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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Therapeutic Health Services

Therapeutic Health Services in Seattle, WA, provides comprehensive outpatient care for substance use disorders, concentrating on medication-assisted treatment with methadone, buprenorphine, or naltrexone. Their approach integrates proven methods like cognitive behavioral therapy, motivational interviewing, and strategies for preventing relapse. The center is dedicated to personalized treatment plans, offering distinct programs for adult men and women, and for individuals affected by domestic or intimate partner violence. Catering to adults and young adults across all gender identities, this establishment delivers a holistic and customized path to addiction recovery and sustained wellness.

Therapeutic Health Services

Therapeutic Health Services in Bellevue, WA, is dedicated to providing specialized care for adults grappling with substance use disorders alongside co-occurring serious mental health conditions or emotional challenges. Their offerings include intensive outpatient and standard outpatient services, employing proven methodologies such as cognitive behavioral therapy, motivational interviewing, and relapse prevention strategies. The center also provides customized programs catering to adult men, women, and survivors of intimate partner violence. Open to adults and young adults across all gender identities, this facility ensures comprehensive support through personalized treatment plans rooted in evidence-based practices. Embrace a nurturing setting designed to foster sustained recovery and enhance overall mental wellness.

Therapeutic Health Services

Therapeutic Health Services in Seattle, WA, provides targeted support for adults struggling with substance use disorders, particularly those also managing serious mental health conditions or emotional challenges in children. Their services include robust intensive outpatient and outpatient care options, featuring medication-assisted treatment like methadone, buprenorphine, or naltrexone. Employing evidence-based methods such as cognitive behavioral therapy, motivational interviewing, and relapse prevention strategies, the center assists adult men and women, including survivors of intimate partner or domestic violence. Therapeutic Health Services is dedicated to offering personalized, high-quality rehabilitation for adults and young adults of all genders in the Seattle community.

Therapeutic Health Services

Therapeutic Health Services located in Seattle, WA, delivers focused treatment for adults dealing with substance use issues alongside mental health disorders, and it also addresses significant emotional difficulties in children. The center features both intensive outpatient and standard outpatient programs designed to offer personalized support, utilizing techniques such as cognitive behavioral therapy, motivational interviewing, and strategies to prevent relapse. Special programs are available for adult men, women, and those who have endured domestic or intimate partner violence. Committed to serving adults and young adults of all genders, this center emphasizes high-quality care and personalized attention to foster sustainable recovery and overall health.

Thomas Memorial Hospital

Located in Charleston, WV, Thomas Memorial Hospital provides expert rehabilitation services designed for both adults and young adults facing challenges with substance abuse and concurrent mental health disorders. This center features a range of treatment options, including intensive outpatient programs, outpatient support, and therapies using methadone, buprenorphine, or naltrexone. Emphasizing approaches like 12-step programs, anger management, and short interventions, it aims to meet the diverse needs of individuals requiring thorough assistance. The facility is especially skilled in addressing the complexities of dual diagnoses and offers customized programs for both male and female clientele. At Thomas Memorial Hospital, you can anticipate a caring environment and treatments grounded in evidence-based practices.

Thrive Treatment
Santa Monica, CA

Nestled in Santa Monica, California, Thrive Treatment delivers a complete spectrum of care for individuals battling substance abuse and co-occurring mental health challenges, serving both youth and adults. They offer structured programs like intensive outpatient, day treatment, and partial hospitalization, employing proven therapeutic methods such as 12-step facilitation, brief intervention, and cognitive behavioral therapy. Thrive Treatment is equipped to support distinct groups, including adolescents, adult men, and adult women, providing individualized support. Committed to high standards and personalized recovery plans, this establishment aims to guide clients toward sustained sobriety and emotional wellness.

Tides Edge Recovery Services
Jacksonville Beach, FL

Tides Edge Recovery Services, situated in Jacksonville Beach, FL, provides extensive care for adults and young adults facing addiction and co-occurring mental health issues. They offer tailored programs for active military personnel, adult men, and women, including round-the-clock hospital-based detoxification and inpatient treatment. The center employs proven methods like 12-step facilitation and anger management, focusing on individualized, high-quality support. Serving both men and women, Tides Edge Recovery Services is dedicated to delivering impactful and empathetic recovery assistance.

Thresholds
Chicago, IL

Located in Chicago, IL, Thresholds delivers a wide array of rehabilitation services aimed at adults and young adults. The center focuses on detoxification, substance abuse treatment, and addressing co-occurring substance use with significant mental health challenges in adults or severe emotional disturbances in children. Treatment modalities include intensive outpatient programs, general outpatient services, and outpatient detox options. Thresholds employs various techniques such as anger management, brief interventions, and cognitive behavioral therapy. The facility also offers specialized programs designed for adult men and women, as well as those who have faced trauma. With a commitment to personalized care, Thresholds ensures a nurturing and effective rehabilitation journey for all clients.

Thelma McMillen Recovery Center

The Thelma McMillen Recovery Center in Torrance, CA, provides extensive care for adults struggling with addiction and co-occurring serious mental health conditions, as well as for children facing significant emotional disorders. They employ a range of therapeutic techniques, including 12-step facilitation, cognitive behavioral therapy, and motivational interviewing, within structured intensive outpatient and outpatient services. The center is equipped to serve adolescents, adult men, and adult women, accommodating diverse age ranges and genders. Their commitment to evidence-based practices and distinct treatment plans guarantees a high standard of support for individuals pursuing recovery from substance abuse and mental health concerns.

Therapeutics LLC
Ann Arbor, MI

Therapeutics LLC, located in Ann Arbor, MI, is a leading provider of outpatient detoxification and comprehensive substance use disorder treatment for adults and young adults. The center is distinguished by its specialized expertise in supporting individuals who have endured trauma, including experiences of intimate partner violence, domestic violence, and sexual abuse. Therapeutics LLC prioritizes personalized care, utilizing evidence-based approaches such as anger management, cognitive behavioral therapy, and motivational incentives to address each client's unique journey. The facility offers outpatient medication-assisted treatment options, including methadone, buprenorphine, and naltrexone, serving both male and female patients. Their integrated treatment model and dedicated programs guarantee effective, high-quality support for those in recovery from addiction.

Therapeutics LLC
Pontiac, MI

Therapeutics LLC, located in Pontiac, MI, provides outpatient detox and treatment services for both adults and young adults dealing with substance use issues. This center has a particular emphasis on assisting individuals who have faced intimate partner violence, domestic abuse, sexual trauma, and related experiences. By implementing techniques such as anger management, cognitive behavioral therapy, and contingency management, Therapeutics LLC ensures personalized care for all clients, regardless of gender. Committed to delivering high-quality, customized treatment, the facility strives to guide clients through their recovery process using proven methods and a dedicated, supportive team.

Therapeutic Health Services

Therapeutic Health Services in Everett, WA, provides outpatient care for individuals struggling with substance use disorders, with a particular focus on those facing co-occurring mental health challenges. They expertly address substance use alongside serious mental illnesses in adults and significant emotional disturbances in children. Employing proven methods like cognitive behavioral therapy, motivational interviewing, and relapse prevention, this center offers tailored support. Therapeutic Health Services features specialized interventions for adolescents, survivors of intimate partner violence, domestic violence, and sexual abuse. Catering to adults, youth, and young adults across all genders, they are dedicated to delivering exceptional care customized to each person's distinct circumstances.

Therapeutic Health Services

Therapeutic Health Services in Everett, WA, delivers an extensive selection of treatment options for substance use and co-occurring disorders, catering to both adults and children. The facility offers various levels of care, including intensive outpatient programs, day treatment, and partial hospitalization. By employing evidence-based methods such as cognitive behavioral therapy, motivational interviewing, and strategies for relapse prevention, this center effectively supports both men and women, including those affected by domestic or intimate partner violence. Therapeutic Health Services provides specialized interventions designed for both adults and young adults, ensuring that each client receives personalized care. With its commitment to high-quality, individualized treatment, the center is a leading option for individuals seeking reliable rehabilitation support.

Therapeutics LLC
Walled Lake, MI

Located in Walled Lake, MI, Therapeutics LLC provides outpatient detox and treatment services for substance use disorders aimed at both adults and young adults. The center has expertise in areas such as anger management, cognitive behavioral therapy, and motivational incentives. They focus on delivering personalized care for individuals who have faced issues like intimate partner violence, sexual abuse, or trauma. Therapeutics LLC emphasizes customized treatment approaches for all clients, regardless of gender, who are in search of thorough rehabilitation options. Renowned for its exceptional care and nurturing atmosphere, this facility is a leading option for individuals seeking effective and empathetic addiction support.

Therapeutics LLC

Therapeutics LLC, located in Monroe, MI, provides outpatient detox services and treatment for substance use disorders, along with tailored programs for those affected by trauma, including intimate partner violence, domestic violence, and sexual abuse. The center specializes in techniques such as anger management, cognitive behavioral therapy, and motivational incentives, serving both adult and young adult males and females who are on the path to recovery. Its facility offers outpatient treatment options like methadone/buprenorphine or naltrexone in a nurturing atmosphere. At Therapeutics LLC, the emphasis is on delivering high-quality, personalized care to support clients in their quest for sobriety and emotional healing.

ThedaCare Behavioral Health

ThedaCare Behavioral Health in Menasha, WI, is dedicated to providing expert care for individuals and families impacted by substance use challenges and co-occurring mental health conditions. They offer a range of treatment options, including intensive outpatient services, for both adults and younger individuals. Their approach incorporates evidence-based therapies such as cognitive behavioral therapy and the Matrix Model, alongside medication-assisted treatment options like methadone, buprenorphine, and naltrexone. Special attention is given to anger management as part of a comprehensive treatment strategy designed for each client's unique journey. ThedaCare Behavioral Health warmly welcomes individuals of all backgrounds and identities, committed to delivering individualized support for lasting recovery. For those in search of thorough addiction treatment with a compassionate, tailored approach, this center stands as a reliable resource.

Thomas Jefferson University Center for

Situated in Philadelphia, PA, the Thomas Jefferson University Center for specializes in a wide range of outpatient programs for substance use recovery. This center offers tailored services for adult men and women, including individuals facing dual diagnoses of mental health and substance use disorders. Emphasizing methods like 12-step support, anger management, and brief interventions, the center is dedicated to providing personalized treatment options for both adults and young adults. With services that include outpatient methadone/buprenorphine or naltrexone therapies alongside standard outpatient care, this facility is committed to delivering high-quality support for all clients, regardless of gender.

Thresholds Inc
Georgetown, DE

Thresholds Inc, situated in Georgetown, DE, delivers focused outpatient services for individuals battling substance use challenges. Their approach encompasses a spectrum of evidence-based modalities, including 12-step integration, cognitive behavioral therapy, and the Matrix Model. They also provide specialized care for those managing dual diagnoses, such as co-occurring mental health and substance use issues, and individuals dealing with pain alongside addiction. Thresholds Inc warmly welcomes adults and young adults, irrespective of gender, fostering an inclusive and encouraging atmosphere. Their commitment lies in providing top-tier care and personalized recovery pathways to support individuals on their journey to sustained sobriety.

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Therapeutic Wellness Services Inc., located in Baltimore, MD, delivers extensive recovery support. Their offerings include programs for substance dependence, temporary accommodations, and care for dual diagnoses involving addiction and significant mental health conditions or emotional distress. The center features intensive outpatient, extended residential stays, and standard outpatient services. Their therapeutic methods incorporate anger de-escalation, cognitive restructuring, and community-based support with incentives. Specialized initiatives are designed for adult males, adult females, and survivors of domestic abuse. Catering to adults and young adults regardless of gender identity, this establishment prioritizes individualized treatment and assistance for those aiming to conquer addiction and mental health struggles.

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Chicago, IL

Thresholds, situated in Chicago, IL, delivers targeted rehabilitation services for adults grappling with substance use issues and concurrent mental health challenges. The center features a range of options including intensive outpatient programs, standard outpatient services, and treatments involving methadone, buprenorphine, or naltrexone. With an emphasis on evidence-based methods such as cognitive behavioral therapy and motivational interviewing, the center prioritizes personalized care to foster recovery. Specifically tailored to assist clients facing both mental health and substance use disorders, Thresholds offers extensive support for adult men and women aiming to conquer addiction and enhance their emotional health.

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Woodstock, IL

Thresholds, situated in Woodstock, IL, delivers targeted substance abuse recovery services for adults experiencing concurrent mental health challenges. This establishment features robust outpatient programs incorporating cognitive behavioral techniques, motivational dialogue, and addiction counseling. Designed for individuals with dual diagnoses, Thresholds provides outpatient management with methadone, buprenorphine, or naltrexone. Prioritizing excellent care, the center serves adult men and women seeking thorough assistance for addiction and accompanying mental health concerns. For specialized care in a nurturing setting, Thresholds is a resource.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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