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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Valley Hope
Cushing, OK

Valley Hope, situated in Cushing, OK, delivers complete addiction recovery care. This center excels in detox and substance abuse treatment for adults and younger individuals. Prioritizing excellent service, Valley Hope features inpatient detox, round-the-clock inpatient stays, and shorter-term residential options. Employing methods like 12-step guidance, concise counseling, and cognitive behavioral techniques, the facility serves both men and women. Distinct programs for veterans and adolescents highlight Valley Hope's adaptable approach to healing. Dedicated to proven methods and tailored support, Valley Hope is recognized as a reliable place for recovery.

Valley Hope of Chandler

Valley Hope of Chandler, located in Chandler, AZ, provides a complete range of addiction recovery services within a nurturing atmosphere. This center specializes in long-term residential care, detoxification, and around-the-clock residential support for both adults and young adults facing substance use challenges. Emphasizing a personalized approach, treatment methodologies include 12-step programs, brief interventions, and cognitive behavioral therapy. The facility also features specialized programs for adult men, women, and those dealing with co-occurring mental health disorders. Valley Hope of Chandler is dedicated to delivering high-quality care and assistance to all clients on their journey to achieve lasting sobriety.

Valley Hope of Denver

Valley Hope of Denver, located in Englewood, CO, delivers thorough substance abuse recovery services for adults and young adults. Their offerings include intensive outpatient programs, standard outpatient services, and medication-assisted treatment options such as methadone, buprenorphine, or naltrexone. This facility emphasizes personalized support, employing methods like 12-step program integration, emotional regulation techniques, and short-term counseling to combat addiction. Valley Hope of Denver serves a diverse clientele, welcoming both men and women into a nurturing atmosphere. For those in search of effective addiction care tailored to individual needs, this center is committed to guiding you toward lasting sobriety.

Valley Hope of Grapevine

Valley Hope of Grapevine, Texas, provides extensive substance abuse treatment for individuals and adolescents. Their offerings include detox, intensive outpatient programs, extended residential care, and standard outpatient services. The center's therapeutic approach incorporates 12-step facilitation, brief intervention techniques, and cognitive behavioral therapy. They feature distinct programs tailored for adult men, adult women, and individuals facing both mental health and substance use challenges, ensuring personalized care in a nurturing setting for all genders. Opt for Valley Hope of Grapevine for scientifically validated treatment and empathetic guidance throughout your recovery path.

Valley Hope of Moundridge

Valley Hope of Moundridge, located in Moundridge, KS, specializes in providing effective services for addiction recovery. The center offers a range of services including detoxification, long-term residential care, and 24-hour support. With techniques such as 12-step programs, brief interventions, and cognitive behavioral therapy, it serves both men and women facing co-occurring mental health and substance abuse issues. Valley Hope of Moundridge is committed to delivering personalized care to adults and young adults of all genders. For those in search of thorough and compassionate addiction treatment, this facility stands out as a top option.

Valley Hope of Norton

Situated in Norton, KS, Valley Hope of Norton delivers a wide range of addiction treatment services tailored for adults and young adults. The center offers detoxification, intensive outpatient programs, outpatient services, and regular outpatient care. Utilizing methods such as 12-step facilitation, anger management, and brief intervention strategies, the facility aims to bolster recovery. Valley Hope of Norton has specialized programs for adult men and women, as well as for those facing co-occurring disorders, ensuring personalized attention for each individual. The center is committed to providing quality care through evidence-based practices, helping clients achieve long-term sobriety.

Valley Hope of ONeill

Situated in O'Neill, NE, Valley Hope of ONeill delivers a wide range of addiction recovery services tailored for adults and young adults. The center features long-term residential care, detoxification, and around-the-clock residential programs, utilizing methodologies like 12-step facilitation, brief interventions, and cognitive behavioral therapy. There are specialized programs designed for adult men, adult women, and those who have faced traumatic experiences. Emphasizing personalized treatment, this facility accommodates clients of all genders, fostering a nurturing and accepting atmosphere for individuals striving to conquer substance use challenges.

Valley Hope of Overland Park

Valley Hope of Overland Park, located in Leawood, KS, provides thorough substance abuse recovery services for adults and young adults. The facility offers intensive outpatient care, standard outpatient programs, and medication-assisted treatment utilizing methadone, buprenorphine, or naltrexone for male and female patients. Employing strategies like 12-step facilitation, brief intervention, and cognitive behavioral therapy, this center crafts individualized treatment plans for each client. Valley Hope of Overland Park is distinguished by its dedication to delivering superior, research-backed treatment within a nurturing atmosphere, positioning it as a leading option for individuals pursuing successful addiction recovery.

Valley Hope of Parker

Valley Hope of Parker, situated in Parker, CO, provides extensive residential rehabilitation services. Their offerings include extended stay residential programs, immediate residential detox, and round-the-clock residential care. These services are designed for adults and young adults facing challenges with substance dependence and requiring detoxification. The center excels in therapeutic interventions such as 12-step program integration, anger management techniques, and brief intervention strategies. Tailored programs are available for adult men, adult women, and individuals managing co-occurring mental health and substance use conditions, ensuring personalized support for all genders. Valley Hope is recognized for delivering high-quality, all-encompassing treatment and is a reliable option for individuals pursuing freedom from addiction and sustained sobriety.

Valley Hope of Wichita

Valley Hope of Wichita, situated in Wichita, KS, delivers tailored substance use disorder interventions for adults and adolescents. Their program offerings encompass intensive outpatient, outpatient, and standard outpatient services. Employing a client-centered philosophy, Valley Hope of Wichita utilizes proven therapeutic modalities, including 12-step support, brief counseling, and cognitive behavioral strategies. The center welcomes both men and women, fostering a nurturing atmosphere for everyone. For those pursuing thorough addiction recovery services with a personalized strategy, this establishment is dedicated to providing excellent treatment to foster enduring sobriety.

Valley Mental Health Inc
Salt Lake City, UT

Valley Mental Health Inc, situated in Salt Lake City, UT, provides an extensive array of rehabilitation services. This center specializes in support for substance abuse, transitional living situations, and sober environments. It emphasizes treatment for co-occurring disorders, addressing the needs of adults with severe mental health conditions as well as children facing emotional challenges. Available treatment options encompass outpatient services, as well as methadone and buprenorphine therapy. The facility employs evidence-based methodologies, including cognitive behavioral therapy and strategies for preventing relapse. Furthermore, there are tailored programs designed for adult men, women, and those who have experienced domestic violence. Catering to adults and young adults across all genders, Valley Mental Health Inc ensures that care is customized to meet the unique requirements of each individual.

Valley Medical and Wellness

Valley Medical and Wellness, located in Burnsville, MN, specializes in extensive treatment for substance use disorders through customized outpatient programs. The center offers outpatient treatments that include methadone, buprenorphine, and naltrexone options, along with regular outpatient services. It also focuses on the unique needs of adolescents, clients facing both mental health and substance use challenges, as well as individuals coping with pain alongside substance use issues. By employing evidence-supported methods such as cognitive behavioral therapy, motivational incentives, and relapse prevention techniques, this facility prioritizes high-quality care for individuals of all ages and genders. Valley Medical and Wellness is committed to assisting clients on their journey towards recovery by providing targeted and effective treatment solutions.

Valley Hope of Omaha

Valley Hope of Omaha in Omaha, NE, delivers diverse substance use recovery options customized for each person. Services include intensive outpatient care, general outpatient support, and partial hospitalization programming. Utilizing approaches like 12-step encouragement, brief counseling, and cognitive behavioral techniques, the facility provides thorough treatment for adult men and women, including active military members. Dedicated tracks are available for various age demographics, encompassing adults and younger adults of all genders. Valley Hope of Omaha is committed to offering high-quality assistance and resources for individuals pursuing successful addiction recovery.

Valley Hope of Tempe

Valley Hope of Tempe, located in Tempe, AZ, provides targeted treatment for substance use disorders aimed at both adults and young adults. The center features programs such as intensive outpatient treatment, general outpatient services, and medication-assisted therapies including methadone, buprenorphine, and naltrexone. Emphasizing methods like 12-step facilitation, brief interventions, and cognitive behavioral therapy, each program is customized to meet the unique needs of individuals. Catering to both men and women, Valley Hope of Tempe delivers a thorough and diverse recovery experience. Clients can anticipate exceptional care and individualized treatment plans designed to facilitate their path to recovery.

Valley Professionals
Terre Haute, IN

Valley Professionals located in Terre Haute, IN, provides outpatient care for adults facing substance use challenges, while also addressing concurrent mental health issues with a customized strategy. The center specializes in outpatient treatment using methadone, buprenorphine, or naltrexone, and employs methods such as 12-step facilitation, anger management, and brief interventions. Catering to both men and women, including young adults, Valley Professionals is distinguished by its holistic and individualized treatment approaches. Committed to delivering high-quality care and a variety of therapeutic options, this facility is an excellent choice for individuals in the Terre Haute region seeking effective rehabilitation.

Valley Oaks Health
Crawfordsville, IN

Valley Oaks Health in Crawfordsville, IN, delivers comprehensive outpatient care for individuals struggling with substance use and co-occurring mental health conditions, serving both youth and adults. Employing evidence-based practices such as cognitive behavioral therapy and motivational interviewing, the center facilitates brief intervention strategies within a nurturing setting. Valley Oaks Health is particularly adept at supporting clients within the criminal justice system, assisting both men and women across adult and senior age groups. The availability of outpatient methadone and buprenorphine treatment underscores their commitment to personalized, high-quality recovery support. For those in need of integrated rehabilitation, including dual diagnosis and specialized interventions, Valley Oaks Health is committed to fostering sustained healing.

Valley Oaks Health
Monticello, IN

Valley Oaks Health in Monticello, IN, delivers complete care for adults struggling with substance misuse, particularly those also experiencing mental health challenges. Their offerings include intensive outpatient, standard outpatient, and regular outpatient care. Employing methods like anger management, brief intervention, and cognitive behavioral therapy, Valley Oaks Health customizes recovery plans. The facility also features dedicated programs for adult women and serves a broad range of individuals, including adults and older adults of all genders. Valley Oaks Health is recognized for its high standards of care and individualized approach, positioning it as a leading option for those pursuing effective recovery within a nurturing setting.

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Valley Hope of Boonville, located in Boonville, MO, provides extensive substance abuse treatment for adults and young adults. They offer services including detoxification, intensive outpatient programs, day treatment, and partial hospitalization. Employing approaches like 12-step facilitation, brief interventions, and cognitive behavioral therapy, the center customizes care to each person's unique requirements. Dedicated tracks are available for adult men and women, ensuring appropriate support for all. Valley Hope of Boonville is committed to delivering high-quality care, with distinct programs for each gender. For those in search of effective addiction recovery in a nurturing setting, this facility is devoted to guiding individuals toward sustained sobriety.

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Valley Oaks Health, located in Attica, IN, provides outpatient services for substance use disorders while also addressing co-existing serious mental health issues in adults and significant emotional challenges in children. The center employs various therapeutic methods, including brief interventions, cognitive behavioral therapy, and motivational interviewing. They offer structured outpatient programs designed for adults and older adults of any gender. Notably, Valley Oaks Health features unique programs aimed at assisting survivors of intimate partner or domestic violence. Committed to delivering quality care driven by evidence-based practices, the center focuses on empowering individuals as they navigate their recovery journey.

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Rensselaer, IN

Valley Oaks Health, located in Rensselaer, IN, provides outpatient services for individuals of all ages dealing with substance use disorders, particularly those facing concurrent significant mental health challenges. The facility specializes in administering methadone, buprenorphine, and naltrexone treatments, alongside traditional outpatient therapies. Emphasizing techniques such as anger management, cognitive behavioral therapy, and motivational interviewing, the program is customized to meet the unique needs of each person. Valley Oaks Health serves both men and women, fostering an inclusive and gender-informed treatment atmosphere. This center is notable for its dedication to crafting individualized treatment plans and employing effective, evidence-based therapeutic methods aimed at supporting long-term recovery.

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Otterbein, IN

Valley Oaks Health in Otterbein, IN, delivers outpatient care for adults and youth dealing with substance use disorders alongside significant mental health challenges. Employing proven techniques such as brief intervention, cognitive behavioral therapy, and motivational interviewing, the center prioritizes a trauma-informed approach. Catering to individuals of all ages and genders, including seniors, Valley Oaks Health offers standard outpatient services, emphasizing high-quality treatment and personalized assistance. For those in search of thorough and empathetic recovery support, Valley Oaks Health is committed to guiding you toward healing.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)