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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Spero Health
Richmond, IN

Spero Health in Richmond, IN, delivers outpatient care for adults and young adults battling substance use disorders. They focus on medication-assisted treatment using methadone, buprenorphine, or naltrexone, complemented by therapies like anger management, brief intervention, and CBT. Services are adapted for adult men, adult women, and survivors of intimate partner or domestic violence, fostering an inclusive atmosphere. Spero Health warmly welcomes all clients, offering personalized support for their recovery path. Dedicated to proven methods and empathetic assistance, Spero Health guides individuals toward sustained sobriety.

Spero Health
Columbia, KY

Spero Health in Columbia, KY, stands as a prominent provider of outpatient addiction recovery services. Their offerings encompass medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside comprehensive outpatient care. Employing a range of therapeutic modalities such as anger management and cognitive behavioral therapy, Spero Health serves adult men and women, including those who have faced intimate partner or domestic violence. The center's specialized programs are designed for adults and young adults, accommodating both male and female clients. Spero Health's dedication to high-quality, individualized treatment makes it a distinguished option for individuals pursuing effective and compassionate substance use disorder recovery.

Spero Health
Bowling Green, KY

Spero Health in Bowling Green, KY, is an outpatient addiction treatment center serving adults and young adults. They offer medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient services. Their therapeutic approaches include anger management, brief intervention, and cognitive behavioral therapy. Spero Health also specializes in supporting adult men, adult women, and individuals affected by intimate partner or domestic violence. Their commitment to personalized care for all genders ensures a comprehensive and effective recovery experience.

Spero Health
Marion, OH

Situated in Marion, OH, Spero Health provides comprehensive outpatient services, including intensive outpatient programs and treatments with methadone, buprenorphine, or naltrexone for those facing substance abuse challenges. The center emphasizes the importance of anger management, brief interventions, and cognitive behavioral therapy. Specialized programs are available for adult men, adult women, and individuals affected by intimate partner or domestic violence. Catering to both adults and young adults, Spero Health delivers personalized care for all genders. With a commitment to evidence-based practices, this facility guarantees effective support for individuals on their journey to recovery from addiction.

Spero Health
Zanesville, OH

Spero Health in Zanesville, OH, provides comprehensive outpatient care for substance use disorders. Their services include medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside regular outpatient services. Therapeutic interventions such as anger management, brief intervention, and cognitive behavioral therapy are integral to their approach. The center is uniquely equipped to support adult men and women, as well as individuals impacted by intimate partner or domestic violence. Spero Health delivers tailored treatment plans for adults and young adults of all genders, fostering successful recovery.

Spero Health
Youngstown, OH

Spero Health, located in Youngstown, OH, provides extensive treatment for substance use disorders with a variety of programs designed to meet the unique needs of each individual. The center focuses on intensive outpatient services, general outpatient care, as well as treatments utilizing methadone, buprenorphine, and naltrexone. Emphasizing techniques such as anger management, brief interventions, and cognitive behavioral therapy, Spero Health supports both adults and young adults, regardless of gender. Additionally, specialized programs are available for adult men, adult women, and those who have faced situations of intimate partner or domestic violence. Spero Health is committed to delivering high-quality, customized care plans to assist individuals on their recovery journey.

Spero Health
Dickson, TN

Spero Health, situated in Dickson, TN, provides extensive outpatient care for substance use disorders. Their expertise lies in outpatient treatment utilizing methadone, buprenorphine, or naltrexone. The facility offers routine outpatient services to adults and young adults across all gender identities. Spero Health's approach is individualized, emphasizing anger management, brief interventions, and cognitive behavioral therapy. They also feature specialized programs designed for adult men, adult women, and individuals who have faced intimate partner or domestic violence. Discover effective treatment and dedicated assistance at this center committed to aiding recovery from addiction.

Spero Health
Wheelersburg, OH

Spero Health, located in Wheelersburg, OH, specializes in outpatient services for adults and young adults dealing with substance use issues. The center provides various treatment options, including outpatient care with methadone, buprenorphine, or naltrexone, along with standard outpatient programs. Their treatment methodologies include anger management, cognitive behavioral therapy, and brief interventions. Spero Health also features tailored programs for adult men and women, as well as support for those who have faced intimate partner or domestic violence. This ensures that both men and women receive comprehensive care that meets their specific needs. For those in search of tailored addiction treatment in a nurturing setting, Spero Health is committed to supporting your recovery journey.

Spero Health
Findlay, OH

In Findlay, Ohio, Spero Health operates as a prominent outpatient treatment center dedicated to addressing substance use disorders. Their services encompass outpatient medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside general outpatient therapy. To facilitate recovery, they utilize a range of therapeutic modalities such as anger management, brief intervention strategies, and cognitive behavioral therapy. Spero Health serves adult men and women, including those who have faced intimate partner or domestic violence. This center is committed to offering tailored support and care to adults and young adults of all genders, guiding them toward lasting recovery.

Spero Health
Muncie, IN

Spero Health, located in Muncie, IN, provides outpatient detoxification and treatment options for individuals dealing with substance use issues, designed specifically for adults and young adults. Their comprehensive services feature outpatient treatments with methadone, buprenorphine, and naltrexone, alongside programs for 12-step support, anger management, and brief intervention strategies. This center focuses on delivering tailored care for both men and women, including those who have faced domestic or intimate partner violence. Spero Health prioritizes personalized attention and quality care, making it an ideal choice for individuals seeking compassionate addiction support in an outpatient environment.

Spero Health
Louisville, KY

Spero Health in Louisville, KY, provides comprehensive outpatient care for substance use disorders, guiding individuals toward lasting recovery. Their services include outpatient treatment with methadone, buprenorphine, or naltrexone, delivered within a carefully structured and nurturing setting. The center emphasizes key therapeutic areas like anger management, brief intervention strategies, and cognitive behavioral therapy, ensuring each client receives a personalized treatment plan. Tailored programs are available for adult men and women, as well as those who have experienced intimate partner or domestic violence. Spero Health is dedicated to delivering high-quality, individualized support for adults and young adults of all gender identities seeking addiction treatment.

Spero Health
Monticello, KY

Situated in Monticello, KY, Spero Health delivers accessible outpatient care for individuals battling substance use disorders. Their services include medication-assisted treatment using methadone, buprenorphine, or naltrexone, alongside general outpatient programs. Spero Health employs therapeutic strategies such as anger management, brief intervention, and cognitive behavioral therapy. They serve a diverse clientele, including adult men and women, individuals affected by intimate partner or domestic violence, and both young adults and older adults. Committed to high standards of treatment, this center provides tailored programs for different demographics, offering a thorough approach to addiction recovery.

Spero Health
Madisonville, KY

Spero Health, located in Madisonville, KY, provides outpatient programs designed for adults and young adults struggling with substance use issues. This center specializes in care for adult males, adult females, and individuals who have faced intimate partner or domestic violence. Treatment methods include anger management, brief intervention strategies, and cognitive behavioral therapy. Spero Health also offers outpatient treatments with methadone, buprenorphine, or naltrexone, complemented by consistent outpatient services. Committed to delivering high-quality care, Spero Health focuses on personalized support for all clients on their journey to recovery from substance use disorders.

Spero Health
Parkersburg, WV

Spero Health in Parkersburg, WV, delivers outpatient care for substance use disorders, utilizing methadone, buprenorphine, or naltrexone. Their services include anger management, brief intervention strategies, and cognitive behavioral therapy. This center supports adult men and women, with specific accommodations for survivors of intimate partner or domestic violence. Spero Health's approach is tailored to adults and young adults, ensuring individualized support throughout their recovery. Their dedication to high-quality, specialized treatment establishes Spero Health as a key provider for those pursuing effective and understanding addiction recovery in Parkersburg.

Spero Health
Somerset, KY

Spero Health in Somerset, KY, delivers specialized outpatient services for adults and young adults grappling with substance use disorders. The center is dedicated to providing high-quality, individualized care, including distinct programs for adult men and women, and for those affected by intimate partner or domestic violence. Their therapeutic framework encompasses strategies such as anger management, brief intervention, and cognitive behavioral therapy. Spero Health provides outpatient treatment utilizing methadone, buprenorphine, or naltrexone, in addition to general outpatient services. Their approach features gender-specific programming for both male and female clients, ensuring that each person receives support aligned with their specific circumstances.

Spero Health
Indianapolis, IN

Spero Health in Indianapolis, IN, provides complete outpatient care for addiction, encompassing detox and substance abuse treatment. They offer outpatient treatment using methadone, buprenorphine, or naltrexone, alongside general outpatient programs. The center utilizes 12-step facilitation, anger management, and brief intervention strategies, serving adult men and women, including those affected by intimate partner or domestic violence. Designed for adults and young adults of any gender, Spero Health's tailored programs ensure personalized treatment plans. This facility is dedicated to high-quality, evidence-based care in a nurturing setting for individuals pursuing sobriety.

Spero Health
Jackson, TN

Spero Health, located in Jackson, TN, provides outpatient substance abuse recovery services for adults and young adults. Their specialized care addresses the needs of individuals who have been affected by intimate partner or domestic violence. Therapies offered include anger management, brief intervention, and cognitive behavioral therapy. Spero Health serves both male and female individuals, with distinct programs for adult men and women. They offer various treatment modalities such as outpatient methadone/buprenorphine or naltrexone treatment, alongside standard outpatient services, ensuring each client receives individualized and complete support for their recovery process.

Spero Health
Mansfield, OH

Spero Health, located in Mansfield, OH, delivers an extensive range of substance abuse treatment options, including intensive outpatient programs, standard outpatient services, and medication-assisted treatments with methadone, buprenorphine, or naltrexone. The facility emphasizes therapeutic modalities such as anger management, brief intervention strategies, and cognitive behavioral therapy. Tailored programs are designed for adult men and women, as well as clients who have faced intimate partner or domestic violence. Catering to both adults and young adults of all genders, Spero Health focuses on personalized care that meets the specific needs of each individual. Committed to high standards and evidence-based methodologies, this center strives to support individuals in achieving long-term recovery from substance use issues.

Spero Health
Crossville, TN

Situated in Crossville, TN, Spero Health specializes in outpatient treatment for substance use issues affecting both adults and young adults. The center provides a range of services including methadone, buprenorphine, or naltrexone treatments, as well as regular outpatient programs. Their methods incorporate techniques such as anger management, brief interventions, and cognitive behavioral therapy. Spero Health serves diverse populations, including adult men and women, as well as individuals who have faced intimate partner or domestic abuse. Committed to delivering high-quality care, this facility creates a welcoming atmosphere for individuals of all genders seeking personalized rehabilitation support.

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Cincinnati, OH

Spero Health, located in Cincinnati, OH, provides expert services for substance use recovery with its array of programs including intensive outpatient, outpatient, and medication-assisted treatments featuring methadone, buprenorphine, and naltrexone. The center emphasizes anger management, short interventions, and cognitive behavioral therapy, catering to both adult men and women, alongside those who have faced domestic violence or intimate partner issues. Spero Health supports adults and young adults of any gender, ensuring a holistic approach to recovery. With a dedication to high-quality care and varied therapeutic methods, it stands out as a reliable option for effective addiction treatment in the Cincinnati area.

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Ashland, KY

Spero Health in Ashland, KY provides specialized outpatient care for substance use disorders, employing scientifically proven methods. Their services include medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside general outpatient services, anger management, brief intervention strategies, and cognitive behavioral therapy. Spero Health supports adult men and women, including those affected by intimate partner or domestic violence, and offers tailored support for adults and young adults of all genders to aid their recovery process.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)