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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Spectrum Health Systems Inc

"Spectrum Health Systems Inc, located in Southbridge, MA, offers comprehensive substance use treatment for adults and young adults. This facility provides outpatient care, including specialized treatment for co-occurring substance use and serious mental health conditions. Utilizing evidence-based approaches such as cognitive behavioral therapy and motivational interviewing, the program also offers contingency management to support recovery. Spectrum Health Systems Inc caters to active duty military personnel, adult men, and women, ensuring individualized care for each patient. With a focus on quality and tailored treatment plans, this center is dedicated to helping individuals achieve lasting recovery."

Spectrum Health Systems Inc

Spectrum Health Systems Inc, located in Saugus, MA, delivers extensive outpatient services for individuals dealing with substance use issues. The center features dedicated programs for men and women, as well as specific support for those who have faced domestic or intimate partner violence. Emphasizing techniques like anger management, brief interventions, and cognitive behavioral therapy, the center serves both adult and young adult populations. Spectrum Health Systems Inc is committed to providing high-quality care through outpatient treatments involving methadone, buprenorphine, or naltrexone, alongside various regular therapeutic approaches. Its customized programs and reliance on evidence-based practices make it an important option for individuals in need of effective addiction recovery solutions.

Spectrum Health Systems Inc

Spectrum Health Systems Inc, situated in Westborough, MA, provides an extensive array of services aimed at treating addiction. The center offers both long-term and short-term residential care for individuals grappling with substance use disorders, along with transitional housing solutions. It focuses on assisting adults with co-occurring issues of addiction and severe mental health disorders, as well as addressing significant emotional challenges in children. With dedicated programs designed for adult men and women, young adults, and survivors of intimate partner or domestic violence, the center delivers customized treatment plans to meet varied requirements. Spectrum Health Systems Inc employs strategies such as anger management, community reinforcement, and the Matrix Model, ensuring high-quality support for every individual on their path to recovery.

Spectrum Health Systems Inc
South Weymouth, MA

Spectrum Health Systems Inc, situated in South Weymouth, MA, is dedicated to providing comprehensive substance use disorder care exclusively for adult men. Their treatment options encompass various residential modalities, including extended stays, round-the-clock supervision, and shorter-term options. The center employs evidence-based methods such as 12-step program integration, anger management techniques, and brief intervention strategies. They are equipped to support individuals who have endured trauma, as well as those managing HIV/AIDS. Spectrum Health Systems Inc ensures personalized, high-quality treatment for adult men, seniors, and young adults, adapting their approach to meet individual requirements.

Spectrum Health Systems Inc

Spectrum Health Systems Inc, located in Weymouth, MA, provides a wide range of substance abuse treatment options. These include outpatient services as well as outpatient care involving methadone, buprenorphine, or naltrexone. The center employs various evidence-based practices such as cognitive behavioral therapy, motivational interviewing, and contingency management/motivational incentives. It serves both men and women, including individuals who have faced intimate partner or domestic violence. Spectrum Health Systems Inc focuses on delivering personalized treatment in a nurturing atmosphere, aiming to support adults and young adults in their journey toward sustained recovery.

Spectrum Health Systems Inc

Spectrum Health Systems Inc., located in Worcester, MA, offers targeted outpatient support for adults grappling with substance use disorders and concurrent severe mental health challenges, as well as for children experiencing emotional disruptions. Their therapeutic offerings encompass a range of methods such as anger management, cognitive behavioral therapy, and brief intervention strategies. Distinctive programs are available for active military personnel, adult men, and women. Primarily serving adults and young adults of all genders, this facility ensures high-quality recovery assistance through outpatient services, medication-assisted treatment with methadone/buprenorphine or naltrexone, and standard outpatient programming. Spectrum Health Systems Inc. is committed to delivering thorough and personalized care to individuals pursuing a path to recovery.

Spectrum Health and Human Services

Situated in Springville, NY, Spectrum Health and Human Services delivers outpatient treatment for substance use disorders, serving both adults and youths who also face co-occurring mental health issues. The center features dedicated programs aimed at individuals managing both mental health challenges and substance use, with emphasis on anger management, cognitive behavioral therapy, and short-term interventions. Offering personalized outpatient options such as methadone/buprenorphine or naltrexone therapy, the facility is dedicated to supporting men and women in pursuit of effective treatment. Spectrum Health and Human Services is recognized for its holistic method in tackling addiction and mental health problems within a nurturing and expert environment.

Spectra Health
Grand Forks, ND

Situated in Grand Forks, ND, Spectra Health specializes in outpatient programs for substance use designed for both adults and young adults. The facility offers various treatment modalities, including standard outpatient services as well as outpatient care for those on methadone, buprenorphine, or naltrexone. Spectra Health employs proven strategies such as brief interventions, cognitive behavioral therapy, and motivational incentives to facilitate the recovery process. With an emphasis on individualized attention, the center serves both men and women. For those in search of effective addiction treatment that is tailored to their needs, Spectra Health is committed to supporting you on your path to recovery.

Spectrum Health Systems Inc

Spectrum Health Systems Inc, located in Worcester, MA, delivers extensive treatment for substance use disorders, addressing the needs of both adults and children with co-existing mental health conditions. This center offers various outpatient therapies, including methadone and buprenorphine protocols along with cognitive behavioral therapy. Specialized programs are available for active duty military personnel, teens, and adult males. By incorporating unique methods such as anger management and short-term interventions, the facility guarantees personalized support for every client. Committed to providing effective, research-backed treatment, Spectrum Health Systems Inc emphasizes recovery and overall wellness for all individuals, regardless of gender.

Spectrum Health Systems Inc
Great Barrington, MA

Spectrum Health Systems Inc, located in Great Barrington, MA, provides comprehensive outpatient care for individuals struggling with substance use disorders, including those with co-occurring mental health conditions. They offer dedicated support for adults who have endured intimate partner and domestic violence. Utilizing therapeutic modalities like anger management and cognitive behavioral therapy, the center serves both men and women. Spectrum Health Systems Inc extends its services to adults and young adults, employing a range of treatment options such as outpatient medication-assisted treatment (methadone/buprenorphine or naltrexone) and standard outpatient programs. For those in search of effective, personalized recovery plans, this center represents a significant resource.

Spectrum Health Systems Inc

Spectrum Health Systems Inc, located in Milford, MA, provides a range of outpatient services for individuals dealing with substance use disorders and co-occurring mental health challenges. They also support children facing emotional disturbances. Their services encompass outpatient methadone/buprenorphine treatment and standard outpatient care, utilizing therapeutic modalities like 12-step facilitation, cognitive behavioral therapy, and brief interventions. The center serves adult men and women, including those with a history of trauma, and focuses on adult and young adult populations of all genders, delivering personalized and thorough care to foster sustained recovery.

SpectraCare Health Systems

SpectraCare Health Systems, located in Ozark, AL, provides extensive treatment options for substance use disorders, along with targeted support for individuals facing co-existing mental health challenges in adults or severe emotional issues in children. Their services encompass intensive outpatient programs, general outpatient care, and treatment options such as methadone/buprenorphine or naltrexone for outpatient clients. The center employs proven therapeutic methods, including cognitive behavioral therapy, the Matrix Model, and relapse prevention strategies, creating customized treatment plans based on each person's unique situation. Catering to active duty military members, adolescents, and adult males, SpectraCare is dedicated to delivering high-quality care for individuals of all ages and genders, facilitating effective and sustained recovery.

SpectraCare Health Systems

SpectraCare Health Systems, situated in Dothan, AL, delivers extensive support for individuals battling substance abuse and those facing dual diagnoses of addiction and significant mental health challenges. This establishment features both long-term and brief residential treatment options, incorporating scientifically validated methods like 12-step programs, cognitive behavioral therapy, and the Matrix Model. SpectraCare Health Systems serves a broad spectrum of clients, including active military members, adult men, adult women, and young adults of any gender, demonstrating a dedication to personalized care and successful recovery.

Spectrum Health Systems Inc

Spectrum Health Systems Inc, located in Pittsfield, MA, delivers a wide array of outpatient services for adults and young adults facing challenges related to substance use disorders alongside concurrent mental health issues. The center has tailored programs designed specifically for active duty military members, adult men, and adult women. Utilizing various treatment methodologies such as 12-step support, anger management, and brief interventions, the facility addresses the specific requirements of each client. They provide outpatient detox services, as well as treatment options involving methadone, buprenorphine, or naltrexone, ensuring effective care for all clients. Spectrum Health Systems Inc places a strong emphasis on individualized, evidence-supported care to aid individuals in their recovery process.

Spectrum Health Systems Inc

Spectrum Health Systems Inc, located in Waltham, MA, provides extensive care for adults facing substance use disorders alongside significant mental health challenges, and for children with serious emotional disturbances. Their outpatient services are designed to address the unique needs of those affected by intimate partner violence. Employing therapeutic methods like 12-step facilitation and anger management, this institution offers personalized support for adult women and teenagers. The center emphasizes ongoing care through its outpatient medication-assisted treatment options, including methadone, buprenorphine, or naltrexone. Spectrum Health Systems Inc welcomes both male and female patients, delivering effective treatment through brief counseling and standard outpatient programs.

Spectrum Health Systems Inc

Spectrum Health Systems Inc, located in Haverhill, MA, provides targeted addiction recovery services via its outpatient offerings. These include medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside cognitive behavioral therapy. The facility also addresses specific needs through programs focused on anger management, brief intervention strategies, and specialized support for adult women, survivors of intimate partner or domestic violence, and individuals who have experienced sexual trauma. Catering to adults and young adults of any gender, Spectrum Health Systems Inc emphasizes personalized treatment plans grounded in proven therapeutic methods to foster complete well-being and sustained recovery. The commitment at Spectrum Health Systems Inc is to deliver excellent care and assistance, enabling individuals to conquer substance dependence and achieve a life of purpose.

Spectrum Health Systems Inc

Spectrum Health Systems Inc, located in Framingham, MA, delivers extensive outpatient services for individuals facing substance use challenges along with co-occurring mental health issues for both adults and children. The center features targeted programs designed for those who have undergone intimate partner violence, sexual trauma, or other adverse experiences. Treatment methodologies incorporate anger management, brief intervention techniques, and cognitive behavioral therapy. Prioritizing high-quality care, this facility serves male and female adults as well as young adults. Their services include standard outpatient programming as well as specialized outpatient options utilizing methadone, buprenorphine, or naltrexone. Spectrum Health Systems Inc is committed to offering effective and empathetic support to aid individuals on their road to recovery.

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Larimore, ND

Spectra Health in Larimore, ND, delivers comprehensive outpatient substance abuse recovery services for adults and adolescents. Their program offerings encompass standard outpatient care, medication-assisted treatment (methadone/buprenorphine or naltrexone), and general outpatient services. Employing proven therapeutic methods including brief interventions, cognitive behavioral therapy, and motivational incentives, the center prioritizes personalized treatment plans. Spectra Health's commitment to gender-specific programming for both men and women underscores their dedication to offering effective addiction treatment and supporting individuals through their recovery journey.

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SpectraCare Health Systems located in Dothan, Alabama, specializes in addressing substance use disorders and concurrent mental health issues for both adults and children. The facility offers a range of treatment modalities, including intensive outpatient programs, standard outpatient services, and options for medication-assisted treatments such as methadone, buprenorphine, or naltrexone. By employing evidence-based methods such as cognitive behavioral therapy, the Matrix Model, and strategies for relapse prevention, the center customizes its services to meet the unique requirements of each client. There are also specialized programs designed for active duty military personnel, as well as for adult men and women. Catering to individuals across the gender spectrum, SpectraCare Health Systems is committed to providing thorough and high-quality support for those pursuing recovery from addiction and mental health difficulties.

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SpectraCare Health Systems in Eufaula, AL, provides extensive care for individuals battling substance abuse, including those also experiencing significant mental health conditions. The center supports adults with dual diagnoses and children with serious emotional challenges. Treatment options include intensive outpatient services, standard outpatient care, and medication-assisted treatment with methadone, buprenorphine, or naltrexone. They are adept at utilizing therapies like cognitive behavioral therapy, the Matrix Model, and relapse prevention strategies. SpectraCare Health Systems serves adolescents, adult men, and adult women, with distinct programs designed for all age groups and genders. Their commitment is to delivering high-quality, research-backed treatment to aid in successful recovery.

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SpectraCare Health Systems, located in Geneva, AL, specializes in providing targeted treatment for substance use disorders in adults, including individuals experiencing simultaneous mental health challenges. The center offers both intensive outpatient and outpatient programs, alongside treatment options such as methadone, buprenorphine, or naltrexone. Employing research-backed methods, including cognitive behavioral therapy and the Matrix Model, SpectraCare prioritizes strategies aimed at preventing relapse. This center also distinguishes itself by offering customized programs specifically for active-duty military members, adolescents, and adult males. Catering to both adults and young people, the facility delivers tailored support for individuals of all genders. With a strong emphasis on high-quality, personalized care, SpectraCare Health Systems is a reliable option for comprehensive rehabilitation solutions.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)