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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Southeast Louisiana Veterans Health

Situated in New Orleans, LA, Southeast Louisiana Veterans Health delivers extensive rehabilitation options for adults and young adults facing challenges with substance use and concurrent mental health concerns. The center provides various treatment modalities, including intensive outpatient programs, outpatient services, and treatments utilizing methadone, buprenorphine, or naltrexone. Their targeted approaches address the needs of those who have endured trauma, those grappling with both pain and substance use issues, as well as individuals facing dual challenges related to mental health and substance use. By emphasizing 12-step support, anger management techniques, and brief intervention strategies, this center guarantees customized care for both male and female clients on their journey to recovery and wellness.

Southern Arizona VA Healthcare Servs

Southern Arizona VA Healthcare Servs, located in Tucson, AZ, provides a wide range of addiction recovery services specifically designed for adults and young adults experiencing substance use disorders alongside mental health challenges. The center features inpatient detoxification and treatment programs, with specialized care available for those who have faced trauma, domestic violence, sexual abuse, or intimate partner violence. By employing evidence-based methods such as 12-step programs, anger management strategies, and brief therapeutic interventions, this facility focuses on delivering customized treatment for both genders. Committed to quality care and personalizing the recovery process, this center aims to guide clients toward a healthier future.

Southeast Missouri Behavioral Health

Southeast Missouri Behavioral Health, situated in Poplar Bluff, MO, delivers thorough care for both addiction and intertwined mental health conditions affecting individuals of all ages. Their approach centers on tailored treatment, featuring intensive outpatient, standard outpatient, and day treatment options. Employing methodologies like 12-step support, emotional regulation skills, and cognitive restructuring, the facility welcomes male and female patients. The dedication to high standards and bespoke recovery paths distinguishes this center as a reliable choice for individuals pursuing successful rehabilitation.

Southeast Missouri Behavioral Health

Situated in Salem, MO, Southeast Missouri Behavioral Health delivers an extensive variety of treatment services for those pursuing recovery from substance use issues and concurrent mental health disorders. The center features options such as residential detoxification, round-the-clock residential support, and short-term residential programs that cater to both adults and youth. Emphasizing personalized care, the facility designs specialized programs to meet the distinct needs of each individual. Treatment modalities encompass 12-step facilitation, anger management, and cognitive behavioral therapy. Southeast Missouri Behavioral Health is inclusive of all genders and is committed to offering superior, evidence-based care to facilitate enduring recovery.

Southeastern Arizona Behavioral Health

At Southeastern Arizona Behavioral Health in Safford, AZ, we provide outpatient care for individuals and young people struggling with substance misuse, especially when it occurs alongside mental health challenges. Our standard outpatient services incorporate techniques like anger management, brief intervention strategies, and cognitive behavioral therapy. This center is particularly adept at assisting those who are dealing with both mental health and addiction issues simultaneously. We cater to adults and older adults of all backgrounds, guaranteeing excellent care and personalized recovery strategies. Southeastern Arizona Behavioral Health is recognized for its thorough methods in addressing addiction and co-occurring conditions, establishing itself as a vital provider of effective and caring recovery solutions.

Southern CA Alcohol and Drug Prog Inc

Southern CA Alcohol and Drug Prog Inc, located in Bellflower, CA, delivers extensive addiction recovery services tailored for women, seniors, and young adults. The center is dedicated to detox programs, treatment for substance use disorders, and addressing dual diagnoses for those facing both substance abuse and significant mental health challenges. They offer a range of options including long-term residential care, residential detox, and round-the-clock residential services. Emphasizing techniques like 12-step support, anger management, and focused intervention strategies, the facility customizes treatment plans to fit the unique requirements of each individual. Additionally, the center features specialized programs for adult women and those who have experienced intimate partner violence, domestic abuse, or sexual trauma, fostering a nurturing environment conducive to recovery. At Southern CA Alcohol and Drug Prog Inc, clients are met with compassionate support and proven treatment methodologies.

Southern CA Alcohol and Drug Prog Inc

Southern CA Alcohol and Drug Prog Inc, located in Downey, CA, provides extensive residential care focused on helping adults overcome addiction and mental health challenges. Their specialized services include detox, comprehensive substance use disorder treatment, and support for adults with serious mental health conditions and children experiencing emotional disturbances. This facility delivers round-the-clock support through evidence-based methods such as 12-step integration, anger management training, and brief intervention strategies. Distinctive programs are available for adult men, including those with a background of domestic violence or past sexual trauma. The center primarily serves adult and senior men, dedicated to offering superior care and encouragement for individuals pursuing sobriety and mental well-being.

Southeast Missouri Behavioral Health

Southeast Missouri Behavioral Health, situated in Rolla, MO, provides extensive care for adults battling substance use disorders and offers tailored programs for children experiencing significant emotional challenges. Their treatment modalities include intensive outpatient, standard outpatient, and day treatment programs, all grounded in proven methods such as 12-step facilitation, cognitive behavioral therapy, and anger management. This center prioritizes personalized treatment plans for both male and female individuals. By integrating substance abuse treatment with mental wellness support, Southeast Missouri Behavioral Health champions a complete recovery journey, positioning it as a premier option for those in the region pursuing effective rehabilitation.

Southeast Missouri Behavioral Health

Southeast Missouri Behavioral Health, situated in Poplar Bluff, MO, provides a wide range of services for addiction recovery. The center specializes in long-term residential programs, detoxification services, and around-the-clock support for both adults and young people facing issues with substance abuse as well as concurrent mental health challenges. Emphasizing personalized treatment, the facility incorporates scientifically proven methods including 12-step programs, anger management strategies, and cognitive behavioral therapy. Southeast Missouri Behavioral Health distinguishes itself through customized treatment strategies and gender-specific options for male and female clients, guaranteeing effective care for everyone on their journey to recovery.

Southeast Missouri Behavioral Health

Southeast Missouri Behavioral Health, situated in Piedmont, MO, provides expert care for individuals of all ages facing substance use challenges and co-occurring mental health conditions. Their comprehensive offerings include intensive outpatient and standard outpatient programs, featuring medication-assisted treatment with methadone or buprenorphine. They employ proven therapeutic strategies such as 12-step facilitation and cognitive behavioral therapy. This center is dedicated to personalized treatment plans for both male and female patients, fostering a nurturing atmosphere conducive to healing. Their services extend to specialized needs like anger management, reflecting a steadfast dedication to delivering high-quality, complete care.

Southeast Missouri Behavioral Health

Southeast Missouri Behavioral Health, situated in Farmington, MO, delivers a full spectrum of substance abuse recovery options. Their offerings include inpatient detox, round-the-clock residential support, and brief residential stays designed for adults and young people. The center's expertise lies in guiding clients through the 12-step process, employing cognitive behavioral strategies, and teaching effective anger management. Emphasizing a personalized approach, they craft treatment paths specific to each individual's circumstances. For those needing detox, addiction treatment, or temporary lodging, Southeast Missouri Behavioral Health provides excellent care within a nurturing setting. Dedicated tracks are provided for male and female patients.

Southeast Missouri Behavioral Health

Southeast Missouri Behavioral Health, situated in Houston, Missouri, delivers targeted substance use treatment for both adults and children facing significant mental health challenges. The facility offers a variety of services including intensive outpatient programs, daytime outpatient care, and partial hospitalization. Treatment methodologies involve 12-step support, anger management sessions, and cognitive behavioral therapy. With an emphasis on personalized attention, the program accommodates clients of all genders. The center’s distinctive methodology guarantees customized treatment plans for every person, prioritizing high-quality care for individuals pursuing thorough rehabilitation in a nurturing setting.

Southeastern Integrated Care LLC

At Southeastern Integrated Care LLC in Pembroke, NC, adults and youth facing substance use challenges alongside serious mental health concerns receive specialized outpatient care. The center features distinct programs catering to adolescents, adult men, and adult women. Treatment options encompass outpatient medication-assisted treatment (methadone/buprenorphine or naltrexone), anger management techniques, and brief intervention strategies. They also offer individualized 12-step facilitation. Serving a diverse population including adults and seniors of all genders, Southeastern Integrated Care LLC is committed to utilizing proven therapeutic approaches and crafting unique recovery journeys. Their focus is on delivering thorough and empathetic rehabilitation services to individuals seeking support.

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Southeast Missouri Behavioral Health, situated in Steelville, MO, provides a wide range of treatment options for adults dealing with substance use disorders, along with focused care for individuals facing both substance use and significant mental health challenges, as well as emotional issues in children. The center features intensive outpatient programs, standard outpatient services, and day treatment alternatives. Emphasizing approaches like 12-step facilitation, anger management, and cognitive behavioral therapy, programming is customized to meet the specific requirements of each individual. Catering to both adults and younger populations, the center ensures gender-specific support for men and women. Dedicated to delivering exceptional care and personalized treatment, this facility fosters a nurturing atmosphere for those on their path to recovery.

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Southeast Missouri Behavioral Health, situated in Cadet, MO, delivers extensive care for substance use issues and co-occurring mental health conditions, serving both young people and adults. They offer robust programs including intensive outpatient, standard outpatient, and day treatment, employing proven methods like 12-step guidance, emotional regulation skills, and cognitive behavioral interventions. This center prioritizes personalized treatment, welcoming both male and female patients and crafting unique recovery strategies for everyone. Southeast Missouri Behavioral Health distinguishes itself through its dedication to high-quality, specialized treatment designed to meet the specific challenges of each individual, establishing it as a premier option for those pursuing effective and customized recovery support.

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Southeast Missouri Behavioral Health, situated in Farmington, MO, delivers extensive support for substance use disorders and targeted assistance for those facing co-occurring severe mental health conditions or emotional distress. Emphasizing personalized care, their offerings encompass intensive outpatient, standard outpatient, and day treatment modalities. The center's therapeutic interventions include 12-step facilitation, anger management techniques, and cognitive behavioral therapy, catering to both adults and young people. Designed to address the distinct requirements of each individual, this institution provides distinct programs for men and women. Southeast Missouri Behavioral Health is committed to delivering exceptional services to aid individuals in their journey toward lasting recovery.

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In Sierra Vista, AZ, Southeastern Arizona Behavioral Health delivers thorough care for addiction and dual diagnosis in both young people and adults. The facility offers various levels of care, including intensive outpatient, outpatient, and standard outpatient services, employing methods like anger management, brief intervention, and cognitive behavioral therapy. Focusing on individuals with both mental health and substance abuse challenges, this establishment serves adults and older adults of any gender. Dedicated to high-quality treatment and proven therapeutic techniques, Southeastern Arizona Behavioral Health strives to support individuals in attaining sustained recovery and improved emotional health.

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Southeastern Arizona Behavioral Health in Benson, AZ provides a variety of distinct treatment options designed for each individual. This center delivers intensive outpatient care, standard outpatient services, and ongoing outpatient treatment for those struggling with addiction, co-occurring psychological issues, and emotional distress. Utilizing therapeutic modalities such as anger management, brief interventions, and cognitive behavioral therapy, patients are provided with thorough support. The facility is equipped to serve adults and older adults, with distinct programs for men and women. Southeastern Arizona Behavioral Health is committed to delivering excellent, personalized support to facilitate sustained recovery and enhanced mental health.

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Southeastern Arizona Behavioral Health in Douglas, AZ, provides extensive outpatient services for individuals grappling with addiction and overlapping mental health conditions. The center is particularly adept at treating significant emotional disruptions in both children and adults who have a dual diagnosis. Their therapeutic framework employs proven techniques including cognitive behavioral therapy, strategies for managing anger, and concise intervention methods, all designed to offer personalized care. Emphasizing clients with co-occurring conditions, the center serves adults and older adults, irrespective of gender. Southeastern Arizona Behavioral Health is committed to offering superior treatment and assistance to those pursuing effective recovery for substance dependency and psychological health challenges.

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Southern Addiction Medicine Services, situated in Covington, LA, delivers comprehensive outpatient care for addiction. Their services encompass detoxification, substance use disorder treatment, and medication-assisted treatment including methadone, buprenorphine, or naltrexone. They offer distinct programs for adult men and women, serving both younger and older adults. Therapeutic methods employed consist of 12-step facilitation, brief intervention, and cognitive behavioral therapy. Dedicated to superior patient outcomes, the center provides personalized care for individuals of all genders pursuing freedom from addiction. Southern Addiction Medicine Services distinguishes itself with its all-encompassing outpatient offerings and customized treatment strategies aimed at fostering enduring recovery and overall well-being.

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Situated in Oakland, CA, the Southern Alameda County Comite offers premium substance use rehabilitation services tailored for adult males. This center provides both long-term and around-the-clock residential treatment options, emphasizing 12-step methodology, anger control strategies, and short intervention techniques. It is dedicated to assisting active duty service members, adult males, and individuals impacted by domestic or intimate partner violence. With customized programs designed for adults, seniors, and younger adults, the facility is committed to delivering exceptional care and support for men pursuing recovery from substance use issues.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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