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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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COPE Community Services Inc

Located in Tucson, AZ, COPE Community Services Inc delivers both intensive outpatient and standard outpatient treatment for substance use issues aimed at adults and young adults. This center focuses on individuals with dual mental health challenges, offering therapy rooted in cognitive behavioral methods and strategies for managing anger. Their program incorporates contingency management to encourage successful recovery. Designed specifically for those with trauma backgrounds, they also tackle substance use disorders. Featuring distinct programs for male and female participants, COPE Community Services Inc ensures holistic support for those facing addiction and mental health obstacles.

CPF Breakthrough LLC

CPF Breakthrough LLC, located in Spokane, WA, provides extensive care for substance use disorders, utilizing several program structures, including intensive outpatient, standard outpatient, and day treatment (partial hospitalization). Their approach emphasizes 12-step facilitation, anger management techniques, and brief intervention strategies. CPF Breakthrough LLC is equipped to support active military members, as well as adult men and women. They extend their services to both young adults and adults of any gender, offering customized treatment plans. This facility is devoted to delivering high-quality, varied therapeutic options to support individuals on their journey to sustained sobriety.

CRC Health Treatment Clinics LLC

CRC Health Treatment Clinics LLC located in Port Saint Lucie, FL, provides extensive treatment options for adults and young adults dealing with substance use issues. This facility is particularly adept at addressing co-occurring substance use disorders alongside significant mental health challenges or emotional issues. Offering outpatient services that feature methadone and buprenorphine treatments, the center employs a range of methodologies, including 12-step facilitation, anger management, and concise interventions. By emphasizing personalized care, CRC Health Treatment Clinics LLC ensures that each client receives a treatment plan tailored to their unique needs. Serving both men and women, the center is dedicated to delivering high-quality support for recovery and overall well-being.

COPE Community Services Inc

COPE Community Services Inc, located in Tucson, AZ, is dedicated to providing targeted addiction recovery services for adults and young adults facing concurrent mental health challenges. This center features robust intensive outpatient and outpatient offerings, which include medication-assisted treatment with methadone or buprenorphine. Their methodology is grounded in proven techniques like cognitive behavioral therapy and anger management, further enhanced by specialized interventions for individuals who have experienced trauma or have dual diagnoses, guaranteeing holistic support. COPE Community Services Inc is distinguished by its individualized treatment strategies and its unwavering dedication to assisting all clients, male and female alike, in their journey toward lasting sobriety.

CPC Integrated Health

CPC Integrated Health, situated in Red Bank, New Jersey, provides targeted recovery programs for adults and young adults managing addiction and related mental health conditions. Their services include comprehensive outpatient treatment, standard outpatient care, and medication-assisted treatment utilizing methadone, buprenorphine, or naltrexone. The center emphasizes therapeutic approaches such as anger management, brief intervention, and cognitive behavioral therapy, creating individualized plans for adult men and women, particularly those affected by intimate partner or domestic violence. CPC Integrated Health fosters a secure environment for all clients, committed to high-quality support and healing for those on their journey to wellness.

CORE Health
Longview, WA

CORE Health in Longview, WA, delivers comprehensive outpatient and intensive outpatient substance use disorder recovery services. They cater to adults and young adults grappling with co-occurring serious mental health conditions. The center offers tailored support for active duty military, adult men, and women. Their therapeutic modalities encompass 12-step facilitation, anger management techniques, and brief intervention strategies. Emphasizing personalized recovery plans, CORE Health provides outpatient medication-assisted treatment options including methadone, buprenorphine, or naltrexone. Serving both genders, CORE Health is dedicated to providing high-quality rehabilitative care, customized to meet the distinct requirements of every patient.

CORE Medical Clinic Inc

CORE Medical Clinic Inc. in Sacramento, California, provides outpatient services for individuals struggling with substance use disorders. The clinic employs proven methods such as cognitive behavioral therapy, motivational interviewing, and relapse prevention techniques. Services are available for adults, young people, and expectant or new mothers. The center also offers tailored programs for individuals facing co-occurring mental health and substance use issues, as well as those navigating the legal system. Both male and female clients can access outpatient treatment, which may include medication-assisted treatment with methadone, buprenorphine, or naltrexone, in addition to standard outpatient support. CORE Medical Clinic is committed to delivering high-quality, personalized care to assist individuals on their journey to recovery.

CPC Integrated Health

CPC Integrated Health, situated in Matawan, NJ, provides extensive support for adults and young adults facing substance use challenges. This center is particularly adept at addressing co-occurring substance use disorders alongside significant mental health issues or emotional difficulties in children. Emphasizing intensive outpatient programs, regular outpatient services, and outpatient treatments using methadone, buprenorphine, or naltrexone, CPC Integrated Health employs a variety of evidence-based strategies, including anger management, brief interventions, and cognitive behavioral therapy. They also offer specialized programs designed for adult men and women, as well as those who have survived intimate partner or domestic violence. Committed to delivering high-quality care, this center aims to assist individuals throughout their recovery process.

CPC Integrated Health

CPC Integrated Health, situated in Howell, NJ, provides an extensive range of treatment options for substance use and co-occurring disorders for both adults and children. The center offers intensive outpatient and outpatient programs along with specialized services including anger management and cognitive behavioral therapy. Focusing on personalized care, CPC Integrated Health has distinct programs designed for adolescents, adult men, and adult women. Emphasizing a client-focused philosophy, the facility serves individuals of all genders in need of effective addiction treatment and mental health support, fostering a nurturing setting for recovery.

CPC Integrated Health

CPC Integrated Health in Freehold, NJ, delivers extensive care for addiction and dual diagnoses involving significant mental health conditions. They offer robust outpatient programs, including intensive options and medication-assisted treatment with methadone, buprenorphine, or naltrexone. Their therapeutic framework incorporates anger management, brief intervention strategies, and cognitive behavioral therapy. CPC Integrated Health provides personalized recovery plans for teens, adult males, and adult females, supporting clients of all ages and genders in their journey toward wellness.

CRASH Inc
San Diego, CA

CRASH Inc, situated in San Diego, CA, stands as a leading facility dedicated to providing advanced care for individuals battling substance use disorders and co-occurring mental health conditions in adults, as well as addressing serious emotional disturbances in children. The center offers diverse care modalities, including inpatient hospital stays, extended residential programs, and round-the-clock residential services, ensuring robust support for adults, older adults, and young adults across all genders. CRASH Inc distinguishes itself with specialized services catering to adult men, adult women, and those who have endured intimate partner or domestic violence. Employing evidence-based strategies such as 12-step facilitation, anger management techniques, and brief intervention methods, this institution guarantees excellent, personalized treatment plans.

CREOKS Health Services

CREOKS Health Services, located in Stilwell, OK, specializes in outpatient care for adults dealing with substance use and accompanying mental health challenges, as well as addressing emotional issues in children. The center offers a variety of programs, including 12-step support, anger management courses, and quick intervention strategies. There are specialized services available for active-duty military, teenagers, and adult men. This facility is committed to serving individuals of all genders across age groups, including seniors. By emphasizing evidence-based practices and individualized treatment plans, this center aims to deliver exceptional care to foster the recovery process. If you are in need of tailored rehabilitation options that meet your specific circumstances, this center is committed to offering thorough assistance and support.

CRI Help Inc
North Hollywood, CA

Situated in North Hollywood, CA, CRI Help Inc delivers an extensive variety of rehabilitation options for both adults and young adults facing substance use challenges. The center features long-term residential accommodations, detoxification services, and round-the-clock residential programs. Emphasizing methods such as 12-step facilitation, anger management, and brief interventions, CRI Help Inc customizes treatment plans to address the unique requirements of each individual. It also provides specialized programs for adult men, adult women, and those who have faced intimate partner or domestic violence. With a commitment to offering gender-specific care for both sexes, this facility guarantees compassionate and effective support for individuals striving to conquer addiction.

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COPE Community Services Inc, located in Tucson, AZ, provides holistic substance abuse treatment for both adults and children who also face mental health challenges. The center features intensive outpatient services, outpatient programs, and targeted therapies, including cognitive behavioral therapy and anger management strategies. Emphasizing support for clients with a history of trauma, the treatment is customized to accommodate personal requirements. There are dedicated programs designed for adolescents and young adults, as well as individuals experiencing dual diagnoses. Committed to delivering exceptional care, COPE Community Services Inc caters to male and female individuals in need of successful rehabilitation options.

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Situated in Kansas City, MO, the COPS Outpatient Treatment Program delivers thorough substance use rehabilitation services for both adults and young adults. This center features a variety of programs, including intensive outpatient treatment, outpatient services, and standard outpatient therapies. Emphasizing high-quality care, the facility employs evidence-based methodologies such as brief intervention, cognitive behavioral therapy, and contingency management with motivational incentives. Tailored programs are offered for adult men, women, seniors, and older individuals. The center is inclusive, catering to both male and female clients to provide personalized recovery support for all individuals battling addiction.

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West Sacramento, CA

CORE Medical Clinic Inc, located in West Sacramento, CA, provides extensive outpatient treatment for substance use for both adults and children/adolescents. The center features dedicated programs specifically for pregnant or postpartum women and clients involved with the criminal justice system. Emphasizing techniques such as cognitive behavioral therapy, motivational interviewing, and strategies for relapse prevention, the clinic customizes its treatment approaches to meet the unique needs of each patient. Catering to both males and females, the services offered include outpatient treatment options with methadone, buprenorphine, or naltrexone, in addition to regular outpatient care. CORE Medical Clinic Inc is committed to delivering high-standard, evidence-supported treatment to facilitate individuals in their recovery journey.

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Spokane, WA

CPF Colonial in Spokane, WA, provides comprehensive outpatient and intensive outpatient programs for individuals of all ages struggling with substance use and co-occurring mental health conditions. Their therapeutic approach incorporates brief intervention, cognitive behavioral therapy, and motivational interviewing, ensuring personalized treatment plans for adult men and women, as well as adolescents. The center excels in supporting clients with dual diagnoses, serving both male and female populations. CPF Colonial stands out as a leading facility for those in the Spokane region requiring in-depth recovery services.

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Situated in Tahlequah, OK, CREOKS Health Services delivers extensive outpatient rehabilitation options for individuals grappling with substance use and concurrent mental health issues, serving both adults and children. The center employs a structured outpatient model that incorporates evidence-supported methods, including 12-step facilitation, anger management techniques, and brief intervention strategies. Tailored programs are available for active military members, teenagers, adult males, and individuals of all ages and genders. With a strong emphasis on personalized care and tailored treatment strategies, this center is dedicated to supporting clients in reaching sustainable recovery and mental health improvement.

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Situated in Sallisaw, OK, CREOKS Health Services delivers extensive outpatient care for individuals facing substance use issues and co-occurring mental health conditions, catering to both adults and children. The center employs targeted strategies such as 12-step facilitation, anger management, and brief interventions to enhance recovery. It features specific programs designed for various demographics, including active duty military personnel, teenagers, and adult males. CREOKS Health Services is committed to providing high-quality support to adults and seniors of all backgrounds who are on their journey toward rehabilitation.

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CRHPC Comprehensive Behav Health Ctr, located in Du Quoin, IL, offers a variety of outpatient services designed for adults and seniors facing challenges with substance use disorders and concurrent mental health conditions. The center specializes in detoxification and treatment for substance use, as well as addressing severe emotional disturbances through therapeutic interventions. It provides outpatient detox options alongside methadone and buprenorphine treatment. The focus includes substance use disorder counseling and telehealth therapy, accommodating active duty military members, adolescents, and adult males. With customized programs for both genders, CRHPC Comprehensive Behav Health Ctr is dedicated to providing exceptional care to those in need.

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CT Renaissance Waterbury Outpatient, located in Waterbury, CT, provides a variety of outpatient services including intensive outpatient treatment and medication-assisted therapies such as methadone, buprenorphine, and naltrexone for addressing substance use disorders. The center employs techniques such as cognitive behavioral therapy, brief interventions, and anger management. It caters to adolescents, adult men, and women, offering tailored programs for individuals of all ages and genders. CT Renaissance Waterbury Outpatient is dedicated to delivering personalized care that meets the unique needs of each client, supporting their recovery journey through diverse treatment options.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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