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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Spero Health
Marion, OH

Situated in Marion, OH, Spero Health provides comprehensive outpatient services, including intensive outpatient programs and treatments with methadone, buprenorphine, or naltrexone for those facing substance abuse challenges. The center emphasizes the importance of anger management, brief interventions, and cognitive behavioral therapy. Specialized programs are available for adult men, adult women, and individuals affected by intimate partner or domestic violence. Catering to both adults and young adults, Spero Health delivers personalized care for all genders. With a commitment to evidence-based practices, this facility guarantees effective support for individuals on their journey to recovery from addiction.

Spero Health
Youngstown, OH

Spero Health, located in Youngstown, OH, provides extensive treatment for substance use disorders with a variety of programs designed to meet the unique needs of each individual. The center focuses on intensive outpatient services, general outpatient care, as well as treatments utilizing methadone, buprenorphine, and naltrexone. Emphasizing techniques such as anger management, brief interventions, and cognitive behavioral therapy, Spero Health supports both adults and young adults, regardless of gender. Additionally, specialized programs are available for adult men, adult women, and those who have faced situations of intimate partner or domestic violence. Spero Health is committed to delivering high-quality, customized care plans to assist individuals on their recovery journey.

Spencer Recovery Centers Inc

Situated in Laguna Beach, California, Spencer Recovery Centers Inc specializes in a wide range of addiction treatment options. This center provides long-term residential care, detoxification services, and round-the-clock support for those working towards recovery from substance abuse issues. It employs methods such as 12-step facilitation, anger management, and brief intervention strategies. Also, it offers specialized programs for active military personnel, as well as distinct options for adult men and women. Catering to both adults and young adults of any gender, this center ensures that care is personalized to meet each individual's needs. For those seeking effective addiction treatment, Spencer Recovery Centers Inc is committed to guiding you on your recovery path.

Spencer Recovery Centers Inc

Spencer Recovery Centers Inc, situated in Los Angeles, CA, delivers extensive treatment for addiction and co-occurring psychological issues. Their offerings include intensive outpatient, long-term residential, and standard outpatient care, incorporating methods like 12-step facilitation, anger management techniques, and brief interventions. The center features tailored programs for adult men and women, alongside those with HIV or AIDS, demonstrating a commitment to serving a broad spectrum of individuals. Additionally, they provide transitional housing and sober living environments, ensuring comprehensive support for adults and young adults across all genders.

Spero Health
Danville, KY

Spero Health, situated in Danville, KY, stands as a premier provider of outpatient recovery services focused on addiction treatment. Their offerings encompass medication-assisted treatment options such as methadone, buprenorphine, and naltrexone, alongside standard outpatient care. The center also integrates targeted therapeutic interventions, including strategies for managing anger, brief counseling approaches, and cognitive behavioral therapy. Spero Health extends its support to adults of all genders, including those affected by domestic or intimate partner violence, ensuring a holistic and empathetic approach to facilitate lasting recovery.

Spero Health
Madison, TN

Situated in Madison, TN, Spero Health stands out as a prominent outpatient rehabilitation facility that focuses on treating substance use disorders. The center provides outpatient options such as methadone, buprenorphine, or naltrexone therapies, alongside conventional outpatient services and a range of therapeutic modalities, including anger management, brief interventions, and cognitive behavioral therapy. Spero Health serves adults of all genders, particularly those who have faced intimate partner violence or domestic abuse. By emphasizing personalized care for men and women, this center becomes an essential support system for individuals pursuing successful addiction recovery initiatives.

Spero Health
Louisville, KY

Spero Health in Louisville, KY, provides comprehensive outpatient care for substance use disorders, guiding individuals toward lasting recovery. Their services include outpatient treatment with methadone, buprenorphine, or naltrexone, delivered within a carefully structured and nurturing setting. The center emphasizes key therapeutic areas like anger management, brief intervention strategies, and cognitive behavioral therapy, ensuring each client receives a personalized treatment plan. Tailored programs are available for adult men and women, as well as those who have experienced intimate partner or domestic violence. Spero Health is dedicated to delivering high-quality, individualized support for adults and young adults of all gender identities seeking addiction treatment.

Spero Health
Warren, OH

Spero Health, situated in Warren, OH, delivers a wide range of treatment options for substance use disorders, designed to meet the unique requirements of each individual. The center specializes in intensive outpatient care, outpatient programs, and medication-assisted treatments with methadone, buprenorphine, or naltrexone. Spero Health employs various therapeutic methods, including cognitive behavioral therapy, anger management, and brief interventions, to address the needs of adult clients, including those affected by intimate partner or domestic violence. Aiming to provide exceptional care for both men and women, this facility is dedicated to offering a supportive and professional setting for those pursuing recovery from addiction.

Spero Health
Dublin, VA

Spero Health, situated in Dublin, VA, specializes in outpatient programs aimed at treating substance use disorders with an emphasis on high-quality, evidence-based care. The center offers various treatment options, including methadone/buprenorphine or naltrexone outpatient services, standard outpatient care, and diverse therapeutic techniques such as anger management, brief intervention, and cognitive behavioral therapy. Spero Health accommodates adult clients, including men and women, as well as those who have faced intimate partner or domestic violence. This facility is committed to delivering personalized and extensive rehabilitation services to assist individuals of all genders, both adults and young adults, on their path to recovery.

Spero Health
Madisonville, KY

Spero Health, located in Madisonville, KY, provides outpatient programs designed for adults and young adults struggling with substance use issues. This center specializes in care for adult males, adult females, and individuals who have faced intimate partner or domestic violence. Treatment methods include anger management, brief intervention strategies, and cognitive behavioral therapy. Spero Health also offers outpatient treatments with methadone, buprenorphine, or naltrexone, complemented by consistent outpatient services. Committed to delivering high-quality care, Spero Health focuses on personalized support for all clients on their journey to recovery from substance use disorders.

Spero Health
Lima, OH

Spero Health, located in Lima, OH, provides extensive treatment for substance use through a range of outpatient options, including therapies such as methadone/buprenorphine and naltrexone, as well as anger management, cognitive behavioral therapy, and brief interventions. The center serves both male and female adults, including those who have faced intimate partner violence or domestic abuse. Catering to the needs of adults and young adults, Spero Health delivers personalized care that aligns with each client's unique circumstances. Emphasizing high-quality, evidence-based practices, Spero Health is committed to guiding individuals on their recovery path, with specialized programs designed to create a nurturing and effective atmosphere for all participants.

Spero Health
Frankfort, KY

Spero Health, located in Frankfort, KY, specializes in outpatient treatment for substance use aimed at both adults and young adults. This center offers a variety of targeted services such as outpatient treatments with methadone, buprenorphine, or naltrexone, alongside additional support for anger management, brief interventions, and cognitive behavioral therapy. Emphasizing personalized care, the facility provides programs tailored for adult men, women, and those who have suffered from intimate partner or domestic violence. Spero Health maintains an inclusive atmosphere for all clients, prioritizing their needs. For those in search of effective addiction treatment delivered with empathy, this center is committed to supporting your recovery process.

Spero Health
Lancaster, OH

Spero Health, located in Lancaster, OH, provides comprehensive outpatient services, including intensive outpatient programs and treatment options utilizing methadone, buprenorphine, or naltrexone for those dealing with substance use challenges. Their methodology encompasses therapies such as anger management, cognitive behavioral therapy, and brief intervention strategies. The center features specialized programs catering to adult men and women, as well as those affected by intimate partner or domestic violence. Spero Health serves a diverse clientele of adults and young adults, ensuring that care is personalized to meet the unique requirements of each individual. Committed to evidence-based methods and holistic support, Spero Health strives to help individuals navigate their recovery journey effectively.

Spero Health
Crossville, TN

Situated in Crossville, TN, Spero Health specializes in outpatient treatment for substance use issues affecting both adults and young adults. The center provides a range of services including methadone, buprenorphine, or naltrexone treatments, as well as regular outpatient programs. Their methods incorporate techniques such as anger management, brief interventions, and cognitive behavioral therapy. Spero Health serves diverse populations, including adult men and women, as well as individuals who have faced intimate partner or domestic abuse. Committed to delivering high-quality care, this facility creates a welcoming atmosphere for individuals of all genders seeking personalized rehabilitation support.

Spero Health
Mansfield, OH

Spero Health, located in Mansfield, OH, delivers an extensive range of substance abuse treatment options, including intensive outpatient programs, standard outpatient services, and medication-assisted treatments with methadone, buprenorphine, or naltrexone. The facility emphasizes therapeutic modalities such as anger management, brief intervention strategies, and cognitive behavioral therapy. Tailored programs are designed for adult men and women, as well as clients who have faced intimate partner or domestic violence. Catering to both adults and young adults of all genders, Spero Health focuses on personalized care that meets the specific needs of each individual. Committed to high standards and evidence-based methodologies, this center strives to support individuals in achieving long-term recovery from substance use issues.

Spero Health
Hopkinsville, KY

Spero Health, situated in Hopkinsville, KY, focuses on outpatient treatment for substance use disorders affecting both adults and young adults. The center delivers targeted support using methods such as anger management, brief interventions, and cognitive behavioral therapy. Catering to specific groups including adult men, adult women, and individuals who have faced intimate partner or domestic violence, Spero Health is committed to providing personalized care. They offer various outpatient treatment options including methadone, buprenorphine, and naltrexone to meet unique patient needs. With a dedication to quality care for all clients, this center stands out as a trustworthy option for those in need of effective and empathetic addiction recovery services.

Spero Health
Danville, VA

Spero Health, situated in Danville, VA, provides outpatient care for substance use disorders aimed at adult men, women, and younger adults. The center features tailored programs for individuals affected by intimate partner or domestic violence. Treatment modalities encompass anger management, brief interventions, and cognitive behavioral therapy. Additionally, Spero Health administers outpatient services for methadone, buprenorphine, or naltrexone, alongside standard outpatient treatment. Committed to delivering high-quality care and personalized treatment strategies, this center strives to support individuals in overcoming addiction and attaining sustained recovery.

Spero Health
Roanoke, VA

Spero Health, situated in Roanoke, VA, delivers extensive outpatient services for substance use treatment, featuring options such as methadone/buprenorphine or naltrexone. The center caters to both adult men and women, and is equipped to support clients who have faced domestic or intimate partner violence. Treatment methods encompass anger management, short interventions, and cognitive behavioral therapy. Spero Health is dedicated to providing tailored care and quality assistance for adults and young adults, regardless of gender, who are on the path to recovery from addiction.

Spero Health
Gallipolis, OH

Situated in Gallipolis, OH, Spero Health stands out as a leading rehabilitation center focused on treatment for substance use disorders. The center provides outpatient services, including methadone, buprenorphine, and naltrexone therapies, alongside traditional outpatient programs. Spero Health also incorporates various therapeutic methods such as anger management and cognitive behavioral therapy, serving adult individuals, including those affected by intimate partner or domestic violence. Catering to all genders, Spero Health emphasizes personalized treatment strategies and utilizes evidence-based practices to ensure quality care. For those in search of supportive and effective addiction recovery options, this center is committed to facilitating your path to healing.

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Cincinnati, OH

Spero Health, located in Cincinnati, OH, provides expert services for substance use recovery with its array of programs including intensive outpatient, outpatient, and medication-assisted treatments featuring methadone, buprenorphine, and naltrexone. The center emphasizes anger management, short interventions, and cognitive behavioral therapy, catering to both adult men and women, alongside those who have faced domestic violence or intimate partner issues. Spero Health supports adults and young adults of any gender, ensuring a holistic approach to recovery. With a dedication to high-quality care and varied therapeutic methods, it stands out as a reliable option for effective addiction treatment in the Cincinnati area.

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Erlanger, KY

Situated in Erlanger, KY, Spero Health stands out as a premier center for substance use recovery, providing outpatient treatments such as methadone, buprenorphine, or naltrexone, alongside standard outpatient services. The facility incorporates various evidence-based methodologies, including cognitive behavioral therapy, anger management, and brief interventions. Spero Health offers dedicated programs for adult men and women, as well as individuals impacted by domestic or intimate partner violence. This center caters to adults and young adults across all genders, emphasizing a tailored approach to meet unique recovery requirements. For those in search of thorough addiction treatment within a nurturing atmosphere, Spero Health is an excellent choice for personalized rehabilitation solutions.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)