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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Spero Health
Pikeville, KY

Spero Health, located in Pikeville, KY, provides outpatient services for those struggling with substance use, specializing in treatments involving methadone, buprenorphine, and naltrexone. The center offers regular outpatient programs as well as tailored initiatives for adult men and women, including support for individuals who have faced intimate partner or domestic violence. Serving both adults and young adults of all genders, Spero Health employs a holistic strategy for recovery that encompasses anger management, brief interventions, and cognitive behavioral therapy. With a dedication to high-quality care and personalized treatment strategies, Spero Health stands out as a reliable option for individuals seeking meaningful and empathetic support in their journey to overcome addiction.

Spero Health
Morehead, KY

Spero Health in Morehead, KY, extends outpatient recovery services to adults of all genders, with particular consideration for individuals affected by domestic abuse. The facility caters to young adults and older individuals, utilizing therapeutic modalities like anger management, cognitive behavioral therapy, and brief intervention. Recognizing diverse needs, Spero Health provides individualized treatment through outpatient medication management with methadone, buprenorphine, or naltrexone, alongside standard outpatient programs. A key feature of this center is its commitment to gender-specific care and holistic support for those on their journey to overcome substance dependency.

Spero Health
Martinsville, VA

Spero Health located in Martinsville, VA, specializes in outpatient treatment for substance use disorders among adults and young adults. The center offers a variety of treatment options, including outpatient services with methadone/buprenorphine or naltrexone, standard outpatient programs, and multiple therapeutic techniques such as anger management, brief interventions, and cognitive behavioral therapy. Spero Health implements specialized programs designed for adult men and women, in addition to those who have faced intimate partner or domestic violence, addressing a wide array of needs. The facility prioritizes personalized care to deliver effective treatment for everyone. As a reliable resource for both male and female clients, Spero Health is dedicated to facilitating thorough addiction recovery.

Spero Health
Dickson, TN

Spero Health, situated in Dickson, TN, provides extensive outpatient care for substance use disorders. Their expertise lies in outpatient treatment utilizing methadone, buprenorphine, or naltrexone. The facility offers routine outpatient services to adults and young adults across all gender identities. Spero Health's approach is individualized, emphasizing anger management, brief interventions, and cognitive behavioral therapy. They also feature specialized programs designed for adult men, adult women, and individuals who have faced intimate partner or domestic violence. Discover effective treatment and dedicated assistance at this center committed to aiding recovery from addiction.

Spero Health
Paducah, KY

Spero Health, situated in Paducah, KY, stands as a complete facility for substance use recovery, providing outpatient care. Services encompass medication-assisted treatment with methadone or buprenorphine, evidence-based therapies like cognitive behavioral therapy, strategies for managing anger, and short-term interventions. The center offers tailored programs designed for adult men and women, and for individuals affected by intimate partner or domestic violence. Spero Health serves adults and young adults across the gender spectrum, emphasizing personalized support and care. By prioritizing effective treatment modalities and customized plans, Spero Health is committed to guiding individuals toward lasting sobriety.

Spero Health
London, KY

Spero Health, located in London, KY, provides outpatient services for individuals seeking help with substance use issues, catering to both adults and young adults. The facility has specific programs designed for men and women, as well as those who have faced domestic or intimate partner violence, fostering a nurturing and safe space for recovery. The center employs various methods, such as cognitive behavioral therapy, anger management, and brief interventions, emphasizing a comprehensive approach to healing. With options for outpatient methadone/buprenorphine or naltrexone treatment, along with regular outpatient services, Spero Health ensures personalized care. The center is committed to delivering effective addiction treatment aimed at helping clients achieve sustainable sobriety.

Spero Health
Wheelersburg, OH

Spero Health, located in Wheelersburg, OH, specializes in outpatient services for adults and young adults dealing with substance use issues. The center provides various treatment options, including outpatient care with methadone, buprenorphine, or naltrexone, along with standard outpatient programs. Their treatment methodologies include anger management, cognitive behavioral therapy, and brief interventions. Spero Health also features tailored programs for adult men and women, as well as support for those who have faced intimate partner or domestic violence. This ensures that both men and women receive comprehensive care that meets their specific needs. For those in search of tailored addiction treatment in a nurturing setting, Spero Health is committed to supporting your recovery journey.

Spero Health
Canton, OH

Spero Health, located in Canton, OH, specializes in outpatient treatment for individuals grappling with substance use, including both adults and young adults. The center employs a range of methodologies, such as anger management, brief intervention sessions, and cognitive behavioral therapy. They offer tailored programs designed for adult men, adult women, and those who have faced intimate partner or domestic violence. Emphasizing personalized care, Spero Health ensures an inclusive and supportive atmosphere for all clients. If you are looking for effective outpatient treatment options like methadone, buprenorphine, or naltrexone, this facility is committed to aiding individuals as they pursue recovery.

Spero Health
Muncie, IN

Spero Health, located in Muncie, IN, provides outpatient detoxification and treatment options for individuals dealing with substance use issues, designed specifically for adults and young adults. Their comprehensive services feature outpatient treatments with methadone, buprenorphine, and naltrexone, alongside programs for 12-step support, anger management, and brief intervention strategies. This center focuses on delivering tailored care for both men and women, including those who have faced domestic or intimate partner violence. Spero Health prioritizes personalized attention and quality care, making it an ideal choice for individuals seeking compassionate addiction support in an outpatient environment.

Spero Health
Murray, KY

Spero Health, located in Murray, KY, presents outpatient programs designed for individuals dealing with substance use issues, including both adults and young adults. This center specializes in providing care specifically for adult males, adult females, and those affected by intimate partner violence or domestic abuse. Their treatment modalities encompass anger management, brief interventions, and cognitive behavioral therapy. Spero Health also provides outpatient options for methadone, buprenorphine, or naltrexone. Committed to delivering high-quality care, Spero Health focuses on personalized treatment strategies to assist individuals in their recovery journey.

Spero Health
Indianapolis, IN

Spero Health, situated in Indianapolis, IN, delivers extensive outpatient rehabilitation programs geared towards overcoming addiction and chemical dependency. The center offers various treatment modalities, including medication-assisted treatment with methadone, buprenorphine, or naltrexone, standard outpatient care, and support for the 12-step recovery process. Dedicated to personalized healing, Spero Health supports adult men and women, including individuals who have faced intimate partner or domestic abuse. This facility accommodates adults and young adults of all gender identities, incorporating strategies like anger management and brief intervention to foster complete and successful recovery.

Spero Health
Owensboro, KY

Spero Health, located in Owensboro, KY, offers outpatient services designed for adults and young adults dealing with substance use issues. This facility provides treatments including methadone, buprenorphine, and naltrexone, alongside regular outpatient services. It incorporates various therapeutic methods such as anger management, brief interventions, and cognitive behavioral therapy. The center features specialized programs for adult men, adult women, and individuals affected by intimate partner or domestic violence. Spero Health is committed to delivering personalized care for both genders, ensuring comprehensive support for clients as they work towards recovery from substance use disorders.

Spero Health
Savannah, TN

Spero Health, located in Savannah, TN, specializes in outpatient treatment for substance use, emphasizing personalized care and high-quality support. The center offers a variety of services including outpatient treatments with methadone, buprenorphine, or naltrexone, alongside traditional outpatient programs. Additionally, Spero Health incorporates multiple therapeutic methods such as anger management, brief interventions, and cognitive behavioral therapy. This facility serves adult men and women, including those who have faced domestic or intimate partner violence. By focusing on tailored care, Spero Health aims to assist both adults and young adults in their recovery journey.

Spero Health
Middlesboro, KY

Spero Health, located in Middlesboro, KY, provides extensive support for substance use disorders through accessible outpatient services, featuring medication-assisted treatment with methadone, buprenorphine, or naltrexone. Their approach incorporates proven therapeutic techniques like anger management, cognitive behavioral therapy, and brief intervention to foster successful addiction recovery. This center welcomes adult men and women, with specific attention given to those who have faced intimate partner or domestic violence. They extend their services to both adults and young adults, tailoring care to suit different age demographics and genders. Spero Health prioritizes high-quality, personalized treatment plans, committed to guiding individuals toward overcoming addiction and securing enduring sobriety.

Spero Health
Indianapolis, IN

Spero Health in Indianapolis, IN, provides complete outpatient care for addiction, encompassing detox and substance abuse treatment. They offer outpatient treatment using methadone, buprenorphine, or naltrexone, alongside general outpatient programs. The center utilizes 12-step facilitation, anger management, and brief intervention strategies, serving adult men and women, including those affected by intimate partner or domestic violence. Designed for adults and young adults of any gender, Spero Health's tailored programs ensure personalized treatment plans. This facility is dedicated to high-quality, evidence-based care in a nurturing setting for individuals pursuing sobriety.

Spero Health
Elyria, OH

Spero Health, situated in Elyria, OH, provides complete care for substance use disorders, featuring intensive outpatient, standard outpatient, and medication-assisted treatment options including methadone, buprenorphine, and naltrexone. Their expertise extends to specialized therapies such as anger management, brief intervention strategies, and cognitive behavioral therapy. The center offers tailored programs for adult men, adult women, and individuals affected by intimate partner or domestic violence. Spero Health is committed to delivering personalized support for adults and young adults of all genders, ensuring each person receives care aligned with their distinct recovery needs. Employing a dedication to high standards and proven therapeutic methods, this facility empowers individuals on their path to lasting recovery.

Spero Health
Jeffersonville, IN

Spero Health, located in Jeffersonville, IN, provides outpatient treatment options for substance use disorders specifically designed for adult men and women, including individuals who have faced issues related to intimate partner violence. Emphasizing anger management, brief interventions, and cognitive behavioral therapy, this center delivers focused assistance for those pursuing recovery. Their services are available to adults and young adults of any gender. Spero Health offers outpatient options such as methadone, buprenorphine, or naltrexone treatments in conjunction with standard outpatient programs. The facility is dedicated to delivering high-quality support and care for those working towards sobriety, making it an excellent option for anyone looking for in-depth addiction treatment solutions.

Spero Health
Cookeville, TN

Spero Health, located in Cookeville, TN, specializes in outpatient treatment for substance abuse, emphasizing tailored care for each individual. The center offers a range of services, including outpatient programs for methadone/buprenorphine or naltrexone, standard outpatient therapy, anger management sessions, brief interventions, and cognitive behavioral therapy. It features specialized programs designed for adult men, women, and individuals who have faced intimate partner or domestic violence. Catering to both adults and young adults of any gender, this facility fosters a caring atmosphere for those pursuing recovery from addiction. With its dedication to high-quality care, Spero Health is recognized for its all-encompassing approach to rehabilitation, making it an excellent option for individuals seeking substance abuse treatment.

Spero Health
Jackson, TN

Spero Health, located in Jackson, TN, provides outpatient substance abuse recovery services for adults and young adults. Their specialized care addresses the needs of individuals who have been affected by intimate partner or domestic violence. Therapies offered include anger management, brief intervention, and cognitive behavioral therapy. Spero Health serves both male and female individuals, with distinct programs for adult men and women. They offer various treatment modalities such as outpatient methadone/buprenorphine or naltrexone treatment, alongside standard outpatient services, ensuring each client receives individualized and complete support for their recovery process.

Spero Health
Seymour, TN

Spero Health, located in Seymour, TN, offers extensive outpatient treatment programs for individuals dealing with substance use issues, including both adults and young adults. The center provides various outpatient options, such as methadone, buprenorphine, and naltrexone therapies, alongside standard outpatient services. It emphasizes specific areas like anger management, brief intervention, and cognitive behavioral therapy. Spero Health supports adult men and women, including those who have faced intimate partner or domestic violence. By prioritizing personalized care, the center guarantees high-quality treatment for patients in a nurturing environment, promoting effective recovery solutions.

Spero Health
Coshocton, OH

Spero Health located in Coshocton, OH, provides outpatient treatment for substance use, featuring services like methadone/buprenorphine or naltrexone treatment along with general outpatient care. The center employs various strategies including anger management, brief intervention, and cognitive behavioral therapy. It offers specialized programs designed for adult men and women, as well as those who have faced intimate partner or domestic violence. Spero Health welcomes adults and young adults from all genders, ensuring that each client receives individualized care that meets their specific requirements. Committed to using evidence-based methods and maintaining high standards of treatment, this center strives to assist clients on their recovery paths with care and professionalism.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)