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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Transformations at Mending Fences LLC

Transformations at Mending Fences LLC in Morriston, FL provides thorough addiction recovery services and dedicated support for those facing concurrent serious mental health conditions or emotional distress. This center offers extended residential stays, outpatient care, and day treatment programs, employing methods like 12-step encouragement, impulse control training, and rapid intervention strategies. Featuring distinct programs for active military members, adult males, and adult females, the facility serves adults and young adults across all gender identities. Transformations at Mending Fences LLC is devoted to offering superior, personalized attention to aid individuals in their path toward healing.

Transformations by the Gulf
Saint Petersburg, FL

Nestled in Saint Petersburg, FL, Transformations by the Gulf is a premier addiction recovery facility serving adults and young adults. They provide a spectrum of care, including intensive outpatient, outpatient, and partial hospitalization programs. The center's therapeutic approach incorporates 12-step facilitation, anger management, and brief intervention strategies, addressing the needs of adult men and women, including those with trauma histories. Transformations by the Gulf delivers personalized recovery plans, making it a distinguished choice for effective and caring substance use disorder treatment.

Transformations Treatment Center Inc

Transformations Treatment Center Inc, located in Delray Beach, FL, delivers a range of rehabilitation services including intensive outpatient, outpatient, and day treatment specifically designed for individuals dealing with substance abuse and concurrent mental health issues. The center features dedicated programs aimed at active duty military personnel as well as separate tracks for adult men and women. Clients benefit from various therapeutic methods such as 12-step support, anger management, and brief intervention strategies. Suitable for adults and young adults of all genders, this facility prioritizes personalized care and employs evidence-based techniques to foster a comprehensive recovery experience. Transformations Treatment Center Inc is recognized for its emphasis on high-quality care and extensive support, making it an excellent option for those in search of effective rehabilitation solutions within the Delray Beach community.

Transition House Inc
Saint Cloud, FL

Transition House Inc, located in Saint Cloud, FL, provides extensive treatment options for adult men, seniors, and young adults struggling with substance use. With expertise in handling co-occurring substance use and significant mental health challenges, this center offers a variety of programs, including long-term, short-term, and 24-hour residential services. Utilizing personalized strategies such as 12-step engagement and anger management, the facility is well-equipped to assist active duty military members and individuals facing challenges related to intimate partner violence. Transition House Inc prioritizes high-quality care through targeted interventions and customized treatment plans. If you are looking for effective rehabilitation that addresses multifaceted needs, this center is committed to aiding you on your path to recovery.

Transitions Center

Transitions Center, situated in Tempe, AZ, specializes in outpatient addiction recovery services, including detox, substance use therapy, and integrated care for those facing concurrent mental health and substance use challenges. They utilize evidence-based methods like motivational interviewing and leverage telemedicine/telehealth to deliver methadone, buprenorphine, or naltrexone treatment. Their personalized programs are designed for adolescents, adult men, and adult women, serving all genders from young adults to seniors. Transitions Center is recognized for its thorough approach and dedication to personalized treatment plans, positioning it as a leading facility for effective and empathetic addiction support.

Transitions Inc
Fort Mitchell, KY

Transitions Inc, situated in Fort Mitchell, KY, offers an extensive range of services for substance use treatment along with specialized support for those facing both substance use disorders and severe mental health challenges. The center provides various programs, including long-term, short-term, and residential options, incorporating evidence-based strategies like 12-step facilitation, anger management, and brief interventions. With unique programs designed for active duty military members, adult men and women, Transitions Inc serves a diverse population of adults and young adults. This facility is dedicated to delivering high-quality care and personalized treatment plans to assist individuals in their recovery journey.

Treatment Centers of America LLC

Situated in Port Saint Lucie, FL, Treatment Centers of America LLC presents an extensive array of rehabilitation programs designed for adults and young adults facing challenges related to substance use and concurrent mental health disorders. The center offers services including residential detox, around-the-clock care, and short-term residential initiatives, emphasizing 12-step support, anger management, and brief intervention strategies. With distinct programs tailored for active duty military members, as well as adult men and women, this facility addresses a wide range of demographic needs. By providing customized care for different genders and age groups, the center aims to deliver effective treatment to assist individuals on their recovery journey.

Treatment Solutions of South Florida

Treatment Solutions of South Florida, located in Pompano Beach, provides a wide range of treatment options for adults and young adults dealing with substance use issues alongside mental health disorders. The center features tailored programs that include intensive outpatient, outpatient, and partial hospitalization designed to meet the unique needs of each individual. With dedicated programs for active duty military, men, and women, the facility incorporates various therapeutic methods such as 12-step facilitation, anger management, and brief interventions to foster enduring recovery. Their gender-specific services ensure that each client receives focused and personalized support. Treatment Solutions of South Florida is committed to offering high-quality, evidence-based care to assist individuals in achieving sustainable sobriety and mental well-being.

Treatment Solutions of South Florida

Treatment Solutions of South Florida in Pompano Beach delivers complete recovery services for adults and adolescents. The center features extended stay inpatient housing, inpatient detox, and round-the-clock inpatient support. Through methods like 12-step engagement, emotional regulation training, and short-term counseling, the facility customizes care plans. Dedicated tracks are available for members of the armed forces, adult men, and adult women. Addressing dual diagnoses involving substance abuse and significant mental health conditions, this establishment guarantees high-standard support for all genders.

Tri County Comm Action Agency

Situated in Johnston, RI, the Tri County Comm Action Agency delivers extensive substance abuse services for both adults and children dealing with concurrent mental health issues. The facility specializes in outpatient care, offering treatments such as methadone and buprenorphine, alongside standard outpatient therapy. Emphasizing brief interventions, cognitive behavioral therapy, and motivational interviewing, the center customizes its programs to meet individual needs. Catering to adults and seniors across all gender identities, it adopts a gender-sensitive approach to treatment. With a dedication to high-quality, individualized care, the Tri County Comm Action Agency is recognized for its distinctive programs and research-supported therapeutic methods.

Tratamiento Ambulatorio Adultos

"Tratamiento Ambulatorio Adultos, situated in Fajardo, PR, provides an all-encompassing program for adult substance use issues, including individuals grappling with simultaneous mental health disorders. The center offers a range of services such as intensive outpatient therapy, day treatment programs, and partial hospitalization. By employing evidence-based techniques like cognitive behavioral therapy and anger management strategies, it serves both men and women, along with clients carrying dual diagnoses. Concentrating on the needs of young adults and adults, the program guarantees tailored care for every participant. Discover exceptional, individualized treatment at Tratamiento Ambulatorio Adultos."

Travas House
Lewiston, ME

Travas House, located in Lewiston, ME, specializes in long-term residential treatment for substance use and transitional housing specifically for adult males. This center emphasizes the 12-step program, anger management strategies, and brief intervention methods, aimed at clients who have faced trauma. The services are designed for adults, including seniors and young adults, within a male-only framework. By concentrating on adult men and individuals who have survived trauma, Travas House creates a nurturing and organized environment for those pursuing effective care and recovery assistance.

Travco Behavioral Health Center Inc

Travco Behavioral Health Center Inc, located in Youngstown, OH, provides targeted treatment programs for substance use disorders. This center features a range of services, including intensive outpatient therapy, general outpatient care, and treatments utilizing methadone, buprenorphine, or naltrexone. Employing methods such as anger management, brief interventions, and cognitive behavioral therapy, the center customizes treatment strategies for each patient. It caters to adults and older individuals across all gender identities, delivering high-quality care to both men and women. The center’s commitment to personalized treatment plans distinguishes it, ensuring that every individual receives the specific support needed to pursue their recovery journey.

Tratamiento Residencial

In San Juan, PR, Tratamiento Residencial is a long-term residential treatment center serving adult women who are struggling with substance use disorders alongside significant emotional health challenges. The center features tailored programs for active duty military members, those impacted by intimate partner violence, and survivors of domestic violence. Their therapeutic approaches include 12-step facilitation, anger management techniques, and brief interventions, designed for adults, seniors, and young adults. By providing a secure and nurturing setting specifically for women, Tratamiento Residencial delivers individualized and impactful care for individuals on their path to recovery.

Treatment Centers LLC

Treatment Centers LLC in Salisbury, NC, delivers complete substance abuse care for adults and adolescents. Services include a range of outpatient options like methadone/buprenorphine or naltrexone therapy and standard outpatient care. Emphasizing brief interventions, cognitive behavioral techniques, and motivational interviewing, the center customizes recovery plans. Distinct programs are offered for adult men, adult women, and individuals affected by intimate partner or domestic violence. The facility welcomes both male and female patients, fostering an inclusive atmosphere. Discover effective treatment and specialized support at Treatment Centers LLC.

Transformations Health Services

Transformations Health Services in Cincinnati, OH provides extensive addiction recovery and tailored support for individuals facing dual diagnoses of substance abuse and significant mental health challenges, as well as for children with emotional disruptions. Their structured intensive outpatient and outpatient services, which may involve medication-assisted treatment such as methadone, buprenorphine, or naltrexone, are designed to meet distinct patient requirements. By offering counseling for substance use disorders and incorporating virtual care via telemedicine, the facility guarantees customized support. Emphasizing a personalized strategy, they assist both adults and young individuals of all genders, delivering targeted interventions. Transformations Health Services is dedicated to high standards of care, establishing itself as a trusted provider of successful addiction treatment.

Treatment Centers LLC
Thomasville, NC

Situated in Thomasville, NC, Treatment Centers LLC specializes in tailored programs for substance use recovery. The center offers various treatment options including outpatient care, outpatient methadone/buprenorphine, naltrexone therapy, and standard outpatient services. By employing methods like brief interventions, cognitive behavioral therapy, and motivational interviewing, the facility supports adult men and women, including those affected by intimate partner or domestic violence. Catering to both adults and young adults of all genders, Treatment Centers LLC is committed to providing personalized care and assistance to individuals striving to conquer addiction in a supportive and professional environment.

Transformations Wellness Center

Transformations Wellness Center is situated in Klamath Falls, Oregon, and specializes in long-term residential treatment for substance use in an encouraging atmosphere. This facility offers transitional housing and sober living arrangements for adults of both genders. Emphasizing 12-step principles, anger management, and cognitive behavioral therapy, the program serves adults and young adults in need of thorough addiction rehabilitation. The center features tailored programs for men and women to ensure personalized care and attention. Transformations Wellness Center is committed to delivering effective treatment and assistance to individuals embarking on their recovery journey.

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Wellsville, NY

Situated in Wellsville, NY, Trapping Brook House specializes in long-term residential treatment for adult men dealing with substance use issues. The center features transitional housing and sober living arrangements, emphasizing 12-step programs, anger management, and targeted brief interventions. It particularly serves individuals who have faced trauma or are dealing with dual diagnoses of mental health and substance use disorders, accommodating adults of various ages seeking thorough care within a nurturing setting. With its commitment to high-quality treatment and personalized programming, Trapping Brook House is recognized as a reliable rehabilitation facility for men aspiring to attain enduring recovery.

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Wellsville, NY

Trapping Brook House, situated in Wellsville, NY, provides sustained residential care for individuals struggling with addiction, fostering a nurturing atmosphere. This establishment's expertise lies in offering transitional living accommodations for adult males experiencing dual diagnoses of mental health and substance abuse issues. Their program emphasizes 12-step engagement and strategies for managing anger, while also serving those confronting pain alongside addiction. Men of all ages, including seniors, adults, and younger individuals, can receive excellent care within this continuously staffed residential facility. Trapping Brook House is a prime option for men desiring a thorough and organized path toward regaining sobriety.

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Situated in Allentown, PA, Treatment Trends Inc specializes in a wide range of programs for substance use rehabilitation. The center offers different types of care, including long-term residential, short-term residential, and 24-hour residential services. Emphasizing methods such as 12-step support, anger management, and cognitive behavioral therapy, this facility is designed for adult men, individuals facing both mental health and substance use challenges, as well as those involved in the criminal justice system. Catering to both men and women, Treatment Trends Inc is committed to providing effective, evidence-based treatment that is customized to address the specific needs of each person pursuing recovery from addiction.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)