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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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South Shore Recovery Home

Situated in Quincy, MA, South Shore Recovery Home provides extensive substance abuse rehabilitation and transitional living arrangements for adult males in a nurturing and secure setting. The facility features inpatient hospital treatment, round-the-clock hospital care, and long-term residential options. Employing evidence-based methods such as 12-step programs, anger management, and cognitive behavioral therapy, the center customizes its treatments to fit the unique requirements of each individual. There are specialized services for active military personnel, adult men, and those who have encountered intimate partner violence. South Shore Recovery Home is committed to offering high-quality support tailored to adult and senior male clients on their journey toward recovery.

South Suburban Council on

Situated in Hazel Crest, IL, South Suburban Council on provides a wide array of substance abuse recovery solutions. They offer distinct programs for adult men, adult women, and those affected by domestic abuse, ensuring personalized support for varied circumstances. Services are available through intensive outpatient, extended residential, and standard outpatient programs. Their therapeutic methods include 12-step guidance, brief counseling, and cognitive behavioral therapy. Committed to high-quality care, South Suburban Council on serves as a source of optimism for adults and young adults pursuing proven, effective addiction treatment within a nurturing setting.

Southeast Healthcare

Situated in Columbus, OH, Southeast Healthcare delivers outpatient services for individuals grappling with substance use issues and those facing severe mental health challenges concurrently. The center offers various therapeutic approaches, including outpatient treatment using methadone, buprenorphine, or naltrexone, alongside standard outpatient options. Emphasizing cognitive behavioral techniques, anger management, and short-term interventions, Southeast Healthcare primarily serves both adult men and women, as well as young adults. The center is recognized for its specific programs designed for clients with dual diagnoses of mental health and substance use conditions, including support for those within the criminal justice system. Clients can anticipate thorough care and extensive assistance at this establishment.

Southeast Louisiana Veterans Health

Situated in New Orleans, LA, Southeast Louisiana Veterans Health delivers extensive rehabilitation options for adults and young adults facing challenges with substance use and concurrent mental health concerns. The center provides various treatment modalities, including intensive outpatient programs, outpatient services, and treatments utilizing methadone, buprenorphine, or naltrexone. Their targeted approaches address the needs of those who have endured trauma, those grappling with both pain and substance use issues, as well as individuals facing dual challenges related to mental health and substance use. By emphasizing 12-step support, anger management techniques, and brief intervention strategies, this center guarantees customized care for both male and female clients on their journey to recovery and wellness.

SouthLight Healthcare

Situated in Raleigh, NC, SouthLight Healthcare specializes in providing treatment for substance use issues and co-occurring disorders for both adults and children. The center offers various levels of care, including intensive outpatient, outpatient, and standard outpatient services, utilizing proven methods such as cognitive behavioral therapy and the Matrix Model. SouthLight Healthcare has developed specific programs for adolescents as well as adult men and women, ensuring support for both young adults and fully grown individuals. With a commitment to personalized care and high-quality services, this facility is notable for its extensive range of offerings and dedication to guiding clients towards sustainable recovery.

SouthLight Healthcare

Located in Raleigh, NC, SouthLight Healthcare specializes in treating substance use issues and co-occurring disorders for both adults and children. The center offers a range of programs, including intensive outpatient and standard outpatient options, as well as treatments using methadone and buprenorphine. SouthLight Healthcare emphasizes customized care through brief interventions, cognitive behavioral therapy, and the Matrix Model, ensuring that each treatment plan meets the unique requirements of individuals. The facility also features specialized programs for adult men, women, and those who have experienced intimate partner violence, providing comprehensive support. Serving a diverse clientele of all genders, this center stands out as a crucial resource for individuals seeking effective solutions for addiction and mental health challenges.

SouthLight Healthcare

Situated in Raleigh, North Carolina, SouthLight Healthcare delivers extensive treatment for substance use through its outpatient services. This center specializes in care for both adult men and women, particularly those affected by intimate partner violence. Emphasizing cognitive behavioral therapy alongside the Matrix Model, the facility customizes its treatments to suit the unique needs of each individual. SouthLight Healthcare provides outpatient options including methadone, buprenorphine, or naltrexone treatments, in addition to general outpatient care. Catering to adults and young adults across all genders, the center is dedicated to providing exceptional care to assist clients in their recovery journey.

Southeast Missouri Behavioral Health

Situated in Salem, MO, Southeast Missouri Behavioral Health delivers an extensive variety of treatment services for those pursuing recovery from substance use issues and concurrent mental health disorders. The center features options such as residential detoxification, round-the-clock residential support, and short-term residential programs that cater to both adults and youth. Emphasizing personalized care, the facility designs specialized programs to meet the distinct needs of each individual. Treatment modalities encompass 12-step facilitation, anger management, and cognitive behavioral therapy. Southeast Missouri Behavioral Health is inclusive of all genders and is committed to offering superior, evidence-based care to facilitate enduring recovery.

Southeast Human Service Center

Southeast Human Service Center, situated in Fargo, ND, provides a wide range of treatment options for substance use disorders, catering to both adults and children facing concurrent mental health issues. The facility offers various levels of care including intensive outpatient programs, outpatient services, and day treatment, all based on proven methodologies like cognitive behavioral therapy and motivational incentives. Specialized tracks are available for adolescents, women, and trauma survivors to ensure focused support. This center serves all genders among adults and seniors, prioritizing personalized treatment plans and high-quality care. Southeast Human Service Center is recognized as a reliable resource for effective and empathetic rehabilitation in the Fargo community.

South Strand Internists
Myrtle Beach, SC

Situated in Myrtle Beach, SC, South Strand Internists specializes in outpatient treatment for substance use disorders, focusing on adults with dual diagnoses of substance use and severe mental health problems, as well as emotional issues in children. The center offers outpatient services with medications such as methadone/buprenorphine or naltrexone, employing a variety of methods including 12-step programs, brief interventions, and motivational strategies. Programs specifically designed for active duty military personnel, as well as separate options for adult men and women, are accessible. This facility provides comprehensive care for adults and seniors of all backgrounds, ensuring a professional and supportive atmosphere for those in need of addiction recovery services.

Southeast Missouri Behavioral Health

Southeast Missouri Behavioral Health, situated in Houston, Missouri, delivers targeted substance use treatment for both adults and children facing significant mental health challenges. The facility offers a variety of services including intensive outpatient programs, daytime outpatient care, and partial hospitalization. Treatment methodologies involve 12-step support, anger management sessions, and cognitive behavioral therapy. With an emphasis on personalized attention, the program accommodates clients of all genders. The center’s distinctive methodology guarantees customized treatment plans for every person, prioritizing high-quality care for individuals pursuing thorough rehabilitation in a nurturing setting.

Southeast Missouri Behavioral Health

Southeast Missouri Behavioral Health, situated in Poplar Bluff, MO, provides a wide range of services for addiction recovery. The center specializes in long-term residential programs, detoxification services, and around-the-clock support for both adults and young people facing issues with substance abuse as well as concurrent mental health challenges. Emphasizing personalized treatment, the facility incorporates scientifically proven methods including 12-step programs, anger management strategies, and cognitive behavioral therapy. Southeast Missouri Behavioral Health distinguishes itself through customized treatment strategies and gender-specific options for male and female clients, guaranteeing effective care for everyone on their journey to recovery.

Southeast Missouri Behavioral Health

Southeast Missouri Behavioral Health, situated in Rolla, MO, provides extensive care for adults battling substance use disorders and offers tailored programs for children experiencing significant emotional challenges. Their treatment modalities include intensive outpatient, standard outpatient, and day treatment programs, all grounded in proven methods such as 12-step facilitation, cognitive behavioral therapy, and anger management. This center prioritizes personalized treatment plans for both male and female individuals. By integrating substance abuse treatment with mental wellness support, Southeast Missouri Behavioral Health champions a complete recovery journey, positioning it as a premier option for those in the region pursuing effective rehabilitation.

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South Texas Rural Health Services Inc. in Cotulla, TX, delivers outpatient substance abuse care for adults and youth experiencing co-occurring mental health concerns. The facility features distinct programs designed for teenagers, adult males, and adult females, accommodating individuals across the lifespan. Therapies employed encompass anger management techniques, cognitive behavioral therapy, and brief intervention strategies. Focusing on outpatient approaches and medication-assisted treatment with methadone/buprenorphine or naltrexone, this establishment offers holistic support for individuals pursuing sobriety. It is dedicated to providing high-quality, personalized assistance to both male and female patients, including older adults, recognizing the distinct needs of each person on their path to well-being.

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South Texas Rural Health Services Inc, situated in Carrizo Springs, TX, delivers extensive addiction recovery services tailored for adults and older adults. The center features outpatient services, including medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient care. Utilizing therapeutic modalities such as anger management, cognitive behavioral therapy, and the Matrix Model, the facility welcomes both male and female patients. Specialized programs are also provided for adolescents, adult men, and adult women. South Texas Rural Health Services Inc is committed to providing superior treatment and assistance to those pursuing successful rehabilitation in a supportive and professional setting.

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South Valley Health Services in Albuquerque, NM, provides comprehensive outpatient services for individuals struggling with substance use disorders. Their offerings encompass detoxification, therapeutic interventions, and counseling for adults and young adults. The center features distinct programs designed for active duty military members, adult men, and adult women. Emphasizing personalized treatment, South Valley Health Services adapts its approach to meet each client's unique requirements. Their specialized services include outpatient care with methadone, buprenorphine, or naltrexone. South Valley Health Services is committed to supporting both male and female clients on their journey to recovery.

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Located in Anchorage, AK, Southcentral Foundation provides extensive services for individuals dealing with substance use issues, alongside specialized care for adults facing serious mental health challenges and children experiencing significant emotional difficulties. The center offers a range of programs, including intensive outpatient care, traditional outpatient services, and medication-assisted treatments with methadone/buprenorphine or naltrexone. Emphasizing therapies such as anger management, brief interventions, and cognitive behavioral approaches, the facility serves active military personnel, as well as adult men and women. Southcentral Foundation is dedicated to delivering tailored treatment plans to both adults and young adults, ensuring high-quality support for sustainable recovery.

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Nestled in Anchorage, AK, Southcentral Foundation provides extensive long-term residential care for adults grappling with substance use disorders and co-occurring severe mental health conditions, along with children experiencing significant emotional disturbances. The facility ensures round-the-clock residential support, employing proven methods like 12-step facilitation, brief intervention, and cognitive behavioral therapy. Distinct programs are available for adult women, survivors of intimate partner violence, domestic abuse, and sexual assault. Catering to adults, seniors, and young adults, Southcentral Foundation exclusively serves female clients, offering personalized and empathetic support for their journey toward recovery and well-being.

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Southeast Healthcare, situated in Columbus, OH, delivers a variety of targeted treatment options for both adults and young adults facing challenges related to substance abuse and concurrent mental health disorders. Their outpatient and intensive outpatient services utilize proven methods such as cognitive behavioral therapy and techniques for managing anger. The center is committed to offering personalized support, particularly for clients who have encountered trauma or struggle with co-occurring conditions. Notably, Southeast Healthcare emphasizes assistance for clients engaged with the criminal justice system. This facility adopts a gender-sensitive approach for both men and women, ensuring effective care and support for those in need of thorough rehabilitation services.

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Southeast Missouri Behavioral Health, situated in Steelville, MO, provides a wide range of treatment options for adults dealing with substance use disorders, along with focused care for individuals facing both substance use and significant mental health challenges, as well as emotional issues in children. The center features intensive outpatient programs, standard outpatient services, and day treatment alternatives. Emphasizing approaches like 12-step facilitation, anger management, and cognitive behavioral therapy, programming is customized to meet the specific requirements of each individual. Catering to both adults and younger populations, the center ensures gender-specific support for men and women. Dedicated to delivering exceptional care and personalized treatment, this facility fosters a nurturing atmosphere for those on their path to recovery.

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SouthWest Behavioral Health Center located in Cedar City, UT, delivers an extensive selection of treatment programs addressing substance abuse and mental health issues for both adults and younger individuals. With targeted services for those facing dual diagnoses, the center offers various treatment formats, including intensive outpatient, long-term residential, and standard outpatient care. Employing research-supported techniques like 12-step programs, anger management strategies, and brief interventions, the center serves both male and female clients. Their commitment to personalized care, along with distinct programs for individuals dealing with combined mental health and addiction challenges, distinguishes this facility, guaranteeing that each client receives tailored and effective treatment.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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