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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Thomas Memorial Hospital

Located in Charleston, WV, Thomas Memorial Hospital provides expert rehabilitation services designed for both adults and young adults facing challenges with substance abuse and concurrent mental health disorders. This center features a range of treatment options, including intensive outpatient programs, outpatient support, and therapies using methadone, buprenorphine, or naltrexone. Emphasizing approaches like 12-step programs, anger management, and short interventions, it aims to meet the diverse needs of individuals requiring thorough assistance. The facility is especially skilled in addressing the complexities of dual diagnoses and offers customized programs for both male and female clientele. At Thomas Memorial Hospital, you can anticipate a caring environment and treatments grounded in evidence-based practices.

Thrive Treatment
Santa Monica, CA

Nestled in Santa Monica, California, Thrive Treatment delivers a complete spectrum of care for individuals battling substance abuse and co-occurring mental health challenges, serving both youth and adults. They offer structured programs like intensive outpatient, day treatment, and partial hospitalization, employing proven therapeutic methods such as 12-step facilitation, brief intervention, and cognitive behavioral therapy. Thrive Treatment is equipped to support distinct groups, including adolescents, adult men, and adult women, providing individualized support. Committed to high standards and personalized recovery plans, this establishment aims to guide clients toward sustained sobriety and emotional wellness.

Tides Edge Recovery Services
Jacksonville Beach, FL

Tides Edge Recovery Services, situated in Jacksonville Beach, FL, provides extensive care for adults and young adults facing addiction and co-occurring mental health issues. They offer tailored programs for active military personnel, adult men, and women, including round-the-clock hospital-based detoxification and inpatient treatment. The center employs proven methods like 12-step facilitation and anger management, focusing on individualized, high-quality support. Serving both men and women, Tides Edge Recovery Services is dedicated to delivering impactful and empathetic recovery assistance.

Tigard Comprehensive Treatment Center

Tigard Comprehensive Treatment Center in Portland, OR, delivers outpatient care for individuals struggling with substance use, serving adults and young adults. Services include medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside regular outpatient programs. Therapeutic interventions such as anger management, brief intervention, and cognitive behavioral therapy are integrated. The center also features specialized programs for adult men, adult women, and those who are pregnant or postpartum. Emphasizing tailored support, Tigard Comprehensive Treatment Center is committed to offering exceptional, individualized recovery assistance within an inclusive setting for all clients.

Toiyabe Indian Health Project

The Toiyabe Indian Health Project in Bishop, CA, provides extensive addiction treatment for adults and older adults. Services include various outpatient options such as methadone, buprenorphine, or naltrexone treatment, alongside general outpatient care. Their approach incorporates proven methods like contingency management, motivational interviewing, and relapse prevention strategies. Dedicated programs exist for teenagers and individuals affected by sexual trauma. This center emphasizes personalized support for both men and women, fostering a welcoming setting for those on their recovery journey.

Tomah VAMC
Tomah, WI

Tomah VAMC located in Tomah, Wisconsin delivers extensive addiction recovery services for both adults and young adults. The center features hospital-based detox programs, comprehensive substance abuse treatment, and transitional living arrangements such as halfway houses and sober living facilities. With dedicated programs for various populations, including active duty service members, adult men, and adult women, this facility customizes its treatment to meet diverse needs. By employing methods like anger management, brief interventions, and cognitive behavioral therapy, Tomah VAMC guarantees quality support for all clients. If you are looking for effective rehabilitation in a nurturing atmosphere, this center is dedicated to guiding you on your journey to recovery.

Top of the World Ranch

Top of the World Ranch, situated in Milan, IL, delivers a full spectrum of recovery support for adults and young adults struggling with addiction and concurrent mental health challenges. Their treatment options include intensive outpatient, extended residential stays, and standard outpatient care. The center utilizes evidence-based therapies such as 12-step integration, emotional regulation training, and rapid intervention strategies. They also offer specialized services for active military members, adult men, and adult women, demonstrating a dedication to gender-specific needs. Top of the World Ranch is recognized for its dedication to high-quality, supportive recovery, positioning it as a leading provider of effective and empathetic addiction therapy.

Thresholds
Chicago, IL

Located in Chicago, IL, Thresholds delivers a wide array of rehabilitation services aimed at adults and young adults. The center focuses on detoxification, substance abuse treatment, and addressing co-occurring substance use with significant mental health challenges in adults or severe emotional disturbances in children. Treatment modalities include intensive outpatient programs, general outpatient services, and outpatient detox options. Thresholds employs various techniques such as anger management, brief interventions, and cognitive behavioral therapy. The facility also offers specialized programs designed for adult men and women, as well as those who have faced trauma. With a commitment to personalized care, Thresholds ensures a nurturing and effective rehabilitation journey for all clients.

Therapeutics LLC
Ann Arbor, MI

Therapeutics LLC, located in Ann Arbor, MI, is a leading provider of outpatient detoxification and comprehensive substance use disorder treatment for adults and young adults. The center is distinguished by its specialized expertise in supporting individuals who have endured trauma, including experiences of intimate partner violence, domestic violence, and sexual abuse. Therapeutics LLC prioritizes personalized care, utilizing evidence-based approaches such as anger management, cognitive behavioral therapy, and motivational incentives to address each client's unique journey. The facility offers outpatient medication-assisted treatment options, including methadone, buprenorphine, and naltrexone, serving both male and female patients. Their integrated treatment model and dedicated programs guarantee effective, high-quality support for those in recovery from addiction.

Therapeutics LLC
Pontiac, MI

Therapeutics LLC, located in Pontiac, MI, provides outpatient detox and treatment services for both adults and young adults dealing with substance use issues. This center has a particular emphasis on assisting individuals who have faced intimate partner violence, domestic abuse, sexual trauma, and related experiences. By implementing techniques such as anger management, cognitive behavioral therapy, and contingency management, Therapeutics LLC ensures personalized care for all clients, regardless of gender. Committed to delivering high-quality, customized treatment, the facility strives to guide clients through their recovery process using proven methods and a dedicated, supportive team.

Therapeutics LLC
Walled Lake, MI

Located in Walled Lake, MI, Therapeutics LLC provides outpatient detox and treatment services for substance use disorders aimed at both adults and young adults. The center has expertise in areas such as anger management, cognitive behavioral therapy, and motivational incentives. They focus on delivering personalized care for individuals who have faced issues like intimate partner violence, sexual abuse, or trauma. Therapeutics LLC emphasizes customized treatment approaches for all clients, regardless of gender, who are in search of thorough rehabilitation options. Renowned for its exceptional care and nurturing atmosphere, this facility is a leading option for individuals seeking effective and empathetic addiction support.

Therapeutics LLC

Therapeutics LLC, located in Monroe, MI, provides outpatient detox services and treatment for substance use disorders, along with tailored programs for those affected by trauma, including intimate partner violence, domestic violence, and sexual abuse. The center specializes in techniques such as anger management, cognitive behavioral therapy, and motivational incentives, serving both adult and young adult males and females who are on the path to recovery. Its facility offers outpatient treatment options like methadone/buprenorphine or naltrexone in a nurturing atmosphere. At Therapeutics LLC, the emphasis is on delivering high-quality, personalized care to support clients in their quest for sobriety and emotional healing.

Thomas Jefferson University Center for

Situated in Philadelphia, PA, the Thomas Jefferson University Center for specializes in a wide range of outpatient programs for substance use recovery. This center offers tailored services for adult men and women, including individuals facing dual diagnoses of mental health and substance use disorders. Emphasizing methods like 12-step support, anger management, and brief interventions, the center is dedicated to providing personalized treatment options for both adults and young adults. With services that include outpatient methadone/buprenorphine or naltrexone therapies alongside standard outpatient care, this facility is committed to delivering high-quality support for all clients, regardless of gender.

Thresholds Inc
Georgetown, DE

Thresholds Inc, situated in Georgetown, DE, delivers focused outpatient services for individuals battling substance use challenges. Their approach encompasses a spectrum of evidence-based modalities, including 12-step integration, cognitive behavioral therapy, and the Matrix Model. They also provide specialized care for those managing dual diagnoses, such as co-occurring mental health and substance use issues, and individuals dealing with pain alongside addiction. Thresholds Inc warmly welcomes adults and young adults, irrespective of gender, fostering an inclusive and encouraging atmosphere. Their commitment lies in providing top-tier care and personalized recovery pathways to support individuals on their journey to sustained sobriety.

Tidewater Psychotherapy Services

Situated in Virginia Beach, VA, Tidewater Psychotherapy Services delivers targeted substance use recovery programs for adults and young adults facing significant mental health challenges or emotional issues. Emphasizing personalized treatment, this facility offers intensive outpatient options in addition to outpatient care using methadone, buprenorphine, or naltrexone. Incorporating techniques such as 12-step support, anger management, and brief interventions, the center serves both men and women. For those in search of thorough addiction recovery solutions with a customized focus, Tidewater Psychotherapy Services is dedicated to offering high-quality support to aid your journey towards healing.

Timberline Knolls

Timberline Knolls, located in Lemont, IL, provides extensive long-term residential treatment for women facing challenges related to substance use and concurrent mental health issues. Catering to adult women, teenagers, and active military personnel, this center employs proven treatment methods, including 12-step facilitation and cognitive behavioral therapy. With an emphasis on fostering a nurturing atmosphere conducive to recovery, Timberline Knolls features residential detox services and round-the-clock care customized to meet each person's needs. This center is distinguished by its dedication to high-quality treatment and specifically designed programs for women aiming for enduring recovery and rehabilitation.

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Therapeutic Wellness Services Inc., located in Baltimore, MD, delivers extensive recovery support. Their offerings include programs for substance dependence, temporary accommodations, and care for dual diagnoses involving addiction and significant mental health conditions or emotional distress. The center features intensive outpatient, extended residential stays, and standard outpatient services. Their therapeutic methods incorporate anger de-escalation, cognitive restructuring, and community-based support with incentives. Specialized initiatives are designed for adult males, adult females, and survivors of domestic abuse. Catering to adults and young adults regardless of gender identity, this establishment prioritizes individualized treatment and assistance for those aiming to conquer addiction and mental health struggles.

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Chicago, IL

Thresholds, situated in Chicago, IL, delivers targeted rehabilitation services for adults grappling with substance use issues and concurrent mental health challenges. The center features a range of options including intensive outpatient programs, standard outpatient services, and treatments involving methadone, buprenorphine, or naltrexone. With an emphasis on evidence-based methods such as cognitive behavioral therapy and motivational interviewing, the center prioritizes personalized care to foster recovery. Specifically tailored to assist clients facing both mental health and substance use disorders, Thresholds offers extensive support for adult men and women aiming to conquer addiction and enhance their emotional health.

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Woodstock, IL

Thresholds, situated in Woodstock, IL, delivers targeted substance abuse recovery services for adults experiencing concurrent mental health challenges. This establishment features robust outpatient programs incorporating cognitive behavioral techniques, motivational dialogue, and addiction counseling. Designed for individuals with dual diagnoses, Thresholds provides outpatient management with methadone, buprenorphine, or naltrexone. Prioritizing excellent care, the center serves adult men and women seeking thorough assistance for addiction and accompanying mental health concerns. For specialized care in a nurturing setting, Thresholds is a resource.

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Situated in Owego, NY, Tioga County Mental Hygiene provides focused outpatient services for individuals struggling with substance use and co-occurring issues in both adults and youth. Emphasizing brief interventions, cognitive behavioral therapy, and the Matrix Model, this center delivers personalized care designed to meet unique requirements. Their specialized programs are aimed at those with dual diagnoses, promoting comprehensive and integrative treatment. Tioga County Mental Hygiene offers outpatient options for methadone, buprenorphine, or naltrexone, catering to male and female clients alike, with a steadfast dedication to delivering high-quality rehabilitation support.

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Situated in Sells, AZ, the Tohono Oodham Dept of Health and Human offers thorough substance use recovery programs for both adults and children facing significant mental health challenges. The center provides various levels of care, including intensive outpatient therapy, day treatment, and partial hospitalization options. With a focus on serving adolescents, adult men, and women, it is equipped to assist individuals of all ages and backgrounds. Incorporating techniques such as 12-step support, anger management strategies, and brief therapeutic interventions, this facility aims to provide exceptional care for adults and seniors on their path to recovery. If you or someone you know is seeking personalized rehabilitation services, this center creates a nurturing and efficient atmosphere for healing.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)