short-term interventions. With tailored programs designed for men, women, and those who have faced trauma, Serenity Lane addresses a variety of needs. The facility prioritizes personalized care for all clients, ensuring high-quality treatment that fosters recovery. For anyone looking for a nurturing setting for detox and substance abuse rehabilitation, this center provides a myriad of services to support your path to sobriety.

Serenity Light Recovery

Serenity Light Recovery in Angleton, TX provides extensive support for those battling substance abuse and accompanying mental health challenges. Their offerings include inpatient detox and treatment, employing methods like 12-step guidance, anger management techniques, and brief intervention strategies. They also feature distinct programs for active military members, adult men, and women, demonstrating a capacity to serve a broad spectrum of individuals. Serenity Light Recovery welcomes adults and young adults of all genders, providing personalized care plans. This dedication to high-quality, customized treatment solidifies its standing as a reliable option for pursuing recovery.

Serenity Park Treatment Center

At Serenity Park Treatment Center in Little Rock, AR, we provide extensive inpatient hospital care for substance use disorders, emphasizing detoxification and comprehensive treatment. Our approach integrates 12-step facilitation, anger management techniques, and brief intervention strategies, with a particular focus on adult men impacted by intimate partner violence. We also offer specialized programs designed for active duty military members. Our services are inclusive of adults, seniors, and young adults, ensuring that Serenity Park Treatment Center delivers personalized, gender-specific care to aid all male clients in achieving lasting recovery.

Serenity Recovery Centers Inc

Serenity Recovery Centers Inc in Memphis, TN, offers a comprehensive range of substance use treatment services and transitional housing. This facility provides treatment for co-occurring substance use disorders alongside serious mental health issues in adults and emotional disturbances in children. With specialized programs catering to adult men and women, as well as clients who have experienced intimate partner or domestic violence, this center ensures personalized care. The treatment formats include intensive outpatient, outpatient, and day treatment options, utilizing approaches such as 12-step facilitation, anger management, and brief interventions. Serving adults and young adults of all genders, Serenity Recovery Centers Inc focuses on delivering quality care to support individuals on their path to recovery.

Serenity Recovery Centers Inc

Serenity Recovery Centers Inc, situated in Memphis, TN, presents an extensive array of services for individuals dealing with substance use disorders. The center specializes in intensive outpatient programs, long-term residential treatment, and various outpatient services. Emphasizing approaches such as 12-step facilitation, anger management, and brief intervention, it welcomes both adult men and women, including those who have encountered intimate partner or domestic violence. Catering to both adults and young adults, Serenity Recovery Centers Inc is dedicated to personalized treatment that meets the unique needs of each individual. The facility also offers transitional housing and tailored programs for specific groups, focusing on high-quality care and a holistic approach to recovery.

Serenity Treatment Center Inc

Serenity Treatment Center Inc, located in Frederick, MD, provides a wide variety of outpatient programs aimed at assisting adults and young adults dealing with substance use issues. The center is particularly focused on clients with co-occurring mental health challenges, offering services such as intensive outpatient treatment, standard outpatient care, and 12-step programs. Prioritizing personalized treatment, Serenity Treatment Center Inc has tailored programs specifically for adult men and women, as well as those with dual diagnoses. By incorporating strategies like anger management and brief interventions, the center is committed to delivering exceptional care that meets the unique needs of every client. This facility is devoted to guiding individuals through their recovery journey with understanding and research-supported treatment methods.

Seven 2 Seven Medical Services LLC

Seven 2 Seven Medical Services LLC, located in Glen Burnie, MD, provides an extensive selection of outpatient treatment options designed for both adults and seniors. With a focus on detoxification, treatment for substance use, and addressing co-occurring disorders, this center offers outpatient detoxification services along with methadone and buprenorphine therapies. The facility employs evidence-based methods, including cognitive behavioral therapy and motivational incentives. Programs are customized for various groups, including active-duty military personnel, adolescents, and adult men, ensuring that each individual receives the appropriate care. Serving both men and women, Seven 2 Seven Medical Services LLC is committed to delivering high-quality support for those aiming to overcome addiction and mental health issues.

Serenity Light Recovery

Serenity Light Recovery in Houston, TX, provides robust outpatient and intensive outpatient therapy for individuals struggling with addiction and co-occurring mental health conditions, serving both adults and young people. Their therapeutic methodologies include 12-step integration, emotional regulation techniques, and short-term counseling, with dedicated services for military members, adult males, and adult females. Catering to a diverse adult and young adult population, the center emphasizes personalized recovery plans and dedicated assistance. Serenity Light Recovery distinguishes itself through its all-encompassing treatment offerings, custom-designed interventions, and dedication to offering superior, scientifically-supported recovery care.

Serenity Lane
Eugene, OR

Located in Eugene, Oregon, Serenity Lane provides targeted addiction recovery services for adults and adolescents. Their offerings include structured programs like intensive outpatient care and partial hospitalization, designed for those needing thorough support. Serenity Lane utilizes proven therapeutic methods including 12-step integration, emotional regulation skills, and crisis intervention to combat addiction effectively. A particular emphasis is placed on supporting individuals with a history of trauma and those involved with the legal system. Catering to both men and women, Serenity Lane distinguishes itself through its dedication to high standards and personalized recovery strategies.

Serenity Lane
Roseburg, OR

In Roseburg, OR, Serenity Lane provides targeted substance abuse care for adults and young adults requiring intensive outpatient, outpatient, or day treatment. Their methods encompass 12-step facilitation, anger management, and brief intervention. Serenity Lane is distinguished by its unique offerings for individuals with trauma histories or those navigating the legal system. The center offers distinct programs for men and women, ensuring individualized attention for effective recovery. The skilled and empathetic team at Serenity Lane is committed to delivering excellent support throughout the recovery process.

Serenity Hills Life Center

Serenity Hills Life Center, located in Wheeling, WV, provides targeted care for individuals facing substance use issues alongside mental health challenges, serving both adults and children. The facility offers a range of services including long-term residential programs and outpatient options, employing various methods such as 12-step guidance, anger management sessions, and short-term interventions. With a strong emphasis on supporting adult women, the center also addresses the needs of seniors and young adults. Serenity Hills Life Center is distinguished by its holistic approach designed specifically for female clients, fostering a nurturing atmosphere that promotes healing and recovery.

SERV Behavioral Health System Inc

SERV Behavioral Health System Inc, located in Clifton, NJ, provides extensive care for individuals struggling with addiction, encompassing adults and adolescents. Their expertise lies in detoxification, substance abuse rehabilitation, and addressing dual diagnoses that include significant mental health conditions or emotional challenges in youth. Committed to high standards of treatment, the facility offers robust partial hospitalization programs, outpatient detox services, and regular outpatient therapy. Employing scientifically validated methods such as cognitive behavioral therapy and motivational interviewing, they customize recovery plans for each person's unique circumstances. Specific services are available for those facing concurrent mental health and substance use issues. SERV Behavioral Health System Inc serves both men and women, fostering a welcoming atmosphere for everyone on their journey to wellness.

Serenity Treatment Center Inc

Serenity Treatment Center Inc, located in Hagerstown, MD, specializes in providing extensive treatment for substance use disorders among adults and young adults. Their services incorporate support for co-existing mental health challenges in adults and emotional issues in children. The center offers various levels of care, including intensive outpatient, outpatient, and standard outpatient programs, ensuring personalized treatment through methods like 12-step programs, anger management, and brief interventions. Additionally, there are dedicated programs for adult men, adult women, and individuals facing co-occurring mental health conditions. By prioritizing customized treatment plans, Serenity Treatment Center Inc delivers effective support for both men and women on their recovery journey.

Sesser Community Health Center

Situated in Sesser, IL, the Sesser Community Health Center provides extensive outpatient services aimed at assisting adults struggling with substance use and concurrent severe mental health disorders, as well as children facing significant emotional challenges. Prioritizing high-quality care, this center features targeted programs for military personnel on active duty, teenagers, and adult males. Catering to individuals of all genders, including seniors, the facility adopts a holistic strategy to meet the specific requirements of every patient. For those in search of meaningful treatment within a nurturing atmosphere, the Sesser Community Health Center is committed to supporting your path to recovery.

Serenity Now Psychiatric and Csl

Serenity Now Psychiatric and Csl, situated in Bedford, IN, is a full-service recovery center. We provide outpatient care for adults dealing with substance use and co-occurring serious mental health conditions, alongside support for children experiencing significant emotional disturbances. Our programs are personalized, incorporating methods like anger management, brief intervention, and cognitive behavioral therapy. Committed to high standards of treatment, we offer outpatient services including methadone/buprenorphine or naltrexone therapy, alongside standard outpatient care for individuals of all ages and genders.

ServiceNet Inc
Greenfield, MA

ServiceNet Inc in Greenfield, MA, delivers all-encompassing addiction recovery care within a nurturing setting. This institution features extended residential stays, round-the-clock assistance, and phased living arrangements for those pursuing sobriety from addiction. Featuring distinct tracks for active military members, adult males, and females, the center addresses a wide spectrum of requirements. Therapeutic methods encompass guided 12-step work, emotional regulation strategies, and short-term counseling, guaranteeing tailored support for every client. ServiceNet Inc embraces adults and adolescents across all gender identities, offering a secure and welcoming environment for restoration and personal development. Rely on the proficient guidance and skilled professionals at this establishment to aid your path to lasting recovery.

ServiceNet Inc
Orange, MA

ServiceNet Inc, located in Orange, MA, provides extended residential recovery services for adult males in a secure and encouraging setting. This center specializes in supporting individuals who have endured intimate partner violence, employing methods like 12-step integration, cognitive behavioral therapy, and brief intervention strategies. Primarily serving active duty military, adult men, and those impacted by domestic abuse, ServiceNet Inc addresses the needs of various individuals pursuing sobriety. Older adults, younger men, and those in search of temporary accommodation or sober living arrangements will find valuable assistance within their dedicated care programs.

ServiceNet OP Behavioral Center

ServiceNet OP Behavioral Center in Northampton, MA, specializes in outpatient treatment for individuals of all ages struggling with substance use disorders, particularly when they occur alongside significant mental health challenges. This center employs evidence-based methodologies, including cognitive behavioral therapy and motivational interviewing, to deliver personalized regular outpatient services and short-term interventions. They have developed specific programs for individuals affected by trauma, those with multiple co-occurring conditions, and those navigating the legal system. ServiceNet OP Behavioral Center is dedicated to providing high-quality care and support for both male and female clients pursuing recovery and improved behavioral health.

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Set Free DAT Center, located in Houston, TX, provides a wide array of treatment options for substance abuse for both adults and youth. Their offerings encompass support for individuals facing combined challenges of substance misuse and significant mental health disorders, accommodating various client needs. The center features multiple treatment formats, including intensive and regular outpatient programs, employing proven strategies like 12-step principles, anger management techniques, and cognitive behavioral therapy. Furthermore, Set Free DAT Center has unique programs designed specifically for active military personnel, as well as distinct services for adult men and women, ensuring individualized treatment plans. The center is committed to delivering high-quality care, fostering a supportive and nurturing environment for all clients.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)