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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Spectrum Healthcare
Cottonwood, AZ

Spectrum Healthcare, situated in Cottonwood, Arizona, provides tailored outpatient rehabilitation for individuals, both young and old, struggling with addiction and concurrent mental health conditions. Their approach emphasizes personalized support through a variety of outpatient options, including medication-assisted treatment with methadone, buprenorphine, or naltrexone. This center is dedicated to serving a diverse clientele, ensuring a welcoming atmosphere for all who are pursuing lasting recovery. Discover dedicated assistance and treatment crafted specifically for your journey at this establishment.

Spectrum Healthcare LLC

Spectrum Healthcare LLC, located in Oak Creek, WI, delivers specialized outpatient addiction recovery services designed for adults and young adults. Their approach focuses on critical areas such as anger management, cognitive behavioral therapy, and motivational interviewing, ensuring each client receives a personalized path toward sustained sobriety. The facility is equipped to serve distinct groups with dedicated programs for active duty military members, adult men, and adult women, recognizing the unique needs of each demographic. Spectrum Healthcare LLC employs scientifically-backed methods for addiction treatment, including outpatient options with methadone, buprenorphine, or naltrexone. They are committed to offering high-quality care to all individuals, both male and female, who are pursuing comprehensive and successful rehabilitation.

Spectrum Health Systems Inc

Spectrum Health Systems Inc, situated in Worcester, MA, presents a wide array of outpatient services specifically designed for both adults and young adults in need of detoxification and substance abuse treatment. This center has expertise in addressing co-occurring substance use disorders alongside significant mental health challenges. Emphasizing methods such as anger management, brief intervention, and cognitive behavioral therapy, Spectrum Health Systems Inc offers personalized care for adult men and women. Additionally, special programs are available for active military personnel. Patients can benefit from outpatient detox, as well as treatments involving methadone, buprenorphine, or naltrexone. With a strong dedication to high-quality, individualized support, this facility aims to assist individuals throughout their recovery journey.

Spencer Recovery Centers Inc

Spencer Recovery Centers Inc, situated in Los Angeles, CA, delivers extensive treatment for addiction and co-occurring psychological issues. Their offerings include intensive outpatient, long-term residential, and standard outpatient care, incorporating methods like 12-step facilitation, anger management techniques, and brief interventions. The center features tailored programs for adult men and women, alongside those with HIV or AIDS, demonstrating a commitment to serving a broad spectrum of individuals. Additionally, they provide transitional housing and sober living environments, ensuring comprehensive support for adults and young adults across all genders.

Spencer Recovery Centers Inc

Situated in Laguna Beach, California, Spencer Recovery Centers Inc specializes in a wide range of addiction treatment options. This center provides long-term residential care, detoxification services, and round-the-clock support for those working towards recovery from substance abuse issues. It employs methods such as 12-step facilitation, anger management, and brief intervention strategies. Also, it offers specialized programs for active military personnel, as well as distinct options for adult men and women. Catering to both adults and young adults of any gender, this center ensures that care is personalized to meet each individual's needs. For those seeking effective addiction treatment, Spencer Recovery Centers Inc is committed to guiding you on your recovery path.

Spero Health
London, KY

Spero Health, located in London, KY, provides outpatient services for individuals seeking help with substance use issues, catering to both adults and young adults. The facility has specific programs designed for men and women, as well as those who have faced domestic or intimate partner violence, fostering a nurturing and safe space for recovery. The center employs various methods, such as cognitive behavioral therapy, anger management, and brief interventions, emphasizing a comprehensive approach to healing. With options for outpatient methadone/buprenorphine or naltrexone treatment, along with regular outpatient services, Spero Health ensures personalized care. The center is committed to delivering effective addiction treatment aimed at helping clients achieve sustainable sobriety.

Spero Health
Lawrenceburg, TN

Situated in Lawrenceburg, TN, Spero Health provides accessible outpatient care for individuals grappling with substance use disorders. This center supports adult men and women, including survivors of intimate partner violence, offering a range of therapeutic modalities. Their services encompass anger management, brief intervention strategies, and cognitive behavioral therapy. Spero Health focuses on outpatient medication-assisted treatment using methadone, buprenorphine, or naltrexone. They welcome both adults and young adults in their pursuit of effective recovery within a nurturing atmosphere. Through tailored treatment plans, Spero Health is dedicated to a holistic path to sobriety, prioritizing safety and successful outcomes.

Spectrum Health Systems Inc

Spectrum Health Systems Inc, located in Westborough, MA, delivers exceptional services for substance use disorders along with specialized attention for individuals facing concurrent mental health challenges. The facility provides both residential and short-term residential treatment options designed for adults and young adults. By employing evidence-based methods such as 12-step programs, brief interventions, and cognitive behavioral therapy, this center effectively supports adult men and women dealing with co-occurring conditions. Committed to personalized care, Spectrum Health Systems Inc effectively distinguishes itself by offering extensive rehabilitation solutions, ensuring clients receive high-quality and impactful treatment tailored to their unique needs.

Spectrum Healthcare

Situated in Prescott, AZ, Spectrum Healthcare provides targeted outpatient services for addiction, co-occurring conditions, and significant mental health issues in adults, as well as emotional issues in children. This center offers outpatient treatments involving methadone, buprenorphine, or naltrexone, along with personalized counseling for substance use disorders and consistent outpatient care. Emphasizing customized treatment, Spectrum Healthcare serves adults and seniors regardless of gender. Its dedication to high-quality care and personalized programs positions it as a leading option for individuals in need of tailored addiction recovery solutions.

Spectrum Healthcare
Camp Verde, AZ

Nestled in Camp Verde, Arizona, Spectrum Healthcare is a dedicated provider of focused treatment for individuals, both young and old, who are navigating substance use challenges alongside significant mental health conditions. The center extends outpatient care options, incorporating medication-assisted treatment like methadone, buprenorphine, or naltrexone. Its core philosophy revolves around providing personalized counseling for substance use disorders, ensuring each client receives an approach tailored to their unique needs. Spectrum Healthcare warmly welcomes adults and seniors, irrespective of gender. The institution distinguishes itself through its commitment to crafting individualized treatment strategies and delivering high-caliber support. For anyone searching for thorough recovery services within an encouraging setting, Spectrum Healthcare is committed to guiding you toward wellness.

Spectrum Healthcare
Cottonwood, AZ

Nestled in Cottonwood, AZ, Spectrum Healthcare delivers extensive addiction recovery services for adults and young people facing combined serious mental health challenges. The facility features intensive outpatient, extended residential, and standard outpatient services, all customized for each person's unique requirements. Spectrum Healthcare distinguishes itself with a personalized care strategy emphasizing substance use disorder counseling. This establishment supports adults and older individuals of every gender, fostering a nurturing atmosphere conducive to healing. For those in search of expert treatment within an empathetic environment, Spectrum Healthcare in Cottonwood, AZ, is dedicated to providing excellent support for individuals on their journey to wellness.

Spero Health
Indianapolis, IN

Spero Health, situated in Indianapolis, IN, delivers extensive outpatient rehabilitation programs geared towards overcoming addiction and chemical dependency. The center offers various treatment modalities, including medication-assisted treatment with methadone, buprenorphine, or naltrexone, standard outpatient care, and support for the 12-step recovery process. Dedicated to personalized healing, Spero Health supports adult men and women, including individuals who have faced intimate partner or domestic abuse. This facility accommodates adults and young adults of all gender identities, incorporating strategies like anger management and brief intervention to foster complete and successful recovery.

Spero Health
Murray, KY

Spero Health, located in Murray, KY, presents outpatient programs designed for individuals dealing with substance use issues, including both adults and young adults. This center specializes in providing care specifically for adult males, adult females, and those affected by intimate partner violence or domestic abuse. Their treatment modalities encompass anger management, brief interventions, and cognitive behavioral therapy. Spero Health also provides outpatient options for methadone, buprenorphine, or naltrexone. Committed to delivering high-quality care, Spero Health focuses on personalized treatment strategies to assist individuals in their recovery journey.

Spero Health
Lima, OH

Spero Health, located in Lima, OH, provides extensive treatment for substance use through a range of outpatient options, including therapies such as methadone/buprenorphine and naltrexone, as well as anger management, cognitive behavioral therapy, and brief interventions. The center serves both male and female adults, including those who have faced intimate partner violence or domestic abuse. Catering to the needs of adults and young adults, Spero Health delivers personalized care that aligns with each client's unique circumstances. Emphasizing high-quality, evidence-based practices, Spero Health is committed to guiding individuals on their recovery path, with specialized programs designed to create a nurturing and effective atmosphere for all participants.

Spero Health
Owensboro, KY

Spero Health, located in Owensboro, KY, offers outpatient services designed for adults and young adults dealing with substance use issues. This facility provides treatments including methadone, buprenorphine, and naltrexone, alongside regular outpatient services. It incorporates various therapeutic methods such as anger management, brief interventions, and cognitive behavioral therapy. The center features specialized programs for adult men, adult women, and individuals affected by intimate partner or domestic violence. Spero Health is committed to delivering personalized care for both genders, ensuring comprehensive support for clients as they work towards recovery from substance use disorders.

Spero Health
Jeffersonville, IN

Spero Health, located in Jeffersonville, IN, provides outpatient treatment options for substance use disorders specifically designed for adult men and women, including individuals who have faced issues related to intimate partner violence. Emphasizing anger management, brief interventions, and cognitive behavioral therapy, this center delivers focused assistance for those pursuing recovery. Their services are available to adults and young adults of any gender. Spero Health offers outpatient options such as methadone, buprenorphine, or naltrexone treatments in conjunction with standard outpatient programs. The facility is dedicated to delivering high-quality support and care for those working towards sobriety, making it an excellent option for anyone looking for in-depth addiction treatment solutions.

Spero Health
Barbourville, KY

Situated in Barbourville, KY, Spero Health delivers outpatient addiction recovery services designed for adult men and women. This center offers distinct support for individuals affected by domestic or intimate partner abuse. Through specialized techniques such as anger management, brief intervention strategies, and cognitive behavioral therapy, Spero Health provides a thorough recovery experience. The facility includes outpatient medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient services, serving adults and young adults across all genders. Spero Health is recognized for its dedication to high-quality, individualized care, positioning it as a dependable resource for addiction recovery.

Spectrum Health Systems Inc

Spectrum Health Systems Inc in North Adams, MA, delivers a full spectrum of addiction recovery solutions for adults and adolescents. They focus on detox, drug and alcohol dependency treatment, and dual diagnosis conditions. The center provides outpatient services encompassing detoxification, methadone/buprenorphine therapy, and a range of therapeutic modalities such as 12-step program support and anger management techniques. Spectrum Health Systems Inc has specialized programs for active military, adult males, and females, addressing a wide array of requirements. Their dedication to high-quality care and personalized recovery plans positions them as a leading option for individuals pursuing successful rehabilitation in the North Adams vicinity.

Spectrum Human Services

Spectrum Human Services, located in Warsaw, NY, delivers an extensive range of outpatient services aimed at addressing substance use disorders and serious co-occurring mental health challenges in adults, alongside emotional issues in children. This center designs programs that meet individual requirements, implementing techniques such as cognitive behavioral therapy, anger management, and brief interventions. Committed to high-quality care, Spectrum serves both adults and younger clients, including boys and girls. Their treatment modalities encompass standard outpatient services as well as specialized outpatient options involving methadone, buprenorphine, or naltrexone, promoting a comprehensive recovery journey for all individuals seeking help.

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Spectrum Healthcare Inc located in Jersey City, NJ, presents an extensive selection of services for addiction recovery for both adults and young adults. This center focuses on detox services, treatment for substance use disorders, and managing co-occurring conditions. They offer intensive outpatient programs along with outpatient treatments using methadone, buprenorphine, or naltrexone. Emphasizing cognitive behavioral therapy, anger management techniques, and short-term intervention strategies, Spectrum Healthcare Inc serves a diverse clientele that includes adult women and men. Furthermore, they provide specialized care for individuals dealing with HIV/AIDS and those facing mental health challenges, ensuring tailored support for each client. Experience exceptional care and assistance at Spectrum Healthcare Inc.

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Spencer Recovery Centers Florida Inc, located in Saint Petersburg, FL, provides extensive addiction treatment within a supportive setting. This establishment features various offerings such as sober living accommodations and rigorous outpatient services designed for adult men, women, and young adults. Emphasizing 12-step principles, emotional regulation techniques, and short-term counseling, the center personalizes treatment plans for each client. Distinctive programs specifically for active military members elevate the standard of care. Adults requiring either outpatient care or partial hospitalization will discover expert assistance at this location. The center's dedication to guiding individuals through their recovery path establishes it as a vital support system for those in need.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)