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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Spero Health
Richmond, IN

Spero Health in Richmond, IN, delivers outpatient care for adults and young adults battling substance use disorders. They focus on medication-assisted treatment using methadone, buprenorphine, or naltrexone, complemented by therapies like anger management, brief intervention, and CBT. Services are adapted for adult men, adult women, and survivors of intimate partner or domestic violence, fostering an inclusive atmosphere. Spero Health warmly welcomes all clients, offering personalized support for their recovery path. Dedicated to proven methods and empathetic assistance, Spero Health guides individuals toward sustained sobriety.

Spero Health
Bowling Green, KY

Spero Health in Bowling Green, KY, is an outpatient addiction treatment center serving adults and young adults. They offer medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient services. Their therapeutic approaches include anger management, brief intervention, and cognitive behavioral therapy. Spero Health also specializes in supporting adult men, adult women, and individuals affected by intimate partner or domestic violence. Their commitment to personalized care for all genders ensures a comprehensive and effective recovery experience.

Spero Health
Columbia, KY

Spero Health in Columbia, KY, stands as a prominent provider of outpatient addiction recovery services. Their offerings encompass medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside comprehensive outpatient care. Employing a range of therapeutic modalities such as anger management and cognitive behavioral therapy, Spero Health serves adult men and women, including those who have faced intimate partner or domestic violence. The center's specialized programs are designed for adults and young adults, accommodating both male and female clients. Spero Health's dedication to high-quality, individualized treatment makes it a distinguished option for individuals pursuing effective and compassionate substance use disorder recovery.

Spero Health
Zanesville, OH

Spero Health in Zanesville, OH, provides comprehensive outpatient care for substance use disorders. Their services include medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside regular outpatient services. Therapeutic interventions such as anger management, brief intervention, and cognitive behavioral therapy are integral to their approach. The center is uniquely equipped to support adult men and women, as well as individuals impacted by intimate partner or domestic violence. Spero Health delivers tailored treatment plans for adults and young adults of all genders, fostering successful recovery.

Spero Health
Lexington, KY

Spero Health, situated in Lexington, KY, provides accessible outpatient care for individuals facing substance use challenges. Their therapeutic offerings encompass crucial areas like anger management, cognitive behavioral therapy, and brief intervention strategies. The center is dedicated to supporting specific populations, including adult men and women, as well as those impacted by intimate partner or domestic violence. Spero Health extends its comprehensive services to adults and young adults across all gender identities, delivering effective treatment options such as outpatient methadone, buprenorphine, or naltrexone, alongside regular outpatient programs. Through a commitment to personalized treatment plans and proven, evidence-based methods, Spero Health strives to guide individuals toward sustained wellness and recovery.

Spero Health
Lawrenceburg, TN

Situated in Lawrenceburg, TN, Spero Health provides accessible outpatient care for individuals grappling with substance use disorders. This center supports adult men and women, including survivors of intimate partner violence, offering a range of therapeutic modalities. Their services encompass anger management, brief intervention strategies, and cognitive behavioral therapy. Spero Health focuses on outpatient medication-assisted treatment using methadone, buprenorphine, or naltrexone. They welcome both adults and young adults in their pursuit of effective recovery within a nurturing atmosphere. Through tailored treatment plans, Spero Health is dedicated to a holistic path to sobriety, prioritizing safety and successful outcomes.

Spero Health
Findlay, OH

In Findlay, Ohio, Spero Health operates as a prominent outpatient treatment center dedicated to addressing substance use disorders. Their services encompass outpatient medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside general outpatient therapy. To facilitate recovery, they utilize a range of therapeutic modalities such as anger management, brief intervention strategies, and cognitive behavioral therapy. Spero Health serves adult men and women, including those who have faced intimate partner or domestic violence. This center is committed to offering tailored support and care to adults and young adults of all genders, guiding them toward lasting recovery.

Spero Health
Elizabethtown, KY

Situated in Elizabethtown, Kentucky, Spero Health delivers outpatient care for individuals struggling with substance use disorders. Their services include medication-assisted treatment options like methadone, buprenorphine, and naltrexone, alongside comprehensive outpatient programs. Spero Health employs therapeutic strategies such as anger management, brief intervention, and cognitive behavioral therapy to address a range of client needs. The center serves adult men and women, including those impacted by domestic or intimate partner violence. Prioritizing a high standard of care, this establishment crafts personalized recovery plans tailored to each person's unique path.

Spero Health
Marietta, OH

Spero Health in Marietta, OH, provides a full spectrum of care for substance use disorders, including intensive outpatient, outpatient, and medication-assisted treatment options like methadone, buprenorphine, and naltrexone. Their expertise extends to anger management, brief intervention strategies, and cognitive behavioral therapy. Spero Health also offers specialized programs tailored for adult men, adult women, and individuals who have faced intimate partner or domestic violence. Catering to adults and young adults across all gender identities, the facility fosters a nurturing atmosphere conducive to healing. Emphasizing personalized treatment plans and scientifically-backed methods, Spero Health in Marietta is committed to guiding clients toward sustained recovery and improved quality of life.

Spero Health
Galax, VA

Spero Health in Galax, VA, offers extensive support for substance use disorders via personalized outpatient services. This center provides medication-assisted treatment (methadone/buprenorphine/naltrexone) alongside standard outpatient care. They also feature distinct programs for adult men, adult women, and individuals affected by intimate partner or domestic violence, ensuring a broad spectrum of support. Employing scientifically validated methods such as anger management, brief intervention, and cognitive behavioral therapy, Spero Health assists adults and young adults across the gender spectrum in achieving lasting recovery. Discover a caring and results-driven approach to rehabilitation at Spero Health.

Spero Health
Chattanooga, TN

Spero Health in Chattanooga, TN, delivers multifaceted substance use recovery services for adults and young adults managing co-occurring mental health challenges. Their offerings include intensive outpatient, outpatient, and specialized medication-assisted treatment options utilizing methadone, buprenorphine, or naltrexone. Emphasizing 12-step facilitation, anger management techniques, and brief intervention strategies, the center customizes treatment to each person's unique situation. They also feature dedicated programs for active military personnel, adult men, and adult women, providing focused assistance. Spero Health welcomes both male and female patients, ensuring professional and effective care. For those pursuing impactful addiction treatment within a nurturing setting, this center provides individualized plans for sustained recovery.

Spero Health
Monticello, KY

Situated in Monticello, KY, Spero Health delivers accessible outpatient care for individuals battling substance use disorders. Their services include medication-assisted treatment using methadone, buprenorphine, or naltrexone, alongside general outpatient programs. Spero Health employs therapeutic strategies such as anger management, brief intervention, and cognitive behavioral therapy. They serve a diverse clientele, including adult men and women, individuals affected by intimate partner or domestic violence, and both young adults and older adults. Committed to high standards of treatment, this center provides tailored programs for different demographics, offering a thorough approach to addiction recovery.

SperoHealth
Columbus, OH

SperoHealth, located in Columbus, OH, provides a wide range of substance use treatment options, including intensive outpatient programs, outpatient services, and medication-assisted treatments such as methadone, buprenorphine, or naltrexone. The facility is known for its specialized programs in anger management, brief intervention, and cognitive behavioral therapy. Tailored initiatives are available for adult men and women, as well as individuals who have faced intimate partner violence. SperoHealth serves both adults and young adults from all backgrounds, ensuring a nurturing atmosphere for those on the path to recovery. Emphasizing high-quality care and research-backed methods, the center develops individualized treatment plans that cater to the varied requirements of each client, promoting effective rehabilitation and overall health.

Spero Health
Somerset, KY

Spero Health in Somerset, KY, delivers specialized outpatient services for adults and young adults grappling with substance use disorders. The center is dedicated to providing high-quality, individualized care, including distinct programs for adult men and women, and for those affected by intimate partner or domestic violence. Their therapeutic framework encompasses strategies such as anger management, brief intervention, and cognitive behavioral therapy. Spero Health provides outpatient treatment utilizing methadone, buprenorphine, or naltrexone, in addition to general outpatient services. Their approach features gender-specific programming for both male and female clients, ensuring that each person receives support aligned with their specific circumstances.

Spero Health
Hazard, KY

Spero Health, situated in Hazard, KY, delivers outpatient care for individuals battling substance use disorders. Their services are designed for adults and young adults, with tailored programs addressing the unique needs of men, women, and those impacted by domestic or intimate partner violence. Treatment methodologies employed include anger management, brief interventions, and cognitive behavioral therapy. Spero Health provides medication-assisted treatment options such as methadone, buprenorphine, or naltrexone, alongside standard outpatient services. The center is committed to delivering high-quality, individualized rehabilitation plans for all clients seeking recovery.

Spero Health
Parkersburg, WV

Spero Health in Parkersburg, WV, delivers outpatient care for substance use disorders, utilizing methadone, buprenorphine, or naltrexone. Their services include anger management, brief intervention strategies, and cognitive behavioral therapy. This center supports adult men and women, with specific accommodations for survivors of intimate partner or domestic violence. Spero Health's approach is tailored to adults and young adults, ensuring individualized support throughout their recovery. Their dedication to high-quality, specialized treatment establishes Spero Health as a key provider for those pursuing effective and understanding addiction recovery in Parkersburg.

Spero Health
Smyrna, TN

Spero Health in Smyrna, TN, delivers comprehensive outpatient recovery services for adults and young adults. Their treatment options include medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient care. The facility also offers specialized programs focusing on anger management, brief intervention strategies, and cognitive behavioral therapy. Spero Health is uniquely equipped to support adult men, adult women, and individuals impacted by intimate partner or domestic violence. They are dedicated to providing personalized treatment and employing proven, effective methods for all clients, irrespective of gender. For those looking for a supportive setting and thorough addiction care, Spero Health provides expert services and tailored programs.

Spero Health
Beckley, WV

Situated in Beckley, West Virginia, Spero Health delivers accessible, outpatient care for individuals grappling with substance use disorders. Their services include medication-assisted treatment utilizing methadone, buprenorphine, or naltrexone, alongside comprehensive outpatient programs. Therapies offered encompass anger management, brief intervention strategies, and cognitive behavioral approaches. Spero Health is equipped to support adult men and women, including those who have faced intimate partner or domestic violence. By offering targeted programs for diverse groups, the center prioritizes personalized recovery plans. Their commitment to high-quality care and a holistic approach establishes Spero Health as a leading provider of effective and empathetic addiction recovery services.

Spero Health
Clarksville, TN

Spero Health in Clarksville, TN, delivers personalized outpatient recovery support for adults and emerging adults. They have distinct programs for adult men and women, as well as those affected by intimate partner or domestic violence. Employing methods such as anger management, brief intervention, and cognitive behavioral therapy, this location emphasizes custom treatment plans. Spero Health provides medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside general outpatient services. Catering to both male and female individuals, the center is dedicated to providing excellent, all-encompassing support for lasting recovery.

Spero Health
Barbourville, KY

Situated in Barbourville, KY, Spero Health delivers outpatient addiction recovery services designed for adult men and women. This center offers distinct support for individuals affected by domestic or intimate partner abuse. Through specialized techniques such as anger management, brief intervention strategies, and cognitive behavioral therapy, Spero Health provides a thorough recovery experience. The facility includes outpatient medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient services, serving adults and young adults across all genders. Spero Health is recognized for its dedication to high-quality, individualized care, positioning it as a dependable resource for addiction recovery.

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Ashland, KY

Spero Health in Ashland, KY provides specialized outpatient care for substance use disorders, employing scientifically proven methods. Their services include medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside general outpatient services, anger management, brief intervention strategies, and cognitive behavioral therapy. Spero Health supports adult men and women, including those affected by intimate partner or domestic violence, and offers tailored support for adults and young adults of all genders to aid their recovery process.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)